e 4031 has been researched along with piperidines in 308 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 134 (43.51) | 18.2507 |
| 2000's | 96 (31.17) | 29.6817 |
| 2010's | 71 (23.05) | 24.3611 |
| 2020's | 7 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Colatsky, TJ; Parsons, RW; Spinelli, W | 1 |
| Arita, M; Kiyosue, T; Sato, T; Wu, B | 1 |
| Grundke, M; Ravens, U; Wettwer, E | 1 |
| Holahan, MA; Lynch, JJ; Stabilito, II; Stranieri, MT | 1 |
| Chinn, K; Martin, CL | 1 |
| Sanguinetti, MC | 1 |
| Anumonwo, JM; Freeman, LC; Kass, RS; Kwok, WM | 1 |
| Sugimoto, T; Yamashita, T | 1 |
| Gehret, JR; Heaney, LA; Lynch, JJ; Selnick, HG; Stein, RB; Wallace, AA | 1 |
| Adaniya, H; Hiraoka, M | 1 |
| Baskin, EP; Cingolani, HE; Lynch, JJ; Stein, RB; Wiedmann, RT | 1 |
| Chi, LG; Lucchesi, BR; Mu, DX | 1 |
| Himmel, H; Ravens, U; Schaad, A; Scholtysik, G; Wettwer, E | 1 |
| Inoue, H; Nozaki, A; Saihara, S; Sugimoto, T; Usui, M; Yamashita, T | 1 |
| Baskin, EP; Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Serik, CM; Wallace, AA | 1 |
| Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Stupienski, RF; Wallace, AA | 1 |
| Jurkiewicz, NK; Sanguinetti, MC | 2 |
| Inoue, H; Nozaki, A; Sugimoto, T; Usui, M; Yamashita, T | 1 |
| Inoue, H; Nozaki, A; Sugimoto, T; Yamashita, T | 1 |
| Dzwonczyk, S; Grover, GJ; Sargent, CA; Sleph, PG; Smith, MA | 1 |
| Jurkiewicz, NK; Sanguinetti, MC; Scott, A; Siegl, PK | 1 |
| Colatsky, TJ; Follmer, CH | 1 |
| Cingolani, HE; Lynch, JJ; Scott, AL; Siegl, PK; Stein, RB; Wenger, HC; Wiedmann, RT | 1 |
| Hanaki, Y; Ozawa, T; Sano, T; Shimada, Y; Sugiyama, S; Taki, K | 1 |
| Furuno, I; Katoh, H; Nakamura, Y; Ogawa, S; Saeki, K; Sato, Y; Yoh, S | 1 |
| Brunden, MN; Buchanan, LV; Gibson, JK; Kabell, G | 1 |
| Krafte, DS; Volberg, WA | 1 |
| Fujiki, A; Inoue, H; Mizumaki, K; Shimono, M; Tani, M | 1 |
| Kane, KA; McIntosh, MA; Pacini, D; Tanira, M | 1 |
| Ohler, A; Ravens, U | 1 |
| Ajiki, K; Inoue, H; Iwasawa, K; Murakawa, Y; Oikawa, N; Omata, M; Sezaki, K; Usui, M; Yamashita, T | 1 |
| Baskin, EP; Lynch, JJ | 2 |
| Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Sakai, R; Shirayama, T | 1 |
| Ito, H; Ono, K | 2 |
| Giles, WR; Habuchi, Y; Imaizumi, Y; Muraki, K; Watanabe, M | 1 |
| Black, SC; Chi, L; Fagbemi, SO; Kuo, PI; Lucchesi, BR | 1 |
| Inoue, H; Saihara, S; Sugimoto, T; Usui, M | 1 |
| Centurion, OA; Fukatani, M; Hashiba, K; Hirata, T; Kaibara, M; Kapuku, G; Shimizu, A; Yano, K | 1 |
| Anumonwo, JM; Delmar, M; Liu, Y; Taffet, SM | 1 |
| Kanno, M; Nakaya, H; Tohse, N | 1 |
| Baskin, EP; Guinosso, PJ; Hamill, T; Lynch, JJ; Nutt, EM; Salata, JJ; Woods, CM | 1 |
| Hara, Y; Masuda, Y; Mori, K; Nakaya, H; Saito, T | 1 |
| Ajiki, K; Inoue, H; Iwasawa, K; Murakawa, Y; Nakajima, T; Oikawa, N; Omata, M; Sezaki, K; Usui, M; Yamashita, T | 1 |
| Chiba, S; Furukawa, Y; Kasama, M; Oguchi, T; Sawaki, S | 1 |
| Gintant, GA | 2 |
| Brochu, RM; Clay, JR; Kristof, AS; Shenasa, J; Shrier, A | 1 |
| Bouman, LN; Bourier, J; van Ginneken, AC; Verheijck, EE | 1 |
| Fermini, B; Nattel, S; Wang, Z | 1 |
| MacKenzie, I; Saville, VL; Waterfall, JF | 1 |
| Katoh, H; Mitamura, H; Ogawa, S | 1 |
| Centurion, OA; Fukatani, M; Isomoto, S; Konoe, A; Shimizu, A; Yano, K | 1 |
| Colatsky, TJ; Moubarak, IF; Parsons, RW; Spinelli, W | 1 |
| Ajiki, K; Inoue, H; Murakawa, Y; Nakajima, T; Ohkawa, S; Oikawa, N; Sugimoto, T; Usui, M; Yamashita, T | 1 |
| Ishii, K; Taira, N; Yamagishi, T | 1 |
| Abrahamsson, C; Carlsson, L; Duker, G; Lundberg, C | 1 |
| Bril, A; Gout, B; Landais, L | 1 |
| Hayashi, Y; Kamibayashi, T; Kawabata, K; Sumikawa, K; Takada, K; Yamatodani, A; Yoshiya, I | 1 |
| Akaishi, M; Handa, S; Iwanaga, S; Ogawa, S; Okada, Y; Sadanaga, T; Tsutsumi, N; Yoshikawa, T | 1 |
| Clark, CD; Hume, JR; Levesque, PC; Rosenshtraukh, LV; Zakarov, SI | 1 |
| Bouman, LN; van Ginneken, AC; Veldkamp, MW | 1 |
| Lee, EW; Lee, KS; Tsai, TD | 1 |
| Centurion, OA; Fukatani, M; Isomoto, S; Kaibara, M; Konoe, A; Shimizu, A; Yano, K | 1 |
| Bouman, LN; Opthof, T; van Ginneken, AC; Veldkamp, MW | 1 |
| Mitamura, H; Ogawa, S; Okada, Y; Sadanaga, T | 1 |
| Clay, JR; Ogbaghebriel, A; Paquette, T; Sasyniuk, BI; Shrier, A | 1 |
| Curran, ME; Keating, MT; Sanguinetti, MC; Spector, PS | 1 |
| Hancox, JC; Howarth, FC; Levi, AJ | 1 |
| Chiba, S; Furukawa, Y; Hoyano, Y; Imamura, H; Kasama, M; Nakano, H | 1 |
| Carrier, M; Feng, J; Li, GR; Nattel, S; Yue, L | 1 |
| Hashimoto, K; Motomura, S; Yamada, A | 1 |
| Chiba, S; Furukawa, Y; Imamura, H; Kasama, M; Yamazaki, K | 1 |
| Gibson, KJ; Groh, WJ; Maylie, JG | 2 |
| Cheng, J; Kamiya, K; Kodama, I; Toyama, J | 1 |
| Sanguinetti, MC; Sudo, GZ | 1 |
| Ajiki, K; Murakawa, Y; Omata, M; Sezaki, K; Yamashita, T | 1 |
| Bursill, JA; Campbell, TJ; Martin, DK; West, PD; Wyse, KR | 1 |
| Heath, BM; Terrar, DA | 2 |
| Masuda, Y; Mori, K; Nakaya, H; Saito, T | 1 |
| Chiba, S; Furukawa, Y; Hoyano, Y; Imamura, H; Kasama, M; Nakano, H; Yamazaki, K | 1 |
| Fujiki, H; Mori, T; Orito, K; Takase, H | 1 |
| Arcangeli, A; Faravelli, L; Olivotto, M; Wanke, E | 1 |
| Herness, MS; Sun, XD | 1 |
| Guo, W; Kamiya, K; Toyama, J | 1 |
| Asano, Y; Baxter, WT; Davidenko, JM; Gray, RA; Jalife, J | 1 |
| Bauer, CK; Schwarz, JR; Weinsberg, F | 1 |
| Feng, J; Li, GR; Nattel, S; Wang, Z | 1 |
| Brachmann, J; Bygrave, A; Camm, AJ; Katritsis, D; Morgan, J; O'Farrell, D; Rowland, E | 1 |
| Ehara, T; Matsuura, H | 1 |
| Liu, S; Morales, MJ; Rasmusson, RL; Strauss, HC; Wang, S | 1 |
| Cheng, J; Kamiya, K; Kodama, I; Lee, JK; Suzuki, R; Toyama, J | 1 |
| Fan, Z; Gong, Q; January, CT; Makielski, JC; Robertson, GA; Ye, B; Zhou, Z | 1 |
| Chiba, S; Furukawa, Y; Hirose, M; Hoyano, Y; Lakhe, M; Nagashima, Y | 1 |
| Clay, JR; Ogbaghebriel, A; Paquette, T; Shrier, A | 1 |
| Chiba, S; Furukawa, Y; Hoyano, Y; Imamura, H; Kasama, M; Yonezawa, T | 1 |
| Bril, A; Cheval, B; Faivre, JF; Forest, MC | 1 |
| Boyden, PA; Pinto, JM | 1 |
| Bril, A; Faivre, JF; Rouanet, S | 1 |
| Aizawa, Y; Naitoh, N; Takahashi, K; Washizuka, T | 1 |
| Danilo, P; Hara, M; Rosen, MR | 1 |
| Bauer, CK | 1 |
| Herzberg, IM; Robertson, GA; Trudeau, MC | 1 |
| Ebihara, Y; Hasegawa, H; Nakamura, Y; Shinmura, K; Tani, M | 1 |
| Antzelevitch, C; Burashnikov, A | 2 |
| Charpentier, F; Escande, D; Le Marec, H; Merot, J; Riochet, D | 1 |
| Aizawa, Y; Furushima, H; Naitoh, N; Tagawa, M; Taneda, K; Yamaura, M | 1 |
| Rocchetti, M; Rosati, B; Wanke, E; Zaza, A | 1 |
| Jones, SE; McDonald, TF; Ogura, T; Shuba, LM | 1 |
| Ebert, SN; Katchman, A; Liu, XK; Woosley, RL | 1 |
| Chiba, S; Furukawa, Y; Hoyano, Y; Kasama, M; Oguchi, T | 1 |
| Furuno, I; Kanki, H; Mitamura, H; Ogawa, S; Sueyoshi, K; Takatsuki, S | 1 |
| Boyett, MR; Honjo, H; Kodama, I; Nikmaram, MR; Niwa, R; Yamamoto, M | 1 |
| Iost, N; Opincariu, M; Papp, JG; Szécsi, J; Varró, A; Virág, L | 1 |
| Johns, DC; Marbán, E; Nuss, HB | 1 |
| Kubota, I; Tachibana, H; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S | 1 |
| Bauer, CK; Hanganu, I; Reid, G; Schäfer, R; Schiemann, D; Schwarz, JR | 1 |
| Chiba, S; Furukawa, Y; Hirose, M; Kurogouchi, F; Miyashita, Y; Nakajima, K | 1 |
| Breit, SN; Bursill, JA; Campbell, TJ; Qiu, MR; Singleton, CB; Tie, H; Valenzuela, SM; Walker, BD; Wyse, KR | 1 |
| Goto, A; Hazama, H; Iwasawa, K; Morita, T; Nakajima, T; Oonuma, H; Wang, Y | 1 |
| Bauer, CK; Schwarz, JR | 1 |
| Meves, H; Schwarz, JR; Wulfsen, I | 1 |
| Imaizumi, Y; Muraki, K; Tokuno, T; Watanabe, M | 1 |
| Meves, H | 1 |
| Gong, Q; January, CT; Zhou, Z | 1 |
| Cheng, J; Kamiya, K; Kodama, I; Liu, W; Toyama, J; Tsuji, Y | 1 |
| Bril, A; Faivre, JF; Forest, MC; Gout, B | 1 |
| Hancox, JC; Mitcheson, JS | 1 |
| Baláti, B; Csaba, L; Iost, N; Lathrop, DA; Papp, JG; Takács, J; Tálosi, L; Varro, A; Virág, L | 1 |
| Earm, YE; Ho, WK; Youm, JB | 1 |
| Iijima, T; Ono, K; Shibata, S | 2 |
| Bianchi, L; Castaldo, P; Emmi, A; Janigro, D; Nerbonne, J; Robertson, GA; Schwartzkroin, PA; Taglialatela, M; Wenzel, HJ | 1 |
| Kanki, H; Mitamura, H; Ogawa, S; Sueyoshi, K; Takatsuki, S | 1 |
| January, CT; Xie, JT; Yuan, CS; Zhou, Z | 1 |
| Kondo, M; Mashima, S; Tsutsumi, T | 1 |
| Kubota, I; Miyashita, T; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S | 1 |
| Charpentier, F; Debailleul, M; Gerlach, U; Le Marec, H; Mérot, J; Moise, NS; Probst, V | 1 |
| Kamiya, K; Kodama, I; Liu, W; Lu, Z; Opthof, T; Tsuji, Y; Yasui, K | 1 |
| January, CT; Studenik, CR; Zhou, Z | 1 |
| Iost, N; Lathrop, DA; Lengyel, C; Papp, JG; Varró, A; Virág, L | 1 |
| Bogáts, G; Iost, N; Opincariu, M; Papp, JG; Szécsi, J; Szenohradszky, P; Szolnoky, J; Varró, A; Virág, L | 1 |
| Choi, BR; Liu, T; Salama, G | 1 |
| Carl, A; Kenyon, JL; Sanders, KM | 1 |
| Lu, JY; Wu, BW; Wu, DM | 1 |
| Danilo, P; de Groot, JR; Feinmark, S; Gainullin, R; Plotnikov, AN; Rosen, MR; Rosenshtraukh, L; Shvilkin, A; Xiong, W | 1 |
| Besana, A; Gurrola, GB; Possani, LD; Rocchetti, M; Zaza, A | 1 |
| Kamiya, K; Kodama, I; Lu, Z; Opthof, T; Yasui, K | 1 |
| Boyett, MR; Honjo, H; Kodama, I; Lei, M | 1 |
| Chartier, D; Han, W; Li, D; Nattel, S | 1 |
| Fukuda, K; Kato, T; Kodama, H; Miyoshi, S; Ogawa, S; Tahara, S | 1 |
| Kobayashi, S; Masuda, Y; Nakaya, H; Ogura, T; Reien, Y; Saito, T | 1 |
| Imai, T; Koike, K; Okamoto, T; Shigenobu, K; Tanaka, H; Tanaka, Y; Yamamoto, Y | 1 |
| Brown, AM; Ficker, E; Obejero-Paz, CA; Zhao, S | 1 |
| Asakura, K; Imaizumi, Y; Muraki, K; Ohya, S; Watanabe, M | 1 |
| Bouman, LN; Verheijck, EE; Wilders, R | 1 |
| Colas, A; Pages, N; Sauviat, MP | 1 |
| Avery, MJ; DePasquale, MJ; Fossa, AA; Leishman, DJ; Raunig, DL | 1 |
| Burton, F; Choi, BR; Salama, G | 1 |
| Cui, XL; Wu, BW; Zhao, LY | 1 |
| Kubota, I; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S; Yuuki, K | 1 |
| Rasmusson, RL; Strauss, HC | 1 |
| Satoh, H | 1 |
| Liu, YC; Wu, SN | 1 |
| Arulkumaran, S; Hill, SJ; Khan, RN; Liu, B | 1 |
| Endoh, M; Ishii, K; Nagai, M; Takahashi, M | 1 |
| Hara, M; Kanki, H; Kurita, Y; Mitamura, H; Ogawa, S; Sato, T; Shinagawa, K; Shiroshita-Takeshita, A; Takatsuki, S | 1 |
| Callaghan, BP; Farrelly, AM; Fleming, N; Horowitz, B; Keef, KD; Khoyi, MA; Ro, S; Sanders, KM | 1 |
| Aiba, T; Hidaka, I; Inagaki, M; Shimizu, W; Sunagawa, K; Tatewaki, T | 1 |
| Akbarali, HI; Golden, CM; Huizinga, JD; Wang, XY; Ye, J; Zhu, Y | 1 |
| Adachi, H; Kakiki, M; Kerns, WD; Kimura, J; Lansdell, K; Mizuno, H; Saito, M; Sawa, Y | 1 |
| Baek, HJ; Ho, WK; Lee, EH; Lee, SH; Lim, W; Rhim, H; Ryu, SY | 1 |
| Cook, DI; Day, ML; Johnson, MH; McConnell, JM; Winston, NJ | 1 |
| Clark, RB; Couette, B; Giles, WR; Lueger, A; Mangoni, ME; Nargeot, J | 1 |
| Gilmour, RF; Hua, F | 1 |
| Avery, M; Fermini, B; Fossa, AA; Raunig, DL; Wang, E; Wisialowski, T; Wolfgang, E | 1 |
| Anderson, CL; Gong, Q; January, CT; Zhou, Z | 1 |
| Antzelevitch, C; Di Diego, JM; Fish, JM; Nesterenko, V | 1 |
| Han, H; Long, H; Wang, H; Wang, J; Wang, Z; Xu, D; Zhang, Y | 1 |
| Pan, YP; Wang, XL; Xu, XH | 1 |
| Belardinelli, L; Shryock, JC; Song, Y; Wu, L | 1 |
| de Groot, MJ; Helliwell, R; Leishman, D; Mitcheson, J; Perry, M; Sanguinetti, MC; Tristani-Firouzi, M | 1 |
| Antzelevitch, C; Belardinelli, L; Burashnikov, A; Cordeiro, JM; Di Diego, JM; Fish, JM; Thomas, G; Zygmunt, AC | 1 |
| Crimin, K; Fossa, AA; Gorczyca, W; Magnano, A; Raunig, DL; Winslow, R; Wisialowski, T; Wolfgang, E | 1 |
| Boyle, KM; Carroll, JL; Kim, I | 1 |
| Bellocq, C; Charpentier, F; Chevallier, JC; Clancy, CE; Demolombe, S; El Harchi, A; Escande, D; Lande, G; Le Quang, K; Loussouarn, G; Mazurais, D; Motoike, HK; Piron, J; Royer, A; Terrenoire, C; Toumaniantz, G | 1 |
| Chan, AP; Guppy, LJ; Leung, MW; So, PP; Walker, MJ | 1 |
| Aiba, T; Ding, WG; Horie, M; Inagaki, M; Matsuura, H; Miyoshi, S; Noda, T; Shimizu, W; Sunagawa, K; Toyoda, F; Zankov, DP | 1 |
| Carmeliet, E; Carmeliet, P; Collen, D; Devriendt, K; Gewillig, M; Heidbüchel, H; Jongbloed, RJ; Mubagwa, K; Rossenbacker, T; Vereecke, J | 1 |
| Abe, J; Hamada, Y; Harada, T; Hashimoto, K; Horii, I; Sawada, Y; Shiotani, M | 1 |
| Dinglasan, JN; Feng, W; Gratton, MA; Mu, KJ; Nie, L; Yamoah, EN | 1 |
| Crimin, K; Fossa, AA; Wisialowski, T | 1 |
| Gong, Q; Jones, MA; Zhou, Z | 1 |
| Kamiya, K; Mitcheson, JS; Niwa, R; Sanguinetti, MC | 1 |
| Boldyriev, OI; Dosenko, VIe; Lazarenko, PM; Shuba, IaM; Sotkis, HV; Tumanovs'ka, LV; Voĭtychuk, OI | 1 |
| Bányász, T; Birinyi, P; Horváth, B; Magyar, J; Nánási, PP; Szentandrássy, N | 1 |
| Hayashi, Y; Ito, I; Iwasaki, M; Kamibayashi, T; Kawai, Y; Mashimo, T; Takada, K; Yamatodani, A | 1 |
| Anderson, CL; Anson, BD; Delisle, BP; Eckhardt, LL; Gillman, BM; Holzem, KM; January, CT; Klemens, CA; Makielski, JC; Rajamani, S; Valdivia, CR | 1 |
| Haverinen, J; Vornanen, M | 1 |
| Andersson, B; Carlsson, L; Duker, G; Jacobson, I; Persson, F | 1 |
| Jin, ZX; Li, SZ; Wang, B; Wei, GZ; Wong, TM; Wu, F; Zang, YM; Zhou, JJ | 1 |
| Bazwinsky, I; Klemenz, A; Mühlbauer, E; Peschke, E; Wolgast, S | 1 |
| Grunnet, M; Hansen, RS; Olesen, SP | 1 |
| Guo, J; Kirshenbaum, LA; Li, W; Luo, T; Massaeli, H; Shaw, J; Xu, J; Zhang, S | 1 |
| Cox, BF; Fischer, C; Gintant, GA; Limberis, JT; Long, MA; Martin, RL; Mikhail, A; Patel, A; Su, Z | 1 |
| Assef, YA; Cavarra, MS; del Mónaco, SM; Ibarra, C; Kotsias, BA | 1 |
| Coker, SJ; Dempster, J; Kane, KA; Michael, G | 1 |
| Bauer, CK; Glassmeier, G; Mewe, M; Middendorff, R; Schuster, AM; Schwarz, JR; Wulfsen, I | 1 |
| Coker, SJ; Kane, KA; Michael, G | 1 |
| Blay, J; Cowley, EA; Linsdell, P; Roy, J; Vantol, B | 1 |
| Grunnet, M; Hansen, RS; Olesen, SP; Rønn, LC | 1 |
| Foster, JA; Huizinga, JD; Park, SJ; White, EJ | 1 |
| Ackerman, MJ; He, JQ; O'Hara, TJ; Phartiyal, P; Robertson, GA; Rudy, Y; Sale, H; Tester, DJ; Wang, J | 1 |
| Faje, A; Hayashi, C; Iino, K; Matsushita, F; Nakamura, H; Oki, Y; Yamashita, M | 1 |
| Cheng, H; Hancox, JC; Orchard, CH; Smith, GL | 1 |
| Limón, A; Pérez, C; Soto, E; Vega, R | 1 |
| Imai, YN; Oiki, S; Ryu, S | 1 |
| Forsythe, ID; Hardman, RM | 1 |
| Chen, X; Du, W; Du, YM; Fan, L; Guo, L; Huang, S; Jie, S; Li, H; Liu, W; Zhang, S; Zhu, J; Zou, A | 1 |
| Block, BA; Galli, GL; Lipnick, MS | 1 |
| Altmannsberger, M; Bockhorn, H; Dolderer, JH; Jonas, D; Lambers, C; Linke, R; Schröder, UH; Schuldes, H; Schwegler, H; von Zabern, D | 1 |
| Belardinelli, L; January, CT; Li, H; Rajamani, S; Shryock, JC; Wu, L | 1 |
| Bauer, CK; Hirdes, W; Napp, N; Schwarz, JR; Schweizer, M; Wulfsen, I | 1 |
| Nakamura, M; Namekata, I; Sakurai, Y; Sasaki, R; Sendo, A; Takahara, A; Tanaka, H | 1 |
| Castle, NA; Gerlach, AC; Stoehr, SJ | 1 |
| Ahrens-Nicklas, RC; Christini, DJ | 1 |
| Clancy, CE; Furukawa, T; Kurokawa, J; Yang, PC | 1 |
| Grunnet, M; Larsen, AP; Olesen, SP; Poelzing, S | 1 |
| Bauer, CK; Mauerhöfer, M; Mewe, M; Schwarz, JR; Szlachta, K; Wulfsen, I; Zhou, XB | 1 |
| Ahara, S; Aizawa, Y; Chinushi, M; Furushima, H; Hosaka, Y; Iijima, K; Izumi, D; Komura, S; Sanada, A; Yagihara, N | 1 |
| Ding, WG; Horie, M; Isono, T; Matsuura, H; Omatsu-Kanbe, M; Toyoda, F; Zankov, DP | 1 |
| Ehmke, H; Friederich, P; Kebernik, J; Schwoerer, AP | 1 |
| Ding, WG; Kawai, H; Maeda, K; Maegawa, H; Matsuura, H; Nakamura, H; Sanada, M | 1 |
| Accordi, B; Amedei, A; Arcangeli, A; Basso, G; Becchetti, A; Campana, D; Cilia, E; Crociani, O; D'Amico, M; De Lorenzo, E; Masselli, M; Pillozzi, S; Veltroni, M | 1 |
| Abi-Gerges, N; Holkham, H; Jones, EM; Pollard, CE; Robertson, GA; Valentin, JP | 1 |
| Belardinelli, L; Bers, DM; Grandi, E; Li, H; Luo, A; Ma, J; Shryock, JC; Wang, C; Wu, L; Zhang, P | 1 |
| Chauhan, VS; Gao, X; Mihic, A; Oudit, GY; Tsushima, RG | 1 |
| Bartos, DC; Delisle, BP; January, CT; McBride, CM; Nataraj, PS; Smith, JL | 1 |
| Du, W; Huang, S; Li, H; Zheng, F | 1 |
| Beekman, JD; de Boer, TP; Duker, G; Houtman, MJ; Jonsson, MK; Nalos, L; Peschar, M; Rook, MB; Sartipy, P; Thomsen, MB; van der Heyden, MA; van der Nagel, R; van Veen, TA; Varkevisser, R; Vos, MA | 1 |
| Brussee, J; IJzerman, AP; Klaasse, E; Overman, J; Scheel, O; Vilums, M | 1 |
| Bauer, CK; Glassmeier, G; Hempel, K; Schumacher, U; Schwarz, JR; Wulfsen, I | 1 |
| Hihara, T; Ito, M; Kohmura, N; Sawada, K; Taniguchi, T; Yamazaki, K; Yoshinaga, T | 1 |
| Bauriedl, J; Bussek, A; Lohmann, H; Ravens, U; Schmidt, M; Wettwer, E | 1 |
| Du, W; Huang, S; Li, H; Li, J; Wang, N; Zheng, F | 1 |
| Fujii, M; Imaizumi, Y; Ohya, S; Yamamura, H | 1 |
| Fossa, AA; Jeyaraj, D; Rosenbaum, DS; Said, TH; Wilson, LD | 1 |
| Bányász, T; Bárándi, L; Farkas, V; Hegyi, B; Horváth, B; Magyar, J; Márton, I; Nánási, PP; Ruzsnavszky, F; Szentandrássy, N | 1 |
| Ashihara, T; Honjo, H; Inada, S; Kamiya, K; Kato, S; Kodama, I; Nakazawa, K; Okuno, Y; Opthof, T; Sakuma, I; Suzuki, T; Takanari, H; Takemoto, Y | 1 |
| Canavier, CC; Horn, JP; Huertas, MA; Ji, H; Levitan, ES; Putzier, I; Shepard, PD; Tucker, KR | 1 |
| Antzelevitch, C; Barajas-Martínez, H; Cordeiro, JM; Desai, M; Di Diego, JM; Doss, MX; Goodrow, RJ; Hu, D; Nesterenko, VV; Sachinidis, A; Treat, JA; Urrutia, J; Wu, Y | 1 |
| Kurose, Y; Nakatsuji, N; Otsuji, TG; Suemori, H; Tada, M | 1 |
| Andersson, A; Andersson, U; Brask, J; Danielsson, B; Danielsson, C; Elinder, F; Genead, R; Grinnemo, KH; Hellmold, H; Pehrson, R; Salari, S; Sköld, AC; Stockling, K; Sylvén, C | 1 |
| Borek, B; Gabriels, J; Glass, L; Hodge, A; Shajahan, TK; Shrier, A | 1 |
| Aguilar, M; Glass, L; Hodge, A; Kim, MY; McVicar, N; Quail, T; Shrier, A | 1 |
| Franco, D | 1 |
| Agarwal, A; Jing, L; Patwardhan, A | 1 |
| Anderson, CL; Bartos, DC; Delisle, BP; Horie, M; January, CT; Moss, AJ; Nataraj, PS; Ohno, S; Reloj, AR; Schroder, EA; Smith, JL | 1 |
| Bode, C; Brunner, M; Cabrera Lozoya, R; Föll, D; Franke, G; Jung, BA; Koren, G; Lang, CN; Menza, M; Odening, KE; Perez Feliz, S; Relan, J; Sermesant, M; Zehender, M; Ziupa, D | 1 |
| Antzelevitch, C; Burashnikov, A; Cordeiro, JM; Di Diego, JM; Goodrow, R; Nesterenko, VV; Panama, BK; Treat, JA; White, C; Zeina, T; Zygmunt, AC | 1 |
| Deng, J; Lin, L; Lv, JG; Wang, WL; Zhang, CT; Zhang, SS; Zhao, CQ; Zhao, JY | 1 |
| Chen, A; Fowlkes, C; Grosberg, A; Khine, M; Lee, E; Santiago, K; Tu, R | 1 |
| Helson, L; Mukerjee, A; Ranjan, AP; Vishwanatha, JK | 1 |
| Arcangeli, A; Caderni, G; Carraresi, L; De Lorenzo, E; Femia, AP; Fiore, A; Fortunato, A; Lastraioli, E; Morabito, A; Polvani, S | 1 |
| Ando, K; Kanda, Y; Matsuo, J; Miyamoto, N; Nakamura, Y; Ojima, A; Sawada, K; Sekino, Y; Sugiyama, A | 1 |
| Ando, K; Cao, X; Izumi-Nakaseko, H; Nakamura, Y; Ohara, H; Sugiyama, A; Ueda, N; Yamazaki, Y | 1 |
| Beck, J; Bode, C; Brunner, M; Franke, G; Hartmann, M; Koren, G; Odening, KE; Perez Feliz, S; Zehender, M; Ziupa, D | 1 |
| Ando, T; Furukawa, T; Hayakawa, T; Kanda, Y; Kobayashi, S; Kunihiro, T; Kurokawa, J; Matsui, E; Yada, H | 1 |
| Bai, XJ; Hao, JT | 1 |
| Antzelevitch, C; Belardinelli, L; Burashnikov, A | 1 |
| Acharya, S; Poulos, J; Schmidt, J; Vijayvergiya, V | 1 |
| Dahlenborg, K; Kunze, A; Sartipy, P; Steel, D; Svedhem, S | 1 |
| Ebana, Y; Furukawa, T; Harada, N; Honda, S; Kodama, M; Kurokawa, J; Li, M; Nakaya, H; Sasano, T | 1 |
| Ando, K; Izumi-Nakaseko, H; Matsuo, J; Nakamura, Y; Sekino, Y; Sugiyama, A | 1 |
| Efimov, IR; Ewald, GA; Glukhov, AV; Gomez, JF; Holzem, KM; Koppel, AC; Madden, EJ; Trenor, B | 1 |
| Aikawa, N; Suzuki, Y; Takaba, K | 1 |
| Cheng, K; Kong, LH; Lai, D; Liu, B; Shen, M; Wu, F; Yi, F; Zhang, JY; Zhou, JJ | 1 |
| Bai, L; Guo, X; Huo, J; Liu, P; Ma, A; Qiang, H; Zhang, A | 1 |
| Clark, PA; Eliceiri, KW; Kuo, JS; Pointer, KB; Robertson, GA; Salamat, MS | 1 |
| Ando, H; Asakura, K; Hayashi, S; Kanda, Y; Kasai, C; Miyamoto, N; Ojima, A; Osada, T; Sawada, K; Sekino, Y; Sugiyama, A; Taniguchi, T; Tashibu, H; Uda, T; Yamamoto, W; Yamazaki, D; Yoshinaga, T | 1 |
| Bai, S; Cao, H; Dong, H; Jiang, J; Ma, Y; Pei, F; Tian, L; Yang, C; Zhao, Y | 1 |
| Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Nakamura, Y; Sugiyama, A; Wada, T; Yamazaki, H | 1 |
| Ma, J; Song, Z; Wang, J; Wang, S; Wang, X; Zhao, Q | 1 |
| Jimbo, Y; Nakasono, S; Saito, A; Takahashi, M | 1 |
| Ashihara, T; Furukawa, T; Hayashi, E; Kanda, Y; Kodama, M; Kurokawa, J; Li, M; Nakai, Y; Sasano, T; Sekino, Y | 1 |
| Luo, C; Wang, K; Zhang, H | 2 |
| Belardinelli, L; El-Bizri, N; Li, CH; Liu, GX; Rajamani, S | 1 |
| Ding, WG; Fujii, Y; Fukumoto, D; Fukuyama, M; Horie, M; Ichikawa, M; Itoh, H; Kato, K; Makiyama, T; Matsuura, H; Ohno, S; Omatsu-Kanbe, M; Takayama, K; Wada, Y | 1 |
| Ando, K; Chiba, K; Goto, A; Hagiwara-Nagasawa, M; Izumi-Nakaseko, H; Naito, AT; Sugiyama, A | 1 |
| Beck, J; Bode, C; Brunner, M; Bugger, H; Foell, D; Franke, G; Jung, BA; Koppermann, S; Koren, G; Mayer, S; Menza, M; Moss, R; Odening, KE; Perez Feliz, S; Seemann, G; Zehender, M; Ziupa, D | 1 |
| Chiba, K; Goto, A; Hagiwara-Nagasawa, M; Izumi-Nakaseko, H; Kanda, Y; Naito, AT; Sekino, Y; Sugiyama, A | 1 |
| Bal, R; Yildirim, C | 1 |
| Bakkers, J; de Boer, TP; Knöpfel, T; Kok, BJM; Koopman, CD; Orger, MB; Renninger, SL; van Opbergen, CJM; van Veen, TAB; Vos, MA | 1 |
| Bot, CT; Cordeiro, JM; Goodrow, RJ; Haedo, RJ; Treat, JA | 1 |
| Aly, KA; Babu, M; Cayabyab, FS; Fonge, H; He, S; Islam, S; Moutaoufik, MT; Persad, A; Wu, A | 1 |
| Charpentier, F; De Waard, M; De Waard, S; Forest, V; Gaborit, N; Lemarchand, P; Loussouarn, G; Mangoni, ME; Montnach, J; Nicolas, S; Ribeiro, B; Ronjat, M | 1 |
| Brandão, KO; Davis, RP; de Korte, T; Grandela, C; Miller, DC; Mol, MPH; Mummery, CL; Sala, L; Tertoolen, LGJ; van den Brink, L; van Meer, BJ; Verkerk, AO | 1 |
| Burnham, MP; Fertig, N; Haddrick, M; Harvey, R; Sargeant, R | 1 |
| Akashi, M; Harada, A; Ito, E; Matsusaki, M; Miyagawa, S; Mochizuki-Oda, N; Sawa, Y; Takeda, M | 1 |
| Abi-Gerges, N; Cotta, T; Espinoza, A; Geft, V; Ghetti, A; Hernandez, E; Indersmitten, T; Macias, A; Mai, C; Miller, PE; Miron, Y; Nguyen, W; Page, G; Rasoul, L; Stafford, A; Sweat, K; Ton, AT; Truong, K; Wong, T | 1 |
| Fukuda, K; Ieda, M; Kurokawa, J; Sakamoto, K; Sugimoto, M; Sugimoto, S; Suzuki, T; Tamura, F; Yamaguchi, M | 1 |
3 review(s) available for e 4031 and piperidines
| Article | Year |
|---|---|
Modulation of potassium channels by antiarrhythmic and antihypertensive drugs.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Muscle, Smooth; Phenethylamines; Piperidines; Potassium Channels; Pyridines; Sulfonamides | 1992 |
A review of the effects of three cardioactive agents on the electrical activity from embryonic chick heart cell aggregates: TTX, ACh, and E-4031.
Topics: Acetylcholine; Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Cell Aggregation; Cells, Cultured; Chick Embryo; Heart; Models, Biological; Myocardial Contraction; Myocardium; Patch-Clamp Techniques; Piperidines; Pyridines; Sulfanilamides; Tetrodotoxin | 1994 |
HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential.
Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Carcinogenesis; Cell Movement; Cell Proliferation; Epigenesis, Genetic; ERG1 Potassium Channel; Fluoxetine; Gene Expression Regulation, Neoplastic; Humans; Integrin beta1; Long QT Syndrome; Membrane Potentials; Molecular Docking Simulation; Mutation; Myocytes, Cardiac; Neoplasms; Piperidines; Protein Conformation, alpha-Helical; Protein Interaction Mapping; Protein Structure, Quaternary; Pyridines; Signal Transduction; STAT1 Transcription Factor; Sulfanilamides | 2020 |
1 trial(s) available for e 4031 and piperidines
| Article | Year |
|---|---|
Assessment of reverse use-dependent blocking actions of class III antiarrhythmic drugs by 24-hour Holter electrocardiography.
Topics: Adult; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Piperidines; Pyridines; Pyrimidinones; Regression Analysis; Sotalol; Statistics, Nonparametric; Sulfonamides | 1996 |
304 other study(ies) available for e 4031 and piperidines
| Article | Year |
|---|---|
Effects of WAY-123,398, a new class III antiarrhythmic agent, on cardiac refractoriness and ventricular fibrillation threshold in anesthetized dogs: a comparison with UK-68798, E-4031, and dl-sotalol.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzimidazoles; Dogs; Electrocardiography; Electrophysiology; Female; Heart; Heart Conduction System; Hemodynamics; In Vitro Techniques; Male; Phenethylamines; Piperidines; Purkinje Fibers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfanilamides; Sulfonamides; Ventricular Fibrillation | 1992 |
Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs.
Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Dinitrophenols; Disopyramide; Flecainide; Glyburide; Guinea Pigs; Heart Ventricles; Imidazoles; Lidocaine; Mexiletine; Myocardium; Piperidines; Potassium; Procainamide; Pyridines | 1992 |
Differential effects of the new class III antiarrhythmic agents almokalant, E-4031 and D-sotalol, and of quinidine, on delayed rectifier currents in guinea pig ventricular myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; In Vitro Techniques; Muscles; Piperidines; Potassium; Potassium Channels; Propanolamines; Pyridines; Quinidine; Sotalol; Time Factors | 1992 |
Effect of E-4031, a class III antiarrhythmic agent, on experimental infarct size in a canine model of myocardial ischemia-reperfusion injury.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Dogs; Female; Hemodynamics; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Piperidines; Pyridines; Ventricular Fibrillation | 1992 |
Contribution of delayed rectifier and inward rectifier to repolarization of the action potential: pharmacologic separation.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzopyrans; Chromans; Chromones; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Membrane Potentials; Microelectrodes; Papillary Muscles; Piperidines; Potassium Channels; Pyridines | 1992 |
Delayed rectification in single cells isolated from guinea pig sinoatrial node.
Topics: Animals; Anti-Arrhythmia Agents; Electrophysiology; Guinea Pigs; In Vitro Techniques; Lanthanum; Membrane Potentials; Piperidines; Potassium; Potassium Channels; Pyridines; Sinoatrial Node | 1992 |
[Medical management of arrhythmias; newer antiarrhythmic drugs].
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Chlorobenzenes; Flecainide; Humans; Membrane Potentials; Moricizine; Piperidines; Propylamines; Pyridines; Sodium Channels | 1991 |
Suppression of lethal ischemic ventricular arrhythmias by the class III agent E4031 in a canine model of previous myocardial infarction.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Blood Pressure; Chloralose; Dogs; Electric Stimulation; Electrocardiography; Electrophysiology; Female; Heart; Male; Myocardial Infarction; Piperidines; Pyridines; Refractory Period, Electrophysiological | 1990 |
Effects of a novel class III antiarrhythmic agent, E-4031, on reentrant tachycardias in rabbit right atrium.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Electric Stimulation; Heart; Heart Atria; In Vitro Techniques; Myocardial Reperfusion; Piperidines; Pyridines; Rabbits; Refractory Period, Electrophysiological; Tachycardia | 1990 |
Myocardial contractile behavior of a new sotalol derivative.
Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Depression, Chemical; Dogs; Electrocardiography; Female; Male; Muscle Relaxation; Myocardial Contraction; Papillary Muscles; Piperidines; Pyridines; Rabbits; Sotalol | 1991 |
Electrophysiology and antiarrhythmic actions of E-4031 in the experimental animal model of sudden coronary death.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Disease; Death, Sudden; Dogs; Electric Stimulation; Electrocardiography; Electrophysiology; Heart Rate; Male; Piperidines; Pyridines; Ventricular Fibrillation | 1991 |
Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Male; Myocardial Contraction; Papillary Muscles; Piperidines; Potassium; Pyridines; Refractory Period, Electrophysiological | 1991 |
Effects of pentisomide and E-4031 on canine atrial flutter due to reentry: a comparative study with disopyramide and propafenone.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Flutter; Disopyramide; Dogs; Electrocardiography; Electrophysiology; Heart Conduction System; Piperidines; Propafenone; Propylamines; Pyridines; Refractory Period, Electrophysiological | 1991 |
Effects of new and potent methanesulfonanilide class III antiarrhythmic agents on myocardial refractoriness and contractility in isolated cardiac muscle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Ferrets; Heart; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides; Temperature | 1991 |
Cardiac electrophysiologic and inotropic actions of new and potent methanesulfonanilide class III antiarrhythmic agents in anesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiology; Female; Heart; Hemodynamics; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides | 1991 |
Delayed rectifier outward K+ current is composed of two currents in guinea pig atrial cells.
Topics: Animals; Anti-Arrhythmia Agents; Buffers; Calcium; Cobalt; Egtazic Acid; Electric Conductivity; Guinea Pigs; Heart; Heart Atria; Kinetics; Myocardium; Nisoldipine; Piperidines; Potassium; Pyridines | 1991 |
Antiarrhythmic drugs preferentially produce conduction block at the area of slow conduction in the re-entrant circuit of canine atrial flutter: comparative study of disopyramide, flecainide, and E-4031.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Flutter; Disopyramide; Dogs; Flecainide; Heart Conduction System; Piperidines; Pyridines | 1991 |
Effects of antiarrhythmic drugs on canine atrial flutter due to reentry: role of prolongation of refractory period and depression of conduction to excitable gap.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Flutter; Cardiac Pacing, Artificial; Disopyramide; Dogs; Electrocardiography; Flecainide; Heart Conduction System; Piperidines; Propafenone; Pyridines; Refractory Period, Electrophysiological | 1991 |
Effect of potassium channel blockade on the anti-ischemic actions of mechanistically diverse agents.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Lidocaine; Male; Piperidines; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred Strains | 1991 |
Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes. Mechanism of action.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cell Separation; Electric Conductivity; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Myocardium; Papillary Muscles; Piperidines; Pyridines; Refractory Period, Electrophysiological | 1991 |
Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytes.
Topics: Animals; Cats; Electric Conductivity; Flecainide; Heart; Heart Ventricles; Myocardium; Osmolar Concentration; Piperidines; Potassium; Pyridines | 1990 |
Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Calcium Channels; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Membrane Potentials; Microelectrodes; Myocardium; Nisoldipine; Ouabain; Piperidines; Potassium Channels; Pyridines; Sodium Channels | 1990 |
Negative lusitropic effect of DPI 201-106 and E4031. Possible role of prolonging action potential duration.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Dogs; Female; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Piperazines; Piperidines; Pyridines; Time Factors | 1990 |
Effects of antiarrhythmic agents classified as class III group on ischaemia-induced myocardial damage in canine hearts.
Topics: Acetylglucosaminidase; Amiodarone; Anesthesia; Animals; Anti-Arrhythmia Agents; Blood Pressure; Coronary Disease; Coronary Vessels; Dogs; Electrocardiography; Female; Heart Rate; In Vitro Techniques; Lysosomes; Male; Mitochondria, Heart; Piperidines; Pyridines; Sotalol | 1990 |
Electrophysiologic effects of E-4031, a class III antiarrhythmic agent, on re-entrant ventricular arrhythmias in a canine 7-day-old myocardial infarction model.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Electric Stimulation; Electrodes; Electrophysiology; Heart Conduction System; Infusions, Intravenous; Myocardial Infarction; Piperidines; Pyridines; Tachycardia | 1990 |
Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Heart Conduction System; Heart Rate; Male; Methoxamine; Phenethylamines; Piperidines; Pyridines; Quaternary Ammonium Compounds; Rabbits; Software; Sotalol; Sulfonamides; Torsades de Pointes | 1993 |
Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Phenethylamines; Piperidines; Procainamide; Pyridines; Sotalol; Stereoisomerism; Sulfonamides; Ventricular Function | 1994 |
Electrophysiologic effects of intravenous E-4031, a novel class III antiarrhythmic agent, in patients with supraventricular tachyarrhythmias.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Electrophysiology; Female; Heart Conduction System; Heart Rate; Humans; Injections, Intravenous; Male; Middle Aged; Piperidines; Pyridines; Refractory Period, Electrophysiological; Tachycardia, Supraventricular | 1994 |
Comparison of the cardiac electrophysiologic effects of NE-10064 with sotalol and E-4031 and their modification by simulated ischaemia.
Topics: Animals; Anti-Arrhythmia Agents; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Myocardial Ischemia; Piperazines; Piperidines; Purkinje Fibers; Pyridines; Sheep; Sotalol | 1994 |
Effects of E-4031, almokalant and tedisamil on postrest action potential duration of human papillary muscles.
Topics: Action Potentials; Adult; Aged; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Female; Heart; Humans; In Vitro Techniques; Ion Channels; Male; Middle Aged; Piperidines; Propanolamines; Pyridines | 1994 |
Shock-induced refractory period extension and pharmacologic modulation of defibrillation threshold.
Topics: Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Electric Countershock; Electric Stimulation; Flecainide; Heart; Infusions, Intravenous; Piperidines; Pyridines; Reproducibility of Results | 1994 |
Comparative effects of increased extracellular potassium and pacing frequency on the class III activities of methanesulfonanilide IKr blockers dofetilide, D-sotalol, E-4031, and MK-499.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Electric Stimulation; Ferrets; Male; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides | 1994 |
Effects of E-4031 on atrial fibrillation threshold in guinea pig atria: comparative study with class I antiarrhythmic drugs.
Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Disopyramide; Electric Stimulation; Female; Flecainide; Guinea Pigs; Heart Atria; Heart Conduction System; In Vitro Techniques; Lidocaine; Male; Piperidines; Procainamide; Pyridines; Refractory Period, Electrophysiological | 1994 |
A rapidly activating delayed rectifier K+ channel in rabbit sinoatrial node cells.
Topics: Animals; Anti-Arrhythmia Agents; Electrophysiology; Homeostasis; Piperidines; Potassium Channels; Probability; Pyridines; Rabbits; Sinoatrial Node | 1995 |
Role of rapidly activating delayed rectifier K+ current in sinoatrial node pacemaker activity.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Computer Simulation; Electrophysiology; Heart Rate; Kinetics; Models, Cardiovascular; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines; Rabbits; Sinoatrial Node | 1995 |
Delayed rectifier K+ current in rabbit atrial myocytes.
Topics: 4-Aminopyridine; Action Potentials; Animals; Atrial Function; Electrophysiology; Kinetics; Myocardium; Piperidines; Potassium; Pyridines; Rabbits; Time Factors | 1995 |
Actions of pinacidil at a reduced potassium concentration: a direct cardiac effect possibly involving the ATP-dependent potassium channel.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Guanidines; Heart; Hemodynamics; In Vitro Techniques; Myocardial Contraction; Myocardium; Oxygen Consumption; Pinacidil; Piperidines; Potassium; Potassium Channels; Pyridines; Rabbits; Ventricular Fibrillation | 1993 |
Antifibrillatory effects of class III antiarrhythmic drugs: comparative study with flecainide.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Dogs; Electric Stimulation; Flecainide; Heart Conduction System; Piperidines; Pyridines; Sotalol; Ventricular Fibrillation | 1993 |
Electrophysiologic effects of a new class III antiarrhythmic agent, E-4031, on atrial flutter, atrial refractoriness, and conduction delay in a canine sterile pericarditis model.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dogs; Electric Stimulation; Electrophysiology; Heart; Heart Conduction System; Models, Cardiovascular; Pericarditis; Piperidines; Pyridines | 1993 |
Characterization of an E4031-sensitive potassium current in quiescent AT-1 cells.
Topics: Animals; Heart Neoplasms; Membrane Potentials; Mice; Mice, Transgenic; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines; Tumor Cells, Cultured | 1994 |
[Electropharmacological properties of class III antiarrhythmic drugs].
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Heart; In Vitro Techniques; Piperidines; Pyridines; Pyrimidinones; Rabbits | 1994 |
Comparison of binding to rapidly activating delayed rectifier K+ channel, IKr, and effects on myocardial refractoriness for class III antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Chromans; Electrophysiology; Guinea Pigs; Heart Ventricles; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Procainamide; Pyridines; Sotalol; Structure-Activity Relationship; Sulfonamides; Tritium | 1995 |
Anticholinergic effects of class III antiarrhythmic drugs in guinea pig atrial cells. Different molecular mechanisms.
Topics: Acetylcholine; Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Atrial Function, Left; Cells, Cultured; Guinea Pigs; Heart Atria; In Vitro Techniques; Myocardial Contraction; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines; Pyrimidinones; Receptors, Muscarinic; Sotalol | 1995 |
Effect of isoproterenol on facilitation of electrical defibrillation by E-4031.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Dogs; Drug Interactions; Electric Countershock; Electric Stimulation; Electrophysiology; Heart Rate; Injections, Intravenous; Isoproterenol; Piperidines; Pyridines | 1995 |
Are negative chronotropic and inotropic responses to adenosine differentiated at the receptor or postreceptor levels in isolated dog hearts?
Topics: 2-Chloroadenosine; 4-Aminopyridine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzazepines; Depression, Chemical; Dogs; Heart Rate; In Vitro Techniques; Myocardial Contraction; Piperidines; Pyridines; Receptors, Purinergic P1; Xanthines | 1995 |
Regional differences in IK density in canine left ventricle: role of IK,s in electrical heterogeneity.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Electrophysiology; Homeostasis; Myocardium; Pericardium; Piperidines; Pyridines; Ventricular Function, Left | 1995 |
Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Diastole; Electrophysiology; Female; In Vitro Techniques; Male; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; Piperidines; Pyridines; Rabbits; Sinoatrial Node | 1995 |
Rapid and slow components of delayed rectifier current in human atrial myocytes.
Topics: Arrhythmias, Cardiac; Cells, Cultured; Coronary Disease; Heart Atria; Humans; Membrane Potentials; Middle Aged; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines | 1994 |
Differential class III and glibenclamide effects on action potential duration in guinea-pig papillary muscle during normoxia and hypoxia/ischaemia.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Glyburide; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Microelectrodes; Myocardial Ischemia; Papillary Muscles; Piperidines; Potassium Channels; Pyrazines; Pyridines; Sotalol | 1993 |
Effect of E-4031, a new class III antiarrhythmic drug, on reentrant ventricular arrhythmias: comparison with conventional class I drugs.
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disease Models, Animal; Disopyramide; Dogs; Electrophysiology; Flecainide; Myocardial Infarction; Piperidines; Potassium Channel Blockers; Pyridines; Tachycardia, Ventricular | 1993 |
Electrophysiological effects of a new class III antiarrhythmic agent (E-4031) on the conduction and refractoriness of the in vivo human atrium.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Evaluation; Electrophysiology; Heart; Heart Atria; Humans; Middle Aged; Piperidines; Pyridines | 1993 |
Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzimidazoles; Cats; Cells, Cultured; Culture Techniques; Dogs; Dose-Response Relationship, Drug; Myocardium; Phenethylamines; Piperidines; Potassium Channels; Purkinje Fibers; Pyridines; Sotalol; Sulfanilamides; Sulfonamides | 1993 |
Slow abnormal conduction in the low right atrium: its anatomic basis and relevance to atrial reentry.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Flutter; Atrial Function, Right; Dogs; Electric Stimulation; Electrocardiography; Female; Heart Atria; Heart Block; Heart Conduction System; Lidocaine; Male; Piperidines; Pyridines; Refractory Period, Electrophysiological; Time Factors | 1994 |
Absence of effects of class III antiarrhythmic agents on cloned cardiac K channels.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Cloning, Molecular; Electrophysiology; Myocardium; Oocytes; Piperidines; Potassium Channels; Pyridines; Pyrimidinones; Quinidine; Sotalol; Xenopus laevis | 1993 |
Electrophysiological and inotropic effects of H 234/09 (almokalant) in vitro: a comparison with two other novel IK blocking drugs, UK-68,798 (dofetilide) and E-4031.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cats; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Phenethylamines; Piperidines; Propanolamines; Purkinje Fibers; Pyridines; Rabbits; Stimulation, Chemical; Sulfonamides | 1993 |
Actions and interactions of E-4031 and tedisamil on reperfusion-induced arrhythmias and QT interval in rat in vivo.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Heart Rate; Male; Piperidines; Pyridines; Rats; Rats, Wistar; Reperfusion Injury | 1993 |
Comparative efficacy of antiarrhythmic agents in preventing halothane-epinephrine arrhythmias in rats.
Topics: Amiodarone; Anesthesia, Inhalation; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Epinephrine; Flecainide; Halothane; Isoflurane; Lidocaine; Male; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Verapamil | 1993 |
Clinical evaluation of the use-dependent QRS prolongation and the reverse use-dependent QT prolongation of class I and class III antiarrhythmic agents and their value in predicting efficacy.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography, Ambulatory; Exercise Test; Female; Heart Rate; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Piperidines; Potassium Channels; Pyridines; Sodium Channels | 1993 |
Anion and cation modulation of the guinea-pig ventricular action potential during beta-adrenoceptor stimulation.
Topics: Action Potentials; Animals; Anions; Anthracenes; Anti-Arrhythmia Agents; Calcium Channels; Cations; Chloride Channels; Cyclic AMP; Guinea Pigs; Heart; Isoproterenol; Membrane Proteins; Piperidines; Potassium Channels; Pyridines; Receptors, Adrenergic, beta; Ventricular Function | 1993 |
Single delayed rectifier channels in the membrane of rabbit ventricular myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cell Membrane; Electrophysiology; Heart Ventricles; Myocardium; Piperidines; Potassium Channels; Pyridines; Rabbits; Time Factors | 1993 |
Membrane activity of class III antiarrhythmic compounds; a comparison between ibutilide, d-sotalol, E-4031, sematilide and dofetilide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Phenethylamines; Piperidines; Potassium Channels; Procainamide; Pyridines; Sotalol; Sulfonamides | 1993 |
Electrophysiologic effects of E-4031, a new class III antiarrhythmic agent, in patients with supraventricular tachyarrhythmias.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Electrocardiography; Female; Humans; Male; Middle Aged; Piperidines; Pyridines; Tachycardia, Supraventricular | 1993 |
Delayed rectifier channels in human ventricular myocytes.
Topics: Action Potentials; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Cells, Cultured; Heart Ventricles; Humans; Myocardial Ischemia; Myocardium; Piperidines; Potassium Channels; Pyridines | 1995 |
A quantitative description of the E-4031-sensitive repolarization current in rabbit ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Biophysical Phenomena; Biophysics; Drug Resistance; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Ion Channel Gating; Ion Transport; Kinetics; Membrane Potentials; Models, Biological; Myocardium; Piperidines; Potassium; Potassium Channels; Pyridines; Rabbits | 1995 |
Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cation Transport Proteins; Cells, Cultured; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ion Channel Gating; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Trans-Activators; Transcriptional Regulator ERG; Xenopus | 1996 |
Characteristics of the delayed rectifier K current compared in myocytes isolated from the atrioventricular node and ventricle of the rabbit heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Heart Ventricles; Membrane Potentials; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pulse; Pyridines; Rabbits | 1996 |
Two components of delayed rectifier current in canine atrium and ventricle. Does IKs play a role in the reverse rate dependence of class III agents?
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Function; Cells, Cultured; Dogs; Electrophysiology; Ion Transport; Piperidines; Potassium; Pyridines; Ventricular Function | 1996 |
Selective inhibition by a class III antiarrhythmic agent, E-4031, of the negative chronotropic response to parasympathetic stimulation in anesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Arginine Vasopressin; Depression, Chemical; Dogs; Female; Heart Conduction System; Male; Myocardial Contraction; Piperidines; Pyridines; Vagus Nerve | 1996 |
Evidence for two components of delayed rectifier K+ current in human ventricular myocytes.
Topics: 4-Aminopyridine; Action Potentials; Adult; Anti-Arrhythmia Agents; Diuretics; Electric Conductivity; Heart Ventricles; Humans; Indapamide; Middle Aged; Myocardium; Piperidines; Potassium; Potassium Channels; Pyridines; Reaction Time; Ventricular Function | 1996 |
Comparison of direct negative chronotropic and positive inotropic effects of sematilide to those of E-4031 and MS-551 and the reverse frequency-dependent prolongation of cardiac refractoriness of sematilide.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Dogs; Female; Heart Rate; Male; Papillary Muscles; Piperidines; Procainamide; Pyridines; Pyrimidinones; Sinoatrial Node | 1996 |
Negative chronotropic and dromotropic effects of E-4031, an IKr blocker, on the atrioventricular node in anesthetized dog hearts.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzazepines; Cardiotonic Agents; Chronobiology Phenomena; Dogs; Electric Stimulation; Piperidines; Potassium Channels; Pyridines | 1996 |
Hypotonic-induced stretch counteracts the efficacy of the class III antiarrhythmic agent E-4031 in guinea pig myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channels; Cell Membrane; Cell Size; Chloride Channels; Guinea Pigs; Heart Ventricles; Hypotonic Solutions; In Vitro Techniques; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines | 1996 |
Differential effects of MS-551 and E-4031 on action potentials and the delayed rectifier K+ current in rabbit ventricular myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Female; Male; Myocardium; Patch-Clamp Techniques; Piperidines; Pyridines; Pyrimidinones; Rabbits; Sodium-Potassium-Exchanging ATPase | 1996 |
Intracellular [Mg++] determines specificity of K+ channel block by a class III antiarrhythmic drug.
Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart; Magnesium; Male; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines | 1996 |
Effects of a class III antiarrhythmic drug and biphasic shocks on the postdefibrillation refractory period of relatively refractory myocardium.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Electric Countershock; Electric Stimulation; Heart; Piperidines; Pyridines; Refractory Period, Electrophysiological; Ventricular Fibrillation | 1996 |
Effect of the class III antiarrhythmic agent E-4031 on the ATP-sensitive potassium channel in rabbit ventricular myocytes.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Female; Heart Ventricles; Male; Myocardium; Piperidines; Potassium Channels; Pyridines; Rabbits | 1996 |
Separation of the components of the delayed rectifier potassium current using selective blockers of IKr and IKs in guinea-pig isolated ventricular myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Central Nervous System Depressants; Colforsin; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Ion Channel Gating; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium Channels; Propofol; Pyridines; Thiopental | 1996 |
The deactivation kinetics of the delayed rectifier components IKr and IKs in guinea-pig isolated ventricular myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Central Nervous System Depressants; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Kinetics; Membrane Potentials; Myocardium; Piperidines; Potassium Channels; Pyridines; Thiopental | 1996 |
Effects of class III antiarrhythmic drugs on the Na(+)-activated K+ channels in guinea-pig ventricular cells.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Ouabain; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines; Pyrimidinones; Sodium | 1996 |
Atrioventricular junctional rhythm induced by sympathetic stimulation in E-4031-treated dog hearts.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Delayed Rectifier Potassium Channels; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Female; Heart Conduction System; Heart Rate; Male; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sinoatrial Node; Sympathetic Nervous System | 1996 |
Effects of toborinone (OPC-18790), a new positive inotropic agent, on action potential in guinea pig sinoatrial node: compared with milrinone and E-4031.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Electrophysiology; Guinea Pigs; Male; Milrinone; Phosphodiesterase Inhibitors; Piperidines; Pyridines; Pyridones; Quinolones; Sinoatrial Node | 1996 |
A HERG-like K+ channel in rat F-11 DRG cell line: pharmacological identification and biophysical characterization.
Topics: Animals; Anti-Arrhythmia Agents; Benzimidazoles; Brain Neoplasms; Cation Transport Proteins; Cations, Divalent; DNA-Binding Proteins; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ganglia, Spinal; Hybrid Cells; Ion Channel Gating; Kinetics; Membrane Potentials; Mice; Models, Biological; Neuroblastoma; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Sulfanilamides; Trans-Activators | 1996 |
Inhibition of potassium currents by the antiarrhythmic drug E4031 in rat taste receptor cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Female; Kinetics; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Taste; Taste Buds | 1996 |
Differential effects of chronic membrane depolarization on the K+ channel activities in cultured rat ventricular cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Heart; Ion Channel Gating; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channels; Pyridines; Rats; Rats, Wistar | 1997 |
Optical mapping of drug-induced polymorphic arrhythmias and torsade de pointes in the isolated rabbit heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Heart; Heart Conduction System; Image Processing, Computer-Assisted; Models, Cardiovascular; Organ Culture Techniques; Perfusion; Piperidines; Pyridines; Quinidine; Rabbits; Torsades de Pointes | 1997 |
The class III antiarrhythmic agent E-4031 selectively blocks the inactivating inward-rectifying potassium current in rat anterior pituitary tumor cells (GH3/B6 cells).
Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Piperidines; Pituitary Neoplasms; Potassium Channels; Pyridines; Rats; Tumor Cells, Cultured | 1997 |
Effects of class III antiarrhythmic drugs on transient outward and ultra-rapid delayed rectifier currents in human atrial myocytes.
Topics: Aminobenzoates; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Heart Atria; Humans; Middle Aged; Piperidines; Potassium Channels; Pyridines; Sotalol | 1997 |
Electrophysiological effects of E 4031, a drug with selective class III properties, in man.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Atrial Function; Atrioventricular Node; Cardiac Pacing, Artificial; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiology; Female; Heart Atria; Heart Conduction System; Humans; Male; Middle Aged; Piperidines; Pyridines | 1997 |
Comparison of the rate-dependent properties of the class III antiarrhythmic agents azimilide (NE-10064) and E-4031: considerations on the mechanism of reverse rate-dependent action potential prolongation.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Guinea Pigs; Heart; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Myocardium; Patch-Clamp Techniques; Piperazines; Piperidines; Potassium Channels; Pyridines; Time Factors | 1997 |
Selective enhancement of the slow component of delayed rectifier K+ current in guinea-pig atrial cells by external ATP.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Delayed Rectifier Potassium Channels; Guinea Pigs; Heart; Heart Atria; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Time Factors | 1997 |
Modulation of HERG affinity for E-4031 by [K+]o and C-type inactivation.
Topics: Animals; Cation Transport Proteins; Electrophysiology; Ether-A-Go-Go Potassium Channels; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Xenopus laevis | 1997 |
Vesnarinone prolongs action potential duration without reverse frequency dependence in rabbit ventricular muscle by blocking the delayed rectifier K+ current.
Topics: Action Potentials; Adjuvants, Immunologic; Animals; Anti-Arrhythmia Agents; Delayed Rectifier Potassium Channels; Electric Conductivity; Male; Myocardium; Papillary Muscles; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyrazines; Pyridines; Quinolines; Rabbits; Reaction Time; Ventricular Function | 1997 |
Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.
Topics: Action Potentials; Anti-Arrhythmia Agents; Cation Transport Proteins; Cell Line; Cell Membrane; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kidney; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Recombinant Proteins; Temperature; Time Factors; Trans-Activators; Transcriptional Regulator ERG; Transfection | 1998 |
Inhibition by E-4031 of the prolongation of the first returning cycle length after overdrive in anesthetized dog hearts.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dogs; Heart; Heart Rate; Parasympathetic Nervous System; Piperidines; Pyridines; Sinoatrial Node | 1998 |
Effects of divalent cations on the E-4031-sensitive repolarization current, I(Kr), in rabbit ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Barium; Cadmium; Calcium; Cation Transport Proteins; Cations, Divalent; Cells, Cultured; Copper; Ether-A-Go-Go Potassium Channels; Heart Ventricles; Kinetics; Magnesium; Manganese; Membrane Potentials; Nickel; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rabbits; Strontium | 1998 |
Inhibition of delayed rectifier K+ current by dofetilide and E-4031 differentially affects electrical cardiac responses to vagus stimulation in anesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Animal; Disopyramide; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Female; Heart Conduction System; Male; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Sulfonamides; Vagus Nerve | 1998 |
Differential atrial versus ventricular activities of class III potassium channel blockers.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Function; Ferrets; Heart; Hydantoins; Imidazoles; Imidazolidines; Male; Papillary Muscles; Phenethylamines; Piperazines; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Sulfonamides; Temperature; Ventricular Function | 1998 |
Combined potassium and calcium channel antagonistic activities as a basis for neutral frequency dependent increase in action potential duration: comparison between BRL-32872 and azimilide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzamides; Calcium Channel Blockers; Electric Stimulation; Guinea Pigs; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Membrane Potentials; Nitrendipine; Papillary Muscles; Piperazines; Piperidines; Potassium Channel Blockers; Pyridines; Random Allocation; Ryanodine; Verapamil | 1998 |
Reduced inward rectifying and increased E-4031-sensitive K+ current density in arrhythmogenic subendocardial purkinje myocytes from the infarcted heart.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Cesium; Data Interpretation, Statistical; Dogs; In Vitro Techniques; Male; Membrane Potentials; Myocardial Infarction; Patch-Clamp Techniques; Piperidines; Potassium Channels; Purkinje Cells; Pyridines | 1998 |
Comparative effects of glibenclamide, tedisamil, dofetilide, E-4031, and BRL-32872 on protein kinase A-activated chloride current in guinea pig ventricular myocytes.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Acetylcholine; Animals; Anti-Arrhythmia Agents; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Cardiotonic Agents; Chlorides; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Glyburide; Guinea Pigs; Heart Ventricles; Hypoglycemic Agents; Ion Transport; Isoproterenol; Male; Myocardium; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channels; Propranolol; Pyridines; Sulfonamides | 1998 |
Effects of class I and III antiarrhythmic drugs on ventricular tachycardia-interrupting critical paced cycle length with rapid pacing.
Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Child; Electrophysiology; Female; Heart Conduction System; Humans; Male; Middle Aged; Piperidines; Pyridines; Pyrimidinones; Tachycardia, Ventricular | 1998 |
Effects of gonadal steroids on ventricular repolarization and on the response to E4031.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dihydrotestosterone; Electrocardiography; Estradiol; Female; Heart; Ovariectomy; Papillary Muscles; Piperidines; Pyridines; Rabbits; Sex Factors; Ventricular Function | 1998 |
The erg inwardly rectifying K+ current and its modulation by thyrotrophin-releasing hormone in giant clonal rat anterior pituitary cells.
Topics: Animals; Clone Cells; Electrophysiology; Isotonic Solutions; Membrane Potentials; Piperidines; Pituitary Gland, Anterior; Potassium Channels; Potassium Channels, Inwardly Rectifying; Potassium Chloride; Pyridines; Rats; Thyrotropin-Releasing Hormone | 1998 |
Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels.
Topics: Amino Acid Sequence; Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ion Channel Gating; Membrane Potentials; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperidines; Point Mutation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Conformation; Pyridines; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Trans-Activators; Transcriptional Regulator ERG | 1998 |
Effect of E4031, a class III antiarrhythmic drug, on ischemia- and reperfusion-induced arrhythmias in isolated rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Energy Metabolism; Heart; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Myocardium; Piperidines; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 1998 |
Acceleration-induced action potential prolongation and early afterdepolarizations.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disease Models, Animal; Dogs; Endocardium; Flunarizine; Heart Ventricles; Membrane Potentials; Microelectrodes; Pericardium; Piperidines; Purkinje Fibers; Pyridines; Torsades de Pointes | 1998 |
Adult KCNE1-knockout mice exhibit a mild cardiac cellular phenotype.
Topics: Action Potentials; Animals; Chromans; Electric Conductivity; Electrophysiology; Heart; Homozygote; In Vitro Techniques; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Long QT Syndrome; Mice; Mice, Knockout; Periodicity; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sulfonamides | 1998 |
Comparison of electrophysiologic effects of intravenous E-4031 and MS-551, novel class III antiarrhythmic agents, in patients with ventricular tachyarrhythmias.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Heart Ventricles; Humans; Infusions, Intravenous; Male; Middle Aged; Piperidines; Pyridines; Pyrimidinones; Tachycardia, Ventricular; Treatment Outcome | 1998 |
Sulfonylureas blockade of neural and cardiac HERG channels.
Topics: Action Potentials; Animals; Cation Transport Proteins; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Glyburide; Guinea Pigs; Humans; Inhibitory Concentration 50; Mice; Myocardium; Neuroblastoma; Neurons; Nisoldipine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Sulfonamides; Sulfonylurea Compounds; Trans-Activators; Transcriptional Regulator ERG; Tumor Cells, Cultured | 1998 |
Inhibition of the rapid component of the delayed-rectifier K+ current by therapeutic concentrations of the antispasmodic agent terodiline.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Butylamines; Calcium Channel Blockers; Cells, Cultured; Female; Heart; Heart Ventricles; In Vitro Techniques; Male; Mice; Papillary Muscles; Parasympatholytics; Piperidines; Potassium; Potassium Channels; Pyridines; Ventricular Function | 1998 |
The antiestrogen tamoxifen blocks the delayed rectifier potassium current, IKr, in rabbit ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Estrogen Antagonists; Heart Ventricles; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channels; Pyridines; Rabbits; Tamoxifen; Time Factors; Torsades de Pointes | 1998 |
Effects of low temperature on the chronotropic and inotropic responses to zatebradine, E-4031 and verapamil in isolated perfused dog atria.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzazepines; Calcium Channel Agonists; Cardiovascular Agents; Cold Temperature; Dogs; Dose-Response Relationship, Drug; Heart Atria; Hypothermia, Induced; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Perfusion; Piperidines; Pyridines; Verapamil | 1998 |
Discordant prolongation of the refractory period and repolarization time by a class III agent, E4031, in the healing phase of myocardial infarction.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Electrophysiology; Female; Heart Conduction System; Humans; Male; Myocardial Infarction; Piperidines; Pyridines; Refractory Period, Electrophysiological | 1998 |
Regional differences in effects of E-4031 within the sinoatrial node.
Topics: Animals; Culture Techniques; Delayed Rectifier Potassium Channels; Electrophysiology; Membrane Potentials; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rabbits; Sinoatrial Node | 1999 |
Delayed rectifier potassium current in undiseased human ventricular myocytes.
Topics: Action Potentials; Adult; Anti-Arrhythmia Agents; Barium Compounds; Cadmium; Calcium Channel Blockers; Chlorides; Female; Humans; Male; Middle Aged; Myocardium; Nifedipine; Patch-Clamp Techniques; Piperidines; Pyridines; Signal Processing, Computer-Assisted; Sodium-Potassium-Exchanging ATPase | 1998 |
Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes.
Topics: Action Potentials; Adenoviridae; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cation Transport Proteins; Cells, Cultured; DNA-Binding Proteins; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart Ventricles; Humans; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rabbits; Recombinant Proteins; Trans-Activators; Transcriptional Regulator ERG; Ventricular Function | 1999 |
Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disopyramide; Dogs; Electrocardiography; Flecainide; Injections; Lidocaine; Piperidines; Pyridines; Sodium Channels; Ventricular Fibrillation; Verapamil | 1999 |
A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs.
Topics: Animals; Anti-Arrhythmia Agents; Calcium Channels; Cells, Cultured; Charybdotoxin; Female; Lactation; Membrane Potentials; Models, Biological; Patch-Clamp Techniques; Piperidines; Pituitary Gland; Potassium Channels; Potassium Channels, Inwardly Rectifying; Prolactin; Pyridines; Rats; Rats, Wistar | 1999 |
Effects of verapamil, zatebradine, and E-4031 on the pacemaker location and rate in response to sympathetic stimulation in dog hearts.
Topics: Animals; Anti-Arrhythmia Agents; Benzazepines; Cardiotonic Agents; Delayed Rectifier Potassium Channels; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Heart; Heart Atria; Heart Conduction System; Heart Rate; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sinoatrial Node; Sympathetic Nervous System; Verapamil | 1999 |
Inhibition of HERG channels stably expressed in a mammalian cell line by the antianginal agent perhexiline maleate.
Topics: Algorithms; Animals; Anti-Arrhythmia Agents; Cardiovascular Agents; Cation Transport Proteins; CHO Cells; Cricetinae; Electric Stimulation; Ether-A-Go-Go Potassium Channels; In Vitro Techniques; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Perhexiline; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Xenopus laevis | 1999 |
Antiarrhythmic effect and its underlying ionic mechanism of 17beta-estradiol in cardiac myocytes.
Topics: Action Potentials; Androgens; Animals; Anti-Arrhythmia Agents; Calcium Channels; Calcium Channels, L-Type; Cardiotonic Agents; Estradiol; Estrogen Antagonists; Estrogens, Non-Steroidal; Female; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines | 1999 |
Ionic mechanisms underlying TRH-induced prolactin secretion in rat lactotrophs.
Topics: Animals; Anti-Arrhythmia Agents; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Patch-Clamp Techniques; Piperidines; Pituitary Gland; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Prolactin; Pyridines; Rats; Thyrotropin-Releasing Hormone | 1999 |
Separation of M-like current and ERG current in NG108-15 cells.
Topics: Animals; Benzimidazoles; Bradykinin; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Indoles; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Transport Proteins; Mice; Neuroblastoma; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Sulfanilamides; Sympathetic Nervous System; Tumor Cells, Cultured | 1999 |
Effects of K+ channel modulators on the relationship between action potential duration and Ca2+ transients in single ventricular myocytes of the guinea pig.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cromakalim; Glyburide; Guinea Pigs; Heart Ventricles; Hypoglycemic Agents; Male; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines; Time Factors; Vasodilator Agents; Ventricular Function | 1999 |
Inactivation of the ERG current in NG108-15 cells.
Topics: Animals; Electric Conductivity; Glioma; Hybrid Cells; Ion Channel Gating; Mice; Neuroblastoma; Normal Distribution; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Tumor Cells, Cultured | 1999 |
Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects.
Topics: Anti-Arrhythmia Agents; Astemizole; Biological Transport; Cation Transport Proteins; Cell Compartmentation; Cisapride; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Glycerol; Humans; Long QT Syndrome; Mutation; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Folding; Pyridines; Recombinant Proteins; Temperature; Trans-Activators; Transcriptional Regulator ERG | 1999 |
Heterogeneous distribution of the two components of delayed rectifier K+ current: a potential mechanism of the proarrhythmic effects of methanesulfonanilideclass III agents.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Female; Heart Ventricles; Isoproterenol; Male; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines; Rabbits; Time Factors | 1999 |
E 4031.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Delayed Rectifier Potassium Channels; Dogs; Drugs, Investigational; Guinea Pigs; Humans; In Vitro Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines | 1999 |
Electrophysiological characterization of BRL-32872 in canine Purkinje fiber and ventricular muscle. Effect on early after-depolarizations and repolarization dispersion.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzamides; Dogs; Electrophysiology; Female; Heart; Heart Ventricles; In Vitro Techniques; Kinetics; Male; Piperidines; Potassium Channel Blockers; Purkinje Fibers; Pyridines; Quaternary Ammonium Compounds | 1999 |
An investigation of the role played by the E-4031-sensitive (rapid delayed rectifier) potassium current in isolated rabbit atrioventricular nodal and ventricular myocytes.
Topics: Animals; Atrioventricular Node; Cell Separation; Delayed Rectifier Potassium Channels; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rabbits; Ventricular Function | 1999 |
The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzodiazepines; Chromans; Delayed Rectifier Potassium Channels; Dogs; Electrophysiology; Female; Male; Papillary Muscles; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Purkinje Fibers; Pyridines; Sotalol; Sulfonamides | 2000 |
Permeability characteristics of monovalent cations in atrial myocytes of the rat heart.
Topics: Animals; Calcium Channel Blockers; Cation Transport Proteins; Cations, Monovalent; Cell Membrane; Cell Membrane Permeability; Electric Conductivity; Ether-A-Go-Go Potassium Channels; Gadolinium; Heart Atria; In Vitro Techniques; Myocardium; Nicardipine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Sprague-Dawley | 2000 |
Properties of the delayed rectifier potassium current in porcine sino-atrial node cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Chromans; Delayed Rectifier Potassium Channels; Heart Rate; In Vitro Techniques; Ion Channel Gating; Kinetics; Membrane Potentials; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rabbits; Sinoatrial Node; Species Specificity; Sulfonamides; Swine; Time Factors | 2000 |
Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes.
Topics: Animals; Anti-Arrhythmia Agents; Astrocytes; Cation Transport Proteins; Cell Communication; Cesium; Dose-Response Relationship, Drug; Electrophysiology; Epilepsy; Ether-A-Go-Go Potassium Channels; Gene Expression; Heart; Hippocampus; In Vitro Techniques; Long QT Syndrome; Male; Membrane Potentials; Microscopy, Electron; Neurons; Oligonucleotide Probes; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord; Sulfonamides | 2000 |
Salutary antiarrhythmic effect of combining a K channel blocker and a beta-blocker in a canine model of 7-day-old myocardial infarction.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Drug Therapy, Combination; Electrocardiography; Female; Heart; Heart Ventricles; Male; Morpholines; Myocardial Infarction; Piperidines; Potassium Channel Blockers; Pyridines; Urea | 2000 |
Enhancement of delayed afterdepolarizations and triggered activity by class III antiarrhythmic drugs: multiple effects of E-4031 and dofetilide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Phenethylamines; Piperidines; Purkinje Fibers; Pyridines; Sheep; Sulfonamides; Time Factors | 2000 |
Potassium channel openers antagonize the effects of class III antiarrhythmic agents in canine Purkinje fiber action potentials. Implications for prevention of proarrhythmia induced by class III agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Purkinje Fibers; Pyridines; Sulfonamides | 1999 |
4-aminopyridine inhibits the occurrence of ventricular fibrillation but not ventricular tachycardia in the reperfused, P6olated rat heart.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Glyburide; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Reperfusion; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Torsades de Pointes; Ventricular Fibrillation; Verapamil | 2000 |
Electropharmacological characterization of cardiac repolarization in German shepherd dogs with an inherited syndrome of sudden death: abnormal response to potassium channel blockers.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromans; Death, Sudden, Cardiac; Dog Diseases; Dogs; Electrocardiography; Endocardium; Heart; In Vitro Techniques; Myocardium; Piperidines; Potassium Channel Blockers; Purkinje Fibers; Pyridines; Reference Values; Sotalol; Sulfonamides | 2000 |
Pacing-induced heart failure causes a reduction of delayed rectifier potassium currents along with decreases in calcium and transient outward currents in rabbit ventricle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channels, L-Type; Cardiac Pacing, Artificial; Heart Failure; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines; Rabbits | 2000 |
Differences in action potential and early afterdepolarization properties in LQT2 and LQT3 models of long QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cell Separation; Electric Stimulation; Electrophysiology; Fourier Analysis; Heart; In Vitro Techniques; Long QT Syndrome; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines; Rabbits; Tetrodotoxin | 2001 |
Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzodiazepines; Cell Separation; Chromans; Colforsin; Electrocardiography; Female; Heart; Heart Ventricles; In Vitro Techniques; Kinetics; Long QT Syndrome; Male; Microelectrodes; Myocardium; Papillary Muscles; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines; Rabbits; Sulfonamides | 2001 |
The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes.
Topics: Adult; Benzodiazepines; Calcium Channel Blockers; Cell Separation; Chromans; Colforsin; Female; Humans; Ion Channel Gating; Long QT Syndrome; Male; Myocardium; Nisoldipine; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines; Sulfonamides | 2001 |
The distribution of refractory periods influences the dynamics of ventricular fibrillation.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Female; Guinea Pigs; Heart Conduction System; Heart Ventricles; Piperidines; Pyridines; Ventricular Fibrillation | 2001 |
Alosetron and the rapid component of delayed rectifying potassium current in cardiac cells.
Topics: Animals; Carbolines; Cisapride; Delayed Rectifier Potassium Channels; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists | 2001 |
Class III anti-arrhythmia drug E-4031 potentiates Na+/Ca2+ exchange current in rat ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Cell Separation; Heart Ventricles; Myocardium; Piperidines; Protein Kinase C; Pyridines; Rats; Sodium-Calcium Exchanger; Tamoxifen; Tetradecanoylphorbol Acetate | 2000 |
Interactions between antiarrhythmic drugs and cardiac memory.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Electrophysiology; Feedback; Lidocaine; Piperidines; Potassium Channels; Pyridines; Quinidine | 2001 |
Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential.
Topics: Action Potentials; Animals; Chromans; Electric Conductivity; Guinea Pigs; Piperidines; Potassium Channels; Pyridines; Reaction Time; Scorpion Venoms; Sulfonamides; Ventricular Function | 2001 |
Density and kinetics of I(Kr) and I(Ks) in guinea pig and rabbit ventricular myocytes explain different efficacy of I(Ks) blockade at high heart rate in guinea pig and rabbit: implications for arrhythmogenesis in humans.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Chromans; Delayed Rectifier Potassium Channels; Guinea Pigs; Heart Rate; Heart Ventricles; Humans; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rabbits; Sulfonamides | 2001 |
Heterogeneous expression of the delayed-rectifier K+ currents i(K,r) and i(K,s) in rabbit sinoatrial node cells.
Topics: Action Potentials; Animals; Cell Separation; Cell Size; Chromans; Electrophysiology; In Vitro Techniques; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Rabbits; Sinoatrial Node; Sulfonamides | 2001 |
Ionic remodeling of cardiac Purkinje cells by congestive heart failure.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Barium; Calcium; Calcium Channels, L-Type; Calcium Channels, T-Type; Disease Models, Animal; Dogs; Heart Failure; In Vitro Techniques; Ion Transport; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channels; Purkinje Fibers; Pyridines; Sodium; Sodium-Calcium Exchanger | 2001 |
Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channels, L-Type; Cells, Cultured; Cytochalasin D; Drug Evaluation, Preclinical; ErbB Receptors; Focal Adhesion Kinase 2; Mitogen-Activated Protein Kinases; Myocardium; Phosphorylation; Piperidines; Potassium Channel Blockers; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Quinidine; Rats; Rats, Wistar; Tetraethylammonium; Time Factors; Tyrphostins | 2001 |
Inhibitory effect of bepridil on hKv1.5 channel current: comparison with amiodarone and E-4031.
Topics: 4-Aminopyridine; Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Bepridil; Dose-Response Relationship, Drug; Gene Expression; Heart Atria; Humans; In Vitro Techniques; Kv1.5 Potassium Channel; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats | 2001 |
Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Apamin; Barium; Benzimidazoles; Calcium Channel Blockers; Cation Transport Proteins; Cromakalim; Diltiazem; Ether-A-Go-Go Potassium Channels; Female; Glyburide; Guinea Pigs; Large-Conductance Calcium-Activated Potassium Channels; Male; Muscle Contraction; Muscle, Smooth; Nisoldipine; Parasympatholytics; Peptides; Periodicity; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Pyridines; Small-Conductance Calcium-Activated Potassium Channels; Urinary Bladder | 2001 |
The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.
Topics: Anti-Arrhythmia Agents; Astemizole; Benzimidazoles; Binding Sites; Blotting, Western; Cation Transport Proteins; Cell Line; Cell Membrane; Cisapride; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Inhibitory Concentration 50; Ions; Long QT Syndrome; Models, Chemical; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Folding; Pyridines; Quaternary Ammonium Compounds; Quinidine; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2002 |
Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Blotting, Western; Cation Transport Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gastric Fundus; Gene Expression; Immunohistochemistry; Indapamide; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Membrane Potentials; Membrane Transport Proteins; Muscle, Smooth; Patch-Clamp Techniques; Piperidines; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Voltage-Gated; Pyloric Antrum; Pyridines; Rats; Rats, Wistar; RNA, Messenger | 2002 |
Atrio-sinus interaction demonstrated by blockade of the rapid delayed rectifier current.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Biological Clocks; Cation Transport Proteins; Computer Simulation; Electrophysiologic Techniques, Cardiac; Ether-A-Go-Go Potassium Channels; Heart Atria; Heart Conduction System; In Vitro Techniques; Long QT Syndrome; Membrane Potentials; Models, Cardiovascular; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rabbits; Sinoatrial Block; Sinoatrial Node | 2002 |
Prominent I(Ks) in epicardium and endocardium contributes to development of transmural dispersion of repolarization but protects against development of early afterdepolarizations.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Chromans; Dogs; Drug Therapy, Combination; Electrophysiology; Endocardium; Microelectrodes; Pericardium; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Sulfonamides | 2002 |
Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K+ current (IKr) in frog atrial myocytes?
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Delayed Rectifier Potassium Channels; Electrophysiology; Heart Atria; Hexachlorocyclohexane; Myocardium; Myocytes, Cardiac; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Quinidine; Ranidae | 2002 |
The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment.
Topics: Animals; Anti-Arrhythmia Agents; Butylamines; Cisapride; Disease Models, Animal; Dogs; Female; Heart Rate; Long QT Syndrome; Male; Piperidines; Pyridines; Terfenadine; Verapamil | 2002 |
Cytosolic Ca2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome.
Topics: Animals; Anti-Arrhythmia Agents; Artifacts; Calcium; Calcium Signaling; Cryosurgery; Cytosol; Female; Kinetics; Long QT Syndrome; Magnesium; Membrane Potentials; Microscopy, Fluorescence; Movement; Piperidines; Potassium; Pyridines; Rabbits; Torsades de Pointes | 2002 |
E-4031 enhanced Ca2+ transient and ventricular myocytes contraction via reverse mode Na+/Ca2+ exchange in normal and hypertrophic rats.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Electric Stimulation; Hypertrophy, Left Ventricular; Myocardial Contraction; Piperidines; Pyridines; Rats; Rats, Wistar; Sodium-Calcium Exchanger | 2002 |
Restitution properties and occurrence of ventricular arrhythmia in LQT2 type of long QT syndrome.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disease Models, Animal; Disease Susceptibility; Dogs; Electrocardiography; Electrophysiologic Techniques, Cardiac; Heart Conduction System; Heart Ventricles; Long QT Syndrome; Models, Cardiovascular; Piperidines; Pyridines; Tachycardia, Ventricular | 2002 |
Restitution, ventricular fibrillation, and drugs: where are we now?
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Electrophysiologic Techniques, Cardiac; Heart Conduction System; Heart Ventricles; Humans; Long QT Syndrome; Piperidines; Pyridines; Ventricular Fibrillation | 2002 |
Cardiac electrophysiological modulation by NS-7, a novel neuroprotective drug, of guinea pig ventricular muscles.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Chromans; Dose-Response Relationship, Drug; Drug Combinations; Electric Stimulation; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Neuroprotective Agents; Papillary Muscles; Piperidines; Potassium Channel Blockers; Pyridines; Pyrimidines; Sulfonamides; Ventricular Function | 2003 |
Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells.
Topics: 8,11,14-Eicosatrienoic Acid; alpha-Linolenic Acid; Amides; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Hydantoins; Imidazoles; Imidazolidines; Infant, Newborn; Linoleic Acids; Membrane Potentials; Neuroblastoma; Patch-Clamp Techniques; Piperazines; Piperidines; Pituitary Neoplasms; Polyunsaturated Alkamides; Potassium Channels; Pyridines; Tumor Cells, Cultured | 2003 |
Comparison of potassium currents in human decidua before and after the onset of labor.
Topics: 4-Aminopyridine; Adult; Cesarean Section; Decidua; Delivery, Obstetric; Female; Fluorescent Antibody Technique; Humans; Labor Onset; Membrane Potentials; Parturition; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channel Blockers; Potassium Channels; Pregnancy; Pyridines; Stromal Cells; Tetraethylammonium Compounds; Thy-1 Antigens | 2003 |
Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency.
Topics: Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Isoleucine; Long QT Syndrome; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Phenethylamines; Piperidines; Point Mutation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sulfonamides; Xenopus | 2003 |
Preserved effects of potassium channel blockers in the pacing-induced remodeled canine atrium: a comparison between E4031 and azimilide.
Topics: Animals; Atrial Fibrillation; Atrial Function; Cardiac Pacing, Artificial; Dogs; Electric Stimulation; Electrocardiography; Electrodes, Implanted; Female; Hydantoins; Imidazoles; Imidazolidines; Male; Piperazines; Piperidines; Potassium Channel Blockers; Pyridines; Refractory Period, Electrophysiological | 2003 |
Expression and function of KCNH2 (HERG) in the human jejunum.
Topics: Acetylcholine; Alternative Splicing; Amino Acid Sequence; Base Sequence; Benzopyrans; Calcium Channels; Cation Transport Proteins; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression Regulation; Humans; In Vitro Techniques; Jejunum; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Piperidines; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Potassium Chloride; Pyridines; RNA, Messenger; Sequence Alignment; Time Factors; Trans-Activators; Transcriptional Regulator ERG | 2003 |
Transmural heterogeneity of the action potential configuration in the feline left ventricle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antioxidants; Cats; Chromans; Electrocardiography; Electrophysiology; Heart Ventricles; Piperidines; Pyridines; Ventricular Function, Left | 2003 |
ERG K+ currents regulate pacemaker activity in ICC.
Topics: Animals; Animals, Newborn; Biological Clocks; Cation Transport Proteins; Cells, Cultured; DNA-Binding Proteins; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Immunohistochemistry; Intestine, Small; Mice; Mice, Inbred Strains; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Potassium Channels, Voltage-Gated; Pyridines; Tetraethylammonium; Trans-Activators; Transcriptional Regulator ERG | 2003 |
Cardiovascular assessment of ER-118585, a selective phosphodiesterase 5 inhibitor.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Action Potentials; Animals; Cardiac Pacing, Artificial; Cardiovascular Diseases; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 5; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrocardiography; Electrophysiology; Guinea Pigs; Humans; Infusions, Intravenous; Kidney; Long QT Syndrome; Male; Papillary Muscles; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phthalazines; Piperidines; Potassium Channels, Voltage-Gated; Protein Binding; Pyridines; Spiro Compounds; Transfection; Ventricular Function; Ventricular Premature Complexes | 2003 |
Role of K(+) channels in frequency regulation of spontaneous action potentials in rat pituitary GH(3) cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Cell Line, Tumor; Cesium; Chelating Agents; Drug Interactions; Egtazic Acid; Electric Conductivity; Extracellular Space; Fura-2; Patch-Clamp Techniques; Piperidines; Pituitary Gland; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Tetraethylammonium | 2003 |
Expression and role of the ether-à-go-go-related (MERG1A) potassium-channel protein during preimplantation mouse development.
Topics: Animals; Blastocyst; Cells, Cultured; Culture Techniques; Embryo, Mammalian; Embryonic and Fetal Development; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; Half-Life; Immunoblotting; Mice; Oocytes; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; RNA, Messenger; Tissue Distribution; Trophoblasts | 2004 |
A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells.
Topics: Animals; Anti-Arrhythmia Agents; Biological Clocks; Delayed Rectifier Potassium Channels; Diastole; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Isoforms; Pyridines; Sinoatrial Node | 2004 |
Contribution of IKr to rate-dependent action potential dynamics in canine endocardium.
Topics: Action Potentials; Animals; Computer Simulation; Delayed Rectifier Potassium Channels; Dogs; Endocardium; Female; Ion Transport; Male; Models, Cardiovascular; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Tachycardia; Ventricular Function, Left | 2004 |
Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.
Topics: Animals; Antipsychotic Agents; Bepridil; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cisapride; Delayed Rectifier Potassium Channels; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gastrointestinal Agents; Guinea Pigs; Heart Rate; Histamine H1 Antagonists; Humans; In Vitro Techniques; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channels, Voltage-Gated; Pyridines; Risperidone; Terfenadine; Verapamil | 2004 |
Pharmacological rescue of trafficking defective HERG channels formed by coassembly of wild-type and long QT mutant N470D subunits.
Topics: Cation Transport Proteins; Cell Line; Cell Membrane; Endoplasmic Reticulum; Ether-A-Go-Go Potassium Channels; Genes, Dominant; Humans; Long QT Syndrome; Mutation; Patch-Clamp Techniques; Phenotype; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines | 2004 |
Epicardial activation of left ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cisapride; Computer Simulation; Delayed Rectifier Potassium Channels; Dogs; Electrocardiography; Endocardium; Heart Ventricles; Membrane Potentials; Models, Cardiovascular; Pericardium; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Torsades de Pointes | 2004 |
HERG K channel conductance promotes H2O2-induced apoptosis in HEK293 cells: cellular mechanisms.
Topics: Anti-Arrhythmia Agents; Caspase 3; Caspase 9; Caspases; Cell Line; DNA Fragmentation; Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; p38 Mitogen-Activated Protein Kinases; Piperidines; Poly(ADP-ribose) Polymerases; Potassium Channels, Voltage-Gated; Pyridines; Signal Transduction | 2004 |
[High throughput screening method of potassium channel regulators].
Topics: 4-Aminopyridine; Animals; Barbiturates; Calcium Channel Blockers; Cromakalim; Isoxazoles; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; PC12 Cells; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Quinidine; Rats | 2004 |
Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes.
Topics: Acetanilides; Action Potentials; Animals; Chromans; Cnidarian Venoms; Delayed Rectifier Potassium Channels; Drug Synergism; Drug Therapy, Combination; Female; Guinea Pigs; Heart Conduction System; Heart Ventricles; Ion Channel Gating; Long QT Syndrome; Male; Myocytes, Cardiac; Piperazines; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Potassium Channels, Voltage-Gated; Pyridines; Ranolazine; Sodium Channels; Sulfonamides; Tetrodotoxin; Time Factors | 2004 |
Structural determinants of HERG channel block by clofilium and ibutilide.
Topics: Amino Acid Substitution; Animals; Anti-Arrhythmia Agents; Aspartic Acid; Benzopyrans; Binding Sites; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oocytes; Phenethylamines; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Quaternary Ammonium Compounds; Serine; Sulfonamides; Tyrosine; Xenopus laevis | 2004 |
Sevoflurane inhibition of the slowly activating delayed rectifier K+ current in guinea pig ventricular cells.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Cells, Cultured; Chromans; Delayed Rectifier Potassium Channels; Guinea Pigs; Halothane; Heart Ventricles; In Vitro Techniques; Methyl Ethers; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Sevoflurane; Sulfonamides; Time Factors | 2004 |
Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties.
Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Cells, Cultured; Delayed Rectifier Potassium Channels; Dogs; Drug Evaluation, Preclinical; Electrocardiography; Heart Ventricles; Ion Channels; Ion Transport; Myocytes, Cardiac; Organ Culture Techniques; Patch-Clamp Techniques; Piperazines; Piperidines; Potassium; Potassium Channels, Voltage-Gated; Pyridines; Ranolazine; Sodium; Sodium-Calcium Exchanger | 2004 |
Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition.
Topics: Adrenergic beta-Agonists; Animals; Bradycardia; Dogs; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart Rate; Humans; Isoproterenol; Long QT Syndrome; Nitroprusside; Phenylephrine; Piperidines; Potassium Channels, Voltage-Gated; Pyridines; Tachycardia | 2005 |
Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells.
Topics: Aging; Animals; Animals, Newborn; Carotid Body; Cells, Cultured; Chemoreceptor Cells; Ion Channel Gating; Membrane Potentials; Piperidines; Potassium; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Sprague-Dawley | 2005 |
Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blotting, Western; Cardiac Pacing, Artificial; Cation Transport Proteins; Computer Simulation; Electrocardiography; Ether-A-Go-Go Potassium Channels; Genetic Engineering; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Microelectrodes; Models, Cardiovascular; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium Channels, Voltage-Gated; Pyridines | 2005 |
Effects of E4031 and quinidine on atrial and ventricular refractoriness in rabbits in vivo.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Blood Pressure; Dose-Response Relationship, Drug; Evoked Potentials; Heart Atria; Heart Ventricles; Piperidines; Pyridines; Quinidine; Rabbits; Refractory Period, Electrophysiological; Sinoatrial Node | 2004 |
Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cats; Chromans; Heart; Long QT Syndrome; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Sulfonamides; Tissue Culture Techniques; Torsades de Pointes; Verapamil | 2005 |
Novel mutation in the Per-Arnt-Sim domain of KCNH2 causes a malignant form of long-QT syndrome.
Topics: Adult; Blotting, Western; Cell Line; Death, Sudden, Cardiac; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Glutamic Acid; Humans; Kidney; Long QT Syndrome; Lysine; Male; Microscopy, Confocal; Middle Aged; Mutation, Missense; Patch-Clamp Techniques; Pedigree; Peptides; Phenotype; Piperidines; Potassium Channels, Voltage-Gated; Protein Structure, Tertiary; Proteins; Pyridines | 2005 |
Practical application of guinea pig telemetry system for QT evaluation.
Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Bepridil; Cisapride; Disease Models, Animal; Electrocardiography; Guinea Pigs; Haloperidol; Heart; Humans; Injections, Intravenous; Long QT Syndrome; Male; Nifedipine; Pimozide; Piperidines; Pyridines; Quinidine; Reproducibility of Results; Telemetry; Terfenadine; Thioridazine | 2005 |
Expression and functional phenotype of mouse ERG K+ channels in the inner ear: potential role in K+ regulation in the inner ear.
Topics: Amino Acid Sequence; Animals; Cell Line; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Ear, Inner; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Gene Expression Regulation; Mice; Molecular Sequence Data; Phenotype; Piperidines; Pyridines; Xenopus | 2005 |
QT prolongation modifies dynamic restitution and hysteresis of the beat-to-beat QT-TQ interval relationship during normal sinus rhythm under varying states of repolarization.
Topics: Acetamides; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzodiazepinones; Dogs; Electrocardiography; Female; Heart Rate; Long QT Syndrome; Male; Myocardial Contraction; Piperidines; Potassium Channels, Voltage-Gated; Pyridines | 2006 |
Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome.
Topics: Calnexin; Detergents; Endoplasmic Reticulum; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Glycosylation; Humans; Long QT Syndrome; Mutation; Piperidines; Protein Folding; Pyridines; Trypsin | 2006 |
Molecular determinants of HERG channel block.
Topics: DNA Primers; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Long QT Syndrome; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Recombinant Proteins; Sulfonamides | 2006 |
[Identification of E-4031-sensitive potassium current component in murine P19 embryonic carcinoma cell line differentiated in cardiomyocytes].
Topics: Actins; Animals; Calcium Channels; Carcinoma, Embryonal; Cell Differentiation; Cell Line, Tumor; Electrophoresis, Agar Gel; Ether-A-Go-Go Potassium Channels; Membranes; Mice; Microscopy, Electron; Mitochondria, Heart; Myocytes, Cardiac; Myosins; Patch-Clamp Techniques; Piperidines; Polymerase Chain Reaction; Potassium Channel Blockers; Pyridines; Sodium Channels | 2006 |
Contribution of I Ks to ventricular repolarization in canine myocytes.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cell Polarity; Chromans; Computer Simulation; Delayed Rectifier Potassium Channels; Dogs; Female; Heart Rate; Heart Ventricles; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocytes, Cardiac; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyridines; Sulfonamides; Sympathetic Nervous System; Ventricular Function | 2006 |
Diabetes mellitus reduces the antiarrhythmic effect of ion channel blockers.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Diabetes Mellitus; Diabetes Mellitus, Experimental; Epinephrine; Flecainide; Halothane; Ion Channels; Male; Piperidines; Potassium Channel Blockers; Pyridines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Verapamil | 2006 |
Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.
Topics: Adult; Antidepressive Agents, Second-Generation; Blotting, Western; Cell Line; Cell Membrane; Cisapride; Dose-Response Relationship, Drug; Drug Overdose; Ether-A-Go-Go Potassium Channels; Female; Fluoxetine; Humans; Long QT Syndrome; Membrane Potentials; Muscle Proteins; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Piperidines; Protein Transport; Pyridines; Sodium Channels; Time Factors; Transfection | 2006 |
Temperature acclimation modifies sinoatrial pacemaker mechanism of the rainbow trout heart.
Topics: Acclimatization; Action Potentials; Animals; Biological Clocks; Calcium Channels; Cell Size; Delayed Rectifier Potassium Channels; Heart; In Vitro Techniques; Microelectrodes; Muscle Cells; Oncorhynchus mykiss; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Ryanodine; Sarcoplasmic Reticulum; Sinoatrial Node; Temperature; Thapsigargin | 2007 |
Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and Purkinje fibre.
Topics: Action Potentials; Animals; CHO Cells; Cricetinae; Cricetulus; Heart; Lidocaine; Male; Muscle Proteins; NAV1.5 Voltage-Gated Sodium Channel; Organic Chemicals; Piperidines; Purkinje Fibers; Pyridines; Rabbits; Sodium Channel Blockers; Sodium Channels | 2007 |
Role of reverse mode Na+/Ca2+ exchanger in the cardioprotection of metabolic inhibition preconditioning in rat ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Cell Survival; Fura-2; Ischemic Preconditioning, Myocardial; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Sodium-Calcium Exchanger; Spectrometry, Fluorescence; Thiourea; Ventricular Function | 2007 |
Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and beta-cell.
Topics: Animals; Calcium; Circadian Rhythm; Electrophysiology; Ether-A-Go-Go Potassium Channels; Gene Expression Regulation; Immunohistochemistry; Insulin-Secreting Cells; Male; Organ Specificity; Perfusion; Piperidines; Protein Isoforms; Protein Transport; Pyridines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Bradycardia; Electrocardiography; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Perfusion; Phenylurea Compounds; Piperidines; Pyridines; Tetrazoles; Ventricular Function | 2007 |
Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cell Line; Cell Membrane; Cells, Cultured; Cesium; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Gene Expression; Humans; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium; Probucol; Protein Transport; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Transfection | 2007 |
Hydroxypropyl beta-cyclodextrins: a misleading vehicle for the in vitro hERG current assay.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; beta-Cyclodextrins; Biological Assay; Cisapride; Dose-Response Relationship, Drug; Electrophysiology; Ether-A-Go-Go Potassium Channels; Excipients; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Inhibitory Concentration 50; Myocytes, Cardiac; Piperidines; Potassium Channel Blockers; Pyridines; Solubility; Terfenadine; Time Factors | 2007 |
HERG1 currents in native K562 leukemic cells.
Topics: Base Sequence; DNA Primers; Ether-A-Go-Go Potassium Channels; Gene Expression; Humans; Hydrogen Peroxide; K562 Cells; Kinetics; Membrane Potentials; Piperidines; Protein Isoforms; Pyridines | 2007 |
Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation.
Topics: Action Potentials; Animals; Chromans; Cnidarian Venoms; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; Drug Synergism; Electrocardiography; Electrophysiology; Forecasting; Long QT Syndrome; Male; Piperidines; Potassium Channels, Voltage-Gated; Pyridines; Rabbits; Sodium Channels; Sulfonamides; Torsades de Pointes | 2007 |
Erg K+ channels modulate contractile activity in the bovine epididymal duct.
Topics: Animals; Blotting, Western; Calcium Channel Blockers; Cattle; Cell Line; Cresols; Cricetinae; Electrophysiology; Epididymis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Immunohistochemistry; In Vitro Techniques; Isometric Contraction; Male; Membranes; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Phenylurea Compounds; Piperidines; Potassium Channel Blockers; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2008 |
Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs.
Topics: Action Potentials; Animals; Chromans; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; Electrocardiography; Epinephrine; Guinea Pigs; Male; Models, Biological; Phenylephrine; Piperidines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Sulfonamides; Torsades de Pointes | 2008 |
Pharmacological separation of hEAG and hERG K+ channel function in the human mammary carcinoma cell line MCF-7.
Topics: Adenocarcinoma; Anti-Allergic Agents; Anti-Arrhythmia Agents; Astemizole; Breast Neoplasms; Cell Proliferation; Cell Size; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Imipramine; Long QT Syndrome; Piperidines; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2008 |
In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig.
Topics: Animals; Anti-Arrhythmia Agents; Consciousness; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Guinea Pigs; Heart Rate; Humans; Long QT Syndrome; Phenylurea Compounds; Piperidines; Pyridines; Tetrazoles | 2008 |
Ether-a-go-go-related gene 3 is the main candidate for the E-4031-sensitive potassium current in the pacemaker interstitial cells of Cajal.
Topics: Animals; Cells, Cultured; Gastrointestinal Motility; Jejunum; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines | 2008 |
Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.
Topics: Action Potentials; Amino Acid Substitution; Anti-Arrhythmia Agents; Cell Line; Ether-A-Go-Go Potassium Channels; Humans; Ion Channel Gating; Kinetics; Long QT Syndrome; Models, Biological; Mutation, Missense; Piperidines; Protein Subunits; Pyridines | 2008 |
The role of ether-a-go-go-related gene K(+) channels in glucocorticoid inhibition of adrenocorticotropin release by rat pituitary cells.
Topics: Adrenocorticotropic Hormone; Animals; Apamin; Cells, Cultured; Corticosterone; Corticotrophs; Corticotropin-Releasing Hormone; Ether-A-Go-Go Potassium Channels; Glucocorticoids; Humans; Male; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2009 |
Acidosis inhibits spontaneous activity and membrane currents in myocytes isolated from the rabbit atrioventricular node.
Topics: Acidosis; Animals; Atrioventricular Node; Calcium Channels, L-Type; Electrophysiology; Hydrogen-Ion Concentration; Ions; Male; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Piperidines; Pyridines; Rabbits; Sensitivity and Specificity; Temperature | 2009 |
The muscarinic inhibition of the potassium M-current modulates the action-potential discharge in the vestibular primary-afferent neurons of the rat.
Topics: Action Potentials; Animals; Animals, Newborn; Anthracenes; Atropine; Biophysical Phenomena; Calcium Channel Blockers; Cells, Cultured; Indoles; Muscarinic Agonists; Muscarinic Antagonists; Neurons, Afferent; Oxotremorine; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rats, Wistar; Receptors, Muscarinic; Vestibule, Labyrinth | 2009 |
Docking model of drug binding to the human ether-à-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach.
Topics: Amino Acid Sequence; Binding Sites; Cell Line; Cisapride; Dimerization; Ether-A-Go-Go Potassium Channels; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Patch-Clamp Techniques; Piperidines; Pyridines; Sequence Homology, Amino Acid; Terfenadine | 2009 |
Ether-à-go-go-related gene K+ channels contribute to threshold excitability of mouse auditory brainstem neurons.
Topics: Action Potentials; Animals; Auditory Pathways; Brain Stem; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Immunohistochemistry; In Vitro Techniques; Kinetics; Long QT Syndrome; Mice; Mice, Inbred CBA; Neurons; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensory Thresholds | 2009 |
The role of hERG1 K+ channels and a functional link between hERG1 K+ channels and SDF-1 in acute leukemic cell migration.
Topics: Adolescent; Adult; Aged; Animals; Anti-Arrhythmia Agents; Cell Movement; Chemokine CXCL12; Child; Child, Preschool; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; HL-60 Cells; Humans; Male; Middle Aged; Neoplastic Stem Cells; Oocytes; Piperidines; Pyridines; Receptors, CXCR4; Xenopus laevis; Young Adult | 2009 |
Effect of thermal acclimation on action potentials and sarcolemmal K+ channels from Pacific bluefin tuna cardiomyocytes.
Topics: Acclimatization; Action Potentials; Animals; Anti-Arrhythmia Agents; Barium Compounds; Cell Enlargement; Chlorides; Electric Capacitance; Electrophysiological Phenomena; Heart; Heart Atria; Heart Ventricles; Humans; Male; Myocytes, Cardiac; Piperidines; Potassium Channels; Pyridines; Sarcolemma; Temperature; Tuna | 2009 |
HERG1 gene expression as a specific tumor marker in colorectal tissues.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoembryonic Antigen; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Female; Gene Expression; Humans; Immunohistochemistry; Keratin-19; Keratin-20; Male; Middle Aged; Piperidines; Polymerase Chain Reaction; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Tumor Cells, Cultured | 2010 |
Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart.
Topics: 4-Aminopyridine; Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Barium Compounds; Cell Line; Chlorides; Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart Conduction System; Humans; Kidney; Patch-Clamp Techniques; Piperazines; Piperidines; Potassium Channel Blockers; Pyridines; Rabbits; Ranolazine; Sodium; Sodium Channel Blockers; Sodium Channels; Tachycardia, Ventricular; Tetrodotoxin; Torsades de Pointes | 2009 |
Erg K+ currents modulate excitability in mouse mitral/tufted neurons.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cells, Cultured; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Immunohistochemistry; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Piperidines; Pyridines; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Clobutinol delays ventricular repolarization in the guinea pig heart: comparison with cardiac effects of HERG K+ channel inhibitor E-4031.
Topics: Action Potentials; Amino Alcohols; Anesthesia; Animals; Antitussive Agents; Blood Pressure; Electric Stimulation; Electrocardiography; Electrophysiological Phenomena; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Guinea Pigs; Halothane; Heart; Heart Rate; Male; Membrane Potentials; Piperidines; Pyridines; Ventricular Function; Ventricular Function, Right | 2009 |
Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574).
Topics: Action Potentials; Animals; Cells, Cultured; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Humans; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines | 2010 |
Anthropomorphizing the mouse cardiac action potential via a novel dynamic clamp method.
Topics: Action Potentials; Algorithms; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cells, Cultured; Computers; Heart; Mice; Models, Cardiovascular; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Pyridines | 2009 |
Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cells, Cultured; Computer Simulation; Disease Susceptibility; Electrocardiography; Estrogens; Female; Gonadal Steroid Hormones; Guinea Pigs; Male; Markov Chains; Menstrual Cycle; Myocytes, Cardiac; Piperidines; Potassium Channels; Progesterone; Pyridines; Testosterone | 2010 |
Pharmacological activation of IKr impairs conduction in guinea pig hearts.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Ether-A-Go-Go Potassium Channels; Flecainide; Guinea Pigs; Heart Conduction System; In Vitro Techniques; Male; Perfusion; Phenylurea Compounds; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Sodium Channel Blockers; Tetrazoles; Time Factors; Voltage-Sensitive Dye Imaging | 2010 |
Modulation of cardiac ERG1 K(+) channels by cGMP signaling.
Topics: Action Potentials; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Female; Guinea Pigs; Heart Ventricles; Male; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Piperidines; Pyridines; Rats; Rats, Wistar; Signal Transduction; Thionucleotides; Trans-Activators; Transcriptional Regulator ERG | 2010 |
Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Blood Pressure; Calcium Channel Blockers; Cerebral Revascularization; Dogs; Electrophysiologic Techniques, Cardiac; Heart Rate; Piperidines; Pyridines; Tachycardia, Ventricular; Ventricular Function, Left | 2010 |
Characterization of the rapidly activating delayed rectifier potassium current, I (Kr), in HL-1 mouse atrial myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Blotting, Western; Cell Line; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Mice; Myocytes, Cardiac; Nisoldipine; Patch-Clamp Techniques; Piperidines; Potassium; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2010 |
The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome.
Topics: Action Potentials; Adult; Animals; Anti-Arrhythmia Agents; Antiemetics; Cardioplegic Solutions; Cell Separation; Chromans; Computer Simulation; Data Interpretation, Statistical; Droperidol; Guinea Pigs; Humans; Long QT Syndrome; Models, Statistical; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines; Sulfonamides | 2010 |
Presence and functional role of the rapidly activating delayed rectifier K(+) current in left and right atria of adult mice.
Topics: Action Potentials; Aminopyridines; Animals; Atrial Function; Cells, Cultured; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart Atria; Kinetics; Kv1.5 Potassium Channel; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Organ Specificity; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines | 2010 |
Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Membrane; Cells, Cultured; Coculture Techniques; Doxorubicin; Drug Resistance, Neoplasm; Ether-A-Go-Go Potassium Channels; Female; Humans; Integrin beta1; Mesenchymal Stem Cells; Mice; Mice, Inbred NOD; Mice, SCID; Multiprotein Complexes; Piperidines; Potassium Channel Blockers; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Pyridines; Receptors, CXCR4; RNA Interference; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2011 |
hERG subunit composition determines differential drug sensitivity.
Topics: Action Potentials; Arrhythmias, Cardiac; Cell Line, Transformed; Drug Evaluation, Preclinical; Ether-A-Go-Go Potassium Channels; Fluoxetine; HEK293 Cells; Humans; Inhibitory Concentration 50; Long QT Syndrome; Piperidines; Protein Subunits; Pyridines; Sensitivity and Specificity; Torsades de Pointes | 2011 |
Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization.
Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Animal; Enzyme Inhibitors; Female; Heart Rate; Long QT Syndrome; Models, Cardiovascular; Myocardial Contraction; Myocytes, Cardiac; Patch-Clamp Techniques; Piperazines; Piperidines; Pyridines; Rabbits; Ranolazine; Sodium; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Torsades de Pointes | 2011 |
Trafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutation.
Topics: Adult; Blotting, Western; Cell Membrane; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Genotype; HEK293 Cells; Humans; Immunohistochemistry; Immunoprecipitation; Long QT Syndrome; Microscopy, Confocal; Models, Biological; Mutation; Piperidines; Proteasome Endopeptidase Complex; Protein Transport; Pyridines | 2011 |
Trafficking-deficient hERG K⁺ channels linked to long QT syndrome are regulated by a microtubule-dependent quality control compartment in the ER.
Topics: Anti-Arrhythmia Agents; Blotting, Western; Endoplasmic Reticulum; Ether-A-Go-Go Potassium Channels; Fluorescent Antibody Technique; Glycosylation; Golgi Apparatus; Green Fluorescent Proteins; HEK293 Cells; Humans; Long QT Syndrome; Microtubules; Mutation; Myocytes, Cardiac; Nocodazole; Patch-Clamp Techniques; Piperidines; Protein Transport; Pyridines; Tubulin Modulators | 2011 |
Role of hERG1 K(+) channels in leukemia cells as a positive regulator in SDF-1a-induced proliferation.
Topics: Apoptosis; beta Catenin; Cell Cycle; Cell Proliferation; Chemokine CXCL12; Cyclin D1; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Flow Cytometry; G1 Phase; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Leukemia; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Piperidines; Proto-Oncogene Proteins c-myc; Pyridines; Resting Phase, Cell Cycle; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aza Compounds; Cell Line; Disease Models, Animal; Dogs; Embryonic Stem Cells; Female; Fluoroquinolones; Heart; Heart Block; Humans; Methoxamine; Moxifloxacin; Myocytes, Cardiac; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Quinolines; Rabbits; Sulfonamides; Torsades de Pointes; Ventricular Remodeling | 2012 |
Understanding of molecular substructures that contribute to hERG K+ channel blockade: synthesis and biological evaluation of E-4031 analogues.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Piperidines; Pyridines; Structure-Activity Relationship | 2012 |
Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells.
Topics: Cell Line, Tumor; Cell Proliferation; Ether-A-Go-Go Potassium Channels; Humans; Lung Neoplasms; Membrane Potentials; Piperidines; Pyridines; RNA, Small Interfering; Small Cell Lung Carcinoma | 2012 |
A novel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval.
Topics: Cisapride; Drug Evaluation, Preclinical; Embryonic Stem Cells; Ether-A-Go-Go Potassium Channels; Humans; Myocytes, Cardiac; Piperidines; Potassium Channel Blockers; Pyridines | 2012 |
Cardiac tissue slices with prolonged survival for in vitro drug safety screening.
Topics: 4-Aminopyridine; Action Potentials; Animal Testing Alternatives; Animals; Animals, Laboratory; Anti-Arrhythmia Agents; Calcium Channel Blockers; Carbenoxolone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Male; Nifedipine; Piperidines; Potassium Channel Blockers; Pyridines; Rats; Rats, Wistar; Risk Assessment; Toxicity Tests | 2012 |
Human ether-a-go-go-related gene K+ channels regulate shedding of leukemia cell-derived microvesicles.
Topics: Anti-Arrhythmia Agents; CD11b Antigen; Cell Adhesion; Cell Line, Tumor; Cell Membrane; Chemotaxis; Ether-A-Go-Go Potassium Channels; Flow Cytometry; Gene Expression Regulation, Leukemic; HL-60 Cells; Human Umbilical Vein Endothelial Cells; Humans; K562 Cells; Microcirculation; Microvessels; Piperidines; Pyridines | 2012 |
Development of recombinant cell line co-expressing mutated Nav1.5, Kir2.1, and hERG for the safety assay of drug candidates.
Topics: Action Potentials; Biological Assay; Cell Line; Cisapride; Drug Evaluation, Preclinical; Ether-A-Go-Go Potassium Channels; HEK293 Cells; High-Throughput Screening Assays; Humans; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyridines; Pyrimidinones; Sodium Channels; Terfenadine; Transfection; Verapamil | 2012 |
Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.
Topics: Action Potentials; Animals; Bepridil; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Ether-A-Go-Go Potassium Channels; Heart Conduction System; Humans; In Vitro Techniques; Long QT Syndrome; Piperidines; Potassium Channel Blockers; Pyridines; Risk Assessment; Risperidone; Time Factors; Torsades de Pointes; Toxicity Tests; Verapamil; Voltage-Sensitive Dye Imaging | 2012 |
Role of action potential configuration and the contribution of C²⁺a and K⁺ currents to isoprenaline-induced changes in canine ventricular cells.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Calcium Channels, L-Type; Chromans; Delayed Rectifier Potassium Channels; Dogs; Female; Isoproterenol; Male; Myocytes, Cardiac; Nisoldipine; Patch-Clamp Techniques; Piperidines; Pyridines; Sulfonamides | 2012 |
Pharmacological blockade of IKs destabilizes spiral-wave reentry under β-adrenergic stimulation in favor of its early termination.
Topics: Action Potentials; Adrenergic Agents; Animals; Arrhythmias, Cardiac; Chromans; Heart Ventricles; Isoproterenol; Myocardium; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Rabbits; Sulfonamides; Sympathetic Nervous System | 2012 |
Functional characterization of ether-à-go-go-related gene potassium channels in midbrain dopamine neurons - implications for a role in depolarization block.
Topics: Animals; Dopaminergic Neurons; Ether-A-Go-Go Potassium Channels; Male; Membrane Potentials; Mesencephalon; Piperidines; Potassium Channel Blockers; Pyridines; Rats; Rats, Sprague-Dawley; Scorpion Venoms | 2012 |
Maximum diastolic potential of human induced pluripotent stem cell-derived cardiomyocytes depends critically on I(Kr).
Topics: Action Potentials; Barium Compounds; Cell Differentiation; Chlorides; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Models, Biological; Myocytes, Cardiac; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyridines; RNA, Messenger; Time Factors | 2012 |
Dynamic link between histone H3 acetylation and an increase in the functional characteristics of human ESC/iPSC-derived cardiomyocytes.
Topics: Acetylation; Adult; Blotting, Western; Cell Differentiation; Cell Line; Electrophysiology; Embryonic Stem Cells; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression Profiling; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Induced Pluripotent Stem Cells; Myocytes, Cardiac; Oligonucleotide Array Sequence Analysis; Piperidines; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2012 |
Exploration of human, rat, and rabbit embryonic cardiomyocytes suggests K-channel block as a common teratogenic mechanism.
Topics: Action Potentials; Animals; Atrioventricular Block; Cells, Cultured; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression Regulation, Developmental; Gestational Age; Heart Defects, Congenital; Humans; KCNQ1 Potassium Channel; Kinetics; Long QT Syndrome; Myocytes, Cardiac; Organogenesis; Patch-Clamp Techniques; Piperidines; Polymerase Chain Reaction; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; RNA, Messenger; Species Specificity; Teratogens | 2013 |
Pacemaker interactions induce reentrant wave dynamics in engineered cardiac culture.
Topics: Animals; Arrhythmias, Cardiac; Chick Embryo; Heart; Models, Cardiovascular; Pacemaker, Artificial; Piperidines; Pyridines; Tissue Culture Techniques; Tissue Engineering | 2012 |
Chaotic dynamics in cardiac aggregates induced by potassium channel block.
Topics: Animals; Cell Aggregation; Cell Movement; Chick Embryo; Heart Ventricles; Intracellular Space; Membrane Potentials; Models, Cardiovascular; Nonlinear Dynamics; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Ventricular Function | 2012 |
Wiring the developing heart: a serious matter for adulthood.
Topics: Animals; Heart Defects, Congenital; Humans; Myocytes, Cardiac; Piperidines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Teratogens | 2013 |
Effect of rapid delayed rectifier current on hysteresis in restitution of action potential duration in swine.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Diastole; Electrophysiological Phenomena; Endocardium; Heart Conduction System; Models, Cardiovascular; Piperidines; Potassium Channels, Inwardly Rectifying; Pyridines; Swine | 2012 |
Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Endoplasmic Reticulum; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; HEK293 Cells; Humans; Long QT Syndrome; Male; Middle Aged; Mutation, Missense; Piperidines; Potassium Channel Blockers; Protein Transport; Pyridines; Young Adult | 2013 |
Spatial correlation of action potential duration and diastolic dysfunction in transgenic and drug-induced LQT2 rabbits.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Diastole; Female; Long QT Syndrome; Magnetic Resonance Imaging; Piperidines; Pyridines; Rabbits | 2013 |
Developmental changes in expression and biophysics of ion channels in the canine ventricle.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Calcium; Dogs; Female; Heart Ventricles; Humans; Ion Channels; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channels; Pyridines; Sodium; Ventricular Function | 2013 |
KN-93, A CaMKII inhibitor, suppresses ventricular arrhythmia induced by LQT2 without decreasing TDR.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Electrocardiography; Electrophysiologic Techniques, Cardiac; Endocardium; Heart; In Vitro Techniques; Long QT Syndrome; Pericardium; Piperidines; Protein Kinase Inhibitors; Pyridines; Rabbits; Sulfonamides; Torsades de Pointes | 2013 |
Integrated platform for functional monitoring of biomimetic heart sheets derived from human pluripotent stem cells.
Topics: Anti-Arrhythmia Agents; Biomimetics; Cell Differentiation; Cells, Cultured; Humans; Inhibitory Concentration 50; Isoproterenol; Myocytes, Cardiac; Piperidines; Pluripotent Stem Cells; Pyridines | 2014 |
Mitigating prolonged QT interval in cancer nanodrug development for accelerated clinical translation.
Topics: Anti-Arrhythmia Agents; Antineoplastic Agents, Phytogenic; Curcumin; Delayed-Action Preparations; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Ion Channel Gating; Liposomes; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Pyridines; Translational Research, Biomedical | 2013 |
Characterization of hERG1 channel role in mouse colorectal carcinogenesis.
Topics: Adenomatous Polyposis Coli; Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Intestine, Large; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Proteins; Neovascularization, Pathologic; Piperidines; Proto-Oncogene Proteins c-akt; Pyridines; Vascular Endothelial Growth Factor A | 2013 |
Assessment of testing methods for drug-induced repolarization delay and arrhythmias in an iPS cell-derived cardiomyocyte sheet: multi-site validation study.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Electrophysiologic Techniques, Cardiac; Heart Rate; Humans; Induced Pluripotent Stem Cells; Myocytes, Cardiac; Piperidines; Prospective Studies; Pyridines | 2014 |
Effects of selective IKr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Output; Delayed Rectifier Potassium Channels; Dogs; Female; Halothane; Heart Rate; Heart Ventricles; Male; Myocardial Contraction; Piperidines; Potassium Channel Blockers; Pyridines; Ventricular Function | 2014 |
Pronounced effects of HERG-blockers E-4031 and erythromycin on APD, spatial APD dispersion and triangulation in transgenic long-QT type 1 rabbits.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Erythromycin; Female; Heart; Long QT Syndrome; Piperidines; Pyridines; Rabbits | 2014 |
Image-based evaluation of contraction-relaxation kinetics of human-induced pluripotent stem cell-derived cardiomyocytes: Correlation and complementarity with extracellular electrophysiology.
Topics: Adrenergic beta-Agonists; Biomechanical Phenomena; Calcium Channel Blockers; Calcium Signaling; Cell Differentiation; Cells, Cultured; Electrophysiologic Techniques, Cardiac; Humans; Induced Pluripotent Stem Cells; Isoproterenol; Kinetics; Microscopy, Video; Myocardial Contraction; Myocytes, Cardiac; Piperidines; Pyridines; Sodium Channel Blockers; Tetrodotoxin; Verapamil | 2014 |
[Effects of E 4031 on isolated cardiac function and resting Ca2+ level of myocardial cells from rats with chronic heart failure].
Topics: Animals; Calcium; Disease Models, Animal; Heart; Heart Failure; In Vitro Techniques; Male; Myocardium; Myocytes, Cardiac; Piperidines; Pyridines; Rats; Rats, Wistar | 2014 |
Inhibition of IKr potentiates development of atrial-selective INa block leading to effective suppression of atrial fibrillation.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Delayed Rectifier Potassium Channels; Dogs; Electrophysiological Phenomena; Heart Atria; Heart Rate; Heart Ventricles; Lidocaine; Models, Anatomic; Piperidines; Pyridines; Sodium Channel Blockers; Sodium Channels | 2015 |
Single channel and ensemble hERG conductance measured in droplet bilayers.
Topics: Animals; Anti-Arrhythmia Agents; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Lipid Bilayers; Mice; Piperidines; Pyridines | 2015 |
Non-Invasive Acoustical sensing of Drug-Induced Effects on the Contractile Machinery of Human Cardiomyocyte Clusters.
Topics: Biosensing Techniques; Cell Line; Cytochalasin D; Humans; Isoproterenol; Myocytes, Cardiac; Nifedipine; Piperidines; Pyridines; Quartz Crystal Microbalance Techniques | 2015 |
Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters.
Topics: Animals; Aromatase; Electrocardiography; ERG1 Potassium Channel; Estrogens; Ether-A-Go-Go Potassium Channels; Female; Heart Rate; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyridines | 2015 |
Possible effects of inhibition of IKr and IKs on field-potential waveforms in the human iPS cell-derived cardiomyocytes sheet.
Topics: Anti-Arrhythmia Agents; Cell Culture Techniques; Cells, Cultured; Chromans; Evoked Potentials; Humans; Induced Pluripotent Stem Cells; Myocytes, Cardiac; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Sulfonamides | 2015 |
Reduced response to IKr blockade and altered hERG1a/1b stoichiometry in human heart failure.
Topics: Action Potentials; Adolescent; Adult; Anti-Arrhythmia Agents; Computer Simulation; ERG1 Potassium Channel; Female; Gene Expression; Heart Failure; Heart Ventricles; Humans; Male; Middle Aged; Models, Biological; Myocardium; Piperidines; Potassium; Pyridines; Young Adult | 2016 |
A Simple Protocol for the Myocardial Differentiation of Human iPS Cells.
Topics: Activins; Bone Morphogenetic Protein 4; Calcium Channel Blockers; Carrier Proteins; Cell Differentiation; Cells, Cultured; Chromans; Embryoid Bodies; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Humans; Induced Pluripotent Stem Cells; Myocardium; Pentamidine; Piperidines; Potassium Channel Blockers; Pyridines; Sulfonamides; Transcription Factors; Troponin T; Verapamil; Wnt3A Protein | 2015 |
Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Ischemic Preconditioning; Male; Mitochondria; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Piperidines; Potassium Channels, Calcium-Activated; Pyridines; Rats; Rats, Sprague-Dawley; Sodium-Calcium Exchanger | 2015 |
Pharmacological rescue of hERG currents carried out by G604S and wide type hERG co-expression.
Topics: Amino Acid Substitution; Cresols; Electrophysiological Phenomena; Ether-A-Go-Go Potassium Channels; Gene Expression; HEK293 Cells; Humans; Ion Channel Gating; Mutation; Phenylurea Compounds; Piperidines; Pyridines; Temperature | 2016 |
Administration of Non-Torsadogenic human Ether-à-go-go-Related Gene Inhibitors Is Associated with Better Survival for High hERG-Expressing Glioblastoma Patients.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Proliferation; Disease Models, Animal; Ether-A-Go-Go Potassium Channels; Gene Expression; Glioblastoma; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Mice; Molecular Targeted Therapy; Piperidines; Pyridines; Spheroids, Cellular; Tissue Array Analysis; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |
Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential.
Topics: Cells, Cultured; Chromans; Cisapride; Electrophysiological Phenomena; Heart Rate; Humans; Induced Pluripotent Stem Cells; Linear Models; Models, Cardiovascular; Myocytes, Cardiac; Piperidines; Pyridines; Sulfonamides; Torsades de Pointes | 2016 |
Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.
Topics: Action Potentials; Antioxidants; Cell Culture Techniques; Cell Differentiation; Cell Line; COUP Transcription Factor II; Culture Media; Homeodomain Proteins; Humans; Induced Pluripotent Stem Cells; Microscopy, Fluorescence; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Piperidines; Pluripotent Stem Cells; Pyridines; Tretinoin | 2017 |
Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiovascular Physiological Phenomena; Electrocardiography; Heart; Heart Rate; Infusions, Intravenous; Lidocaine; Piperidines; Pyridines; Swine; Swine, Miniature; Verapamil | 2017 |
Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes.
Topics: Cardiotoxicity; Cell Differentiation; Drug Discovery; Haloperidol; Human Embryonic Stem Cells; Humans; Induced Pluripotent Stem Cells; Isoproterenol; Myocytes, Cardiac; Piperidines; Pyridines; Quinidine | 2017 |
Evaluation of the effects of power-frequency magnetic fields on the electrical activity of cardiomyocytes differentiated from human induced pluripotent stem cells.
Topics: Anti-Arrhythmia Agents; Calcium Channel Blockers; Cell Differentiation; Cell Line; Humans; Induced Pluripotent Stem Cells; Magnetic Fields; Myocytes, Cardiac; Piperidines; Pyridines; Verapamil | 2017 |
Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs.
Topics: Action Potentials; Arrhythmias, Cardiac; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Models, Biological; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyridines | 2017 |
In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles.
Topics: Action Potentials; Arrhythmias, Cardiac; Cell Line; Disopyramide; Electrocardiography; ERG1 Potassium Channel; Heart Ventricles; Humans; Models, Biological; Piperidines; Polymorphism, Single Nucleotide; Pyridines; Quinidine | 2017 |
Modelling the effects of quinidine, disopyramide, and E-4031 on short QT syndrome variant 3 in the human ventricles.
Topics: Action Potentials; Arrhythmias, Cardiac; Disopyramide; Heart Conduction System; Heart Defects, Congenital; Heart Ventricles; Humans; Models, Biological; Piperidines; Pyridines; Quinidine | 2017 |
Selective inhibition of physiological late Na
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Disease Models, Animal; Female; Heart Rate; Heart Ventricles; In Vitro Techniques; Isolated Heart Preparation; Kinetics; Myocytes, Cardiac; Piperidines; Pyridines; Rabbits; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Triazoles | 2018 |
Novel intracellular transport-refractory mutations in KCNH2 identified in patients with symptomatic long QT syndrome.
Topics: Adult; Animals; CHO Cells; Cricetinae; Cricetulus; ERG1 Potassium Channel; Female; Humans; Kv1.1 Potassium Channel; Long QT Syndrome; Loss of Function Mutation; Mutation, Missense; Patch-Clamp Techniques; Phenotype; Piperidines; Protein Transport; Pyridines | 2018 |
Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjects.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Chronic Disease; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Humans; Infusions, Intravenous; Piperidines; Pyridines; Torsades de Pointes | 2018 |
Electro-mechanical (dys-)function in long QT syndrome type 1.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Anti-Arrhythmia Agents; Biomechanical Phenomena; Disease Models, Animal; Electrocardiography; Magnetic Resonance Imaging, Cine; Male; Myocardial Contraction; Myocytes, Cardiac; Piperidines; Pyridines; Rabbits; Romano-Ward Syndrome | 2019 |
Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers.
Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Bepridil; Calcium Channel Blockers; Cells, Cultured; Drug Evaluation, Preclinical; Electrophysiological Phenomena; Humans; Induced Pluripotent Stem Cells; Microelectrodes; Myocytes, Cardiac; Piperidines; Potassium Channel Blockers; Pyridines; Sodium Channel Blockers | 2018 |
ERG Channels Regulate Excitability in Stellate and Bushy Cells of Mice Ventral Cochlear Nucleus.
Topics: Action Potentials; Animals; Auditory Pathways; Cochlear Nucleus; Electrophysiology; Ether-A-Go-Go Potassium Channels; Membrane Potentials; Mice; Piperidines; Pyridines; Stellate Ganglion; Terfenadine | 2018 |
Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis.
Topics: Animals; Anti-Arrhythmia Agents; Biological Clocks; Electrophysiologic Techniques, Cardiac; Electrophysiological Phenomena; Heart; Heart Rate; Humans; Isoproterenol; Microscopy, Fluorescence; Optogenetics; Piperidines; Propranolol; Pyridines; Zebrafish | 2018 |
Pharmacological enhancement of repolarization reserve in human induced pluripotent stem cells derived cardiomyocytes.
Topics: Action Potentials; Cell Differentiation; Cells, Cultured; Humans; Induced Pluripotent Stem Cells; Myocytes, Cardiac; Phenylurea Compounds; Piperidines; Potassium Channels; Pyridines; Tetrazoles | 2019 |
Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells.
Topics: Action Potentials; Anti-Arrhythmia Agents; Calcium; Calcium Channels; Cell Differentiation; ERG1 Potassium Channel; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Ion Transport; Long QT Syndrome; Models, Biological; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Scorpion Venoms; Sulfonamides | 2020 |
Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias.
Topics: Arrhythmias, Cardiac; Cell Line; Electrophysiology; ERG1 Potassium Channel; Gene Editing; Genetic Predisposition to Disease; Humans; Induced Pluripotent Stem Cells; Long QT Syndrome; Models, Biological; Mutation; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Pyridines | 2020 |
A Scalable Approach Reveals Functional Responses of iPSC Cardiomyocyte 3D Spheroids.
Topics: Anti-Arrhythmia Agents; Barium Compounds; Biological Assay; Calcium; Cell Differentiation; Chlorides; Coculture Techniques; Ferric Compounds; Fibroblasts; Gold; Humans; Induced Pluripotent Stem Cells; Ion Transport; Metal Nanoparticles; Models, Biological; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Piperidines; Pyridines; Spheroids, Cellular | 2021 |
Development of a drug screening system using three-dimensional cardiac tissues containing multiple cell types.
Topics: Animals; Drug Evaluation, Preclinical; Extracellular Matrix; Gene Expression Regulation; Heart; Heart Rate; Imaging, Three-Dimensional; Induced Pluripotent Stem Cells; Ion Channels; Isoproterenol; Mice; Myocardial Contraction; Piperidines; Pyridines | 2021 |
Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart.
Topics: Adult; Atrial Fibrillation; Calcium; Cnidarian Venoms; ERG1 Potassium Channel; Heart Atria; Humans; Membrane Potentials; Models, Cardiovascular; Myocytes, Cardiac; Piperidines; Pyridines; Ranolazine; Sodium; Triazoles | 2021 |
The Effect of a Synthetic Estrogen, Ethinylestradiol, on the hERG Block by E-4031.
Topics: Estradiol Congeners; Ether-A-Go-Go Potassium Channels; Ethinyl Estradiol; HEK293 Cells; Humans; Ion Channel Gating; Piperidines; Pyridines | 2021 |