dipyrone has been researched along with naloxone in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.00) | 18.7374 |
| 1990's | 7 (23.33) | 18.2507 |
| 2000's | 13 (43.33) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bantoutova, I; Sourcheva, S; Vlaskovska, M | 1 |
| Popova, Y; Staneva-Stoycheva, D | 1 |
| Carlsson, KH; Helmreich, J; Jurna, I | 1 |
| Ivanov, D; Staneva-Stoycheva, D | 1 |
| Chambers, JP; Livingston, A; Waterman, AE | 1 |
| Tortorici, V; Vanegas, H; Vásquez, E | 1 |
| Akman, H; Aksu, F; Baysal, F; Doran, F; Gültekin, I; Oral, U; Ozbek, H | 1 |
| Coudert, P; Couquelet, J; Rohet, F; Rubat, C | 1 |
| Fernaud, I; Mellström, B; Naranjo, JR; Taylor, J | 1 |
| Vanegas, H; Vasquez, E | 1 |
| Aguirre-Bañuelos, P; Granados-Soto, V | 2 |
| Tortorici, V; Vanegas, H | 1 |
| Hernández, N; Vanegas, H | 1 |
| Díaz Reval, MI; Domínguez Ramírez, AM; Hernández-Delgadillo, GP; López-Muñoz, FJ; Ventura Martínez, R | 1 |
| Planas, E; Pol, O; Poveda, R; Puig, MM; Romero, A; Sánchez, S | 1 |
| Doretto, MC; Duarte, ID; Reis, GM; Tatsuo, MA | 1 |
| Herbert, MK; Holzer, P; Roewer, N; Weis, R | 1 |
| Escobar, W; Hernandez, N; Vanegas, H; Vazquez, E | 1 |
| Cruz, SL; Hernández-Delgadillo, GP | 1 |
| Deveci, MS; Dogrul, A; Gul, H; Gülmez, SE; Ossipov, MH; Porreca, F; Tulunay, FC | 1 |
| Beck, P; Bonacorso, HG; Drewes, C; Ferreira, J; Machado, P; Martins, MA; Mello, CF; Milano, J; Oliveira, SM; Rossato, MF; Rubin, MA; Zanatta, N | 1 |
| Arslan, R; Bektas, N | 1 |
| Abzianidze, E; Gurtskaia, G; Nozadze, I; Tsagareli, MG; Tsiklauri, N | 1 |
| Castor, MG; Duarte, ID; Navarro, LC; Romero, TR; Silva, LC | 1 |
| Abzianidze, E; Gorgiladze, T; Nozadze, I; Tsagareli, M | 1 |
| Bassani da Silva, B; Fernandes Magalhães, S; Gonçalves Dos Santos, G; Parada, CA; Tambeli, CH; Vendramini, PH; Vieira, WF | 1 |
| Baumann, F; Bingel, U; Kleine-Borgmann, J; Kratel, J; Schmidt, K; Wilhelmi, J; Zunhammer, M | 1 |
1 trial(s) available for dipyrone and naloxone
| Article | Year |
|---|---|
Tilidine and dipyrone (metamizole) in cold pressor pain: A pooled analysis of efficacy, tolerability, and safety in healthy volunteers.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cold Temperature; Dipyrone; Double-Blind Method; Female; Healthy Volunteers; Humans; Male; Naloxone; Pain; Pain Measurement; Tilidine; Treatment Outcome; Young Adult | 2021 |
29 other study(ies) available for dipyrone and naloxone
| Article | Year |
|---|---|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Participation of the POMC-system in the effects of morphine on the avoidance reaction in albino rats.
Topics: Adrenalectomy; Animals; Aspirin; Avoidance Learning; Dexamethasone; Dipyrone; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Pro-Opiomelanocortin; Rats; Rats, Inbred Strains; Stress, Psychological | 1990 |
Lack of direct interaction of metamyzole with the brain opiate receptors of rats.
Topics: Aminopyrine; Animals; Brain Chemistry; Dipyrone; Kinetics; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
Activation of inhibition from the periaqueductal grey matter mediates central analgesic effect of metamizol (dipyrone).
Topics: Action Potentials; Aminopyrine; Animals; Dipyrone; Female; Male; Morphine; Naloxone; Nerve Fibers; Neural Inhibition; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Inbred Strains; Reflex; Spinal Cord; Substantia Nigra | 1986 |
On some presynaptic effects of meramyzole (analgine-pharmachim).
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Dipyrone; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrazolones; Sodium; Synapses; Vas Deferens | 1984 |
The effects of opioid and alpha 2 adrenergic blockade on non-steroidal anti-inflammatory drug analgesia in sheep.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Dipyrone; Double-Blind Method; Drug Interactions; Female; Foot Rot; Imidazoles; Injections, Intravenous; Lameness, Animal; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Random Allocation; Sheep; Sheep Diseases; Thromboxane B2 | 1995 |
Naloxone partial reversal of the antinociception produced by dipyrone microinjected into the periaqueductal gray of rats. Possible involvement of medullary off- and on-cells.
Topics: Animals; Dipyrone; Male; Microinjections; Naloxone; Nociceptors; Periaqueductal Gray; Rats; Rats, Sprague-Dawley | 1996 |
A possible central antinociceptive effect of dipyrone in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Spinal Cord Injuries | 1996 |
Synthesis and analgesic effects of 3-substituted 4,6-diarylpyridazine derivatives of the arylpiperazine class.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoquinones; Dipyrone; Dose-Response Relationship, Drug; Drug Design; Drug Interactions; Injections, Intraperitoneal; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Neurotoxins; Pain; Pyrazolones; Pyridazines; Receptors, Opioid; Reference Standards; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Trazodone | 1997 |
Metamizol potentiates morphine effects on visceral pain and evoked c-Fos immunoreactivity in spinal cord.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug Synergism; Immunohistochemistry; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Morphine; Naloxone; Narcotic Antagonists; Pain; Proto-Oncogene Proteins c-fos; Spinal Cord; Visceral Afferents | 1998 |
The antinociceptive effect of PAG-microinjected dipyrone in rats is mediated by endogenous opioids of the rostral ventromedical medulla.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Endorphins; Male; Medulla Oblongata; Microinjections; Naloxone; Narcotic Antagonists; Nociceptors; Periaqueductal Gray; Rats; Rats, Sprague-Dawley | 2000 |
Evidence for a peripheral mechanism of action for the potentiation of the antinociceptive effect of morphine by dipyrone.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Dipyrone; Drug Synergism; Female; Morphine; Naloxone; Narcotics; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar | 1999 |
Peripheral antinociceptive interaction of dipyrone and morphine in the formalin test.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain Measurement; Peripheral Nervous System; Rats; Rats, Wistar | 2000 |
Opioid tolerance induced by metamizol (dipyrone) microinjections into the periaqueductal grey of rats.
Topics: Animals; Dipyrone; Drug Tolerance; Hot Temperature; Male; Mesencephalon; Microinjections; Morphine; Naloxone; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Time Factors; Wakefulness | 2000 |
Antinociception induced by PAG-microinjected dipyrone (metamizol) in rats: involvement of spinal endogenous opioids.
Topics: Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Male; Microinjections; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Spinal Cord | 2001 |
Metamizol potentiates morphine antinociception but not constipation after chronic treatment.
Topics: Analgesics; Animals; Constipation; Dipyrone; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Male; Morphine; Naloxone; Pain Measurement; Rats; Rats, Wistar | 2002 |
Interaction between metamizol and tramadol in a model of acute visceral pain in rats.
Topics: Abdominal Pain; Acute Disease; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Drug Synergism; Ethacrynic Acid; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Tramadol; Visceral Afferents | 2003 |
Do endogenous opioids and nitric oxide participate in the anticonvulsant action of dipyrone?
Topics: Animals; Anticonvulsants; Dipyrone; Electroshock; Epilepsy, Reflex; Female; Naloxone; Narcotic Antagonists; Nitric Oxide; Nitroarginine; Opioid Peptides; Prostaglandins; Rats; Rats, Wistar | 2003 |
Peristalsis in the Guinea pig small intestine in vitro is impaired by acetaminophen but not aspirin and dipyrone.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dipyrone; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Female; Guinea Pigs; In Vitro Techniques; Indoles; Intestine, Small; Male; Methysergide; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peristalsis; Serotonin Antagonists; Tropisetron | 2005 |
Antinociception induced by intravenous dipyrone (metamizol) upon dorsal horn neurons: involvement of endogenous opioids at the periaqueductal gray matter, the nucleus raphe magnus, and the spinal cord in rats.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug Interactions; Injections, Intraventricular; Lower Extremity; Male; Microinjections; Naloxone; Pain; Pain Measurement; Periaqueductal Gray; Physical Stimulation; Posterior Horn Cells; Raphe Nuclei; Rats; Rats, Sprague-Dawley | 2005 |
Endogenous opioids are involved in morphine and dipyrone analgesic potentiation in the tail flick test in rats.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Dose-Response Relationship, Drug; Drug Synergism; Male; Morphine; Naloxone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Time Factors | 2006 |
The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dipyrone; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Injections, Intradermal; Injections, Intraperitoneal; Ketorolac; Lysine; Male; Mice; Mice, Inbred BALB C; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Reaction Time; Sodium Salicylate; Tail; Time Factors | 2007 |
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dipyrone; Freund's Adjuvant; Indomethacin; Inflammation; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain, Postoperative; Postural Balance; Pyrazoles; Stomach Ulcer | 2008 |
Antinociceptive effect of methanol extract of Capparis ovata in mice.
Topics: Acetic Acid; Analgesics; Animals; Capparis; Dipyrone; Dose-Response Relationship, Drug; Flowers; Hot Temperature; Injections, Intraperitoneal; Male; Medicine, Traditional; Methanol; Mice; Morphine; Naloxone; Pain; Pain Measurement; Plant Extracts; Reaction Time; Solvents; Turkey | 2010 |
Opioid sensitivity of nucleus raphe magnus ater analgesia by nonsteroidal anti-inflammatory drugs.
Topics: Analgesia; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug Interactions; Drug Tolerance; Ketorolac; Male; Microinjections; Morphine; Naloxone; Nociceptors; Pain; Periaqueductal Gray; Piroxicam; Raphe Nuclei; Rats; Spinal Cord | 2011 |
κ-Opioid receptor participates of NSAIDs peripheral antinociception.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dipyrone; Hindlimb; Hyperalgesia; Male; Naloxone; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2016 |
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS'S ANTINOCICEPTION MEDIATED BY THE OPIOID MECHANISM IN THE NUCLEUS RAPHE MAGNUS.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dipyrone; Ketorolac; Male; Microinjections; Naloxone; Narcotic Antagonists; Nociception; Nucleus Raphe Magnus; Opioid Peptides; Piroxicam; Rats; Reaction Time | 2017 |
Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB
Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Carrageenan; Dipyrone; Hydrolysis; Hyperalgesia; Indoles; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Opioid, kappa; Somatostatin | 2020 |