clonidine has been researched along with wb 4101 in 180 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 61 (33.89) | 18.7374 |
| 1990's | 103 (57.22) | 18.2507 |
| 2000's | 14 (7.78) | 29.6817 |
| 2010's | 2 (1.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Timmermans, PB; van Zwieten, PA | 1 |
| Butler, M; Jenkinson, DH | 1 |
| Briley, M; Langer, SZ; Raisman, R | 1 |
| Etgen, AM; Karkanias, GB; Petitti, N | 1 |
| Aniukhovskiĭ, EP; Rozen, MP; Staĭnberg, SF | 1 |
| Kojima, C; Satoh, M; Takayanagi, I | 2 |
| Kowatch, MA; Miyamoto, A; Roth, GS; Villalobos-Molina, R | 1 |
| Chiba, S; Skrbic, R | 1 |
| Bevan, JA; Bevan, RD; Oriowo, MA | 1 |
| Takano, M; Takano, Y; Yaksh, TL | 1 |
| Hayakawa, H; Shimizu, M; Yamawaki, S | 1 |
| Kigoshi, S; Muramatsu, I; Ohmura, T; Oshita, M | 1 |
| Harada, M; Koike, K; Satoh, M; Takayanagi, I | 1 |
| Anyukhovsky, EP; Rosen, MR | 1 |
| Abel, PW; Feng, F; Jeffries, WB; Pettinger, WA | 1 |
| García-Sáinz, JA; Torres-Márquez, ME; Villalobos-Molina, R | 1 |
| Anyukhovsky, EP; Molina-Viamonte, V; Rosen, MR | 1 |
| Piascik, MT; Pruitt, TA; Soltis, EE; Sparks, MS | 1 |
| Han, CD; Minneman, KP | 1 |
| Atlas, D; Manolopoulos, VG; Pipili-Synetos, E; Synetos, D | 1 |
| Moriya, M; Takayanagi, I | 1 |
| Han, C; Li, J; Minneman, KP | 1 |
| Hashimoto, S; Kigoshi, S; Muramatsu, I; Ohmura, T; Oshita, M | 1 |
| Deth, RC; Gupta, S; Tian, WN | 1 |
| Butler, BT; Kusiak, JW; Piascik, MT; Pruitt, TA | 1 |
| Terman, BI | 1 |
| Hashimoto, K; Suzuki, E; Tamura, K; Tsujimoto, G | 1 |
| Hashimoto, K; Suzuki, E; Tsujimoto, G | 1 |
| Giardinà, D; Gulini, U; Melchiorre, C; Pigini, M; Piloni, MG | 1 |
| Minneman, KP; Wilson, KM | 1 |
| del Balzo, U; Kaplan, LM; Malfatto, G; Rosen, MR; Steinberg, SF | 1 |
| Bevan, JA; Oriowo, MA | 1 |
| Bowersox, S; Ciaranello, R; Dement, WC; Frusthofer, B; Guilleminault, C; Maddaluno, J; Mignot, E; Nishino, S | 1 |
| Dermon, CR; Kouvelas, ED | 2 |
| Abel, PW; Han, C; Minneman, KP | 1 |
| Cohen, RM; Dauphin, M; Hirata, F; McLellan, C | 1 |
| Honda, K; Miyata-Osawa, A; Shiono, K; Takenaka, T; Terai, M | 1 |
| Horng, JS; Messick, K; Ruffolo, RR | 1 |
| Varma, DR; Yue, TL | 1 |
| Brasili, L; Giannella, M; Giardinà, D; Gulini, U; Melchiorre, C; Pigini, M; Quaglia, W | 1 |
| Consolo, S; Forloni, GL; Ladinsky, H; Vinci, R; Wang, JX | 1 |
| Crist-Orlando, SG; Giron, LT; McCann, SA | 1 |
| Audiau, F; Benavides, J; Guérémy, C; Le Fur, G; Renault, C; Uzan, A | 1 |
| Jhanwar-Uniyal, M; Leibowitz, SF | 1 |
| Costa, LG; Murphy, SD | 1 |
| Agnati, LF; Andersson, K; Fuxe, K; Gustafsson, JA; Hansson, T; Härfstrand, A; Martire, M; von Euler, G | 1 |
| Cerrito, F; Martire, M; Preziosi, P | 1 |
| Lyon, TF; Randall, WC | 1 |
| Deck, J; Seeman, P; Weinreich, P | 1 |
| Braunwalder, A; Lovell, RA; Stone, G | 1 |
| Humphrey, SJ; McCall, RB | 1 |
| Chiu, A; Seeman, P; Warsh, J; Weinreich, P | 1 |
| Bockaert, J; Ebersolt, C; Perez, M | 1 |
| Astrachan, DI; Davis, M | 1 |
| Heym, J; Jacobs, BL; Trulson, ME | 1 |
| Seeman, P; Weinreich, P | 1 |
| Demarinis, RM; Foley, JJ; Hieble, JP; Pendleton, RG; Sarau, HM | 1 |
| Campbell, IC; Cohen, RM; Dauphin, M; Murphy, DL; Tallman, JF | 1 |
| Enna, SJ; Jones, DJ; Kendall, DE | 2 |
| Drew, GM | 1 |
| Pirke, KM; Spyra, B | 1 |
| Gerald, MC; Snider, RM | 1 |
| Osborne, NN | 1 |
| Campbell, IC; Feer, H; Kräuchi, K; Wirz-Justice, A | 1 |
| Mottram, DR | 1 |
| Edwards, E; Friedman, R; McCaughran, JA; Schechter, N | 1 |
| Brasili, L; Castagnino, E; Corsano, S; Gallucci, P; Giardinà, D; Strappaghetti, G | 1 |
| Levin, BE | 1 |
| Kuhar, MJ; Young, WS | 1 |
| Culvenor, AJ; Jarrott, B; Louis, WJ; Summers, RJ | 1 |
| Cantacuzene, D; Creveling, CR; Daly, JW; Kirk, KL; Nimit, Y | 1 |
| Burns, TW; Bylund, DB; Fain, JN; García-Saínz, JA; Hoffman, BB; Langley, PE; Lefkowitz, RJ; Terry, BE; Tharp, MD | 1 |
| Gerkens, JF; Goldberg, MR; Oates, JA; Robertson, D | 1 |
| Stone, EA | 1 |
| Bockaert, J; Cardo, B; Velley, L | 1 |
| Seeman, P; Titeler, M | 1 |
| Roeske, WR; Yamada, S; Yamamura, HI | 1 |
| Lai, RT; Watanabe, Y; Yoshida, H | 1 |
| Hartley, EJ; Seeman, P | 1 |
| Del Rio, J; Garzon, J; Guisado, E; Lopez de Ceballos, M; Sanchez-Blazquez, P | 1 |
| Closse, A; Frick, W; Markstein, R | 1 |
| Oide, M | 1 |
| Peters, DA | 2 |
| Kawai, M; Nomura, Y; Sakaue, T; Segawa, T; Watanabe, C | 1 |
| Ackerman, DM; Hieble, JP; Jain, TC; Sarau, HM | 1 |
| Kwan, S; Seeman, P; Tang, SW | 1 |
| Kow, LM; Pfaff, DW | 1 |
| Akino, H; Gobara, M; Kigoshi, S; Muramatsu, I; Ohmura, T; Okada, K; Oshita, M | 1 |
| Han, C; Yu, GS | 1 |
| Iwanov, V; Jiang, GC; Moulds, RF | 2 |
| Badia, A; Gascón, S; Ivorra, D; Vila, E | 1 |
| Adachi, M; Manita, S; Matsuda, T; Shigenobu, K; Tanaka, H | 1 |
| Kennedy, RH; Lindemann, JP; Seifen, E; Williamson, AP | 4 |
| Hatano, A; Koizumi, T; Komeyama, T; Takahashi, H; Takeda, M; Tamaki, M | 1 |
| Aston, N; Chess-Williams, R; Couldwell, C | 1 |
| Bowdish, DM; Gaspar, V; Low, AM; Prashad, TR | 1 |
| Kigoshi, S; Muramatsu, I; Muraoka, R; Noguchi, H | 1 |
| Kokubu, N; Satoh, M; Takayanagi, I | 1 |
| Edwards, FR; Hill, CE; Hirst, GD; Klemm, M | 1 |
| Badia, A; Dierssen, M; Gascón, S; Màrmol, F; Vivas, NM | 1 |
| Chess-Williams, R; Couldwell, C; Jackson, A; O'Brien, H | 1 |
| Aniukhovskiĭ, EP; Rosen, MR | 1 |
| Anyukhovsky, EP; Cohen, IS; Rosen, MR; Steinberg, SF | 1 |
| Badia, A; Sallés, J | 1 |
| Chen, MZ; Han, QD; Yu, GS | 1 |
| Daniel, EE; Hoo, KH; Kwan, CY | 1 |
| Cable, DG; Dreyer, ER; Martins, JB; Rath, TE | 1 |
| Oriowo, MA | 1 |
| Anversa, P; Capasso, JM; Cheng, W; Coupet, J; Hamby, CV; Li, P; Meggs, LG; Reiss, K | 1 |
| Nagashima, M | 1 |
| Luo, L; Puke, MJ; Xu, XJ | 1 |
| Lepor, H; Meretyk, S; Shapiro, E; Tang, R | 1 |
| Kennedy, RH; Lindemann, JP; Seifen, E; Stimers, JR; Williamson, AP | 1 |
| Giannella, M; Marucci, G; Melchiorre, C; Piergentili, A; Pigini, M; Quaglia, W; Tayebati, SK | 1 |
| Lepor, H; Shapiro, E; Tang, R | 1 |
| Lee, JH; Rosen, MR | 1 |
| Hagino, Y; Hasegawa, S; Kondo, H; Nomura, H; Nomura, T; Sumi-Ichinose, C; Tachibana, M; Ukai, K; Watanabe, T; Yokoyama, R | 1 |
| Mironneau, C; Mironneau, J; Neuilly, G; Rakotoarisoa, L; Sayet, I | 1 |
| Hatano, A; Koizumi, T; Komeyama, T; Takahashi, H; Takeda, M; Tamaki, M; Tsutsui, T | 1 |
| Docherty, JR; Kearns, S; O'Rourke, M | 1 |
| Kiem, DT; Makara, GB; Vizi, ES | 1 |
| Cua, M; Danilo, P; Geller, JC; Guo, SD; Prieto, L; Rosen, MR | 1 |
| Anwar, N; Klein, DC; Sugden, D | 1 |
| Akaishi, Y; Hattori, Y; Kanno, M; Nagashima, M | 1 |
| Akaishi, Y; Hattori, Y; Kanno, M; Kitabatake, A; Nagashima, M; Sakuma, I; Tohse, N | 1 |
| Benoit, JN; Gao, H; Korthuis, RJ | 1 |
| Choe, EU; Ferrara, JJ; Flint, LM; Hoang, TV; Hyman, AL; Lippton, HL | 1 |
| Arias-Montaño, JA; De la Vega, MT; Trejo, F | 1 |
| Aceves, J; Arias-Montaño, JA; Nuñez, A | 1 |
| Homuth, V; Luther, HP; Wallukat, G | 1 |
| Moulds, RF; Tognarini, DP | 1 |
| Osnes, JB; Sandnes, D; Skomedal, T; Viko, H | 1 |
| Dyer, DC; Hu, XQ | 1 |
| Hattori, Y; Kanno, M; Nagashima, M; Tohse, N | 1 |
| Cheng, JT; Tong, YC | 1 |
| Han, C; Zhang, Y; Zhu, W | 1 |
| Hattori, Y; Kanno, M | 1 |
| Benoit de Coignac, A; Coudouel, N; Legrand, C; Limon-Boulez, I; Maltier, JP; Mhaouty-Kodja, S | 1 |
| Macmillan, JB; McGrath, JC; Smith, KM | 1 |
| Asakura, Y; Ebihara, Y; Hasegawa, H; Nakamura, Y; Shinmura, K; Suganuma, Y; Tani, M | 1 |
| Chevalier, P; Danilo, P; Rosen, MR; Ruffy, F | 1 |
| Hasegawa, Y; Ono, H; Wada, T | 1 |
| Han, C; Lu, Z; Wei, H; Xu, K; Zhang, Y | 1 |
| Capogrossi, MC; Gambassi, G; Lakatta, EG; Spurgeon, HA; Ziman, BD | 1 |
| Brown, RD; Daniel, EE; Kwan, CY; Low, AM; Lu-Chao, H; Wang, YF | 1 |
| Avkiran, M; Yasutake, M; Yokoyama, H | 1 |
| Pupo, AS | 1 |
| Hattori, K; Makara, Y; Maruyama, K; Nagatomo, T; Ohnuki, T; Suzuki, M; Tsuchiya, M; Watanabe, K | 1 |
| Campos-Mello, C; Correa, FM; de Oliveira, AM; Leitão, MC | 1 |
| García-Sáinz, JA; Torres-Padilla, ME | 1 |
| Barna, I; Kiem, DT; Makara, GB; Zelena, D | 1 |
| Kocić, I | 1 |
| Avellar, MC; Megale, A; Porto, CS; Silva, MA | 1 |
| Arias-Montaño, JA; Berger, VA; Soria-Jasso, LE; Young, JM | 1 |
| Antzelevitch, C; Burashnikov, A | 1 |
| Sasa, M; Tanimitsu, N; Tsuru, H; Yajin, K | 1 |
| Chen, PC; Cheng, JT; Liu, IM; Yen, ST | 1 |
| Gaivin, RJ; Gonzalez-Cabrera, P; Perez, DM; Ross, SA; Waugh, DJ; Yun, J; Zuscik, MJ | 1 |
| Hillier, C; Jarajapu, YP; MacDonald, A | 1 |
| Koike, K; Yamamoto, Y | 1 |
| Chiba, S; Taguchi, Y; Yang, XP | 1 |
| Chiba, S; Tsukada, M | 1 |
| Katus, HA; Kemken, D; Kurz, T; Mier, K; Richardt, G | 1 |
| Campos, M; Morais, Pde L; Pupo, AS | 1 |
| Avellar, MC; Hamamura, M; Mendes, FR; Porto, CS; Queiróz, DB | 1 |
| Gray, KT; Ventura, S | 1 |
| Avellar, MC; Caricati-Neto, A; Jurkiewicz, A; Jurkiewicz, NH; Reuter, HR; Verde, LF | 1 |
| Doze, VA; Hillman, KL; Porter, JE | 1 |
| Centurión, D; Görnemann, T; Jähnichen, S; Kleuser, B; Pertz, HH; Villalón, CM; von Wenckstern, H | 1 |
| Bockman, CS; Dang, HK; Gruber, DD; Scofield, MA; Wangemann, P; Witt, KM | 1 |
| Dementieva, RE; Fashutdinov, LI; Zefirov, TL; Ziyatdinova, NI | 1 |
1 review(s) available for clonidine and wb 4101
| Article | Year |
|---|---|
alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.
Topics: Adipose Tissue; Animals; Blood Platelets; Central Nervous System; Humans; Islets of Langerhans; Melanocytes; Muscle, Smooth, Vascular; Nerve Endings; Norepinephrine; Parasympathetic Nervous System; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Serotonin; Synapses | 1982 |
179 other study(ies) available for clonidine and wb 4101
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Blockade by WB 4101 of alpha-adrenoceptors in the rat vas deferens and guinea-pig taenia caeci.
Topics: Adrenergic alpha-Antagonists; Animals; Cecum; Clonidine; Dioxanes; Dioxins; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phenyl Ethers; Rats; Vas Deferens | 1978 |
Specific labelling of postsynaptic alpha 1 adrenoceptors in rat heart ventricle by 3H-WB 4101.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; Dioxanes; Dioxins; Hydroxydopamines; In Vitro Techniques; Kinetics; Male; Myocardium; Phenyl Ethers; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1979 |
Estradiol selectively regulates alpha 1B-noradrenergic receptors in the hypothalamus and preoptic area.
Topics: Animals; Clonidine; Cyclic AMP; Dioxanes; Estradiol; Female; Hypothalamus; Ovariectomy; Piperazines; Prazosin; Preoptic Area; Rats; Receptors, Adrenergic | 1992 |
[Modulation of heart rhythm by alpha-1 adrenoreceptors].
Topics: Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Electrocardiography; Heart Rate; Myocardial Ischemia; Phentolamine; Rats; Receptors, Adrenergic, alpha | 1992 |
Characterization of alpha 1-adrenoceptor subtypes labeled by [3H]prazosin in single cells prepared from rabbit thoracic aorta.
Topics: Animals; Aorta, Thoracic; Binding Sites; Calcium; Clonidine; Dioxanes; In Vitro Techniques; Methoxamine; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Spiperone | 1992 |
Alpha 1-adrenoceptors in parotid cells: age does not alter the ratio of alpha 1A and alpha 1B subtypes.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Calcium; Clonidine; Dioxanes; Epinephrine; In Vitro Techniques; Inosine Triphosphate; Male; Parotid Gland; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1992 |
Pharmacological properties of alpha 1-adrenoceptor-mediated vasoconstrictions in dog and monkey lingual arteries: evidence for subtypes of alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channels; Clonidine; Diltiazem; Dioxanes; Dogs; Dose-Response Relationship, Drug; Macaca; Muscle, Smooth, Vascular; Norepinephrine; Receptors, Adrenergic; Signal Transduction; Species Specificity; Tongue; Vasoconstriction | 1992 |
Vascular alpha-adrenoceptor affinity variation is not due to varying populations of subtypes distinguished by WB 4101 and chlorethylclonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Dioxanes; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Receptors, Adrenergic, alpha | 1992 |
The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Imidazoles; Injections, Spinal; Male; Medetomidine; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Spinal Cord | 1992 |
The effects of electroconvulsive shock or imipramine on subtypes of alpha 1-adrenoceptors in the frontal cortex of the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Clonidine; Dioxanes; Electroshock; Hippocampus; Imipramine; In Vitro Techniques; Kinetics; Male; Prazosin; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1992 |
Identification of alpha 1-adrenoceptor subtypes in the rat vas deferens: binding and functional studies.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Electric Stimulation; Epididymis; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Nifedipine; Norepinephrine; Oxathiins; Prazosin; Prostate; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Vas Deferens | 1992 |
Pharmacological characterization of contractile responses induced by alpha 1-agonists, norepinephrine and clonidine, by selective antagonists of their subtypes in rabbit thoracic aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Dioxanes; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Piperazines; Prazosin; Rabbits | 1992 |
Differences in alpha 1-adrenoceptor mechanisms for phenylephrine and tizanidine in rabbit thoracic aorta and common iliac artery.
Topics: Animals; Aorta, Thoracic; Clonidine; Dioxanes; Iliac Artery; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Phenylephrine; Rabbits; Receptors, Adrenergic, alpha; Tissue Distribution; Vasoconstriction | 1991 |
Abnormal automatic rhythms in ischemic Purkinje fibers are modulated by a specific alpha 1-adrenergic receptor subtype.
Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Calcium; Clonidine; Coronary Disease; Dioxanes; Dogs; Extracellular Space; Heart Rate; Phenylephrine; Propranolol; Purkinje Fibers; Receptors, Adrenergic, alpha | 1991 |
Regional distribution of alpha 1-adrenoceptor subtypes in rat kidney.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Cell Membrane; Clonidine; Dioxanes; Kidney; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1991 |
Alpha 1-adrenoceptor subtypes in aorta (alpha 1A) and liver (alpha 1B).
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Epinephrine; In Vitro Techniques; Liver; Membranes; Muscle, Smooth, Vascular; Phosphatidylinositols; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha | 1991 |
An alpha-1-adrenergic receptor subtype is responsible for delayed afterdepolarizations and triggered activity during simulated ischemia and reperfusion of isolated canine Purkinje fibers.
Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Myocardial Reperfusion Injury; Phenylephrine; Purkinje Fibers; Receptors, Adrenergic, alpha | 1991 |
Evidence for a complex interaction between the subtypes of the alpha 1-adrenoceptor.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Dioxanes; In Vitro Techniques; Kinetics; Male; Methoxamine; Muscle, Smooth, Vascular; Phenoxybenzamine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1991 |
Interaction of subtype-selective antagonists with alpha 1-adrenergic receptor binding sites in rat tissues.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Clonidine; Dihydropyridines; Dioxanes; Kinetics; Male; Membranes; Phentolamine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Time Factors | 1991 |
Human plasma-derived material with clonidine displacing substance (CDS)-like properties contracts the isolated rat aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Blood; Brain; Clonidine; Dioxanes; Female; In Vitro Techniques; Male; Methoxamine; Muscle Contraction; Prazosin; Rats; Rats, Inbred WKY; Yohimbine | 1991 |
Alpha 1A-adrenoceptors in rabbit bronchus.
Topics: Adrenergic alpha-Antagonists; Animals; Bronchi; Clonidine; Dioxanes; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Phenylephrine; Piperazines; Rabbits; Receptors, Adrenergic, alpha | 1991 |
Subtypes of alpha 1-adrenoceptors in rat blood vessels.
Topics: Animals; Aorta, Thoracic; Blood Vessels; Clonidine; Dioxanes; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Renal Artery | 1990 |
Pharmacological subclassification of alpha 1-adrenoceptors in vascular smooth muscle.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Animals; Blood Vessels; Clonidine; Dioxanes; Dogs; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Phentolamine; Prazosin; Rabbits; Rats; Receptors, Adrenergic, alpha; Species Specificity; Yohimbine | 1990 |
Species differences in chlorethylclonidine antagonism at vascular alpha-1 adrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Male; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Rats; Receptors, Adrenergic, alpha; Species Specificity; Vasoconstriction | 1990 |
Agonist interaction with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Clonidine; Diltiazem; Dioxanes; Drug Interactions; Heart; Inositol Phosphates; Male; Muscle, Smooth, Vascular; Myocardium; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1990 |
[The identification and characteristics of subpopulations of alpha 1-adrenergic receptors].
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain Chemistry; Calcium; Clonidine; Dioxanes; GTP-Binding Proteins; Liver; Microsomes; Phentolamine; Prazosin; Rats; Receptors, Adrenergic, alpha | 1990 |
Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Binding Sites; Calcium; Clonidine; Dioxanes; In Vitro Techniques; Models, Biological; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenethylamines; Phenoxybenzamine; Piperazines; Rabbits; Receptors, Adrenergic, alpha; Signal Transduction; Tetralones; Vasoconstriction | 1990 |
Different desensitization mechanisms of two alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Dioxanes; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenethylamines; Rabbits; Receptors, Adrenergic, alpha; Tetralones | 1990 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 2. Role of the amine function on alpha-adrenoreceptor blocking activity.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cocaine; Dioxanes; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Propranolol; Rats; Structure-Activity Relationship; Vas Deferens | 1990 |
Pertussis toxin inhibits norepinephrine-stimulated inositol phosphate formation in primary brain cell cultures.
Topics: Animals; Brain; Calcium; Carbachol; Cells, Cultured; Clonidine; Cyclic AMP; Dioxanes; GTP-Binding Proteins; Inositol Phosphates; Norepinephrine; Pertussis Toxin; Phenethylamines; Prazosin; Rats; Receptors, Adrenergic, alpha; Tetralones; Virulence Factors, Bordetella; Yohimbine | 1990 |
Specific alpha 1-adrenergic receptor subtypes modulate catecholamine-induced increases and decreases in ventricular automaticity.
Topics: Age Factors; Animals; Binding Sites; Cells, Cultured; Clonidine; Dioxanes; Dogs; Electrophysiology; Heart Ventricles; Inositol Phosphates; Norepinephrine; Purkinje Fibers; Receptors, Adrenergic, alpha; Stimulation, Chemical; Ventricular Function | 1990 |
Chloroethylclonidine unmasks a non-alpha-adrenoceptor noradrenaline binding site in the rat aorta.
Topics: Animals; Aorta, Thoracic; Clonidine; Dioxanes; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Phenoxybenzamine; Prazosin; Rats; Receptors, Adrenergic; Yohimbine | 1990 |
Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cataplexy; Clonidine; Dioxanes; Dogs; Narcolepsy; Phenoxybenzamine; Prazosin; Receptors, Adrenergic, alpha; Sleep, REM | 1989 |
Quantitative analysis of the localization of adrenergic binding sites in chick brain.
Topics: Alprenolol; Animals; Autoradiography; Brain; Chickens; Clonidine; Dihydroalprenolol; Dioxanes; Dioxins; Receptors, Adrenergic | 1989 |
Comparison of alpha 1-adrenergic receptor subtypes distinguished by chlorethylclonidine and WB 4101.
Topics: Animals; Clonidine; Dioxanes; Dioxins; Hippocampus; In Vitro Techniques; Inositol Phosphates; Male; Norepinephrine; Osmolar Concentration; Rats; Receptors, Adrenergic, alpha; Solubility; Spleen; Tissue Distribution; Vas Deferens | 1988 |
Glutaraldehyde pretreatment blocks phospholipase A2 modulation of adrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Aldehydes; Animals; Cell Membrane; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dioxanes; Glutaral; Kinetics; Phospholipases; Phospholipases A; Phospholipases A2; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1985 |
Studies on YM-12617: a selective and potent antagonist of postsynaptic alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Blood Pressure; Brain; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle Contraction; Phenylephrine; Pulmonary Artery; Quinoxalines; Rabbits; Rats; Receptors, Adrenergic, alpha; Sulfonamides; Tritium; Vas Deferens | 1985 |
Interactions of dimethoxy-substituted tolazoline derivatives with alpha 1- and alpha 2-adrenoreceptors in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Aorta; Brain; Brimonidine Tartrate; Clonidine; Dioxanes; Electric Stimulation; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Norepinephrine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tolazoline | 1985 |
Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats.
Topics: Adrenergic beta-Antagonists; Animals; Atropine; Brain; Cardiovascular System; Clonidine; Dioxanes; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Phenylephrine; Rats; Rats, Inbred Strains; Scopolamine Derivatives; Solanaceous Alkaloids; Vasodilator Agents | 1986 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha 1-adrenoreceptor blocking activity.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Chemical Phenomena; Chemistry; Clonidine; Dioxanes; Dioxins; Male; Muscle Contraction; Norepinephrine; Oxathiins; Oxygen; Rats; Structure-Activity Relationship; Sulfur; Vas Deferens | 1988 |
Characterization of the alpha adrenergic receptor population in hippocampus up regulated by serotonergic raphe deafferentiation.
Topics: Animals; Clonidine; Dioxanes; Female; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Norepinephrine; Prazosin; Propranolol; Raphe Nuclei; Rats; Receptors, Adrenergic, alpha; Serotonin; Sodium; Yohimbine | 1985 |
Pharmacological characterization and regional distribution of alpha-noradrenergic binding sites of rat spinal cord.
Topics: Animals; Catecholamines; Clonidine; Dioxanes; Female; In Vitro Techniques; Kinetics; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Spinal Cord; Stereoisomerism | 1985 |
4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for alpha 2-adrenoceptors.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Clonidine; Corpus Striatum; Dioxanes; Idazoxan; Piperazines; Pyrimidines; Rats; Receptors, Adrenergic, alpha; Spiperone; Structure-Activity Relationship | 1986 |
Impact of food deprivation on alpha 1- and alpha 2-noradrenergic receptors in the paraventricular nucleus and other hypothalamic areas.
Topics: Animals; Clonidine; Dioxanes; Food Deprivation; Hypothalamus; Male; Paraventricular Hypothalamic Nucleus; Prazosin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Satiety Response | 1986 |
Interaction of the pesticide chlordimeform with adrenergic receptors in mouse brain: an in vitro study.
Topics: Amidines; Animals; Brain Chemistry; Chlorphenamidine; Clonidine; Diazepam; Dihydroalprenolol; Dioxanes; In Vitro Techniques; Kinetics; Male; Mice; Muscimol; Proteins; Quinuclidinyl Benzilate; Receptors, Adrenergic; Receptors, GABA-A | 1987 |
Effects of subacute treatment with toluene on cerebrocortical alpha- and beta-adrenergic receptors in the rat. Evidence for an increased number and a reduced affinity of beta-adrenergic receptors.
Topics: Animals; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dioxanes; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Toluene | 1987 |
Binding properties, regional ontogeny and localization of adrenergic receptors in chick brain.
Topics: Alprenolol; Animals; Binding, Competitive; Brain; Chick Embryo; Chickens; Clonidine; Dihydroalprenolol; Dioxanes; Dioxins; Kinetics; Receptors, Adrenergic | 1988 |
Long-term treatment with clonidine and alpha-receptors in the brain of normotensive rats.
Topics: Animals; Clonidine; Dioxanes; Frontal Lobe; Hypothalamus; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission; Synaptosomes | 1984 |
Multiple central WB-4101 binding sites and the selectivity of prazosin.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Cattle; Clonidine; Dioxanes; Dioxins; In Vitro Techniques; Kinetics; Membranes; Norepinephrine; Prazosin; Quinazolines; Receptors, Adrenergic, alpha | 1980 |
Multiple binding sites in human brain for [3H]-clonidine and [3H]-WB-4101.
Topics: Adrenergic alpha-Antagonists; Binding Sites; Brain; Brain Chemistry; Clonidine; Depression, Chemical; Dioxanes; Dioxins; Humans; In Vitro Techniques; Kinetics | 1980 |
Characterization of [3H]clonidine binding to two sites in calf brain membranes.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Cattle; Cerebral Cortex; Clonidine; Dioxanes; Guanosine Triphosphate; Kinetics; Receptors, Adrenergic, alpha | 1981 |
Evidence for a central depressor action of postsynaptic alpha 1-adrenergic receptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Depression, Chemical; Dioxanes; Hemodynamics; Phentolamine; Piperoxan; Prazosin; Pressoreceptors; Receptors, Adrenergic; Sympathetic Nervous System | 1981 |
Multiple binding sites for [3H]clonidine and [3H]WB-4101 in rat brain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Clonidine; Dioxanes; Dioxins; Guanfacine; Guanidines; Hydroxydopamines; Male; Phenylacetates; Rats; Rats, Inbred Strains | 1981 |
Alpha 1 and alpha 2 Adrenergic receptors in mouse brain astrocytes from primary cultures.
Topics: Adrenergic alpha-Antagonists; Animals; Astrocytes; Brain; Cells, Cultured; Cerebral Cortex; Clonidine; Dioxanes; Kinetics; Mice; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Sodium Chloride | 1981 |
Spinal modulation of acoustic startle: opposite effects of clonidine and d-amphetamine.
Topics: Acoustic Stimulation; Adrenergic alpha-Antagonists; Animals; Clonidine; Cyproheptadine; Dextroamphetamine; Dioxanes; Injections, Spinal; Male; Norepinephrine; Phenylephrine; Rats; Rats, Inbred Strains; Reflex, Startle; Spinal Cord; Yohimbine | 1981 |
Effects of adrenergic drugs on raphe unit activity in freely moving cats.
Topics: Adrenergic alpha-Antagonists; Animals; Arousal; Behavior, Animal; Brain Stem; Cats; Clonidine; Dextroamphetamine; Dioxanes; Electroencephalography; Female; Raphe Nuclei; Receptors, Adrenergic; Receptors, Serotonin; Sympathomimetics | 1981 |
Binding of adrenergic ligands ([3H]clonidine and [3H]WB-4101) to multiple sites in human brain.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Binding Sites; Brain; Clonidine; Dioxanes; Dioxins; Hot Temperature; Humans; Kinetics; Middle Aged; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Tritium | 1981 |
Comparison of central and peripheral alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Animals; Arteries; Cerebral Cortex; Clonidine; Dioxanes; Ear; In Vitro Techniques; Male; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Dopamine; Structure-Activity Relationship | 1982 |
Changes in alpha- and beta-receptor densities in rat brain as a result of treatment with monoamine oxidase inhibiting antidepressants.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Brain Stem; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dioxanes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1982 |
Adrenergic receptors in rat spinal cord.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cyclic AMP; Dihydroalprenolol; Dioxanes; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Spinal Cord | 1982 |
Evidence in favour of a selective alpha 1-adrenoceptor blocking action of WB 4101 in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxanes; Dioxins; Dose-Response Relationship, Drug; Heart Rate; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1982 |
Binding of [3H]clonidine and [3H]WB4101 to the pre- and postsynaptic alpha-adrenoceptors of the basal hypothalamus of the starved male rat.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dioxins; Hypothalamus; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Starvation; Synaptic Membranes | 1982 |
Noradrenergic-mediated potentiation of acetylcholine release from the phrenic nerve: evidence for presynaptic alpha 1-adrenoceptor involvement.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Phentolamine; Phenylephrine; Phrenic Nerve; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Yohimbine | 1982 |
Binding of (-)[3H]noradrenaline to bovine membrane of the retina. Evidence for the existence of alpha 2-receptors.
Topics: Adrenergic alpha-Agonists; Animals; Cattle; Cell Membrane; Clonidine; Dioxanes; Dose-Response Relationship, Drug; In Vitro Techniques; Norepinephrine; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Retina; Time Factors; Tritium | 1982 |
Adrenoceptor changes in spontaneous hypertensive rats: a circadian approach.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain; Brain Stem; Cerebral Cortex; Circadian Rhythm; Clonidine; Dihydroalprenolol; Dioxanes; Hypertension; Hypothalamus; Kinetics; Male; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic | 1983 |
Pre-junctional alpha 2-adrenoceptor activity of B-HT920.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Dioxanes; Drug Interactions; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Yohimbine | 1983 |
Alpha 1- and alpha 2-adrenoceptor binding in the Dahl rat model of hypertension.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain; Cerebral Cortex; Clonidine; Dioxanes; Disease Models, Animal; Hypertension; Hypothalamus; Kinetics; Male; Medulla Oblongata; Rats; Rats, Inbred Strains | 1984 |
Synthesis and pharmacological evaluation of some WB4101 analogues bearing a naphthodioxanic nucleus.
Topics: Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Clonidine; Dioxanes; Dioxins; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Rats; Synapses | 1984 |
Axonal transport and presynaptic location of alpha 2-adrenoreceptors in locus coeruleus neurons.
Topics: Animals; Axonal Transport; Clonidine; Dioxanes; Hydroxydopamines; Locus Coeruleus; Neural Pathways; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1984 |
Noradrenergic alpha 1 and alpha 2 receptors: light microscopic autoradiographic localization.
Topics: Animals; Autoradiography; Brain; Cerebral Cortex; Clonidine; Dioxanes; Dioxins; Hypothalamus; Kinetics; Locus Coeruleus; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1980 |
Characterization of alpha-adrenoceptors in rat and guinea pig tissues using radiolabeled agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Clonidine; Dioxanes; Dioxins; Guinea Pigs; Male; Prazosin; Quinazolines; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1980 |
The binding of fluorocatecholamines to adrenergic and dopaminergic receptors in rat brain membranes.
Topics: Animals; Cerebellum; Cerebral Cortex; Clonidine; Corpus Striatum; Dioxanes; Dopamine; Male; Membranes; Norepinephrine; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Dopamine | 1980 |
Pharmacological characterizations of adrenergic receptors in human adipocytes.
Topics: Adenylyl Cyclases; Adipose Tissue; Cells, Cultured; Clonidine; Cyclic AMP; Dihydroalprenolol; Dioxanes; Humans; Lipolysis; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1981 |
alpha-Methylepinephrine, a methyldopa metabolite that binds to alpha-receptors in rat brain.
Topics: Animals; Binding, Competitive; Brain; Clonidine; Dioxanes; Epinephrine; Kinetics; Male; Methyldopa; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1981 |
Mechanism of stress-induced subsensitivity to norepinephrine.
Topics: Adenylyl Cyclases; Animals; Brain; Clonidine; Cyclic AMP; Dihydroalprenolol; Dioxanes; Electroshock; Humans; Male; Norepinephrine; Rats; Stress, Psychological | 1981 |
Modulation of rat brain alpha-adrenoreceptor populations four weeks after stimulation of the nucleus locus coeruleus.
Topics: Animals; Brain; Clonidine; Dihydroalprenolol; Dioxanes; Electric Stimulation; Locus Coeruleus; Male; Motor Activity; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1981 |
Adrenergic receptors in rat spinal cord.
Topics: Animals; Clonidine; Dihydroalprenolol; Dioxanes; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Spinal Cord | 1982 |
Effects of antihypertensive clonidine congeners on alpha-adrenergic receptors.
Topics: Animals; Antihypertensive Agents; Binding Sites; Binding, Competitive; Cattle; Cerebral Cortex; Clonidine; Dioxanes; In Vitro Techniques; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1982 |
An increase in cardiac alpha 1-adrenoceptors following chronic clonidine treatment.
Topics: Animals; Clonidine; Dihydroalprenolol; Dioxanes; Heart; In Vitro Techniques; Male; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1982 |
Increase of [3H]clonidine binding sites induced by adenosine receptor agonists in rat vas deferens in vitro.
Topics: Animals; Binding Sites; Clonidine; Dihydroalprenolol; Dioxanes; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Reserpine; Vas Deferens | 1982 |
Development of receptors for dopamine and noradrenaline in rat brain.
Topics: Animals; Brain; Clonidine; Dioxanes; Female; Limbic System; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Dopamine; Spiperone | 1983 |
Long-term social isolation in the rat induces opposite changes in binding to alpha 1- and alpha 2-adrenoceptors in the brain and vas deferens.
Topics: Animals; Brain; Clonidine; Dioxanes; Male; Rats; Receptors, Adrenergic, alpha; Social Isolation; Time Factors; Vas Deferens | 1983 |
Interaction of ergot alkaloids and their combination (co-dergocrine) with alpha-adrenoceptors in the CNS.
Topics: Animals; Brain; Clonidine; Cyclic AMP; Dihydroergotoxine; Dioxanes; Drug Combinations; Ergot Alkaloids; In Vitro Techniques; Norepinephrine; Rats; Receptors, Adrenergic, alpha; Yohimbine | 1983 |
Effect of alpha-methyldopa on alpha-noradrenergic receptor binding sites in the mouse brain.
Topics: Animals; Brain; Brocresine; Clonidine; Dioxanes; Ditiocarb; Fusaric Acid; Male; Methyldopa; Methyltyrosines; Mice; Mice, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Reserpine | 1984 |
Prenatal stress: effect on development of rat brain adrenergic receptors.
Topics: Age Factors; Analysis of Variance; Animals; Brain; Clonidine; Dihydroalprenolol; Dioxanes; Female; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Stress, Physiological | 1984 |
Specific binding of [3H]WB 4101, [3H]clonidine and [3H]dihydroalprenolol in cerebral cortical membranes in developing, adult and old rats.
Topics: Aging; Alprenolol; Animals; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dioxanes; Dioxins; Female; Male; Membranes; Rats; Rats, Inbred Strains; Synapses | 1984 |
Prenatal nicotine exposure increases adrenergic receptor binding in the rat cerebral cortex.
Topics: Animals; Body Weight; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dioxanes; Female; Neurons; Nicotine; Norepinephrine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Time Factors | 1984 |
Pharmacological characterization of dopamine-4-O-sulfate.
Topics: Adenylyl Cyclase Inhibitors; Anesthesia; Animals; Clonidine; Dioxanes; Dogs; Dopamine; Ear; Female; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Rabbits; Regional Blood Flow; Renal Circulation; Spiperone | 1984 |
Differential effect of chronic desipramine and amitriptyline treatment on rat brain adrenergic and serotonergic receptors.
Topics: Amitriptyline; Animals; Brain; Cerebral Cortex; Clonidine; Desipramine; Dihydroalprenolol; Dioxanes; Male; Radioligand Assay; Rats; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Spiperone | 1981 |
Functional analyses of alpha 1-adrenoceptor subtypes in rat hypothalamic ventromedial nucleus neurons.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Female; Hypothalamus, Middle; In Vitro Techniques; Neurons; Phenylephrine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 1995 |
Pharmacological characterization of alpha 1-adrenoceptor subtypes in the human prostate: functional and binding studies.
Topics: Adrenergic alpha-Antagonists; Binding, Competitive; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Humans; Male; Muscle Contraction; Muscles; Norepinephrine; Phenylephrine; Prazosin; Prostatic Hyperplasia; Receptors, Adrenergic, alpha-1 | 1994 |
Role of alpha 1A- and alpha 1B-adrenoceptors in phenylephrine-induced positive inotropic response in isolated rat left atrium.
Topics: Adrenergic alpha-Antagonists; Animals; Atrial Function; Binding, Competitive; Calcium; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Heart Atria; In Vitro Techniques; Inositol Phosphates; Male; Myocardial Contraction; Phenethylamines; Phenylephrine; Piperazines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Tetralones | 1994 |
Increased sensitivity to inhibition by nifedipine of responses of the mesenteric artery bed of the SHRSP to noradrenaline is not dependent on alpha 1-adrenoceptor subtypes.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Clonidine; Dioxanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Hypertension; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-1; Vascular Resistance | 1995 |
Alpha 1-adrenoceptor subtypes and inositol phosphates production in heart ventricles of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Heart Ventricles; Hypertension; Inositol Phosphates; Male; Myocardium; Norepinephrine; Prazosin; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha | 1993 |
Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Atropine; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Mice; Myocardial Contraction; Myocardium; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Yohimbine | 1995 |
Alpha 1a-adrenergic receptor mediated positive chronotropic effect in right atria isolated from rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Atrial Function; Clonidine; Dioxanes; Heart Atria; Heart Rate; In Vitro Techniques; Male; Phenoxybenzamine; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 1994 |
The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Aorta, Thoracic; Clonidine; Dioxanes; Hypertension; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium Chloride; Rats; Rats, Inbred WKY | 1995 |
Pharmacological evidence of distinct alpha 1-adrenoceptor subtypes mediating the contraction of human prostatic urethra and peripheral artery.
Topics: Aged; Aged, 80 and over; Arteries; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Phenylephrine; Receptors, Adrenergic, alpha-1; Urethra; Vasoconstriction | 1994 |
Alpha 1A-adrenoceptor subtype mediates contraction of the rat urethra.
Topics: Aminoquinolines; Animals; Calcium; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tetrahydroisoquinolines; Urethra | 1994 |
Interactions of chloroethylclonidine with rauwolscine- and prazosin-sensitive adrenoceptors in dog saphenous vein.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Calcium; Calcium Channel Blockers; Clonidine; Dioxanes; Dogs; Extracellular Space; In Vitro Techniques; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Saphenous Vein; Yohimbine | 1994 |
Alpha 1-adrenoceptor subtype involved in the positive inotropic response to phenylephrine in rat atria.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1993 |
Chloroethylclonidine discriminates between alpha 1A- and alpha 1B-adrenoceptors in the presence of guanosine 5'-triphosphate in rabbit thoracic aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding Sites; Clonidine; Dioxanes; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Phenylephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha | 1993 |
Sympathetic transmission to the dilator muscle of the rat iris.
Topics: Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Clonidine; Dioxanes; Iris; Membrane Potentials; Neuroeffector Junction; Norepinephrine; Parasympathetic Nervous System; Prazosin; Rats; Receptors, Adrenergic, alpha-1; Sympathetic Nervous System; Synaptic Transmission; Synaptic Vesicles; Yohimbine | 1993 |
Effects of age on alpha 1-adrenoceptor subtypes in the heart ventricular muscle of the rat.
Topics: Adrenergic alpha-Antagonists; Aging; Alkylating Agents; Animals; Binding, Competitive; Clonidine; Dioxanes; In Vitro Techniques; Myocardium; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 1993 |
Characterization of the alpha 1-adrenoceptors of the rat prostate gland.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Clonidine; Dioxanes; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Phenylephrine; Prostate; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Vas Deferens | 1993 |
Effects of WB4101 and chloroethylclonidine on the positive and negative inotropic actions of phenylephrine in rat cardiac muscle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Drug Antagonism; In Vitro Techniques; Male; Myocardial Contraction; Phenylephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 1994 |
[The modulation of anomalous automatism in ischemic Purkinje fibers by a specific subclass of alpha 1-adrenoblockers].
Topics: Action Potentials; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Heart Rate; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion; Perfusion; Purkinje Fibers; Receptors, Adrenergic, alpha-1 | 1993 |
Receptor-effector coupling pathway for alpha 1-adrenergic modulation of abnormal automaticity in 'ischemic' canine Purkinje fibers.
Topics: Adrenergic alpha-Antagonists; Animals; Barium; Clonidine; Dioxanes; Dogs; Membrane Potentials; Myocardial Ischemia; Pertussis Toxin; Phenylephrine; Purkinje Fibers; Receptors, Adrenergic, alpha-1; Virulence Factors, Bordetella | 1994 |
Selective enrichment with alpha 1A- and alpha 1B-adrenoceptor subtypes in rat brain cortical membranes.
Topics: Adrenergic alpha-Antagonists; Alkylating Agents; Alkylation; Animals; Binding Sites; Cerebral Cortex; Clonidine; Cystamine; Dihydropyridines; Dioxanes; Phenoxybenzamine; Phentolamine; Prazosin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1994 |
A new alpha 1-adrenergic receptor subtype with low affinity for 5-methyl-urapidil but insensitive to chlorethylclonidine.
Topics: Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Clonidine; Dioxanes; Male; Myocardium; Phenethylamines; Piperazines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tetralones | 1993 |
Investigation of alpha 1-adrenoceptor subtypes in canine aorta, using alkylating agents.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Aorta; Binding, Competitive; Clonidine; Dioxanes; Dogs; Female; In Vitro Techniques; Male; Mesenteric Veins; Muscle, Smooth, Vascular; Oxymetazoline; Prazosin; Radioligand Assay; Receptors, Adrenergic, alpha-1 | 1994 |
WB4101- and CEC-sensitive positive inotropic actions of phenylephrine in rat cardiac muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Heart; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Osmolar Concentration; Papillary Muscles; Phenylephrine; Rats; Rats, Sprague-Dawley | 1994 |
Refractory period response of cardiac Purkinje tissue to alpha 1- and alpha 2-adrenergic influences.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxanes; Dogs; Female; Male; Norepinephrine; Phenylephrine; Purkinje Fibers; Receptors, Adrenergic, alpha; Refractory Period, Electrophysiological | 1994 |
Alpha 1-adrenoceptor subtype(s) mediating noradrenaline-induced contractions of the guinea-pig aorta.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Clonidine; Dioxanes; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Oxazines; Prazosin; Receptors, Adrenergic, alpha-1 | 1994 |
Coronary artery constriction in rats affects the activation of alpha 1 adrenergic receptors in cardiac myocytes.
Topics: Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Base Sequence; Calcium; Cell Size; Cells, Cultured; Clonidine; Constriction; Coronary Vessels; Cytosol; Dioxanes; Inositol Phosphates; Male; Molecular Sequence Data; Myocardium; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 1994 |
[Pharmacological study on functional significance of alpha 1-adrenoceptor subtypes in mammalian ventricular myocardium].
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Heart Ventricles; Hydrolysis; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Phenylephrine; Phosphatidylinositols; Rabbits; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Stimulation, Chemical | 1994 |
The spinal analgesic role of alpha 2-adrenoceptor subtypes in rats after peripheral nerve section.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesia; Animals; Behavior, Animal; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electrophysiology; Guanfacine; Injections, Spinal; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reflex; Sciatic Nerve | 1994 |
Alpha 1 adrenoceptor subtypes in the human prostate.
Topics: Adrenergic alpha-Antagonists; Aged; Binding, Competitive; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Middle Aged; Phenethylamines; Piperazines; Prostate; Receptors, Adrenergic, alpha; Tetralones | 1993 |
Alpha 1b-adrenoceptor-mediated stimulation of Na-K pump current in adult rat ventricular myocytes.
Topics: Adrenergic alpha-Antagonists; Animals; Cells, Cultured; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Heart; Heart Ventricles; Male; Myocardium; Ouabain; Phenoxybenzamine; Phenylephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sodium-Potassium-Exchanging ATPase; Ventricular Function, Left | 1993 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 4. Effect of aryl and alkyl substituents at position 3 on alpha-adrenoreceptor blocking activity.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Rats; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1993 |
The alpha-adrenoceptor subtype mediating the tension of human prostatic smooth muscle.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Binding, Competitive; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Phenylephrine; Piperazines; Prostate; Receptors, Adrenergic, alpha | 1993 |
Modulation of delayed afterdepolarisations by alpha 1 adrenergic receptor subtypes.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Calcium; Clonidine; Culture Techniques; Dioxanes; Dogs; Heart; Ouabain; Phenylephrine; Purkinje Fibers; Receptors, Adrenergic, alpha | 1993 |
Alpha 1B-adrenoceptor-mediated stimulation of Ca2+ mobilization and cAMP accumulation in isolated rat hepatocytes.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Clonidine; Cyclic AMP; Dioxanes; In Vitro Techniques; Liver; Male; Methoxamine; Norepinephrine; Pertussis Toxin; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Vasopressins; Virulence Factors, Bordetella | 1993 |
Relation between alpha 1-adrenoceptor subtypes and noradrenaline-induced contraction in rat portal vein smooth muscle.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Clonidine; Dioxanes; Horses; In Vitro Techniques; Isometric Contraction; Kinetics; Microsomes; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Prazosin; Rats; Receptors, Adrenergic, alpha-1 | 1993 |
Alpha 1-adrenoceptors in the human prostatic urethra are different from those of the human peripheral arteries.
Topics: Arteries; Atropine; Clonidine; Dioxanes; Humans; Iliac Artery; Isometric Contraction; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Phenylephrine; Piperazines; Prazosin; Propranolol; Receptors, Adrenergic, alpha-1; Urethra; Yohimbine | 1993 |
Investigation of the actions of chloroethylclonidine in rat aorta.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Aorta; Clonidine; Cystamine; Dioxanes; Dose-Response Relationship, Drug; Drug Synergism; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxathiins; Phenoxybenzamine; Phentolamine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spiperone; Xylazine; Yohimbine | 1995 |
Hypothalamic alpha 2A-adrenoceptors stimulate growth hormone release in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Berberine; Clonidine; Dioxanes; Growth Hormone-Releasing Hormone; Hypothalamus; Injections, Intraventricular; Male; Oxymetazoline; Prazosin; Rats; Rats, Wistar; Somatostatin | 1995 |
Chloroethylclonidine increases the incidence of lethal arrhythmias during coronary occlusion in anesthetized dogs.
Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Female; Male; Myocardial Ischemia; Receptors, Adrenergic, alpha-1 | 1995 |
The positive inotropic effect of alpha 1A-adrenoceptor stimulation is inhibited by 4-aminopyridine.
Topics: 4-Aminopyridine; Adrenergic alpha-Antagonists; Animals; Cardiotonic Agents; Clonidine; Dioxanes; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Staurosporine | 1996 |
Rat pineal alpha 1-adrenoceptor subtypes: studies using radioligand binding and reverse transcription-polymerase chain reaction analysis.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; Dioxanes; Male; Phenethylamines; Pineal Gland; Polymerase Chain Reaction; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Tetralones; Transcription, Genetic | 1996 |
Alpha 1-adrenoceptor subtype distribution and the coupling to phosphoinositide hydrolysis in rat and rabbit ventricular myocardium.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Female; Heart Ventricles; Hydrolysis; Kinetics; Lithium Chloride; Male; Myocardium; Phosphatidylinositols; Prazosin; Rabbits; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tritium | 1996 |
Alpha 1-adrenoceptor subtypes mediating inotropic and electrophysiological effects in mammalian myocardium.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Electric Conductivity; Electrophysiology; Female; Heart; Male; Myocardial Contraction; Papillary Muscles; Phenylephrine; Rabbits; Rats; Receptors, Adrenergic, alpha | 1996 |
Hypoxia/reoxygenation selectively impairs alpha 1b-adrenoceptor function in small mesenteric arteries.
Topics: Adrenergic alpha-Antagonists; Aerobiosis; Animals; Catalase; Clonidine; Dioxanes; Hypoxia; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Piperazines; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Superoxide Dismutase; Yohimbine | 1996 |
Characterization of alpha-adrenoceptor activity in term-newborn piglet mesentery.
Topics: Animals; Animals, Newborn; Benzazepines; Clonidine; Dioxanes; Female; Male; Mesenteric Arteries; Receptors, Adrenergic, alpha; Swine; Vasoconstriction | 1996 |
Functional characterisation of alpha 1-adrenoceptor subtypes mediating noradrenaline-induced inositol phosphate formation in rat thalamus slices.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Clonidine; Dioxanes; In Vitro Techniques; Inositol Phosphates; Male; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Thalamus | 1996 |
Noradrenaline-induced inositol phosphate formation in rat striatum is mediated by alpha 1A-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Calcium; Calcium Channel Blockers; Clonidine; Dihydropyridines; Dioxanes; In Vitro Techniques; Inositol Phosphates; Male; Neostriatum; Norepinephrine; Piperazines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 1996 |
Alpha 1-adrenergic receptor antibodies in patients with primary hypertension.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Aged; Amino Acid Sequence; Animals; Animals, Newborn; Autoantibodies; Blood Proteins; Cells, Cultured; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Heart; Humans; Hypertension; Male; Middle Aged; Molecular Sequence Data; Peptides; Phenylephrine; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Vascular Resistance | 1997 |
Intracellular Ca2+ and contractile responses to alpha 1-adrenoceptor subtype activation in rat aortic vascular smooth muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Calcium; Clonidine; Dioxanes; Female; Fluorescent Dyes; Fura-2; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Sprague-Dawley | 1997 |
Alpha 1-adrenoceptor subtypes involved in increased 86Rb+ influx rate and inositol 1,4,5-trisphosphate mass in adult rat cardiomyocytes.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Cells, Cultured; Clonidine; Dioxanes; Heart Ventricles; Inositol 1,4,5-Trisphosphate; Myocardium; Piperazines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Rubidium Radioisotopes | 1997 |
Heterogeneity and complexity of alpha 1-adrenoceptors in the ovine uterine artery and umbilical vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Binding, Competitive; Calcium Channel Blockers; Clonidine; Dioxanes; Drug Interactions; Drug Synergism; Female; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Prazosin; Pregnancy; Receptors, Adrenergic, alpha-1; Sheep; Umbilical Veins; Uterus; Vasoconstriction | 1997 |
Alpha 1-adrenoceptor subtype involved in the positive and negative inotropic responses to phenylephrine in rat papillary muscle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Carcinogens; Cardiotonic Agents; Clonidine; Dioxanes; Electrophysiology; In Vitro Techniques; Myocardial Contraction; Nifedipine; Papillary Muscles; Phenylephrine; Phorbol 12,13-Dibutyrate; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 1997 |
Subtyping of alpha1-adrenoceptors responsible for the contractile response in the rat corpus cavernosum.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Penis; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 1997 |
Characterization of subtype of alpha1-adrenoceptor mediating vasoconstriction in perfused rat hind limb.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Cell Line; Clonidine; Cloning, Molecular; Dioxanes; Dose-Response Relationship, Drug; Extremities; Humans; Indoles; Norepinephrine; Perfusion; Piperazines; Rats; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Vasoconstriction | 1997 |
Involvement of alpha1B-adrenoceptors in the positive inotropic effect of endogenous noradrenaline in rabbit myocardium.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Female; Male; Myocardial Contraction; Norepinephrine; Papillary Muscles; Phenylephrine; Propranolol; Rabbits; Receptors, Adrenergic, alpha-1; Stimulation, Chemical; Tyramine | 1997 |
The alpha1B-adrenergic receptor subtype activates the phospholipase C signaling pathway in rat myometrium at parturition.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Membrane; Clonidine; Dioxanes; Female; Guanylyl Imidodiphosphate; Labor, Obstetric; Myometrium; Pregnancy; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Signal Transduction; Type C Phospholipases | 1997 |
Investigation of alpha1-adrenoceptor subtypes mediating vasoconstriction in rabbit cutaneous resistance arteries.
Topics: Acetonitriles; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Male; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha-1; Skin; Tetrahydronaphthalenes; Vascular Resistance; Vasoconstriction | 1997 |
Effects of alpha 1-adrenoreceptor subtype blockade on ischemia-reperfusion injury.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Clonidine; Dioxanes; Energy Metabolism; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Quinazolines; Rats; Rats, Sprague-Dawley | 1997 |
Interaction between alpha-1 adrenergic and vagal effects on cardiac rate and repolarization.
Topics: Animals; Clonidine; Dioxanes; Electrocardiography; GTP-Binding Proteins; Guinea Pigs; Heart; Heart Rate; Male; Membrane Potentials; Phenylephrine; Receptors, Adrenergic, alpha-1; Vagus Nerve | 1998 |
Characterization of alpha1-adrenoceptor subtypes in facilitation of rat spinal motoneuron activity.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Bridged-Ring Compounds; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Epinephrine; Male; Methoxamine; Motor Neurons; Norepinephrine; Oxazines; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Wistar; Spinal Cord | 1997 |
Alteration of alpha1-adrenoceptor subtypes in aortas of 12-month-old spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Dioxanes; Hypertension; Indoles; Male; Muscle Contraction; Norepinephrine; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-1; Ribonucleases | 1998 |
Opposing effects of alpha 1-adrenergic receptor subtypes on Ca2+ and pH homeostasis in rat cardiac myocytes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Clonidine; Dioxanes; Drug Combinations; Drug Synergism; Fluorescent Dyes; Homeostasis; Hydrogen; Hydrogen-Ion Concentration; Indoles; Male; Myocardial Contraction; Myocardium; Phenylephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 1998 |
Pharmacological and immunocytochemical characterization of subtypes of alpha-1 adrenoceptors in dog aorta.
Topics: Animals; Aorta; Clonidine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Immunohistochemistry; Indoles; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Spiro Compounds | 1998 |
Alpha1-adrenergic stimulation of sarcolemmal Na+-H+ exchanger activity in rat ventricular myocytes: evidence for selective mediation by the alpha1A-adrenoceptor subtype.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Clonidine; Dioxanes; Heart Ventricles; Humans; Imidazoles; Kinetics; Myocardium; Phenylephrine; Piperazines; Prazosin; Rats; Receptors, Adrenergic, alpha-1; Sarcolemma; Sodium-Hydrogen Exchangers; Tetrahydronaphthalenes | 1998 |
Functional effects of castration on alpha1-adrenoceptors in rat vas deferens.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Castration; Clonidine; Dioxanes; Male; Muscle Contraction; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Vas Deferens; Vasoconstrictor Agents | 1998 |
Discrimination of alpha1-adrenoceptor subtypes in rat aorta and prostate.
Topics: Acetonitriles; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Piperazines; Prazosin; Prostate; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Sulfonamides; Tamsulosin; Vasoconstriction; Vasodilator Agents | 1998 |
Maturation and aging-related differences in responsiveness of rat aorta and carotid arteries to alpha1-adrenoceptor stimulation.
Topics: Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Aorta, Thoracic; Carotid Arteries; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Drug Interactions; Male; Muscle, Smooth, Vascular; Phenylephrine; Potassium Chloride; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Vasoconstrictor Agents | 1998 |
Modulation of basal intracellular calcium by inverse agonists and phorbol myristate acetate in rat-1 fibroblasts stably expressing alpha1d-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Cell Line; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Endothelin-1; Fibroblasts; Norepinephrine; Phentolamine; Piperazines; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Alpha 2-adrenoreceptor subtypes regulate ACTH and beta-endorphin secretions during stress in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Animals; beta-Endorphin; Clonidine; Dioxanes; Ether; Kinetics; Male; Methoxamine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Stress, Physiological | 1999 |
Preconditioning prevents the negative inotropic action of phenylephrine in rat isolated stunned papillary muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Cardiotonic Agents; Clonidine; Dioxanes; Female; Ischemic Preconditioning, Myocardial; Isoproterenol; Male; Muscle Contraction; Papillary Muscles; Phenylephrine; Rats; Rats, Wistar; Reperfusion Injury; Yohimbine | 1999 |
Expression and pharmacological characterization of alpha1-adrenoceptors in rat seminal vesicle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Clonidine; Dioxanes; Epinephrine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Phenoxybenzamine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seminal Vesicles | 1999 |
Characterisation of alpha1B-adrenoceptors linked to inositol phosphate formation and calcium mobilisation in human astrocytoma U373 MG cells.
Topics: Adrenergic alpha-Antagonists; Astrocytoma; Calcium; Cell Membrane; Clonidine; Dihydropyridines; Dioxanes; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Thymidine; Tumor Cells, Cultured | 1999 |
Differences in the electrophysiologic response of four canine ventricular cell types to alpha 1-adrenergic agonists.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Clonidine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Endocardium; Heart Ventricles; In Vitro Techniques; Methoxamine; Microelectrodes; Pericardium; Phenylephrine; Prazosin; Propranolol; Purkinje Fibers | 1999 |
alpha(1)-adrenoceptor subtypes and effect of alpha(1A)-adrenoceptor agonist NS-49 on guinea pig nasal mucosa vasculature.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anilides; Animals; Blood Vessels; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Male; Nasal Mucosa; Norepinephrine; Oxymetazoline; Piperazines; Prazosin; Spiperone; Vasoconstriction; Yohimbine | 2000 |
Role of alpha1A-adrenoceptor in the regulation of glucose uptake into white adipocyte of rats in vitro.
Topics: Adipocytes; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkaloids; Animals; Benzophenanthridines; Biological Transport, Active; Chromones; Clonidine; Deoxyglucose; Dioxanes; Enzyme Inhibitors; Estrenes; Glucose; Glucose Transporter Type 4; Indoles; Male; Maleimides; Methoxamine; Monosaccharide Transport Proteins; Morpholines; Muscle Proteins; Phenanthridines; Phosphoinositide-3 Kinase Inhibitors; Prazosin; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Sulfonamides; Tamsulosin; Type C Phospholipases | 2000 |
Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Cell Membrane; Clonidine; Conserved Sequence; Cricetinae; Dihydropyridines; Dioxanes; Humans; Imidazoles; Models, Molecular; Molecular Sequence Data; Oxymetazoline; Phenylalanine; Piperazines; Prazosin; Protein Structure, Secondary; Rats; Receptors, Adrenergic, alpha-1; Structure-Activity Relationship | 2001 |
The alpha(1A)-adrenoceptor subtype mediates contraction in rat femoral resistance arteries.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Femoral Artery; Imidazoles; In Vitro Techniques; Isoquinolines; Male; Naphthyridines; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tetrahydronaphthalenes; Vascular Resistance; Vasoconstriction | 2001 |
Characterization of alpha1-adrenoceptor-mediated contraction in the mouse thoracic aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Buspirone; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; In Vitro Techniques; Male; Methoxamine; Mice; Models, Biological; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Serotonin Receptor Agonists; Statistics as Topic; Vasoconstriction | 2001 |
Existence of alpha(1A)- and alpha(1B)-adrenoceptor subtypes in canine mandibular alveolar arteries.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alveolar Process; Animals; Arteries; Clonidine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Mandible; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Vasoconstriction; Xylazine; Yohimbine | 2001 |
Existence of functional alpha1A- and alpha1D- but no alpha1B-adrenoceptor subtypes in rat common carotid arteries.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carotid Arteries; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Male; Methoxamine; Norepinephrine; Phenylephrine; Piperazines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Vasoconstriction | 2002 |
Adrenergic activation of cardiac phospholipase D: role of alpha(1)-adrenoceptor subtypes.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Clonidine; Dioxanes; Male; Myocardium; Norepinephrine; Perfusion; Phospholipase D; Piperazines; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Signal Transduction; Stimulation, Chemical | 2002 |
Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens.
Topics: Animals; Castration; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Male; Muscle Contraction; Neuronal Plasticity; Norepinephrine; Phentolamine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Testosterone; Time Factors; Vas Deferens; Yohimbine | 2003 |
Effects of androgen manipulation on alpha1-adrenoceptor subtypes in the rat seminal vesicle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analysis of Variance; Androgens; Animals; Autoradiography; Barium Compounds; Chlorides; Clonidine; Cyproterone Acetate; Dioxanes; Gene Expression Regulation; Male; Orchiectomy; Organ Size; Phenylephrine; Piperazines; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; RNA, Messenger; Seminal Vesicles; Testosterone | 2004 |
Alpha1L-adrenoceptors mediate contractions of the isolated mouse prostate.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Analysis of Variance; Animals; Clonidine; Dioxanes; Dopamine; Dose-Response Relationship, Drug; Epinephrine; In Vitro Techniques; Indoles; Isoproterenol; Male; Mice; Muscle Contraction; Norepinephrine; Phenylephrine; Prazosin; Prostate; Receptors, Adrenergic, alpha-1; Yohimbine | 2006 |
Sympathetic neurotransmission in the rat testicular capsule: functional characterization and identification of mRNA encoding alpha1-adrenoceptor subtypes.
Topics: Acetyl-CoA C-Acyltransferase; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Calcium Channel Blockers; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Male; Muscle Contraction; Nifedipine; Norepinephrine; Prazosin; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Purinergic P2; Reserpine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spiperone; Suramin; Sympathetic Nervous System; Synaptic Transmission; Testis | 2006 |
Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electrophysiology; Hippocampus; In Vitro Techniques; Interneurons; Isoproterenol; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 2007 |
Characterization of the postjunctional alpha 2C-adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Gene Expression; Imidazoles; In Vitro Techniques; Indoles; Isoindoles; Isoquinolines; Neuromuscular Junction; Norepinephrine; Piperazines; Prazosin; Pulmonary Veins; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Vasoconstriction; Yohimbine | 2007 |
Molecular and pharmacological characteristics of the gerbil α(1a)-adrenergic receptor.
Topics: Adrenergic alpha-1 Receptor Antagonists; Amino Acid Sequence; Animals; Arteries; Chlorocebus aethiops; Clonidine; Cloning, Molecular; Cochlea; Conserved Sequence; COS Cells; Dioxanes; Dose-Response Relationship, Drug; Gerbillinae; Humans; Mice; Molecular Sequence Data; Piperazines; Prazosin; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Sequence Analysis, Protein; Transfection; Vasoconstriction | 2012 |
Blockade of different subtypes of α(1)-adrenoceptors produces opposite effect on heart chronotropy in newborn rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Animals, Newborn; Clonidine; Dioxanes; Heart Rate; Piperazines; Rats; Receptors, Adrenergic, alpha-1 | 2012 |