Page last updated: 2024-09-04

atrasentan and bq 123

atrasentan has been researched along with bq 123 in 14 studies

Compound Research Comparison

Studies (atrasentan)	Trials (atrasentan)	Recent Studies (post-2010) (atrasentan)	Studies (bq 123)	Trials (bq 123)	Recent Studies (post-2010) (bq 123)
358	41	108	1,391	63	152

Protein Interaction Comparison

Protein	Taxonomy	atrasentan (IC50)	bq 123 (IC50)
Endothelin-1 receptor	Homo sapiens (human)		0.017
Endothelin-1 receptor	Rattus norvegicus (Norway rat)		0.014

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (7.14)	18.2507
2000's	12 (85.71)	29.6817
2010's	1 (7.14)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Berens, KL; Blok, N; Bourgoyne, AR; Brock, TA; Bui, H; Decker, ER; Dixon, RA; Holland, GW; Knowles, V; Wang, J; Wu, C; You, TJ	1
Drimal, J; Funk, OF; Kettmann, V; Langer, T	1
Alexiou, K; Baumann, G; Dschietzig, T; Laule, M; Schrör, K; Stangl, K	1
D'Orléans-Juste, P; Piovezan, AP; Rae, GA; Souza, GE	1
Chen, YF; Oparil, S	1
Curtis, TM; Scholfield, CN	1
Bagnato, A; Cirilli, A; Flamini, S; Muller, A; Padley, R; Salani, D; Simeone, P; Venuti, A	1
Austin, PC; Lapointe, N; Lee, DS; Nguyen, QT; Ohlsson, A; Rouleau, JL; Stewart, DJ; Tu, JV	1
Henriques, Md; Rae, GA; Sampaio, AL	1
Fujimori, A; Fujiyasu, N; Miyata, K; Noguchi, Y; Ohtake, A; Sasamata, M; Sato, S; Sudoh, K; Ukai, M; Yuyama, H	1
Fujimori, A; Miyata, K; Noguchi, Y; Ohtake, A; Sasamata, M; Sato, S; Sudoh, K; Ukai, M; Yuyama, H	1
Chichorro, JG; Rae, GA; Souza, GE; Zampronio, AR	1
Elgebaly, MM; Ergul, A; Harris, AK; Hutchinson, JR; Mezzetti, EM; Portik-Dobos, V; Sachidanandam, K	1
Bkaily, G; Brochu, I; D'Orléans-Juste, P; Desbiens, L; Gobeil, F; Houde, M; Semaan, W; Simard, E	1

Reviews

2 review(s) available for atrasentan and bq 123

Article	Year
Endothelial dysfunction in the pulmonary vascular bed. The American journal of the medical sciences, 2000, Volume: 320, Issue:4 Topics: Animals; Antihypertensive Agents; Atrasentan; Bosentan; Controlled Clinical Trials as Topic; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Endothelium, Vascular; Epoprostenol; Heart Failure; Humans; Hypertension, Pulmonary; Hypoxia; Lung Diseases, Obstructive; Nitric Oxide; Oligopeptides; Peptides, Cyclic; Piperidines; Pulmonary Circulation; Pyrrolidines; Receptors, Endothelin; RNA, Messenger; Sulfonamides; Time Factors; Vasoconstriction; Vasodilation	2000
Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure. Journal of cardiac failure, 2003, Volume: 9, Issue:5 Topics: Animals; Atrasentan; Cardiotonic Agents; Endothelin Receptor Antagonists; Heart Failure; Peptides, Cyclic; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Risk; Survival Rate	2003

Article

Year

Endothelial dysfunction in the pulmonary vascular bed.

The American journal of the medical sciences, 2000, Volume: 320, Issue:4

Topics: Animals; Antihypertensive Agents; Atrasentan; Bosentan; Controlled Clinical Trials as Topic; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Endothelium, Vascular; Epoprostenol; Heart Failure; Humans; Hypertension, Pulmonary; Hypoxia; Lung Diseases, Obstructive; Nitric Oxide; Oligopeptides; Peptides, Cyclic; Piperidines; Pulmonary Circulation; Pyrrolidines; Receptors, Endothelin; RNA, Messenger; Sulfonamides; Time Factors; Vasoconstriction; Vasodilation

2000

Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure.

Journal of cardiac failure, 2003, Volume: 9, Issue:5

Topics: Animals; Atrasentan; Cardiotonic Agents; Endothelin Receptor Antagonists; Heart Failure; Peptides, Cyclic; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Risk; Survival Rate

2003

Trials

1 trial(s) available for atrasentan and bq 123

Article	Year
Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist. Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8 Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones	2004

Article

Year

Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.

Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones

2004

Other Studies

11 other study(ies) available for atrasentan and bq 123

Article	Year
Chemical function based pharmacophore generation of endothelin-A selective receptor antagonists. Journal of medicinal chemistry, 2004, May-20, Volume: 47, Issue:11 Topics: Algorithms; Animals; Binding, Competitive; Chlorocebus aethiops; Databases, Factual; Endothelin A Receptor Antagonists; Heterocyclic Compounds; Humans; Models, Molecular; Molecular Structure; Radioligand Assay; Receptor, Endothelin A; Stereoisomerism; Structure-Activity Relationship; Vero Cells	2004
Coronary constriction and consequent cardiodepression in pulmonary embolism are mediated by pulmonary big endothelin and enhanced in early endothelial dysfunction. Critical care medicine, 1998, Volume: 26, Issue:3 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arteriosclerosis; Aspartic Acid Endopeptidases; Atrasentan; Coronary Circulation; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Endothelium, Vascular; Glycopeptides; In Vitro Techniques; Male; Metalloendopeptidases; Myocardial Contraction; Oligopeptides; Peptides, Cyclic; Protein Precursors; Pulmonary Embolism; Pyrrolidines; Rabbits; Thromboxane B2; Vasoconstriction	1998
Endothelin-1-induced ET(A) receptor-mediated nociception, hyperalgesia and oedema in the mouse hind-paw: modulation by simultaneous ET(B) receptor activation. British journal of pharmacology, 2000, Volume: 129, Issue:5 Topics: Animals; Atrasentan; Capsaicin; Edema; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hyperalgesia; Male; Mice; Nociceptors; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Viper Venoms	2000
Evidence for two endothelin Et(A) receptor subtypes in rabbit arteriolar smooth muscle. British journal of pharmacology, 2001, Volume: 134, Issue:8 Topics: Animals; Arterioles; Atrasentan; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Choroid; Culture Techniques; Endothelin Receptor Antagonists; Endothelin-1; Female; Ion Transport; Male; Membrane Potentials; Muscle, Smooth, Vascular; Oligopeptides; Patch-Clamp Techniques; Peptides, Cyclic; Piperidines; Pyrrolidines; Rabbits; Receptor, Endothelin A; Receptors, Endothelin	2001
Endothelin receptor blockade inhibits the growth of human papillomavirus-associated cervical carcinoma. Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48 Topics: Atrasentan; Cell Division; Endothelin Receptor Antagonists; Endothelin-1; Female; Humans; Papillomaviridae; Peptides, Cyclic; Pyrrolidines; Receptor, Endothelin A; Tumor Cells, Cultured; Uterine Cervical Neoplasms	2002
Effects of endothelin ETA receptor antagonism on granulocyte and lymphocyte accumulation in LPS-induced inflammation. Journal of leukocyte biology, 2004, Volume: 76, Issue:1 Topics: Animals; Antihypertensive Agents; Atrasentan; Cell Adhesion Molecules; Chemokines; Chemotaxis, Leukocyte; Disease Models, Animal; Endothelin A Receptor Antagonists; Granulocytes; Inflammation; Lipopolysaccharides; Lung; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Peptides, Cyclic; Pleurisy; Pyrrolidines	2004
Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist. European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3 Topics: Atrasentan; Binding, Competitive; Blood Pressure; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Iodine Radioisotopes; Oligopeptides; Peptides, Cyclic; Piperidines; Pyrimidines; Pyrrolidines; Radioligand Assay; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Time Factors; Viper Venoms	2004
Pharmacological characterization of YM598, a selective endothelin-A receptor antagonist. Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1 Topics: Administration, Oral; Animals; Atrasentan; Binding, Competitive; Biological Availability; Blood Pressure; Bosentan; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Injections, Intravenous; Muscle, Smooth, Vascular; Oligopeptides; Peptides, Cyclic; Piperidines; Pyrimidines; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Viper Venoms	2004
Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs. Pain, 2006, Volume: 123, Issue:1-2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrasentan; Bosentan; Carrageenan; Celecoxib; Cold Temperature; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelin-1; Endothelins; Grooming; Hyperalgesia; Indomethacin; Male; Maxillary Nerve; Nerve Compression Syndromes; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Pyrazoles; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Trigeminal Neuralgia	2006
Effect of chronic and selective endothelin receptor antagonism on microvascular function in type 2 diabetes. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:6 Topics: Acetylcholine; Animals; Atrasentan; Cardiovascular Agents; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Male; Mesenteric Arteries; Microcirculation; Myography; Peptides, Cyclic; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Viper Venoms	2008
High salt-induced hypertension in B2 knockout mice is corrected by the ETA antagonist, A127722. British journal of pharmacology, 2013, Volume: 170, Issue:2 Topics: Animals; Antihypertensive Agents; Arterial Pressure; Atrasentan; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Female; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Peptides, Cyclic; Pyrrolidines; Receptor, Bradykinin B2; Sodium; Sodium Chloride, Dietary; Telemetry	2013