dynorphins has been researched along with dezocine* in 2 studies
2 other study(ies) available for dynorphins and dezocine
| Article | Year |
|---|---|
Increased neuropeptide-converting enzyme activities in cerebrospinal fluid of opiate-tolerant rats.
Rats were given a continuous subcutaneous infusion at constant rate with either morphine, the opioid agonist/antagonist analgesic dezocine or saline. Tolerance to the antinociceptive effect of morphine or dezocine was complete on day 8, when cisterna magnum cerebrospinal fluid (CSF) was sampled under anesthesia. The activity of the enzymes cleaving dynorphin A (DCE) and substance P (SPE) was measured in the CSF. It was found that the animals treated with morphine had a 2- to 3-fold increase in both DCE and SPE activities. The animals treated with dezocine showed a similar increase in the activity of DCE, whereas SPE did not significantly change. These enzymes may therefore play a role in the development of tolerance to opioid analgesic drugs. The experiments show that chronic opioid treatment affects peptidergic mechanisms. Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cycloparaffins; Drug Tolerance; Dynorphins; Male; Metalloendopeptidases; Morphine; Rats; Rats, Inbred Strains; Serine Endopeptidases; Substance P; Tetrahydronaphthalenes | 1989 |
The partial opiate receptor agonists, dezocine and ciramadol act as mu receptor antagonists at the feline ileocecal sphincter.
The effects of two novel synthetic narcotic agonist/antagonists dezocine and ciramadol were examined at the ileocecal sphincter (ICS) in the intact anesthetized cat. Changes in blood pressure were seen with higher doses of both dezocine and ciramadol. No ICS pressure changes were seen in the ICS to dezocine and an increase in ICS pressure was seen only to the highest dose of ciramadol examined (10 mg/kg). The antagonist action of the two drugs were examined against submaximal doses of the mu receptor agonist morphine sulfate, delta receptor agonist methionine enkephalin and the k-receptor agonist dynorphin. Both drugs inhibit the ICS response to morphine sulfate. No inhibition of the responses to methionine enkephalin or dynorphin were seen with dezocine and only partial inhibition of the ICS response to dynorphin was seen with ciramadol. Topics: Analgesics; Animals; Benzylamines; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cats; Cycloparaffins; Dynorphins; Enkephalin, Methionine; Ileocecal Valve; Male; Morphine; Muscle Contraction; Narcotic Antagonists; Pressure; Receptors, Opioid, mu; Tetrahydronaphthalenes | 1989 |