cimetidine and diazepam
cimetidine has been researched along with diazepam in 77 studies
Research
Studies (77)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 35 (45.45) | 18.7374 |
1990's | 4 (5.19) | 18.2507 |
2000's | 19 (24.68) | 29.6817 |
2010's | 19 (24.68) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
Topliss, JG; Yoshida, F | 1 |
Artursson, P; Luthman, K; Norinder, U; Stenberg, P | 1 |
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
Adachi, Y; Sugiyama, Y; Suzuki, H | 1 |
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
Chang, TK; Ensom, MH; Kiang, TK | 1 |
Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Campillo, NE; Guerra, A; Páez, JA | 1 |
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
Avdeef, A; Tam, KY | 1 |
Glen, RC; Lowe, R; Mitchell, JB | 1 |
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S | 1 |
Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Artursson, P; Mateus, A; Matsson, P | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E | 1 |
Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E | 1 |
Kessler, HJ; Patschke, D | 1 |
Anttila, VJ; Klotz, U; Reimann, T | 1 |
Hsieh, CY; Huang, JD | 1 |
Andersson, T; Andrén, K; Cederberg, C; Edvardsson, G; Heggelund, A; Lundborg, P | 1 |
Bannister, SJ; Houser, VP; Hulse, JD; Kisicki, JC; Rasmussen, JG | 1 |
Barclay, AM | 1 |
Arvela, P; Klotz, U; Rosenkranz, B | 1 |
Greenblatt, DJ; Harmatz, JS; Locniskar, A; Shader, RI; Zinny, MA | 1 |
Arvela, P; Klotz, U; Pasanen, M; Pelkonen, O; Sotaniemi, E | 1 |
Guidobono, F; Netti, C; Pagani, F; Pecile, A; Sibilia, V | 1 |
Alazia, M; Cano, JP; Crevat-Pisano, P; Drouet, C; Francois, G; Lacarelle, B | 1 |
Ayrton, A; Chenery, RJ; Norman, SJ; Oldham, HG; Standring, P | 1 |
Hatakeyama, H; Hirose, K; Jyoyama, H; Matsubara, T; Otsubo, S; Touchi, A | 1 |
Ghignone, M; Orko, R; Pouttu, J; Rosenberg, PH | 1 |
Gillespie, WR; Veng-Pedersen, P | 1 |
Bastien, O; Lehot, JJ; Quintin, L | 1 |
Avant, GR; Parker, R; Schenker, S; Speeg, KV; Wang, S | 1 |
Ruffalo, RL; Segal, JL; Thompson, JF | 1 |
Dundee, JW; McGowan, WA | 1 |
Falkowski, AJ; Hepler, BR; Hiss, J; Sunshine, I | 1 |
Bergamo, ML; Sudol, TE | 1 |
Abernethy, DR; Greenblatt, DJ; Shader, RI | 1 |
Feely, J | 1 |
Abernethy, DR; Greenblatt, DJ; Harmatz, JS; Morse, DS; Shader, RI | 1 |
Altrudi, RD; Kischinefsky, JS; Vadra, JE | 1 |
Hino, T; Ito, Y; Kunieda, T; Ohashi, H; Sakata, K; Tsuchiya, J | 1 |
Klotz, U; Reimann, I | 3 |
Abernethy, DR; Ameer, B; Divoll, M; Greenblatt, DJ; Shader, RI | 1 |
Neumayr, A; Weiss, W | 1 |
Jenike, MA | 1 |
Araujo, OE; Curry, SH; Dallman, JJ; Gough, PA; Robinson, JD | 1 |
Coombs, DW | 1 |
Babb, RR | 1 |
Ali, BH; Banna, NR; Bashir, AK; Tanira, MO | 1 |
Amabeoku, GJ; Chikuni, O | 1 |
Yao, TW; Yu, LS; Zeng, S | 1 |
Honda, K; Inomata, S; Nakamura, T; Tanaka, E | 1 |
Reviews
5 review(s) available for cimetidine and diazepam
Article | Year |
---|---|
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Diazepam-cimetidine drug interaction: a clinically significant effect.
Topics: Anti-Anxiety Agents; Cimetidine; Cytochrome P-450 Enzyme System; Depression, Chemical; Diazepam; Drug Interactions; Guanidines; Humans; Kinetics; Lorazepam; Oxazepam; Oxidation-Reduction | 1981 |
Interaction of cimetidine with other drugs.
Topics: Aged; Chlormethiazole; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Lidocaine; Liver; Liver Circulation; Phenytoin; Propranolol; Tissue Distribution; Warfarin | 1983 |
Cimetidine in elderly patients: review of uses and risks.
Topics: Administration, Oral; Aged; Antacids; Chemical Phenomena; Chemistry; Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Duodenal Ulcer; Female; Gastric Acid; Guanidines; Humans; Mental Disorders; Middle Aged; Peptic Ulcer; Phenytoin; Zollinger-Ellison Syndrome | 1982 |
Trials
7 trial(s) available for cimetidine and diazepam
Article | Year |
---|---|
Effect of omeprazole and cimetidine on plasma diazepam levels.
Topics: Adult; Cimetidine; Diazepam; Double-Blind Method; Drug Interactions; Half-Life; Humans; Male; Nordazepam; Omeprazole | 1990 |
Famotidine, a new H2-receptor antagonist, does not affect hepatic elimination of diazepam or tubular secretion of procainamide.
Topics: Adult; Cimetidine; Diazepam; Famotidine; Histamine H2 Antagonists; Humans; In Vitro Techniques; Kidney Tubules; Kinetics; Liver; Male; Microsomes, Liver; Middle Aged; Procainamide; Random Allocation; Thiazoles | 1985 |
Effect of clonidine on haemodynamic responses to endotracheal intubation and on gastric acidity.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Clonidine; Diazepam; Female; Gastric Acid; Heart Rate; Hemodynamics; Humans; Intubation, Intratracheal; Male; Middle Aged; Preanesthetic Medication; Random Allocation | 1987 |
The effect of intravenous cimetidine on the absorption of orally administered diazepam and lorazepam.
Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Capsules; Cimetidine; Diazepam; Drug Interactions; Female; Guanidines; Humans; Injections, Intravenous; Intestinal Absorption; Lorazepam; Tablets | 1982 |
Clinical importance of the interaction of diazepam and cimetidine.
Topics: Adult; Anxiety; Cimetidine; Clinical Trials as Topic; Diazepam; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; Humans; Male; Middle Aged; Nordazepam; Psychomotor Performance; Reaction Time; Sleep Wake Disorders | 1984 |
Influence of cimetidine on oral diazepam elimination with measurement of subsequent cognitive change.
Topics: Administration, Oral; Adult; Cimetidine; Cognition; Diazepam; Double-Blind Method; Drug Interactions; Female; Guanidines; Humans; Kinetics; Male; Metabolic Clearance Rate | 1982 |
Elevation of steady-state diazepam levels by cimetidine.
Topics: Adult; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Kinetics | 1981 |
Other Studies
65 other study(ies) available for cimetidine and diazepam
Article | Year |
---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Experimental and computational screening models for the prediction of intestinal drug absorption.
Topics: Biological Transport; Carbon Radioisotopes; Cell Line; Cell Membrane; Cell Membrane Permeability; Ciprofloxacin; Computational Biology; Drug Design; Foscarnet; Humans; Hydrogen Bonding; Intestinal Absorption; Intestinal Mucosa; Lactulose; Mannitol; Models, Biological; Raffinose; Surface Properties; Tritium; Verapamil | 2001 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Dose-Response Relationship, Drug; Humans; Hydrolysis; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Models, Biological; Pharmaceutical Preparations; Swine; Tissue Distribution; Transfection | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship | 2013 |
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship | 2017 |
[Histamine H2-receptor blockade and thrombosis prophylaxis with heparin in tetanus. A case report (author's transl)].
Topics: Ampicillin; Baclofen; Cimetidine; Diazepam; Heparin; Histamine H2 Antagonists; Humans; Male; Middle Aged; Peptic Ulcer; Tetanus; Tetanus Antitoxin; Tetanus Toxoid; Thrombosis | 1978 |
Cimetidine/diazepam interaction.
Topics: Biological Availability; Cimetidine; Diazepam; Drug Synergism; Guanidines; Half-Life; Humans | 1979 |
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism.
Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole | 1992 |
Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin.
Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Diazepam; Digoxin; Drug Interactions; Humans; Male; Paroxetine; Piperidines; Serotonin Antagonists; Warfarin | 1989 |
Psychotropic drugs in the elderly. Selection of the appropriate agent.
Topics: Age Factors; Aged; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Chlordiazepoxide; Cimetidine; Diazepam; Flurazepam; Haloperidol; Humans; Kinetics; Lithium; Phenothiazines; Physostigmine; Psychotropic Drugs; Thiothixene; Trazodone | 1985 |
Interaction of diazepam with famotidine and cimetidine, two H2-receptor antagonists.
Topics: Adult; Biotransformation; Cimetidine; Diazepam; Drug Interactions; Famotidine; Half-Life; Histamine H2 Antagonists; Humans; Infusions, Parenteral; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Nordazepam; Thiazoles | 1986 |
Effect of five structurally diverse H2-receptor antagonists on drug metabolism.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cimetidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Diazepam; Famotidine; Histamine H2 Antagonists; Humans; Imidazoles; Kinetics; Male; Microsomes, Liver; Nizatidine; Oxidoreductases; Oxygenases; Pharmaceutical Preparations; Ranitidine; Rats; Rats, Inbred Strains; Thiazoles | 1986 |
Cimetidine-induced prolactin release: possible involvement of the GABA-ergic system.
Topics: Animals; Cimetidine; Diazepam; gamma-Aminobutyric Acid; Imidazoles; Impromidine; Male; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Histamine H1; Synaptic Transmission | 1985 |
Validation of a radioreceptor assay technique for monitoring pharmacological active material during intensive diazepam tetanus therapy.
Topics: Biotransformation; Chromatography, Gas; Cimetidine; Diazepam; Humans; Kinetics; Middle Aged; Nordazepam; Oxazepam; Radioligand Assay; Tetanus | 1987 |
The interaction of omeprazole with rat liver cytochrome P450-mediated monooxygenase reactions in vitro and in vivo.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cimetidine; Diazepam; Ethylmorphine-N-Demethylase; In Vitro Techniques; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Omeprazole; Oxidoreductases; Oxygenases; Rats; Rats, Inbred Strains; Species Specificity | 1988 |
[Effect of the nonsteroidal anti-inflammatory drug 480156-S on hepatic drug-metabolizing activity and pharmacological action of diazepam and pentobarbital in rats].
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Cytochrome P-450 Enzyme System; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Ibuprofen; Liver; Male; Oxygenases; Pentobarbital; Phenylpropionates; Rats; Rats, Inbred Strains | 1988 |
Theorems and implications of a model-independent elimination/distribution function decomposition of linear and some nonlinear drug dispositions. IV. Exact relationship between the terminal log-linear slope parameter beta and drug clearance.
Topics: Cimetidine; Diazepam; Humans; Injections, Intravenous; Mathematics; Models, Biological; Pentobarbital; Pharmacokinetics; Software; Tissue Distribution | 1987 |
[Hemodynamic and effects of preoperative sedation with the diazepam-droperidol combination].
Topics: Blood Pressure; Cardiac Surgical Procedures; Catheterization; Cimetidine; Diazepam; Droperidol; Drug Therapy, Combination; Hemodynamics; Humans; Middle Aged; Oxygen; Preanesthetic Medication; Prospective Studies | 1986 |
In vitro antagonism of benzodiazepine binding to cerebral receptors by H1 and H2 antihistamines.
Topics: Binding, Competitive; Brain; Cimetidine; Diazepam; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Receptors, Adrenergic, beta; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Opioid; Structure-Activity Relationship | 1981 |
Fatal bradycardia after intentional overdose of cimetidine and diazepam.
Topics: Adult; Bradycardia; Cimetidine; Diazepam; Drug Synergism; Female; Guanidines; Humans; Suicide | 1982 |
Cimetidine drug interactions.
Topics: Anti-Anxiety Agents; Cimetidine; Diazepam; Drug Interactions; Humans; Kinetics | 1984 |
Anxiolytic drug therapy in patients with medical disease: clinical importance of pharmacokinetic drug interactions.
Topics: Anti-Anxiety Agents; Cimetidine; Diazepam; Drug Interactions; Humans; Kinetics | 1984 |
Interaction of diazepam and cimetidine.
Topics: Cimetidine; Diazepam; Drug Interactions; Humans; Metabolic Clearance Rate | 1984 |
[Acute bleeding digestive lesions].
Topics: Acute Disease; Animals; Cimetidine; Diazepam; Dogs; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Meperidine; Middle Aged; Peptic Ulcer Hemorrhage; Promethazine; Stress, Psychological | 1983 |
Stress ulcer accompanying subarachnoid hemorrhage--a new rat model.
Topics: Animals; Cimetidine; Diazepam; Disease Models, Animal; Gastric Mucosa; Male; Pentobarbital; Phenytoin; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological; Subarachnoid Hemorrhage | 1983 |
Delayed clearance of diazepam due to cimetidine.
Topics: Adult; Antipyrine; Cimetidine; Diazepam; Drug Interactions; Drug Synergism; Female; Guanidines; Half-Life; Humans; Kinetics; Male; Nordazepam | 1980 |
Influence of cimetidine on the pharmacokinetics of desmethyldiazepam and oxazepam.
Topics: Adult; Cimetidine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Humans; Kinetics; Liver; Male; Nordazepam; Oxazepam | 1980 |
Differential effect of cimetidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine.
Topics: Acetaminophen; Adult; Animals; Antipyrine; Biotransformation; Cimetidine; Diazepam; Guanidines; Humans; Kinetics; Lethal Dose 50; Lorazepam; Male; Mice; Oxidation-Reduction | 1983 |
[Conservative therapy of peptic ulcer].
Topics: Antacids; Benzodiazepinones; Cimetidine; Diazepam; Gastrointestinal Hormones; Humans; Hypnosis; Metoclopramide; Parasympatholytics; Peptic Ulcer; Piperazines; Pirenzepine | 1980 |
Cimetidine induced psychosis--varied mechanism of action.
Topics: Cimetidine; Diazepam; Drug Synergism; Guanidines; Humans; Psychoses, Substance-Induced | 1981 |
Drug interactions with cimetidine.
Topics: Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Phenytoin; Propranolol; Theophylline; Warfarin | 1981 |
Central nervous system activity of Rhazya stricta (Decne) in mice.
Topics: Abdomen; Analgesia; Animals; Behavior, Animal; Body Temperature; Central Nervous System; Cimetidine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Hypnotics and Sedatives; Male; Medicine, Arabic; Mice; Motor Activity; Naloxone; Pentobarbital; Picrotoxin; Plant Extracts; Plant Leaves; Plants, Medicinal; Seizures; Sleep; Tail | 1995 |
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; Mice; Muscimol; Phenobarbital; Phenytoin; Picrotoxin; Receptors, GABA; Seizures; Strychnine | 1993 |
In vitro metabolism of zolmitriptan in rat cytochromes induced with beta-naphthoflavone and the interaction between six drugs and zolmitriptan.
Topics: Animals; beta-Naphthoflavone; Cimetidine; Cytochrome P-450 CYP1A2; Diazepam; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Fluvoxamine; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Moclobemide; Oxazolidinones; Propranolol; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Species Specificity; Tryptamines | 2003 |
Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro.
Topics: Amides; Anesthetics, Local; Bupivacaine; Cells, Cultured; Cimetidine; Clonidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Lidocaine; Microsomes, Liver; Midazolam; Premedication; Ropivacaine; Thiamylal; Vecuronium Bromide | 2006 |