clonidine and heroin

clonidine has been researched along with heroin in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (36.59)	18.7374
1990's	13 (31.71)	18.2507
2000's	7 (17.07)	29.6817
2010's	5 (12.20)	24.3611
2020's	1 (2.44)	2.80

Authors

Authors	Studies
Alamo, C; Alguacil, LF; Lopez-Trabada, JR; Pascual, J; Rubio, G	1
Camí, J; de la Torre, R; Gilabert, M; San, L	1
Altés, J; Forteza-Rei, J; Jacas, C; Mestre, L; Muga, R; Tor, J	1
Bourdel, MC; Hartmann, F; Lecomte, JM; Loo, H; Poirier, MF; Schwartz, JC	1
Bradley, B; Gossop, M; Griffiths, P; Kasvikis, Y; Marks, I	1
Bozarth, MA; Murray, A; Wise, RA	1
Beroniade, V; Cuthill, JD; Salvatori, VA; Viguié, F	1
Hand, TH; Le Moal, M; Stinus, L	1
Drummond, DC; Turkington, D	1
Gregory, M; Spencer, L	1
Gurpegui, M	1
Peachey, JE	1
Brewer, C	2
Gupta, AK; Jha, BK	1
Kleber, HD; Kosten, TR; Vining, E	1
Täschner, KL	1
Cirera, E; García-Esteve, L; García-Giralt, M; Treserra, J; Vilalta, J	1
Gaspari, J; Kleber, HD; Kosten, T; Riordan, CE; Topazian, M	1
Camí, J; de Torres, S; Guerra, D; San, L; Solé, A; Ugena, B	1
Hermann, P; Presslich, O; Schanda, H	1
Aguado, A; Cerdeño, V; Galván, B; García de Lorenzo, A; Pintado, R	1
Bradley, JW; Dark, CH; Jahangiri, M; Jayatunga, AP	1
Carroll, KM; Kosten, TR; O'Connor, PG; Rounsaville, BJ; Schottenfeld, RS; Shi, JM	1
Hu, WH; Lin, SK; Strang, J; Su, LW; Tsai, CJ	1
Alamo, C; Arias, A; López-Muñoz, F; Rubio, G	1
Bammer, G; Bell, JR; Masterman, SC; Mattick, RP; Morris, A; Young, MR	1
Chiang, CT; Demuth, KL; Hoover, DR; Montoya, ID; Preston, KL; Umbricht, A	1
Delfs, J; Highfield, D; Leung, S; Shaham, Y; Stewart, J	1
Csorba, J; Gerevich, J; Kiss, N; Sós, I	1
Kishioka, S; Ko, MC; Woods, JH	1
Buechler, NL; Eisenach, JC; Kim, SA; Martin, TJ; Porreca, F	1
Boverman, JF; Kovas, AE; McCarty, DJ; McFarland, BH; Thayer, JA	1
Negus, SS; Rice, KC	1
Agthe, AG; Chavez-Valdez, R; Gauda, EB; Hendrix, CW; Jansson, L; Kim, GR; Lewis, TR; Mathias, KB; Yaster, M	1
Day, E; Strang, J	1
Edwards, S; Koob, GF; Park, PE; Schlosburg, JE; Schulteis, G; Vendruscolo, LF	2
Boughner, E; Cummins Jacklin, E; Kent, K; Kwiatkowski, D; Leri, F; MacDonald, T	1
Dong, L; Li, G; Pang, G; Stackman, RW; Wu, X; Xu, S; Zhang, G; Zhang, YM	1
Manu, P; Rogozea, LM; Shulman, M	1

Trials

14 trial(s) available for clonidine and heroin

Article	Year
Hypercortisolism after opioid discontinuation in rapid detoxification of heroin addicts. British journal of addiction, 1992, Volume: 87, Issue:8 Topics: Adult; Circadian Rhythm; Clonidine; Double-Blind Method; Guanfacine; Heroin; Heroin Dependence; Humans; Hydrocortisone; Male; Methadone; Substance Withdrawal Syndrome	1992
[Comparative effectiveness of alpha-2 adrenergic agonists (clonidine-guanfacine) in the hospital detoxification of opiate addicts]. Medicina clinica, 1990, Feb-10, Volume: 94, Issue:5 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Double-Blind Method; Drug Evaluation; Female; Guanfacine; Guanidines; Heart Rate; Heroin; Hospitalization; Humans; Male; Phenylacetates; Random Allocation; Substance Withdrawal Syndrome	1990
Comparison of acetorphan with clonidine for opiate withdrawal symptoms. The American journal of psychiatry, 1991, Volume: 148, Issue:5 Topics: Adolescent; Adult; Clonidine; Double-Blind Method; Female; Heroin; Humans; Male; Narcotics; Neprilysin; Opioid-Related Disorders; Substance Withdrawal Syndrome; Thiorphan	1991
Clonidine transdermal patches for use in outpatient opiate withdrawal. Journal of substance abuse treatment, 1989, Volume: 6, Issue:2 Topics: Administration, Cutaneous; Adult; Ambulatory Care; Clinical Trials as Topic; Clonidine; Female; Heroin; Heroin Dependence; Humans; Male; Prospective Studies; Substance Withdrawal Syndrome	1989
Clonidine in heroin withdrawal syndrome: a controlled study in India. British journal of addiction, 1988, Volume: 83, Issue:9 Topics: Adolescent; Adult; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Clonidine; Drug Therapy, Combination; Female; Heroin; Heroin Dependence; Humans; India; Male; Random Allocation; Substance Withdrawal Syndrome	1988
A controlled comparison of clonidine and doxepin in the treatment of the opiate withdrawal syndrome. Pharmacopsychiatry, 1986, Volume: 19, Issue:3 Topics: Adolescent; Adult; Clinical Trials as Topic; Clonidine; Double-Blind Method; Doxepin; Female; Heroin; Humans; Male; Substance Withdrawal Syndrome	1986
[Methadone, clonidine and levomepromazine in the treatment of opiate abstinence syndrome: double-blind clinical trial in heroin-addicted patients admitted to a general hospital for organic pathology]. Medicina clinica, 1987, May-02, Volume: 88, Issue:17 Topics: Clonidine; Double-Blind Method; Female; Heroin; Hospitalization; Hospitals, General; Humans; Male; Methadone; Methotrimeprazine; Random Allocation; Substance Withdrawal Syndrome	1987
Prevention of phantom pain after major lower limb amputation by epidural infusion of diamorphine, clonidine and bupivacaine. Annals of the Royal College of Surgeons of England, 1994, Volume: 76, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Amputation, Surgical; Analgesics; Bupivacaine; Clonidine; Drug Combinations; Female; Follow-Up Studies; Heroin; Humans; Infusions, Parenteral; Leg; Male; Middle Aged; Pain, Postoperative; Phantom Limb; Premedication; Prospective Studies	1994
Three methods of opioid detoxification in a primary care setting. A randomized trial. Annals of internal medicine, 1997, Oct-01, Volume: 127, Issue:7 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Buprenorphine; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Heroin; Heroin Dependence; Humans; Inactivation, Metabolic; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Primary Health Care; Substance Withdrawal Syndrome	1997
Double-blind randomised controlled trial of lofexidine versus clonidine in the treatment of heroin withdrawal. Drug and alcohol dependence, 1997, Nov-25, Volume: 48, Issue:2 Topics: Adult; Circadian Rhythm; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heroin; Humans; Hypotension, Orthostatic; Male; Narcotic Antagonists; Severity of Illness Index; Substance Withdrawal Syndrome	1997
A pilot study of naltrexone-accelerated detoxification in opioid dependence. The Medical journal of Australia, 1999, Jul-05, Volume: 171, Issue:1 Topics: Adolescent; Adult; Analgesics; Anti-Anxiety Agents; Clonidine; Conscious Sedation; Female; Flunitrazepam; Heroin; Heroin Dependence; Hormones; Humans; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Narcotics; Octreotide; Pilot Projects; Substance Withdrawal Syndrome; Time Factors	1999
Naltrexone shortened opioid detoxification with buprenorphine. Drug and alcohol dependence, 1999, Oct-01, Volume: 56, Issue:3 Topics: Adult; Analgesics; Area Under Curve; Buprenorphine; Clonidine; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Heroin; Heroin Dependence; Humans; Male; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome	1999
Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial. Pediatrics, 2009, Volume: 123, Issue:5 Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Blood Pressure; Clonidine; Drug Therapy, Combination; Female; Heart Rate; Heroin; Humans; Infant, Newborn; Male; Methadone; Neonatal Abstinence Syndrome; Opium; Prospective Studies; Treatment Outcome	2009
Outpatient versus inpatient opioid detoxification: a randomized controlled trial. Journal of substance abuse treatment, 2011, Volume: 40, Issue:1 Topics: Analgesics, Opioid; Clonidine; Female; Heroin; Heroin Dependence; Humans; Inpatients; Male; Methadone; Narcotics; Opioid-Related Disorders; Outcome Assessment, Health Care; Outpatients; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome	2011

Other Studies

27 other study(ies) available for clonidine and heroin

Article	Year
Relapse to opiate use provokes biphasic changes of blood pressure in heroin-withdrawn addicts treated with clonidine. Drug and alcohol dependence, 1992, Volume: 30, Issue:2 Topics: Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Heroin; Heroin Dependence; Humans; Male; Recurrence; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome	1992
Clonidine versus long- and short-term methadone-aided withdrawal from opiates. An uncontrolled comparison. The International journal of the addictions, 1990, Volume: 25, Issue:10 Topics: Adult; Clonidine; Drug Administration Schedule; Female; Heroin; Heroin Dependence; Hospitalization; Humans; Male; Methadone; Neuropsychological Tests; Substance Withdrawal Syndrome	1990
Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats. Psychopharmacology, 1990, Volume: 100, Issue:3 Topics: Animals; Bromocriptine; Clonidine; Cocaine; Conditioning, Operant; Ethanol; Heroin; Male; Nicotine; Rats; Reinforcement Schedule; Reinforcement, Psychology; Self Administration	1990
Evaluation of clonidine suppression of opiate withdrawal reactions: a multidisciplinary approach. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1990, Volume: 35, Issue:5 Topics: Arousal; Clonidine; Dose-Response Relationship, Drug; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Neurologic Examination; Patient Compliance; Referral and Consultation; Substance Withdrawal Syndrome	1990
Differential mechanisms in the acquisition and expression of heroin-induced place preference. Psychopharmacology, 1989, Volume: 98, Issue:1 Topics: Animals; Choice Behavior; Clonidine; Dose-Response Relationship, Drug; Heroin; Male; Naloxone; Pimozide; Rats; Rats, Inbred Strains	1989
Naltrexone and clonidine in heroin withdrawal treatment. The British journal of psychiatry : the journal of mental science, 1989, Volume: 154 Topics: Clonidine; Heroin; Humans; Naltrexone; Substance Withdrawal Syndrome	1989
[Heroin withdrawal syndrome and noradrenergic activity]. Medicina clinica, 1987, Oct-31, Volume: 89, Issue:14 Topics: Clonidine; Heroin; Humans; Receptors, Adrenergic, alpha; Substance Withdrawal Syndrome	1987
The role of drugs in the treatment of opioid addicts. The Medical journal of Australia, 1986, Oct-20, Volume: 145, Issue:8 Topics: Alcoholism; Anxiety; Clonidine; Dextropropoxyphene; Heroin; Humans; Inactivation, Metabolic; Kinetics; Methadone; Mood Disorders; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders	1986
Blood pressure monitoring at home for rapid opioid withdrawal with clonidine and naltrexone. Lancet (London, England), 1987, Mar-14, Volume: 1, Issue:8533 Topics: Administration, Oral; Adult; Blood Pressure Determination; Clonidine; Drug Therapy, Combination; Female; Heroin; Home Nursing; Humans; Monitoring, Physiologic; Naltrexone; Substance Withdrawal Syndrome; Telephone	1987
Opiate withdrawal: inpatient versus outpatient programmes. British medical journal (Clinical research ed.), 1986, Aug-09, Volume: 293, Issue:6543 Topics: Clonidine; Heroin; Hospitalization; Humans; Naltrexone; Substance Withdrawal Syndrome	1986
Clinical utility of rapid clonidine-naltrexone detoxification for opioid abusers. British journal of addiction, 1988, Volume: 83, Issue:5 Topics: Adult; Clinical Protocols; Clonidine; Drug Therapy, Combination; Female; Heroin; Humans; Male; Naltrexone; Substance-Related Disorders	1988
Clonidine and naltrexone in the outpatient treatment of heroin withdrawal. The American journal of drug and alcohol abuse, 1987, Volume: 13, Issue:1-2 Topics: Adult; Ambulatory Care; Clonidine; Drug Therapy, Combination; Female; Heroin; Humans; Male; Naltrexone; Substance Withdrawal Syndrome	1987
Efficacy of clonidine and of methadone in the rapid detoxification of patients dependent on heroin. Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:3 Topics: Adolescent; Adult; Analysis of Variance; Anxiety; Blood Pressure; Clonidine; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Female; Flunitrazepam; Heart Rate; Heroin; Humans; Inactivation, Metabolic; Male; Methadone; Substance-Related Disorders	1985
[Clonidine for the treatment of heroin withdrawal syndrome]. Wiener klinische Wochenschrift, 1983, Aug-26, Volume: 95, Issue:16 Topics: 2-Hydroxyphenethylamine; Clonidine; Dose-Response Relationship, Drug; Doxepin; Drug Administration Schedule; Heroin; Humans; Nitrazepam; Octopamine; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome; Vertigo	1983
[Intrahospital treatment of acute opiate withdrawal syndrome using the non-opiate agent clonidine]. Medicina clinica, 1983, Oct-15, Volume: 81, Issue:11 Topics: Clonidine; Heroin; Humans; Narcotics; Substance Withdrawal Syndrome	1983
[Cardiovascular changes during alpha-2 agonist treatment of opiate withdrawal syndrome]. Revista clinica espanola, 1998, Volume: 198, Issue:4 Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Guanfacine; Heart Rate; Heroin; Heroin Dependence; Rats; Substance Withdrawal Syndrome; Time Factors	1998
Clonidine blocks stress-induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neurons. The European journal of neuroscience, 2000, Volume: 12, Issue:1 Topics: Animals; Cerebral Ventricles; Clonidine; Electroshock; Extinction, Psychological; Heroin; Heroin Dependence; Injections, Intraventricular; Locus Coeruleus; Male; Medial Forebrain Bundle; Neurons; Norepinephrine; Oxidopamine; Parasympathomimetics; Rats; Rats, Long-Evans; Self Administration; Stress, Psychological	2000
[Tizanidine in the treatment of acute withdrawal symptoms in heroin dependent patients]. Orvosi hetilap, 2000, Apr-09, Volume: 141, Issue:15 Topics: Acute Disease; Adult; Analgesics; Anticonvulsants; Case-Control Studies; Clonidine; Female; Heroin; Heroin Dependence; Humans; Male; Muscle Relaxants, Central; Narcotics; Substance Withdrawal Syndrome; Treatment Outcome	2000
Diltiazem enhances the analgesic but not the respiratory depressant effects of morphine in rhesus monkeys. European journal of pharmacology, 2000, May-26, Volume: 397, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzimidazoles; Calcium Channel Blockers; Clonidine; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Female; Fentanyl; Heroin; Macaca mulatta; Male; Morphine; Nalbuphine; Pain Measurement; Receptors, Opioid; Respiration; Time Factors	2000
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology, 2007, Volume: 106, Issue:2 Topics: Adenosine; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Fentanyl; Heroin; Hydromorphone; Infusions, Intravenous; Injections, Spinal; Male; Methadone; Morphine; Neuralgia; Pain; Rats; Rats, Inbred F344; Self Administration	2007
Buprenorphine for acute heroin detoxification: diffusion of research into practice. Journal of substance abuse treatment, 2007, Volume: 32, Issue:2 Topics: Acute Disease; Adult; Buprenorphine; Clonidine; Diffusion of Innovation; Female; Heroin; Heroin Dependence; Humans; Length of Stay; Male; Middle Aged; Narcotics; Oregon; Patient Acceptance of Health Care; Retrospective Studies; Substance Withdrawal Syndrome; Treatment Outcome	2007
Mechanisms of withdrawal-associated increases in heroin self-administration: pharmacologic modulation of heroin vs food choice in heroin-dependent rhesus monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:4 Topics: Adrenergic Agents; Adrenergic Agonists; Amphetamine; Animals; Behavior, Addictive; Choice Behavior; Clonidine; Dopamine Agents; Dose-Response Relationship, Drug; Food; Heroin; Heroin Dependence; Macaca mulatta; Male; Morphine; Narcotic Antagonists; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Self Administration; Substance Withdrawal Syndrome	2009
Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats. The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:8 Topics: Acoustic Stimulation; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analysis of Variance; Animals; Clonidine; Conditioning, Operant; Corticotropin-Releasing Hormone; Disease Models, Animal; Heroin; Male; Narcotics; Norepinephrine; Psychoacoustics; Pyrimidines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reflex, Startle; Self Administration; Substance Withdrawal Syndrome; Time Factors; Yohimbine	2013
Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia. Addiction biology, 2015, Volume: 20, Issue:2 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Behavior, Animal; Clonidine; Drug-Seeking Behavior; Heroin; Heroin Dependence; Hyperalgesia; Narcotics; Prazosin; Propranolol; Pyrimidines; Rats; Receptors, Corticotropin-Releasing Hormone; Self Administration	2015
Memory of a drug lapse: Role of noradrenaline. Neuropharmacology, 2015, Volume: 99 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Animals; Basolateral Nuclear Complex; Clonidine; Cocaine; Conditioning, Psychological; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Heroin; Locus Coeruleus; Male; Memory; Narcotics; Norepinephrine; Prazosin; Propranolol; Rats, Sprague-Dawley; Spatial Behavior; Substance-Related Disorders	2015
Activation of serotonin 5-HT(2C) receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in heroin-treated mice. Neuroscience letters, 2015, Oct-21, Volume: 607 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Behavior, Animal; Benzazepines; Central Nervous System Stimulants; Clonidine; Heroin; Male; Mice; Motor Activity; Naloxone; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Substance Withdrawal Syndrome	2015
Pharmacological Management of Heroin Withdrawal Syndrome: A Century of Expert Opinions in Cecil Textbook of Medicine. American journal of therapeutics, 2022, Feb-14, Volume: 29, Issue:2 Topics: Analgesics, Opioid; Buprenorphine; Clonidine; Expert Testimony; Heroin; Humans; Methadone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome	2022