cimetidine and diazepam

cimetidine has been researched along with diazepam in 77 studies

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-199035 (45.45)18.7374
1990's4 (5.19)18.2507
2000's19 (24.68)29.6817
2010's19 (24.68)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Topliss, JG; Yoshida, F1
Artursson, P; Luthman, K; Norinder, U; Stenberg, P1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Adachi, Y; Sugiyama, Y; Suzuki, H1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Chang, TK; Ensom, MH; Kiang, TK1
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Avdeef, A; Tam, KY1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S1
Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Artursson, P; Mateus, A; Matsson, P1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E1
Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E1
Kessler, HJ; Patschke, D1
Anttila, VJ; Klotz, U; Reimann, T1
Hsieh, CY; Huang, JD1
Andersson, T; Andrén, K; Cederberg, C; Edvardsson, G; Heggelund, A; Lundborg, P1
Bannister, SJ; Houser, VP; Hulse, JD; Kisicki, JC; Rasmussen, JG1
Barclay, AM1
Arvela, P; Klotz, U; Rosenkranz, B1
Greenblatt, DJ; Harmatz, JS; Locniskar, A; Shader, RI; Zinny, MA1
Arvela, P; Klotz, U; Pasanen, M; Pelkonen, O; Sotaniemi, E1
Guidobono, F; Netti, C; Pagani, F; Pecile, A; Sibilia, V1
Alazia, M; Cano, JP; Crevat-Pisano, P; Drouet, C; Francois, G; Lacarelle, B1
Ayrton, A; Chenery, RJ; Norman, SJ; Oldham, HG; Standring, P1
Hatakeyama, H; Hirose, K; Jyoyama, H; Matsubara, T; Otsubo, S; Touchi, A1
Ghignone, M; Orko, R; Pouttu, J; Rosenberg, PH1
Gillespie, WR; Veng-Pedersen, P1
Bastien, O; Lehot, JJ; Quintin, L1
Avant, GR; Parker, R; Schenker, S; Speeg, KV; Wang, S1
Ruffalo, RL; Segal, JL; Thompson, JF1
Dundee, JW; McGowan, WA1
Falkowski, AJ; Hepler, BR; Hiss, J; Sunshine, I1
Bergamo, ML; Sudol, TE1
Abernethy, DR; Greenblatt, DJ; Shader, RI1
Feely, J1
Abernethy, DR; Greenblatt, DJ; Harmatz, JS; Morse, DS; Shader, RI1
Altrudi, RD; Kischinefsky, JS; Vadra, JE1
Hino, T; Ito, Y; Kunieda, T; Ohashi, H; Sakata, K; Tsuchiya, J1
Klotz, U; Reimann, I3
Abernethy, DR; Ameer, B; Divoll, M; Greenblatt, DJ; Shader, RI1
Neumayr, A; Weiss, W1
Jenike, MA1
Araujo, OE; Curry, SH; Dallman, JJ; Gough, PA; Robinson, JD1
Coombs, DW1
Babb, RR1
Ali, BH; Banna, NR; Bashir, AK; Tanira, MO1
Amabeoku, GJ; Chikuni, O1
Yao, TW; Yu, LS; Zeng, S1
Honda, K; Inomata, S; Nakamura, T; Tanaka, E1

Reviews

5 review(s) available for cimetidine and diazepam

ArticleYear
UDP-glucuronosyltransferases and clinical drug-drug interactions.
    Pharmacology & therapeutics, 2005, Volume: 106, Issue:1

    Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Diazepam-cimetidine drug interaction: a clinically significant effect.
    Southern medical journal, 1981, Volume: 74, Issue:9

    Topics: Anti-Anxiety Agents; Cimetidine; Cytochrome P-450 Enzyme System; Depression, Chemical; Diazepam; Drug Interactions; Guanidines; Humans; Kinetics; Lorazepam; Oxazepam; Oxidation-Reduction

1981
Interaction of cimetidine with other drugs.
    Southern medical journal, 1983, Volume: 76, Issue:6

    Topics: Aged; Chlormethiazole; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Lidocaine; Liver; Liver Circulation; Phenytoin; Propranolol; Tissue Distribution; Warfarin

1983
Cimetidine in elderly patients: review of uses and risks.
    Journal of the American Geriatrics Society, 1982, Volume: 30, Issue:3

    Topics: Administration, Oral; Aged; Antacids; Chemical Phenomena; Chemistry; Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Duodenal Ulcer; Female; Gastric Acid; Guanidines; Humans; Mental Disorders; Middle Aged; Peptic Ulcer; Phenytoin; Zollinger-Ellison Syndrome

1982

Trials

7 trial(s) available for cimetidine and diazepam

ArticleYear
Effect of omeprazole and cimetidine on plasma diazepam levels.
    European journal of clinical pharmacology, 1990, Volume: 39, Issue:1

    Topics: Adult; Cimetidine; Diazepam; Double-Blind Method; Drug Interactions; Half-Life; Humans; Male; Nordazepam; Omeprazole

1990
Famotidine, a new H2-receptor antagonist, does not affect hepatic elimination of diazepam or tubular secretion of procainamide.
    European journal of clinical pharmacology, 1985, Volume: 28, Issue:6

    Topics: Adult; Cimetidine; Diazepam; Famotidine; Histamine H2 Antagonists; Humans; In Vitro Techniques; Kidney Tubules; Kinetics; Liver; Male; Microsomes, Liver; Middle Aged; Procainamide; Random Allocation; Thiazoles

1985
Effect of clonidine on haemodynamic responses to endotracheal intubation and on gastric acidity.
    Acta anaesthesiologica Scandinavica, 1987, Volume: 31, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Clonidine; Diazepam; Female; Gastric Acid; Heart Rate; Hemodynamics; Humans; Intubation, Intratracheal; Male; Middle Aged; Preanesthetic Medication; Random Allocation

1987
The effect of intravenous cimetidine on the absorption of orally administered diazepam and lorazepam.
    British journal of clinical pharmacology, 1982, Volume: 14, Issue:2

    Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Capsules; Cimetidine; Diazepam; Drug Interactions; Female; Guanidines; Humans; Injections, Intravenous; Intestinal Absorption; Lorazepam; Tablets

1982
Clinical importance of the interaction of diazepam and cimetidine.
    The New England journal of medicine, 1984, Jun-21, Volume: 310, Issue:25

    Topics: Adult; Anxiety; Cimetidine; Clinical Trials as Topic; Diazepam; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; Humans; Male; Middle Aged; Nordazepam; Psychomotor Performance; Reaction Time; Sleep Wake Disorders

1984
Influence of cimetidine on oral diazepam elimination with measurement of subsequent cognitive change.
    British journal of clinical pharmacology, 1982, Volume: 14, Issue:5

    Topics: Administration, Oral; Adult; Cimetidine; Cognition; Diazepam; Double-Blind Method; Drug Interactions; Female; Guanidines; Humans; Kinetics; Male; Metabolic Clearance Rate

1982
Elevation of steady-state diazepam levels by cimetidine.
    Clinical pharmacology and therapeutics, 1981, Volume: 30, Issue:4

    Topics: Adult; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Kinetics

1981

Other Studies

65 other study(ies) available for cimetidine and diazepam

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Experimental and computational screening models for the prediction of intestinal drug absorption.
    Journal of medicinal chemistry, 2001, Jun-07, Volume: 44, Issue:12

    Topics: Biological Transport; Carbon Radioisotopes; Cell Line; Cell Membrane; Cell Membrane Permeability; Ciprofloxacin; Computational Biology; Drug Design; Foscarnet; Humans; Hydrogen Bonding; Intestinal Absorption; Intestinal Mucosa; Lactulose; Mannitol; Models, Biological; Raffinose; Surface Properties; Tritium; Verapamil

2001
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.
    Pharmaceutical research, 2001, Volume: 18, Issue:12

    Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Dose-Response Relationship, Drug; Humans; Hydrolysis; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Models, Biological; Pharmaceutical Preparations; Swine; Tissue Distribution; Transfection

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
    Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21

    Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship

2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
    European journal of medicinal chemistry, 2013, Volume: 63

    Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship

2013
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
    Bioorganic & medicinal chemistry, 2013, May-15, Volume: 21, Issue:10

    Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine

2016
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
    Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2

    Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship

2017
[Histamine H2-receptor blockade and thrombosis prophylaxis with heparin in tetanus. A case report (author's transl)].
    Der Anaesthesist, 1978, Volume: 27, Issue:8

    Topics: Ampicillin; Baclofen; Cimetidine; Diazepam; Heparin; Histamine H2 Antagonists; Humans; Male; Middle Aged; Peptic Ulcer; Tetanus; Tetanus Antitoxin; Tetanus Toxoid; Thrombosis

1978
Cimetidine/diazepam interaction.
    Lancet (London, England), 1979, Sep-29, Volume: 2, Issue:8144

    Topics: Biological Availability; Cimetidine; Diazepam; Drug Synergism; Guanidines; Half-Life; Humans

1979
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism.
    Journal of chromatography, 1992, Mar-13, Volume: 575, Issue:1

    Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole

1992
Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Diazepam; Digoxin; Drug Interactions; Humans; Male; Paroxetine; Piperidines; Serotonin Antagonists; Warfarin

1989
Psychotropic drugs in the elderly. Selection of the appropriate agent.
    Postgraduate medicine, 1985, Volume: 77, Issue:8

    Topics: Age Factors; Aged; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Chlordiazepoxide; Cimetidine; Diazepam; Flurazepam; Haloperidol; Humans; Kinetics; Lithium; Phenothiazines; Physostigmine; Psychotropic Drugs; Thiothixene; Trazodone

1985
Interaction of diazepam with famotidine and cimetidine, two H2-receptor antagonists.
    Journal of clinical pharmacology, 1986, Volume: 26, Issue:4

    Topics: Adult; Biotransformation; Cimetidine; Diazepam; Drug Interactions; Famotidine; Half-Life; Histamine H2 Antagonists; Humans; Infusions, Parenteral; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Nordazepam; Thiazoles

1986
Effect of five structurally diverse H2-receptor antagonists on drug metabolism.
    Biochemical pharmacology, 1986, Dec-15, Volume: 35, Issue:24

    Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cimetidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Diazepam; Famotidine; Histamine H2 Antagonists; Humans; Imidazoles; Kinetics; Male; Microsomes, Liver; Nizatidine; Oxidoreductases; Oxygenases; Pharmaceutical Preparations; Ranitidine; Rats; Rats, Inbred Strains; Thiazoles

1986
Cimetidine-induced prolactin release: possible involvement of the GABA-ergic system.
    Neuroendocrinology, 1985, Volume: 40, Issue:3

    Topics: Animals; Cimetidine; Diazepam; gamma-Aminobutyric Acid; Imidazoles; Impromidine; Male; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Histamine H1; Synaptic Transmission

1985
Validation of a radioreceptor assay technique for monitoring pharmacological active material during intensive diazepam tetanus therapy.
    International journal of clinical pharmacology, therapy, and toxicology, 1987, Volume: 25, Issue:7

    Topics: Biotransformation; Chromatography, Gas; Cimetidine; Diazepam; Humans; Kinetics; Middle Aged; Nordazepam; Oxazepam; Radioligand Assay; Tetanus

1987
The interaction of omeprazole with rat liver cytochrome P450-mediated monooxygenase reactions in vitro and in vivo.
    Biochemical pharmacology, 1988, Apr-01, Volume: 37, Issue:7

    Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cimetidine; Diazepam; Ethylmorphine-N-Demethylase; In Vitro Techniques; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Omeprazole; Oxidoreductases; Oxygenases; Rats; Rats, Inbred Strains; Species Specificity

1988
[Effect of the nonsteroidal anti-inflammatory drug 480156-S on hepatic drug-metabolizing activity and pharmacological action of diazepam and pentobarbital in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1988, Volume: 92, Issue:4

    Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Cytochrome P-450 Enzyme System; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Ibuprofen; Liver; Male; Oxygenases; Pentobarbital; Phenylpropionates; Rats; Rats, Inbred Strains

1988
Theorems and implications of a model-independent elimination/distribution function decomposition of linear and some nonlinear drug dispositions. IV. Exact relationship between the terminal log-linear slope parameter beta and drug clearance.
    Journal of pharmacokinetics and biopharmaceutics, 1987, Volume: 15, Issue:3

    Topics: Cimetidine; Diazepam; Humans; Injections, Intravenous; Mathematics; Models, Biological; Pentobarbital; Pharmacokinetics; Software; Tissue Distribution

1987
[Hemodynamic and effects of preoperative sedation with the diazepam-droperidol combination].
    Cahiers d'anesthesiologie, 1986, Volume: 34, Issue:3

    Topics: Blood Pressure; Cardiac Surgical Procedures; Catheterization; Cimetidine; Diazepam; Droperidol; Drug Therapy, Combination; Hemodynamics; Humans; Middle Aged; Oxygen; Preanesthetic Medication; Prospective Studies

1986
In vitro antagonism of benzodiazepine binding to cerebral receptors by H1 and H2 antihistamines.
    The Journal of laboratory and clinical medicine, 1981, Volume: 97, Issue:1

    Topics: Binding, Competitive; Brain; Cimetidine; Diazepam; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Receptors, Adrenergic, beta; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Opioid; Structure-Activity Relationship

1981
Fatal bradycardia after intentional overdose of cimetidine and diazepam.
    Lancet (London, England), 1982, Oct-30, Volume: 2, Issue:8305

    Topics: Adult; Bradycardia; Cimetidine; Diazepam; Drug Synergism; Female; Guanidines; Humans; Suicide

1982
Cimetidine drug interactions.
    The Journal of family practice, 1984, Volume: 18, Issue:2

    Topics: Anti-Anxiety Agents; Cimetidine; Diazepam; Drug Interactions; Humans; Kinetics

1984
Anxiolytic drug therapy in patients with medical disease: clinical importance of pharmacokinetic drug interactions.
    Psychopharmacology bulletin, 1984,Fall, Volume: 20, Issue:4

    Topics: Anti-Anxiety Agents; Cimetidine; Diazepam; Drug Interactions; Humans; Kinetics

1984
Interaction of diazepam and cimetidine.
    The New England journal of medicine, 1984, Dec-27, Volume: 311, Issue:26

    Topics: Cimetidine; Diazepam; Drug Interactions; Humans; Metabolic Clearance Rate

1984
[Acute bleeding digestive lesions].
    Acta gastroenterologica Latinoamericana, 1983, Volume: 13, Issue:1

    Topics: Acute Disease; Animals; Cimetidine; Diazepam; Dogs; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Meperidine; Middle Aged; Peptic Ulcer Hemorrhage; Promethazine; Stress, Psychological

1983
Stress ulcer accompanying subarachnoid hemorrhage--a new rat model.
    The Japanese journal of surgery, 1983, Volume: 13, Issue:4

    Topics: Animals; Cimetidine; Diazepam; Disease Models, Animal; Gastric Mucosa; Male; Pentobarbital; Phenytoin; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological; Subarachnoid Hemorrhage

1983
Delayed clearance of diazepam due to cimetidine.
    The New England journal of medicine, 1980, May-01, Volume: 302, Issue:18

    Topics: Adult; Antipyrine; Cimetidine; Diazepam; Drug Interactions; Drug Synergism; Female; Guanidines; Half-Life; Humans; Kinetics; Male; Nordazepam

1980
Influence of cimetidine on the pharmacokinetics of desmethyldiazepam and oxazepam.
    European journal of clinical pharmacology, 1980, Volume: 18, Issue:6

    Topics: Adult; Cimetidine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Humans; Kinetics; Liver; Male; Nordazepam; Oxazepam

1980
Differential effect of cimetidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:3

    Topics: Acetaminophen; Adult; Animals; Antipyrine; Biotransformation; Cimetidine; Diazepam; Guanidines; Humans; Kinetics; Lethal Dose 50; Lorazepam; Male; Mice; Oxidation-Reduction

1983
[Conservative therapy of peptic ulcer].
    Wiener medizinische Wochenschrift (1946), 1980, Sep-15, Volume: 130, Issue:17

    Topics: Antacids; Benzodiazepinones; Cimetidine; Diazepam; Gastrointestinal Hormones; Humans; Hypnosis; Metoclopramide; Parasympatholytics; Peptic Ulcer; Piperazines; Pirenzepine

1980
Cimetidine induced psychosis--varied mechanism of action.
    Critical care medicine, 1981, Volume: 9, Issue:11

    Topics: Cimetidine; Diazepam; Drug Synergism; Guanidines; Humans; Psychoses, Substance-Induced

1981
Drug interactions with cimetidine.
    Postgraduate medicine, 1981, Volume: 70, Issue:5

    Topics: Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Phenytoin; Propranolol; Theophylline; Warfarin

1981
Central nervous system activity of Rhazya stricta (Decne) in mice.
    Clinical and experimental pharmacology & physiology, 1995, Volume: 22, Issue:4

    Topics: Abdomen; Analgesia; Animals; Behavior, Animal; Body Temperature; Central Nervous System; Cimetidine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Hypnotics and Sedatives; Male; Medicine, Arabic; Mice; Motor Activity; Naloxone; Pentobarbital; Picrotoxin; Plant Extracts; Plant Leaves; Plants, Medicinal; Seizures; Sleep; Tail

1995
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
    Biochemical pharmacology, 1993, Dec-14, Volume: 46, Issue:12

    Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; Mice; Muscimol; Phenobarbital; Phenytoin; Picrotoxin; Receptors, GABA; Seizures; Strychnine

1993
In vitro metabolism of zolmitriptan in rat cytochromes induced with beta-naphthoflavone and the interaction between six drugs and zolmitriptan.
    Chemico-biological interactions, 2003, Dec-15, Volume: 146, Issue:3

    Topics: Animals; beta-Naphthoflavone; Cimetidine; Cytochrome P-450 CYP1A2; Diazepam; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Fluvoxamine; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Moclobemide; Oxazolidinones; Propranolol; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Species Specificity; Tryptamines

2003
Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro.
    Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:2

    Topics: Amides; Anesthetics, Local; Bupivacaine; Cells, Cultured; Cimetidine; Clonidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Lidocaine; Microsomes, Liver; Midazolam; Premedication; Ropivacaine; Thiamylal; Vecuronium Bromide

2006
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