Page last updated: 2024-08-18

chalcone and indole

chalcone has been researched along with indole in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gestwicki, JE; Reinke, AA; Seh, HY1
Dezfulian, M; Ebrahim-Habibi, A; Haeri-Rohani, A; Kheirbakhsh, R; Larijani, B; Yaghmaei, P1
Chen, J; Hu, J; Huang, L; Li, X; Yan, J; Zhang, S1
Banerjee, D; Gupta, S; Krishna, S; Kushwaha, P; Maurya, P; Sashidhara, KV; Siddiqi, MI; Upadhyay, A1
Chen, J; Jiang, S; Li, L; Li, X; Liu, Y; Su, J1
Ahmad, K; Azam, A; Hassan, MI; Khan, P; Peerzada, MN1

Reviews

1 review(s) available for chalcone and indole

ArticleYear
Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site.
    European journal of medicinal chemistry, 2018, May-10, Volume: 151

    Topics: Animals; Benzene Derivatives; Binding Sites; Biological Products; Chalcone; Clinical Trials as Topic; Colchicine; Drug Discovery; Humans; Indoles; Microtubules; Molecular Docking Simulation; Stilbenes; Tubulin; Tubulin Modulators

2018

Trials

1 trial(s) available for chalcone and indole

ArticleYear
Indole and trans-chalcone attenuate amyloid β plaque accumulation in male Wistar rat: in vivo effectiveness of two anti-amyloid scaffolds.
    Archives italiennes de biologie, 2013, Volume: 151, Issue:3

    Topics: Amyloid beta-Peptides; Animals; Antipsychotic Agents; Avoidance Learning; CA1 Region, Hippocampal; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Frontal Lobe; Indoles; Male; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Wistar; Time Factors

2013

Other Studies

4 other study(ies) available for chalcone and indole

ArticleYear
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
    Bioorganic & medicinal chemistry letters, 2009, Sep-01, Volume: 19, Issue:17

    Topics: Amyloid beta-Peptides; Benzothiazoles; Coloring Agents; Congo Red; Fluorescent Dyes; Indoles; Spectrometry, Fluorescence; Thiazoles

2009
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo.
    Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Cells, Cultured; Chalcone; Dose-Response Relationship, Drug; Humans; Indoles; Membrane Potential, Mitochondrial; Mice; Microsomes, Liver; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship

2016
Synthesis and bio-evaluation of indole-chalcone based benzopyrans as promising antiligase and antiproliferative agents.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Antineoplastic Agents; Benzopyrans; Cell Proliferation; Cell Survival; Chalcone; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Indoles; Ligases; Molecular Structure; Structure-Activity Relationship; Tumor Cells, Cultured

2018
Synthesis, characterization and biological evaluation of tertiary sulfonamide derivatives of pyridyl-indole based heteroaryl chalcone as potential carbonic anhydrase IX inhibitors and anticancer agents.
    European journal of medicinal chemistry, 2018, Jul-15, Volume: 155

    Topics: Antineoplastic Agents; Apoptosis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Cell Line, Tumor; Cell Proliferation; Chalcone; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Indoles; Molecular Docking Simulation; Molecular Structure; Pyridines; Structure-Activity Relationship; Sulfonamides

2018
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