calcitriol and oxetane
calcitriol has been researched along with oxetane* in 1 studies
Other Studies
1 other study(ies) available for calcitriol and oxetane
| Article | Year |
|---|---|
Design and synthesis of novel 1,25-dihydroxyvitamin D3 analogues having a spiro-oxetane fused at the C2 position in the A-ring.
Four structurally novel stereoisomeric analogues of 1,25-dihydroxyvitamin D3 (3a-d) bearing a spiro-oxetane fused at the C2 position of the A-ring have been designed and synthesised in a convergent manner. The requisite A-ring enyne precursors (13a,b) for the vitamin D analogues (3a,b) and (3c,d), respectively, were synthesised from pentaerythritol according to an eleven-step procedure. Preliminary biological evaluation of the analogues using the bovine thymus vitamin D receptor (VDR) suggested that the incorporation of the spiro-oxetane moiety instead of a gem-dimethyl group at the C2 position had a beneficial effect on the VDR affinity. Topics: Animals; Cattle; Drug Design; Ethers, Cyclic; Protein Binding; Receptors, Calcitriol; Spiro Compounds; Structure-Activity Relationship; Vitamin D | 2013 |