caffeine has been researched along with prazosin in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.11) | 18.7374 |
| 1990's | 5 (13.51) | 18.2507 |
| 2000's | 15 (40.54) | 29.6817 |
| 2010's | 12 (32.43) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Sen, S; Sinha, N | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Groer, CE; Lehner, K; Navarro, H; Prisinzano, TE; Vasiljevik, T | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Large, WA; Wang, Q | 1 |
| Bennett, T; Mangroo, T; Neves, M; Rahmani, MA | 1 |
| Fujiwara, Y; Kazahaya, Y; Otsuki, S; Sandyk, R; Takeda, T | 1 |
| Curatolo, PW; Goldberg, MR; Robertson, D; Tung, CS | 1 |
| Doak, GJ; Reid, AR; Sawynok, J | 1 |
| Matlib, MA; Motley, ED; Paul, RJ | 1 |
| Garland, CJ; Mistry, DK | 1 |
| Gudme, CN; Nielsen, MS; Nielsen, R | 1 |
| Anselmi, E; Bermejo, A; Cabedo, N; Catret, M; Cortes, D; D'Ocon, P; Elorriaga, M; Ivorra, MD; Magraner, J; Tur, R | 1 |
| Brain, KL; Cunnane, TC; Dass, N; Jackson, VM; Trout, SJ | 1 |
| Murai, Y; Negi, A; Nishi, K; Okuda, T; Tokutomi, N; Tokutomi, Y | 1 |
| Brain, KL; Cunnane, TC; Cuprian, AM; Williams, DJ | 1 |
| Alada, AR; Salahdeen, HM | 1 |
| Chen, L; Huang, F; Li, W; Li, X; Liu, Z; Luo, Z; Wu, H; Xu, Y; Young, C; Zhou, S | 1 |
| Al-Qaim, FF; Alqaim, ZH; Latip, J; Mussa, ZH | 1 |
| Abdullah, N; Ali, IH; Azizan, NAZ; Elboughdiri, N; Kamyab, H; Sohrabi, M; Vasseghian, Y; Yuzir, A | 1 |
1 review(s) available for caffeine and prazosin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
36 other study(ies) available for caffeine and prazosin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Studies toward the Development of Antiproliferative Neoclerodanes from Salvinorin A.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Proliferation; Central Nervous System Agents; Diterpenes, Clerodane; Drug Screening Assays, Antitumor; Female; Humans; Molecular Structure; Receptors, Opioid, kappa; Salvia | 2014 |
Modulation of noradrenaline-induced membrane currents by papaverine in rabbit vascular smooth muscle cells.
Topics: Animals; Caffeine; Calcium; Chlorides; Dose-Response Relationship, Drug; Female; Ion Channels; Ionomycin; Male; Membrane Potentials; Muscle, Smooth, Vascular; Norepinephrine; Papaverine; Potassium Channels; Prazosin; Rabbits | 1991 |
In vitro caffeine induced aortic smooth muscle reactivity in rat.
Topics: Animals; Aorta; Caffeine; Hypertension; In Vitro Techniques; Magnesium; Male; Muscle, Smooth, Vascular; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Vasoconstriction; Vasodilation; Verapamil; Yohimbine | 1990 |
Inhibitory effects of carbamazepine on clonidine-induced aggressive behavior in mice.
Topics: Adenosine; Aggression; Animals; Behavior, Animal; Caffeine; Carbamazepine; Clonidine; Haloperidol; Male; Mice; Prazosin; Receptors, Cell Surface; Yohimbine | 1988 |
Caffeine down-regulates beta adrenoreceptors in rat forebrain.
Topics: alpha-Methyltyrosine; Animals; Binding, Competitive; Brain; Caffeine; Clonidine; Dihydroalprenolol; Dopamine; Female; Methyltyrosines; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta; Synaptic Transmission | 1982 |
Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Dioxanes; Drug Synergism; Formaldehyde; Hot Temperature; Idazoxan; Male; Motor Activity; Norepinephrine; Pain; Pain Measurement; Phentolamine; Prazosin; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
Role of Na(+)-Ca2+ exchange in the regulation of vascular smooth muscle tension.
Topics: Animals; Caffeine; Calcium; Carrier Proteins; Dose-Response Relationship, Drug; Female; Hydrogen-Ion Concentration; Intracellular Membranes; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Endings; Ouabain; Phentolamine; Prazosin; Rabbits; Sarcolemma; Sodium; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase; Vascular Resistance; Verapamil | 1993 |
The influence of phenylephrine outward potassium currents in single smooth muscle cells from the rabbit mesenteric artery.
Topics: 4-Aminopyridine; Adrenergic alpha-Antagonists; Amifampridine; Animals; Caffeine; Calcium; Chelating Agents; Drug Interactions; Egtazic Acid; Female; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Potassium; Potassium Channels; Prazosin; Rabbits; Tetraethylammonium; Vasoconstrictor Agents | 1999 |
Effect of alpha1-adrenergic stimulation of Cl- secretion and signal transduction in exocrine glands (Rana esculenta).
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Biological Transport; Caffeine; Calcium; Chlorides; Cyclic AMP; Dose-Response Relationship, Drug; Exocrine Glands; Female; Fluorescent Dyes; Fura-2; Inositol 1,4,5-Trisphosphate; Male; Norepinephrine; Phosphodiesterase Inhibitors; Prazosin; Propranolol; Rana esculenta; Receptors, Adrenergic, alpha-1; Ryanodine; Signal Transduction; Skin Physiological Phenomena | 2000 |
Mechanism of vascular relaxation by thaligrisine: functional and binding assays.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkaloids; Animals; Aorta, Thoracic; Arteries; Binding Sites; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Diltiazem; Female; In Vitro Techniques; Membranes; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrendipine; Norepinephrine; Potassium Chloride; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tail; Trees; Tritium; Vasoconstrictor Agents | 2000 |
Nicotine induces calcium spikes in single nerve terminal varicosities: a role for intracellular calcium stores.
Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Calcium; Calcium Channels; Calcium Signaling; Electric Stimulation; Excitatory Postsynaptic Potentials; Fluorescent Dyes; Hexamethonium; Intracellular Fluid; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Nicotine; Nicotinic Antagonists; Organic Chemicals; Prazosin; Presynaptic Terminals; Receptors, Nicotinic; Ryanodine; Sympathetic Fibers, Postganglionic; Tetrodotoxin; Vas Deferens | 2001 |
Noradrenaline receptor-mediated potentiation of caffeine-induced Ca( 2+)-activated K(+) currents in bovine ciliary muscle cells.
Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Calcium; Cattle; Ciliary Body; Dose-Response Relationship, Drug; Fluorescent Dyes; Fura-2; Membrane Potentials; Muscle, Smooth; Norepinephrine; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Prazosin; Receptors, Adrenergic, alpha-1 | 2001 |
The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Channels, T-Type; Calcium Signaling; Chelating Agents; Electric Stimulation; Electrophysiology; In Vitro Techniques; Indoles; Male; Mibefradil; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Models, Biological; Muscle Contraction; Muscle, Smooth; Nickel; Prazosin; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X; Ryanodine; Thapsigargin; Vas Deferens | 2003 |
Role of adrenergic receptors in the caffeine-induced increase in glucose uptake by the canine hindlimb.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Biological Transport; Blood Glucose; Caffeine; Dogs; Electric Stimulation; Hindlimb; Hyperglycemia; Male; Muscle Contraction; Muscle, Skeletal; Prazosin; Propranolol; Receptors, Adrenergic; Regional Blood Flow; Time Factors; Up-Regulation | 2009 |
The novel compound liguzinediol exerts positive inotropic effects in isolated rat heart via sarcoplasmic reticulum Ca2+ ATPase-dependent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart; Male; Myocardial Contraction; Myocytes, Cardiac; Nimodipine; Ouabain; Prazosin; Propranolol; Pyrazines; Rats; Rats, Sprague-Dawley; Ruthenium Red; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin | 2012 |
Electrochemical Oxidation of Different Therapeutic Classes of Pharmaceuticals Using Graphite-PVC Composite Electrode.
Topics: Caffeine; Chromatography, High Pressure Liquid; Electrochemical Techniques; Electrodes; Graphite; Oxidation-Reduction; Pharmaceutical Preparations; Polyvinyl Chloride; Prazosin; Simvastatin; Sodium Chloride; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Water | 2021 |
The selectivity of electron acceptors for the removal of caffeine, gliclazide, and prazosin in an up-flow anaerobic sludge blanket (UASB) reactor.
Topics: Anaerobiosis; Bioreactors; Caffeine; Electrons; Gliclazide; Pharmaceutical Preparations; Prazosin; RNA, Ribosomal, 16S; Sewage; Waste Disposal, Fluid | 2022 |