caffeine and warfarin
caffeine has been researched along with warfarin in 112 studies
Research
Studies (112)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (11.61) | 18.7374 |
| 1990's | 12 (10.71) | 18.2507 |
| 2000's | 30 (26.79) | 29.6817 |
| 2010's | 48 (42.86) | 24.3611 |
| 2020's | 9 (8.04) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Conradi, R; Lee, PH; Shanmugasundaram, V | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Du, Y; Fu, H; Li, S; Obianyo, O; Qi, Q; Ye, K | 1 |
| Grimm, K | 2 |
| Clarke, CH; Shankel, DM | 1 |
| Brogger, A; Stene, J; Waksvik, H | 1 |
| Huang, TF; Ko, FN; Liou, MJ; Teng, CM; Wu, TS | 1 |
| Gibaldi, M | 1 |
| Agache, P; Coumes-Marquet, S; Muret, P; Muret-D'Aniello, P; Treffel, P | 1 |
| Apseloff, G; Gerber, N; Hilliard, JB; Mays, DC | 1 |
| Hippius, M; Hoffmann, A; Kraul, H; Machnik, G; Sigusch, H; Truckenbrodt, J | 1 |
| Russel, S | 1 |
| Grigg, GW | 1 |
| Vorherr, H | 1 |
| Nitz, RE; Scholtholt, J; Schraven, E | 1 |
| Brown, DJ; Edwards, MJ; Grigg, GW | 1 |
| Singh, RN; Subbaramaiah, K | 1 |
| Broda, B; Frej, E; Swiatek, L | 1 |
| Kihlman, BA; Norlén, K; Sturelid, S; Tidriks, D | 1 |
| Guttman, DE; Meyer, MC | 1 |
| Arvela, P; Klebovich, I; Pelkonen, O; Rautio, A; Salonpää, P; Sotaniemi, EA | 1 |
| Bracken, W; Bullock, P; Draper, A; Parkinson, A; Pearce, R; Podval, J; Thomas, P; Veltman, J | 1 |
| Harris, JE | 1 |
| Arvela, P; Mustajoki, P; Mustajoki, S; Pelkonen, O; Rautio, A | 1 |
| Darroudi, F; Knasmüller, S; Nagao, M; Parzefall, W; Sanyal, R | 1 |
| Ammar, HO; el-Nahhas, SA; Ghorab, M; Makram, TS | 1 |
| Inoue, K; Kamataki, T; Kodama, T; Nagashima, K; Nakamura, K; Shimada, N; Shimizu, T; Yokoi, T | 1 |
| Dorne, JL; Renwick, AG; Walton, K | 1 |
| Ortega, X; Pérez, LM | 1 |
| Abel, R; Alvey, CW; Bron, NJ; Hounslow, NJ; Koup, JR; Randinitis, EJ; Rausch, G; Sedman, AJ; Vassos, AB | 1 |
| Medeiros, IA; Oliveira, EJ; Romero, MA; Silva, BA; Silva, MS | 1 |
| Ikemoto, N; Rodriguez, J; Yamamoto, T | 1 |
| Cannon, JM; Kostoryz, E; Russo, KA; Smith, RE; Yourtee, DM | 1 |
| Bertino, JS; Chainuvati, S; Gaedigk, A; Kashuba, AD; Kearns, GL; Leeder, JS; Nafziger, AN; Rowland, E; Sellers, E; Zhang, Y | 1 |
| Medling, T; Raner, GM; Yang, SP | 1 |
| Fuhr, U; Kober, S; Mutschler, E; Spahn-Langguth, H; Zaigler, M | 1 |
| Bertino, JS; Gaedigk, A; Kashuba, AD; Kearns, G; Leeder, JS; Nafziger, AN; Rowland, E; Sellers, E; Shelepova, T; Victory, J; Zhang, Y | 1 |
| Adkison, KK; Berrey, MM; Bertino, JS; Borland, J; Fang, L; Johnson, BM; Lou, Y; Nafziger, AN; Piscitelli, SC; Song, IH | 1 |
| Baxter-Meheux, F; Blake, MJ; Eron, JJ; Gaver, VE; Kashuba, AD; Klein, CE; Patterson, KB; Rezk, NL; Rublein, JC; Yeh, RF | 1 |
| Ashton, M; Asimus, S; Elsherbiny, D; Hai, TN; Huong, NV; Jansson, B; Petzold, MG; Simonsson, US | 1 |
| Laures, AM; Weaver, PJ; Wolff, JC | 1 |
| Arakawa, T; Hirano, A; Shiraki, K | 1 |
| Boulenc, X; Brian, W; Donazzolo, Y; Poitiers, F; Santoni, A; Turpault, S; Van Horn, R | 1 |
| Crispim, SP; De Vries, JH; Geelen, A; Le Donne, C; Leclercq, C; Ocke, MC; Raffo, A; Sette, S; Siebelink, E; van't Veer, P | 1 |
| Nováková, L; Opletal, L; Seifrtová, M; Solich, P; Spácil, Z | 1 |
| Benchimol-Barbosa, PR; Clapauch, SH | 1 |
| Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD | 1 |
| Iwasaki, K; Izumi, H; Kusumoto, S; Mogi, M; Murayama, N; Shimizu, M; Takehara, H; Toda, A; Utoh, M; Yamazaki, H | 1 |
| Berka, K; Otyepka, M; Paloncýová, M | 1 |
| Aharchi, F; De Smedt, G; Hoetelmans, RM; Kakuda, TN; Leopold, L; Onkelinx, J; Peeters, M; Stevens, T; Van Solingen-Ristea, RM | 1 |
| Briesen, H; Gajewska, M; Schramm, KW; Urani, C; Worth, A | 1 |
| Erastov, AA; Kostanyan, AE; Shishilov, ON | 1 |
| Ikeda, K; Kim, S; Koyanagi, T; Murayama, N; Nakanishi, Y; Uehara, S; Uno, Y; Utoh, M; Yamaura, Y; Yamazaki, H; Yano, K | 1 |
| Capelo, JL; Cavaleiro, JA; Faustino, MA; Lodeiro, C; Menezes, JC; Neves, Mda G; Oliveira, E; Santos, CI; Santos, HM | 1 |
| Achterbergh, R; Boelen, A; de Vries, EM; Klümpen, HJ; Lammers, LA; Mathôt, RA; Romijn, JA; Soeters, MR; van Nierop, FS | 1 |
| Chen, D; Davis, HM; de Vries, DE; Leon, F; Marciniak, SJ; Xu, Z; Zhou, H; Zhuang, Y | 1 |
| Murayama, N; Shida, S; Shimizu, M; Uno, Y; Utoh, M; Yamazaki, H | 1 |
| Inoue, T; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H | 1 |
| Kawano, M; Mitsui, M; Sasaki, E; Shimizu, M; Suemizu, H; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H | 1 |
| Cubberley, R; Duplan, H; Eilstein, J; Gerstel, D; Grégoire, S; Hewitt, N; Jacques-Jamin, C; Klaric, M; Rothe, H; Schepky, A | 1 |
| Achterbergh, R; Boelen, A; de Vries, EM; Klümpen, HJ; Lammers, LA; Mathot, RA; Romijn, JA | 1 |
| Erastov, AA; Kostanyan, AE | 2 |
| Achterbergh, R; Lammers, LA; Mathôt, RAA; Romijn, JA; van Schaik, RHN | 1 |
| Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H | 1 |
| Edwards, JE; Eliot, L; Karan, S; MacConell, L; Parkinson, A | 1 |
| Gajee, R; Papadopoulos, KP; Puzanov, I; Strickler, JH; Tachibana, M; Wang, Y; Zahir, H | 1 |
| Achterbergh, R; Lammers, LA; Mathôt, RAA; Romijn, JA | 1 |
| Capone, D; Contaldi, P; Gianno, A; Tarantino, G; Teresa, M; Tufano, A | 1 |
| Gong, Z; Huang, J; Li, Y; Liu, C; Liu, T; Lu, Y; Pan, J; Sun, J; Wang, Y; Zheng, J; Zheng, L | 1 |
| Akram, M; Ali, A; Andleeb, R; Ashraf, A; Ashraf, MM; Aslam, N; Daniyal, M; Khadam, MW; Shah, SMA; Tahir, IM; Zafar, S | 1 |
| Bailey-Smith, C; Bodrug, I; Cheng, A; Glasgow, XS; Hussain, A; Iwamoto, M; Khalilieh, S; Levine, V; Martinho, M; Mekokishvili, L; Montgomery, D; Shaw, PM | 1 |
| Amor, S; Bertrand, B; Bettaïeb, A; Bodio, E; Chotard, F; Connat, JL; Le Gendre, P; Paul, C; Richard, P; Trommenschlager, A | 1 |
| Camez, A; Cheng, L; Ignatenko, S; Khatri, A; Othman, AA; Pang, Y | 1 |
| Ducray, PS; Endo-Tsukude, C; Gardner, I; Gill, KL; Hatley, OJ; Machavaram, KK; Parrott, N; Terao, K | 1 |
| Enejosa, JV; Feng, T; Fisniku, O; Mohamed, MF; Othman, AA | 1 |
| Kostanyan, A; Martynova, M | 1 |
| Baltazar, MT; Lee, MY; Li, H; Moxon, TE; Nicol, B; Pendlington, R; Pickles, J; Piechota, P; Sorrell, I | 1 |
| Chen, D; Piantone, A; Sharma, A; Shu, C; Xu, Y; Xu, Z; Zhou, H; Zhu, Y; Zhuang, Y | 1 |
| Mohamed, MF; Othman, AA; Sathe, AG | 1 |
| Carmichael, PL; Chang, L; Gao, H; Jiang, S; Kukic, P; Li, J; Li, K; Li, Y; Liddell, M; Lyu, Z; Peng, S; Tulum, L; Xu, F; Xu, P; Zhang, Q; Zhang, Y; Zhang, Z; Zuo, T | 1 |
| Chang, L; Feng, L; Li, Y; Long, Q; Xu, P; Zhang, Z; Zuo, T | 1 |
| Bhatia, M; Kapoor, A; Kumar, A; Kumar, P; Kumar, S | 1 |
| Newman, EM; Rowland, A | 1 |
Reviews
9 review(s) available for caffeine and warfarin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Antimutagenesis in microbial systems.
Topics: Acridines; Antipsychotic Agents; Bacteria; Caffeine; Chloramphenicol; Dactinomycin; Dibenzocycloheptenes; DNA Repair; Escherichia coli; Fungi; Genes; Histidine; Manganese; Mutagens; Mutation; Phenothiazines; Polyamines; Purine Nucleosides; Quinacrine; Radiation Effects; Rosaniline Dyes; Ultraviolet Rays; Uracil; Warfarin | 1975 |
Drug interactions: Part I.
Topics: Antidepressive Agents, Tricyclic; Caffeine; Cimetidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Fluconazole; Fluoxetine; Hexobarbital; Humans; Ketoconazole; Nimodipine; Oxidoreductases; Pharmaceutical Preparations; Rifampin; Stereoisomerism; Warfarin; Zidovudine | 1992 |
Drug excretion in breast milk.
Topics: Anti-Bacterial Agents; Barbiturates; Biological Transport, Active; Breast; Breast Feeding; Caffeine; Chloramphenicol; Contraceptives, Oral; Coumarins; Female; Fluorine; Humans; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neonatal; Lactation; Meprobamate; Milk, Human; Models, Biological; Morphine; Nicotine; Pesticides; Pharmaceutical Preparations; Phenytoin; Potassium Iodide; Pregnancy; Salicylates; Sulfonamides; Time Factors | 1974 |
Interaction of dietary factors with oral anticoagulants: review and applications.
Topics: Administration, Oral; Alcoholic Beverages; Allium; Anticoagulants; Beverages; Caffeine; Coumarins; Dietary Fats; Food-Drug Interactions; Humans; Peptide Hydrolases; Silicones; Vitamin K; Vitamins | 1995 |
Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates.
Topics: Adult; Aged; Area Under Curve; Caffeine; Child; Cytochrome P-450 CYP1A2; Humans; Infant, Newborn; Models, Biological; Pharmacokinetics; Probability; Reproducibility of Results; Risk Assessment; Substrate Specificity; Theobromine; Theophylline; Warfarin | 2001 |
Therapeutic Protein Drug Interaction Potential in Subjects With Psoriasis: An Assessment Based on Population Pharmacokinetic Analyses of Sensitive Cytochrome P450 Probe Substrates.
Topics: Adult; Biological Availability; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytokines; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Models, Biological; Patient Acuity; Psoriasis; Warfarin; Young Adult | 2021 |
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies.
Topics: Aldehydes; Ammonia; Caffeine; Chalcones; Chromones; Clorgyline; Coumarins; Hydrogen Peroxide; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Pyrazoles; Selegiline; Structure-Activity Relationship; Thiazoles; Thiourea | 2022 |
A Physiologically Based Pharmacokinetic Model to Predict the Impact of Metabolic Changes Associated with Metabolic Associated Fatty Liver Disease on Drug Exposure.
Topics: Animals; Caffeine; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dextromethorphan; Metoprolol; Midazolam; Non-alcoholic Fatty Liver Disease; Omeprazole; Rosiglitazone; Warfarin | 2022 |
Trials
18 trial(s) available for caffeine and warfarin
| Article | Year |
|---|---|
Antipyrine, coumarin and glipizide affect n-acetylation measured by caffeine test.
Topics: Acetylation; Adult; Analysis of Variance; Antipyrine; Caffeine; Coumarins; Diabetes Mellitus, Type 2; Female; Glipizide; Humans; Hypoglycemic Agents; Male; Middle Aged; Uracil; Xanthines | 1995 |
Drug interactions with clinafloxacin.
Topics: Adult; Aged; Anti-Infective Agents; Anticonvulsants; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Female; Fluoroquinolones; Humans; Male; Middle Aged; Phenytoin; Theophylline; Warfarin | 2001 |
Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Topics: Acetyltransferases; Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Genotype; Humans; Midazolam; Middle Aged; Mixed Function Oxygenases; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Phosphodiesterase Inhibitors; Reproducibility of Results; Vitamins; Warfarin; Xanthine Oxidase | 2003 |
Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Contraceptives, Oral; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Genotype; Humans; Midazolam; Norgestrel; Omeprazole; Therapeutic Equivalency; Vitamin K; Warfarin; Xanthine Oxidase | 2005 |
Evaluation of the drug interaction potential of aplaviroc, a novel human immunodeficiency virus entry inhibitor, using a modified cooperstown 5 + 1 cocktail.
Topics: Adult; Anti-HIV Agents; Aryl Hydrocarbon Hydroxylases; Benzoates; Caffeine; CCR5 Receptor Antagonists; Dextromethorphan; Diketopiperazines; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Omeprazole; Piperazines; Spiro Compounds; Warfarin | 2006 |
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Caffeine; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Middle Aged | 2007 |
Pharmacokinetic assessment of a five-probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A.
Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Anti-Ulcer Agents; Anticoagulants; Area Under Curve; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Humans; Male; Metabolic Clearance Rate; Midazolam; Omeprazole; Warfarin; Young Adult | 2009 |
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.
Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult | 2014 |
Short-term fasting alters cytochrome P450-mediated drug metabolism in humans.
Topics: Adult; Animals; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Fasting; Gene Expression Regulation, Enzymologic; Humans; Liver; Male; Metabolic Clearance Rate; Metoprolol; Midazolam; Omeprazole; Rats, Wistar; Warfarin; Young Adult | 2015 |
Evaluation of disease-mediated therapeutic protein-drug interactions between an anti-interleukin-6 monoclonal antibody (sirukumab) and cytochrome P450 activities in a phase 1 study in patients with rheumatoid arthritis using a cocktail approach.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Caffeine; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Interleukin-6; Male; Midazolam; Middle Aged; Omeprazole; Warfarin; Young Adult | 2015 |
Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach.
Topics: Administration, Intravenous; Administration, Oral; Adult; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Drug Combinations; Fasting; Healthy Volunteers; Humans; Male; Metoprolol; Midazolam; Omeprazole; Pharmaceutical Preparations; Time Factors; Warfarin; Young Adult | 2017 |
Evaluation of the pharmacokinetic drug interaction potential of tivantinib (ARQ 197) using cocktail probes in patients with advanced solid tumours.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Caffeine; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Midazolam; Middle Aged; Neoplasms; Omeprazole; Proto-Oncogene Proteins c-met; Pyrrolidinones; Quinolines; Tandem Mass Spectrometry; Warfarin | 2018 |
Short-Term Fasting Alters Pharmacokinetics of Cytochrome P450 Probe Drugs: Does Protein Binding Play a Role?
Topics: Administration, Intravenous; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Fasting; Humans; Male; Metoprolol; Midazolam; Omeprazole; Pharmaceutical Preparations; Protein Binding; Warfarin | 2018 |
Phenotyping of CYP 4501A2 Activity by Total Overnight Salivary Caffeine Assessment (TOSCA) in Patients on Warfarin Treatment: A Cross-Sectional Study.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Cross-Sectional Studies; Cytochrome P-450 CYP1A2; Female; Humans; International Normalized Ratio; Isoenzymes; Male; Middle Aged; Phenazines; Saliva; Warfarin | 2018 |
Effect of tildrakizumab (MK-3222), a high affinity, selective anti-IL23p19 monoclonal antibody, on cytochrome P450 metabolism in subjects with moderate to severe psoriasis.
Topics: Administration, Oral; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Injections, Subcutaneous; Interleukin-23 Subunit p19; Male; Midazolam; Middle Aged; Omeprazole; Psoriasis; Severity of Illness Index; Treatment Outcome; Warfarin; Young Adult | 2018 |
Lack of Effect of 12-Week Treatment with Risankizumab on the Pharmacokinetics of Cytochrome P450 Probe Substrates in Patients with Moderate to Severe Chronic Plaque Psoriasis.
Topics: Antibodies, Monoclonal; Area Under Curve; Caffeine; Chronic Disease; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Injections, Subcutaneous; Male; Midazolam; Omeprazole; Psoriasis; Severity of Illness Index; Substrate Specificity; Warfarin | 2019 |
Effects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates: A Study With the Modified Cooperstown 5+1 Cocktail.
Topics: Adult; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Drug Interactions; Female; Genotype; Healthy Volunteers; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Male; Midazolam; Middle Aged; Omeprazole; Phenotype; Vitamin K; Warfarin | 2020 |
Evaluating Potential Disease-Mediated Protein-Drug Interactions in Patients With Moderate-to-Severe Plaque Psoriasis Receiving Subcutaneous Guselkumab.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Humanized; Area Under Curve; Caffeine; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Omeprazole; Psoriasis; Severity of Illness Index; Warfarin; Young Adult | 2020 |
Other Studies
85 other study(ies) available for caffeine and warfarin
| Article | Year |
|---|---|
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.
Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Humans; Lung; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Invasiveness; Structure-Activity Relationship; Xanthine | 2017 |
Comparison of spontaneous, UV-induced, and nitrosoguanidine-induced mutability to drug resistance in myxobacteria.
Topics: Acriflavine; Caffeine; Coumarins; Drug Resistance, Microbial; Mutation; Myxococcales; Nitrosoguanidines; Ultraviolet Rays | 1978 |
Evidence for repair of ultraviolet-induced damage in Cystobacter species (Myxobacterales).
Topics: Acriflavine; Caffeine; Coumarins; DNA Repair; Dose-Response Relationship, Radiation; Escherichia coli; Myxococcales; Soil Microbiology; Species Specificity; Ultraviolet Rays | 1978 |
Psoralen/UVA treatment and chromosomes. I. Aberrations and sister chromatid exchange in human lymphocytes in vitro and synergism with caffeine.
Topics: Caffeine; Chromatids; Chromosome Aberrations; Chromosomes, Human; Coumarins; Drug Synergism; Female; Humans; Methoxsalen; Time Factors; Trioxsalen; Ultraviolet Rays | 1977 |
Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens.
Topics: Animals; Aorta, Thoracic; Caffeine; Calcium; Coumarins; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; In Vitro Techniques; Inositol Phosphates; Male; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Vasodilation | 1992 |
Effect of occlusion on in vitro percutaneous absorption of two compounds with different physicochemical properties.
Topics: Caffeine; Chemical Phenomena; Chemistry, Physical; Coumarins; Diffusion; Female; Humans; In Vitro Techniques; Middle Aged; Skin Absorption; Skin Physiological Phenomena; Solubility | 1992 |
Inhibition and induction of drug metabolism by psoralens: alterations in duration of sleep induced by hexobarbital and in clearance of caffeine and hexobarbital in mice.
Topics: Animals; Caffeine; Coumarins; Furocoumarins; Half-Life; Hexobarbital; Male; Methoxsalen; Mice; Sleep; Time Factors; Warfarin | 1991 |
[Comparison of ICG elimination with biotransformation of model substances and histological features of liver biopsy in liver diseases].
Topics: 7-Alkoxycoumarin O-Dealkylase; Adult; Biopsy; Biotransformation; Caffeine; Coumarins; Dipyrone; Female; Humans; Indocyanine Green; Liver; Liver Diseases; Male; Regression Analysis | 1991 |
Inhibition of Verticillium albo-atrum cellulase.
Topics: Caffeine; Catechols; Cell-Free System; Cellulase; Chlorogenic Acid; Coumarins; Dinitrophenols; Glycoside Hydrolases; Hydroquinones; Methylcellulose; Mitosporic Fungi; Nitro Compounds; Plant Extracts; Salicylates; Species Specificity; Tannins | 1974 |
Effects of coumarin, pyronin Y, 6,9-dimethyl 2-methylthiopurine and caffeine on excision repair and recombination repair in Escherichia coli.
Topics: Caffeine; Cell Survival; Coumarins; DNA Repair; DNA, Bacterial; Escherichia coli; Purines; Quaternary Ammonium Compounds; Radiation Effects; Recombination, Genetic; Ultraviolet Rays; Xanthenes | 1972 |
On the mechanism of the antagonistic action of xanthine derivatives against adenosine and coronary vasodilators.
Topics: Acetamides; Adenosine; Animals; Blood Flow Velocity; Caffeine; Cell Membrane Permeability; Coronary Vessels; Coumarins; Dipyridamole; Dogs; Drug Interactions; Erythrocytes; Female; Glycolates; Humans; Male; Piperazines; Receptors, Drug; Structure-Activity Relationship; Theophylline; Vasodilator Agents; Xanthines; Xylenes | 1972 |
Effects of coumarin, thiopurines, and pyronin Y on amplification of phleomycin-induced death and deoxyribonucleic acid breakdown in Escherichia coli.
Topics: Antibiotics, Antineoplastic; Caffeine; Carbon Isotopes; Coumarins; Dialysis; DNA, Bacterial; Drug Resistance, Microbial; Drug Synergism; Escherichia coli; Filtration; Genetics, Microbial; Models, Structural; Mutation; Nucleic Acid Denaturation; Peptides; Protein Binding; Purines; Quaternary Ammonium Compounds; Spectrophotometry; Sulfides; Thymidine; Tritium; Xanthenes | 1971 |
Effects of chemicals on Fischerella muscicola (Thuret) Gom.
Topics: Acetates; Caffeine; Chlorides; Colchicine; Coloring Agents; Coumarins; Culture Media; Cyanobacteria; Formaldehyde; Gases; Histocytochemistry; Hydrazines; Lanthanum; Maleates; Manganese; Nitrates; Pigments, Biological; Spectrophotometry; Tetrazolium Salts; Thioglycolates; Uranium | 1970 |
[Chemical constituents of the plant Veronica chamaedrys L].
Topics: Benzoates; Caffeine; Chromatography, Paper; Coumarins; Glucose; Hydrolysis; Phenylacetates; Plants, Medicinal | 1971 |
Caffeine, caffeine derivatives and chromosomal aberrations. II. Different responses of Allium root tips and Chinese hamster cells to treatments with caffeine, 8-ethoxycaffeine and 6-methylcoumarin.
Topics: Adenosine Triphosphate; Animals; Caffeine; Cells, Cultured; Chromatids; Chromosome Aberrations; Coumarins; Cricetinae; DNA; Plants; Temperature; Time Factors | 1971 |
Dynamic dialysis as a method for studying protein binding. II. Evaluation of the method with a number of binding systems.
Topics: Caffeine; Coloring Agents; Dialysis; Hydrogen-Ion Concentration; Kinetics; Methods; Protein Binding; Serum Albumin, Bovine; Spectrophotometry; Theophylline; Warfarin | 1970 |
Induction of liver microsomal cytochrome P450 in cynomolgus monkeys.
Topics: Alkylation; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Caffeine; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochromes b5; Dexamethasone; Enzyme Induction; Female; Hydroxylation; Isoenzymes; Macaca fascicularis; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxazines; Oxidation-Reduction; Phenobarbital; Sex Factors; Species Specificity; Testosterone | 1995 |
Effects of heme arginate on cytochrome P450-mediated metabolism of drugs in patients with variegate porphyria and in healthy men.
Topics: Adult; Arginine; Caffeine; Coumarins; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Heme; Humans; Isoenzymes; Lidocaine; Male; Middle Aged; Porphyrias, Hepatic; Reference Values | 1994 |
Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens.
Topics: Acrolein; Amines; Antimutagenic Agents; Benzaldehydes; Caffeine; Carbolines; Carcinoma, Hepatocellular; Coumarins; DNA Repair; Heterocyclic Compounds; Humans; Hydrolyzable Tannins; Imidazoles; Micronucleus Tests; Mutagens; Quinolines; Tumor Cells, Cultured | 1997 |
Interaction of oral anticoagulants with methyl xanthines.
Topics: Animals; Anticoagulants; Biological Availability; Caffeine; Central Nervous System Stimulants; Dicumarol; Drug Interactions; Male; Rabbits; Spectrophotometry, Ultraviolet; Theophylline; Thermodynamics; Warfarin; Xanthines | 1997 |
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
Topics: 1-Propanol; Caffeine; Chlorzoxazone; Coumarins; Cyclosporine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Phenothiazines; Precipitin Tests; Sulfaphenazole; Tolbutamide | 1998 |
Participation of the phosphoinositide metabolism in the hypersensitive response of Citrus limon against Alternaria alternata.
Topics: Alternaria; Caffeine; Calcium; Citrus; Coumarins; Fibrinolytic Agents; Heparin; Inositol 1,4,5-Trisphosphate; Neomycin; Phenylalanine Ammonia-Lyase; Phosphatidylinositols; Phosphodiesterase Inhibitors; Protein Synthesis Inhibitors; Seeds; Signal Transduction | 2001 |
Intracellular calcium mobilization as a target for the spasmolytic action of scopoletin.
Topics: Animals; Aorta; Caffeine; Calcium; Coumarins; Dinoprost; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Intracellular Membranes; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Parasympatholytics; Phenylephrine; Plant Extracts; Plant Roots; Potassium Chloride; Rats; Rats, Wistar; Scopoletin; Serotonin; Solanaceae; Vasoconstriction | 2001 |
Ca2+-dependent dual functions of peptide C. The peptide corresponding to the Glu724-Pro760 region (the so-called determinant of excitation-contraction coupling) of the dihydropyridine receptor alpha 1 subunit II-III loop.
Topics: Animals; Caffeine; Calcium; Calcium Channels, L-Type; Calpain; Coumarins; Fluorescent Dyes; Microsomes; Muscle, Skeletal; Myocardium; Peptide Fragments; Polylysine; Protein Binding; Protein Structure, Secondary; Rabbits; Ryanodine; Ryanodine Receptor Calcium Release Channel | 2002 |
Bisphenol A and its biomaterial monomer derivatives alteration of in vitro cytochrome P450 metabolism in rat, minipig, and human.
Topics: Animals; Benzhydryl Compounds; Caffeine; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Diclofenac; Enzyme Inhibitors; Humans; Isoenzymes; Liver; Male; Microsomes, Liver; Phenols; Rats; Rats, Sprague-Dawley; Species Specificity; Swine; Swine, Miniature | 2000 |
Cytochrome P450 expression and activities in rat, rabbit and bovine tongue.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzyl Alcohols; Caffeine; Catalysis; Cattle; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Mixed Function Oxygenases; Nitrophenols; Protein Isoforms; Rabbits; Rats; RNA, Messenger; Substrate Specificity; Tongue | 2003 |
Adverse drug reactions in Canada.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Anemia, Hemolytic, Autoimmune; Anti-Infective Agents; Anticoagulants; Benzodiazepines; Caffeine; Canada; Ceftriaxone; Central Nervous System Stimulants; Child; Drug Interactions; Female; Humans; Ketolides; Middle Aged; Olanzapine; Peripheral Nervous System Diseases; Phytotherapy; Pulmonary Embolism; Rhabdomyolysis; Selective Serotonin Reuptake Inhibitors; Warfarin; Weight Loss | 2005 |
Rate-limiting biotransformation of triamterene is mediated by CYP1A2.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene | 2005 |
Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Enzyme Induction; Female; HIV Protease Inhibitors; HIV Seronegativity; Humans; Injections, Intravenous; Intestinal Mucosa; Intestines; Liver; Lopinavir; Male; Midazolam; Middle Aged; Mixed Function Oxygenases; Omeprazole; Pyrimidinones; Ritonavir; Substrate Specificity; Warfarin | 2006 |
Investigation of the advanced functionalities of a hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometer.
Topics: Caffeine; Pharmaceutical Preparations; Reproducibility of Results; Reserpine; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Warfarin | 2007 |
Arginine increases the solubility of coumarin: comparison with salting-in and salting-out additives.
Topics: Arginine; Benzyl Alcohols; Biochemistry; Caffeine; Coumarins; Dose-Response Relationship, Drug; Guanidine; Hydrogen-Ion Concentration; Models, Biological; Salts; Solubility; Surface Properties; Urea; Water | 2008 |
Dietary exposure to flavouring substances: from screening methods to detailed assessments using food consumption data collected with EPIC-Soft software.
Topics: Aged; Butanones; Caffeine; Coumarins; Diet; Diet Records; Female; Flavoring Agents; Food; Glycyrrhizic Acid; Humans; Male; Middle Aged; Netherlands; Software; Surveys and Questionnaires | 2010 |
Rapid qualitative and quantitative ultra high performance liquid chromatography method for simultaneous analysis of twenty nine common phenolic compounds of various structures.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Flavonoids; Phenols; Reproducibility of Results; Sensitivity and Specificity; Tea; Time Factors | 2010 |
Warfarin resistance and caffeine containing beverages.
Topics: Adolescent; Adult; Beverages; Caffeine; Coffee; Female; Food-Drug Interactions; Humans; International Normalized Ratio; Male; Warfarin | 2012 |
Predicted metabolic drug clearance with increasing adult age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; Male; Mephenytoin; Metabolic Clearance Rate; Midazolam; Middle Aged; Models, Biological; Warfarin | 2013 |
Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs.
Topics: Administration, Oral; Animals; Biological Availability; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Drug Combinations; Female; Humans; Injections, Intravenous; Male; Metoprolol; Midazolam; Models, Animal; Omeprazole; Substrate Specificity; Swine; Swine, Miniature; Tandem Mass Spectrometry; Warfarin | 2012 |
Molecular insight into affinities of drugs and their metabolites to lipid bilayers.
Topics: Caffeine; Cell Membrane; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Ibuprofen; Lipid Bilayers; Molecular Dynamics Simulation; Pharmaceutical Preparations; Phosphatidylcholines; Phosphatidylglycerols; Thermodynamics; Xenobiotics | 2013 |
Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients.
Topics: Administration, Cutaneous; Administration, Oral; Algorithms; Animals; Antioxidants; Caffeine; Calibration; Central Nervous System Stimulants; Cosmetics; Coumarins; Data Interpretation, Statistical; Humans; Hydroquinones; Liver; Models, Statistical; No-Observed-Adverse-Effect Level; Pharmacokinetics; Quantitative Structure-Activity Relationship; Rats; Skin; Skin Absorption; Species Specificity | 2014 |
Multiple dual mode counter-current chromatography with variable duration of alternating phase elution steps.
Topics: Aspirin; Caffeine; Coumarins; Countercurrent Distribution; Models, Theoretical; Salicylic Acid | 2014 |
Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.
Topics: Administration, Oral; Age Factors; Animals; Caffeine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Macaca fascicularis; Male; Metoprolol; Microsomes, Liver; Midazolam; Models, Animal; Models, Biological; Omeprazole; Warfarin | 2015 |
Untangling interactions of a zinc(II) complex containing a coumarin-porphyrin unit with alkaloids in water solutions: a photophysical study.
Topics: Caffeine; Cotinine; Coumarins; Ethanol; Fresh Water; Molecular Structure; Nicotine; Photochemical Processes; Porphyrins; Portugal; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analysis; Ultraviolet Rays; Zinc | 2015 |
Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.
Topics: Administration, Intravenous; Administration, Oral; Animals; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Macaca fascicularis; Microsomes, Liver; Midazolam; Models, Biological; Omeprazole; Pharmacokinetics; Warfarin | 2015 |
Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus).
Topics: Administration, Intravenous; Administration, Oral; Animals; Biological Availability; Caffeine; Callithrix; Chromatography, Liquid; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Humans; Intestine, Small; Liver; Metoprolol; Midazolam; Models, Animal; Omeprazole; Tandem Mass Spectrometry; Warfarin | 2016 |
Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling.
Topics: Animals; Caffeine; Chimera; Cytochrome P-450 Enzyme System; Dogs; Humans; Macaca fascicularis; Mice; Midazolam; Models, Biological; Omeprazole; Pharmaceutical Preparations; Pharmacokinetics; Swine; Swine, Miniature; Warfarin | 2016 |
Comparison of protocols for measuring cosmetic ingredient distribution in human and pig skin.
Topics: Administration, Topical; Adult; Animals; Biological Availability; Caffeine; Cosmetics; Coumarins; Female; Humans; In Vitro Techniques; Male; Middle Aged; Resorcinols; Risk Assessment; Skin; Skin Absorption; Swine; Young Adult | 2016 |
Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR.
Topics: Animals; Caffeine; Constitutive Androstane Receptor; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Fasting; Female; Gene Expression Regulation; Inactivation, Metabolic; Liver; Membrane Proteins; Metoprolol; Mice; Mice, Inbred C57BL; Mice, Knockout; Midazolam; Omeprazole; Receptors, Cytoplasmic and Nuclear; Warfarin | 2016 |
Theoretical study of closed-loop recycling liquid-liquid chromatography and experimental verification of the theory.
Topics: Acetates; Aspirin; Caffeine; Coumarins; Countercurrent Distribution; Ethanol; Hexanes; Models, Theoretical; Recycling; Reproducibility of Results; Solutions; Solvents; Water | 2016 |
Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19.
Topics: Administration, Intravenous; Aging; Animals; Caffeine; Callithrix; Cytochrome P-450 CYP2C19; Genotype; Humans; Male; Metoprolol; Midazolam; Omeprazole; Rifampin; Substrate Specificity; Warfarin | 2018 |
Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Chenodeoxycholic Acid; Cholangitis; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Omeprazole; Rosuvastatin Calcium; Warfarin | 2017 |
Influence of Shenxiong Glucose Injection on the Activities of Six CYP Isozymes and Metabolism of Warfarin in Rats Assessed Using Probe Cocktail and Pharmacokinetic Approaches.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Drugs, Chinese Herbal; Enzyme Activation; Herb-Drug Interactions; Isoenzymes; Midazolam; Omeprazole; Rats; Steroid 16-alpha-Hydroxylase; Tolbutamide; Warfarin | 2017 |
Effect of caffeine on anti-clotting activity of warfarin in healthy male albino rabbits.
Topics: Animals; Anticoagulants; Blood Coagulation; Caffeine; Drug Synergism; International Normalized Ratio; Male; Prothrombin Time; Rabbits; Warfarin | 2018 |
Industrial countercurrent chromatography separations based on a cascade of centrifugal mixer-settler extractors.
Topics: Caffeine; Centrifugation; Coumarins; Countercurrent Distribution; Metals, Rare Earth; Models, Theoretical; Solvents | 2018 |
Gold(I)-Coumarin-Caffeine-Based Complexes as New Potential Anti-Inflammatory and Anticancer Trackable Agents.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Caffeine; Cell Line, Tumor; Coordination Complexes; Coumarins; Fluorescence; Fluorescent Dyes; Gold; HEK293 Cells; Humans; Microscopy, Fluorescence, Multiphoton; Ultraviolet Rays | 2018 |
Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations.
Topics: Administration, Oral; Adult; Caffeine; Clinical Trials as Topic; Computer Simulation; Cytochrome P-450 Enzyme System; Dextromethorphan; Down-Regulation; Drug Development; Drug Interactions; Female; Humans; Interleukin-6; Male; Midazolam; Middle Aged; Models, Biological; Neuromyelitis Optica; Omeprazole; Rare Diseases; Serum Albumin, Human; Simvastatin; Warfarin | 2019 |
Modeling of two semi-continuous methods in liquid-liquid chromatography: Comparing conventional and closed-loop recycling modes.
Topics: Caffeine; Chemistry Techniques, Analytical; Coumarins; Hexanes; Models, Chemical; Solvents; Water | 2020 |
Application of physiologically based kinetic (PBK) modelling in the next generation risk assessment of dermally applied consumer products.
Topics: Administration, Cutaneous; Caffeine; Computer Simulation; Consumer Product Safety; Cosmetics; Coumarins; Detergents; Humans; Isothiocyanates; Models, Biological; Risk Assessment; Skin Absorption; Sulfoxides | 2020 |
Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells.
Topics: Caffeine; Coumarins; Hep G2 Cells; Humans; Phosphorylation; Protein Kinases; Proteomics; Quercetin | 2022 |
Time-resolved quantitative phosphoproteomics reveals cellular responses induced by caffeine and coumarin.
Topics: Caffeine; Coumarins; Phosphoproteins; Phosphorylation; Proteomics; Signal Transduction | 2022 |