Page last updated: 2024-08-18

chalcone and kava

chalcone has been researched along with kava in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (17.65)29.6817
2010's11 (64.71)24.3611
2020's3 (17.65)2.80

Authors

AuthorsStudies
Simoneau, AR; Zi, X1
Häberlein, H; Meissner, O1
Shahandeh, B; Simoneau, AR; Tang, Y; Xie, J; Zi, X1
Hecht, SS; Hermanson, D; Johnson, TE; Kassie, F; Lu, J; O'Sullivan, MG; Upadhyaya, P; Wang, L; Xing, C1
Bhatia, NN; Eskander, RN; Guo, Y; Hoang, BH; Hopkins, J; Kim, KJ; Mefford, J; Sakai, T; Zi, X1
Charlson, AT; Solberg, EL; Srinivasan, B; Warmka, JK; Wattenberg, EV; Xing, C; Zeliadt, NA1
Eskander, R; Guo, Y; Hoang, BH; Ji, T; Krill, LS; Lin, C; Zi, X1
He, F; Li, X; Liu, S; Liu, Z; Simoneau, AR; Wu, XR; Xu, X; Zi, X1
Do, TK; Lebot, V; Legendre, L1
Leitzman, P; Narayanapillai, SC; O'Sullivan, MG; Xing, C1
Agnolet, S; Kraus, B; Schneider, B; Zenger, K1
Abdullah, MP; Abu, N; Akhtar, MN; Alitheen, NB; Mohameda, NE; Omar, AR; Tangarajoo, N; Yeap, SK1
Gristock, RA; Jacobs, AT; Pinner, KD; So, N; Vo, HT; Wales, CT1
Bastos-Rodrigues, L; Caldas, H; Carvalho, JL; De Marco, L; Friedman, E; Gomes, DA; Moraes, DC; Romano-Silva, MA; Rossette, MC; Sacramento, EK1
Celentano, A; Cirillo, N; Farah, CS; McCullough, M; Paolini, R; Yap, T; Yiannis, C; Zhang, P1
Lu, F; Ma, X; Ren, R; Su, C; Su, X; Wang, Y; Yang, L; Zhang, B; Zhang, W; Zhao, X; Zong, R1
Chen, Y; Cheng, R; Gu, X; Hu, D; Jiang, T; Miao, M; Teichmann, AT; Wei, Z; Yang, Y; Zhang, J; Zhou, H1

Other Studies

17 other study(ies) available for chalcone and kava

ArticleYear
Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.
    Cancer research, 2005, Apr-15, Volume: 65, Issue:8

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Transitional Cell; Caspase 3; Caspase 9; Caspases; Cell Growth Processes; Chalcone; Cytochromes c; Flavonoids; Humans; Inhibitor of Apoptosis Proteins; Kava; Membrane Potentials; Mice; Mice, Nude; Microtubule-Associated Proteins; Mitochondria; Neoplasm Proteins; Plant Extracts; Poly(ADP-ribose) Polymerases; Proteins; Proto-Oncogene Proteins c-bcl-2; Survivin; Urinary Bladder Neoplasms; X-Linked Inhibitor of Apoptosis Protein; Xenograft Model Antitumor Assays

2005
HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Nov-05, Volume: 826, Issue:1-2

    Topics: Chalcone; Chromatography, High Pressure Liquid; Flavonoids; Kava

2005
Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53.
    Cancer prevention research (Philadelphia, Pa.), 2008, Volume: 1, Issue:6

    Topics: Animals; Antineoplastic Agents; Carcinoma, Papillary; Cell Cycle; Cell Line, Tumor; Chalcone; Chalcones; Drug Resistance, Neoplasm; Genes, p53; HCT116 Cells; Humans; Kava; Mice; Mice, Nude; Mutant Proteins; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays

2008
Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice.
    The American journal of Chinese medicine, 2011, Volume: 39, Issue:4

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Carcinogens; Cell Death; Cell Proliferation; Chalcone; Dose-Response Relationship, Drug; Female; Kava; Liver; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Phytotherapy; Plant Extracts

2011
Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2012, Volume: 30, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Chalcone; Endometrium; Female; Fibroblasts; Flavonoids; Humans; In Vitro Techniques; Inhibitor of Apoptosis Proteins; Kava; Membrane Proteins; Proto-Oncogene Proteins; Receptors, TNF-Related Apoptosis-Inducing Ligand; Sarcoma, Synovial; Soft Tissue Neoplasms; Survivin

2012
Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog.
    Biochemical and biophysical research communications, 2012, Aug-03, Volume: 424, Issue:3

    Topics: Cell Survival; Chalcone; Chalcones; Drug Resistance, Neoplasm; Humans; Kava; Lung Neoplasms; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasms

2012
Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis.
    Molecular cancer, 2013, Jun-10, Volume: 12

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chalcone; Flavonoids; G2 Phase Cell Cycle Checkpoints; Gene Expression; Humans; Kava; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Osteosarcoma

2013
Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model.
    Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:12

    Topics: Animals; Antigens, Polyomavirus Transforming; Apoptosis; Blotting, Southern; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Chalcone; Chromatography, Liquid; Disease Models, Animal; Female; Humans; Immunoenzyme Techniques; Kava; Male; Mice; Mice, Transgenic; Tandem Mass Spectrometry; Urinary Bladder Neoplasms; Uroplakin II

2013
Detection of flavokavins (A, B, C) in cultivars of kava (Piper methysticum) using high performance thin layer chromatography (HPTLC).
    Food chemistry, 2014, May-15, Volume: 151

    Topics: Beverages; Chalcone; Chromatography, Thin Layer; Flavonoids; Food Quality; Kava; Pacific Islands; Plant Roots; Quality Control

2014
Flavokawains a and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice.
    Chemical research in toxicology, 2014, Oct-20, Volume: 27, Issue:10

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chalcone; Drug Synergism; Female; Flavonoids; Kava; Liver; Mice; Mice, Inbred C57BL; Pyrones

2014
Biotransformation of Flavokawains A, B, and C, Chalcones from Kava (Piper methysticum), by Human Liver Microsomes.
    Journal of agricultural and food chemistry, 2015, Jul-22, Volume: 63, Issue:28

    Topics: Chalcone; Chalcones; Flavonoids; Glucuronides; Humans; Kava; Microsomes, Liver; Uridine Diphosphate Glucuronic Acid

2015
In vitro Toxicity and in vivo Immunomodulatory Effects of Flavokawain A and Flavokawain B in Balb/C Mice.
    Natural product communications, 2015, Volume: 10, Issue:7

    Topics: Animals; Chalcone; Flavonoids; Immunologic Factors; Kava; Male; Mice, Inbred BALB C; Spleen; Toxicity Tests

2015
Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes.
    Pharmaceutical biology, 2016, Volume: 54, Issue:9

    Topics: Antioxidants; Cell Survival; Chalcone; Cytoprotection; Dose-Response Relationship, Drug; Flavonoids; Glutamate-Cysteine Ligase; Glutathione; Heat-Shock Response; Heme Oxygenase-1; Hep G2 Cells; Hepatocytes; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Hydrogen Peroxide; Kava; NF-E2-Related Factor 2; Oxidative Stress; Phytotherapy; Plant Extracts; Plants, Medicinal; Time Factors; Up-Regulation

2016
The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B.
    Phytotherapy research : PTR, 2017, Volume: 31, Issue:10

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Movement; Cell Proliferation; Chalcone; Embryo, Nonmammalian; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Kava; Plant Extracts; Plant Roots; Zebrafish

2017
Kava constituents exert selective anticancer effects in oral squamous cell carcinoma cells in vitro.
    Scientific reports, 2020, 09-28, Volume: 10, Issue:1

    Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Chalcone; Flavonoids; Gas Chromatography-Mass Spectrometry; Humans; Kava; Keratinocytes; Mouth Neoplasms; Plant Extracts; Pyrans; Pyrones; Squamous Cell Carcinoma of Head and Neck

2020
Simultaneous determination of both kavalactone and flavokawain constituents by different single-marker methods in kava.
    Journal of separation science, 2021, Volume: 44, Issue:14

    Topics: Chalcone; Chromatography, High Pressure Liquid; Dietary Supplements; Kava; Lactones; Phytotherapy; Plant Extracts; Plant Roots; Plants, Medicinal; Pyrones

2021
Beneficial biological effects of Flavokawain A, a chalcone constituent from kava, on surgically induced endometriosis rat model.
    Journal of ethnopharmacology, 2024, Jan-10, Volume: 318, Issue:Pt A

    Topics: Animals; Apoptosis; Chalcone; Chalcones; Cytokines; Endometriosis; Female; Humans; Kava; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats

2024
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