am 251 and piperidines
am 251 has been researched along with piperidines in 904 studies
Research
Studies (904)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (0.55) | 18.2507 |
| 2000's | 335 (37.06) | 29.6817 |
| 2010's | 519 (57.41) | 24.3611 |
| 2020's | 45 (4.98) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Gatley, SJ; Gifford, AN; Lan, R; Makriyannis, A; Volkow, ND | 1 |
| Gatley, SJ; Gifford, AN; Lan, R; Makriyannis, A; Pyatt, B; Volkow, ND | 1 |
| Andrenyak, DM; Deng, H; Dey, SK; Ma, W; Makriyannis, A; Moody, DE; Paria, BC; Schmid, HH; Schmid, PC | 1 |
| Fan, P; Fernando, SR; Lan, R; Lin, S; Liu, Q; Makriyannis, A; McCallion, D; Pertwee, R | 1 |
| Díaz-Laviada, I; Miguel, A; Ruiz, L | 1 |
| Díaz-Laviada, I; Ruiz, L; Sánchez, MG; Velasco, L | 1 |
| Kreitzer, AC; Regehr, WG | 1 |
| Hamza, MS; Makriyannis, A; Malan, TP; Mata, HP; Porreca, F; Siegel, EM; Simoneau, II; Vanderah, TW | 1 |
| Gitlin, JM; Mitchell, JA; Stanford, SJ | 1 |
| Deng, H; Ibrahim, MM; Liu, Q; Makriyannis, A; Malan, PT; Mata, HP; Porreca, F; Vanderah, T | 1 |
| Brune, K; Hinz, B; Pahl, A; Ramer, R | 1 |
| Cheng, JS; Chou, KJ; Fang, HC; Jan, CR; Law, YP; Lee, KC; Su, W; Tseng, LL; Wang, JL | 1 |
| Bottrill, FE; Ford, WR; Hiley, CR; Ho, WS; White, R | 1 |
| Kato, H; Kurihara, J; Nakane, S; Nishigaki, M; Okubo, Y; Sugiura, T; Suzuki, S; Takata, Y; Waku, K | 1 |
| Alger, BE; Carlson, GC; Ledent, C; Varma, N | 1 |
| Boland, B; Campbell, V; Downer, E; Fogarty, M | 1 |
| Diana, MA; Levenes, C; Mackie, K; Marty, A | 1 |
| Dubinett, SM; Gardner, B; Liu, Q; Makriyannis, A; Sharma, S; Tashkin, DP; Zu, LX | 1 |
| Bennett, T; Gardiner, SM; Kemp, PA; March, JE | 3 |
| Carter, AG; Kreitzer, AC; Regehr, WG | 1 |
| Nováková, J; Sulcová, A; Vinklerová, J | 1 |
| Breuer, A; Järvinen, K; Järvinen, T; Laine, K; Mechoulam, R | 1 |
| Freund, TF; Hájos, N | 1 |
| Alger, BE; Isokawa, M; Kim, J; Ledent, C | 1 |
| Ates, M; Gühring, H; Hamza, M; Seidel, K | 1 |
| Ates, M; Gühring, H; Hamza, M; Kotalla, CE; Ledent, C; Seidel, K | 1 |
| New, DC; Wong, YH | 1 |
| Black, SC; Hildebrandt, AL; Kelly-Sullivan, DM | 1 |
| Levine, ES; Trettel, J | 1 |
| Choi, JI; Yoon, MH | 1 |
| Akar, A; Bilgin, F; Dogrul, A; Gul, H; Guzeldemir, E; Yildiz, O | 1 |
| Brenowitz, SD; Brown, SP; Regehr, WG | 1 |
| Chiou, LC; Gean, PW; Huang, YC; Wang, SJ | 1 |
| Köfalvi, A; Ledent, C; Sperlágh, B; Vizi, ES | 1 |
| Järvinen, T; Laitinen, JT; Niemi, R; Saario, SM; Savinainen, JR | 1 |
| Brotchie, JM; Brown, TM; Fitzjohn, SM | 1 |
| Fowler, CJ; Jacobsson, SO; Nilsson, O | 2 |
| Fleischer, R; Rocha, BA; Rosko, KM; Shearman, LP; Tong, XS; Wang, J; Xu, S | 1 |
| Dougalis, A; Lees, G | 1 |
| Alger, BE; Mason, SE; Reich, CG | 1 |
| Akerman, S; Goadsby, PJ; Kaube, H | 1 |
| Krishnamurthy, M; Li, W; Moore, BM | 1 |
| Shearman, LP; Zhou, D | 1 |
| David, LS; Liao, C; Nicholson, RA; Zheng, J | 1 |
| Chen, RZ; Fong, TM; Huang, RR; MacNeil, DJ; Shen, CP | 1 |
| Engler, C; Feuerstein, TJ; Steffens, M; Zentner, J | 1 |
| Caraballo, I; El Banoua, F; Fernandez-Espejo, E; Ferrer, B; Flores, JA; Galan-Rodriguez, B; Rodriguez de Fonseca, F | 1 |
| Bátkai, S; Járai, Z; Kunos, G; Pacher, P; Wagner, JA | 1 |
| Konishi, S; Rusakov, D; Saitow, F; Satake, S | 1 |
| Hayashi, M; Ichihara, A; Kaneshiro, Y; Koura, Y; Okada, H; Saruta, T; Tada, Y; Temm, CJ | 1 |
| Johanek, LM; Simone, DA | 1 |
| Mendiguren, A; Pineda, J | 3 |
| Dinh, T; Freund, TF; Hájos, N; Kathuria, S; Piomelli, D | 1 |
| Alger, BE; Kim, J | 2 |
| Duvoisin, RM; Grandes, P; Kushmerick, C; Price, GD; Puente, N; Renden, R; Taschenberger, H; von Gersdorff, H; Wadiche, JI | 1 |
| Davison, JS; Ho, W; Mathison, R; Pittman, QJ; Sharkey, KA | 1 |
| Freund, TF; Haller, J; Ledent, C; Varga, B | 1 |
| Dehpour, AR; Hajrasouliha, AR; Homayoun, H; Moezi, L; Sadeghipour, H; Samini, M; Shafaroodi, H; Tavakoli, S | 1 |
| Castillo, PE; Chevaleyre, V | 1 |
| Chambers, AP; Koopmans, HS; Sharkey, KA | 1 |
| Bátkai, S; Bukoski, RD; Harvey-White, J; Kunos, G; Liu, J; Mackie, K; Offertáler, L; Osei-Hyiaman, D; Pacher, P; Radaeva, S; Rudd, MA | 1 |
| Brar, AK; Buckley, AR; Handwerger, S; Kessler, CA; Moghadam, KK; Schroeder, JK | 1 |
| Cole, RB; Ma, P; Wang, G; Wang, W; Zhang, Q | 1 |
| Pertwee, RG | 2 |
| Bianchi, R; Borsani, E; Buffoli, B; Rezzani, R; Ricci, F; Rodella, LF | 1 |
| Camboim, C; de Oliveira Alvares, L; de Oliveira, LF; Diehl, F; Genro, BP; Lanziotti, VB; Quillfeldt, JA | 1 |
| Inoue, A; Kawamoto, M; Nakata, Y; Oshita, K; Tang, HB; Yuge, O | 1 |
| Cunha, RA; Köfalvi, A; Ledent, C; Mackie, K; Rodrigues, RJ; Sperlágh, B; Vizi, ES | 1 |
| Chen, P; Fang, X; Hu, S; Moore, SA; Spector, AA; Yao, J | 1 |
| Bellone, C; Lüscher, C | 1 |
| Kendall, DA; O'Sullivan, SE; Randall, MD | 1 |
| Nomikos, GG; Panagis, G; Vlachou, S | 1 |
| Boxberger, M; Choritz, L; Krauss, A; Meissner, S; Rosenthal, R; Stumpff, F; Thieme, H; Wiederholt, M | 1 |
| Brotchie, JM; Brown, TM; Venderova, K | 1 |
| Tang, SL; Tran, V; Wagner, EJ | 1 |
| Baker, D; Greig, IR; Idris, AI; Ralston, SH; Ridge, SA; Ross, RA; van 't Hof, RJ | 1 |
| Gorzalka, BB; Hill, MN; Sun, JC | 1 |
| Gorzalka, BB; Hill, MN | 1 |
| Limebeer, CL; Makriyannis, A; McLaughlin, PJ; Parker, LA; Salamone, JD; Winston, KM | 1 |
| Gamber, KM; Macarthur, H; Westfall, TC | 1 |
| Baik, SK; Gaskari, SA; Lee, SS; Li, Y; Liu, H; Moezi, L | 1 |
| Alger, BE; Jones, LM; Karnup, SV; Karson, MA; Reich, CG | 1 |
| Fujihara, H; Nakamura, J; Onaka, T; Ozaki, Y; Saito, T; Serino, R; Soya, A; Ueta, Y | 1 |
| Egawa, S; Fukuyama, S; Maruyama, I; Matsuda, K; Matsuno, S; Mikami, Y; Sunamura, M; Takeda, K | 1 |
| Nomikos, GG; Tzavara, ET; Witkin, JM | 1 |
| Evans, PM; Murphy, A; Rodgers, RJ | 1 |
| Brown, CM; Lu, D; Makriyannis, A; McLaughlin, PJ; Salamone, JD; Thakur, G; Winston, KM | 1 |
| Antoniou, K; Daifoti, Z; Galanopoulos, A; Kourouli, T; Marselos, M; Nahmias, V; Panagis, G; Papahatjis, D; Spyraki, C; Thermos, K; Vlachou, S | 1 |
| Barun, S; Dileköz, E; Ercan, ZS; Sarioglu, Y; Vural, IM | 1 |
| Bazan, NG; Boudaba, C; Di, S; Harris, C; Marcheselli, VL; Popescu, IR; Tasker, JG; Weng, FJ | 1 |
| Chambers, AP; Koopmans, HS; Pittman, QJ; Sharkey, KA | 1 |
| Hoffman, AF; Lupica, CR; Macgill, AM; Oz, M; Smith, D | 1 |
| Kreitzer, AC; Malenka, RC | 2 |
| Freund, TF; Kelsch, W; Mackie, K; Mátyás, F; Misgeld, U; Yanovsky, Y | 1 |
| Järbe, TU; Liu, Q; Makriyannis, A | 1 |
| Fujimoto, S; Kunimatsu, M; Mori, M; Tsushima, H | 1 |
| Bermúdez-Siva, FJ; Diaz-Molina, FJ; Fuentes, E; Juan-Pico, P; Nadal, A; Rodríguez de Fonseca, F; Sánchez Vera, I; Serrano, A | 1 |
| Armstrong, H; Fong, TM; Hagmann, W; Shen, CP; Xiao, JC | 1 |
| Da Costa, JC; de Oliveira Alvares, L; Genro, BP; Pedroso, MF; Quillfeldt, JA; Vaz Breda, R | 1 |
| Beaulieu, P; De Léan, A; Guindon, J | 1 |
| Adinolfi, B; Breschi, MC; Chicca, A; Fogli, S; Iacopetti, P; Mariotti, V; Nieri, P; Pellegrini, S | 1 |
| Fukaya, M; Kano, M; Kawamura, Y; Maejima, T; Miura, E; Ohno-Shosaku, T; Watanabe, M; Yoshida, T | 1 |
| Barsvári, B; Dombi, T; Freund, TF; Haller, J; Ledent, C; Mikics, E; Varga, B | 1 |
| Fazli-Tabaei, S; Kangarlu-Haghighi, K; Khalilzadeh, A; Zarrindast, MR | 1 |
| Bender, KJ; Bender, VA; Brasier, DJ; Feldman, DE | 1 |
| Cheer, JF; Wassum, KM; Wightman, RM | 1 |
| Gorzalka, BB; Hill, MN; Hillard, CJ; Ho, WS; Sinopoli, KJ; Viau, V | 1 |
| Arenos, JD; Bucci, DJ; Musty, RE | 1 |
| Floresco, SB; Froese, LM; Hill, MN; Morrish, AC; Sun, JC | 1 |
| Grace, AA; Laviolette, SR | 1 |
| Abesser, M; Ertl, G; Harvey-White, J; Wagner, JA | 1 |
| Best, AR; Brenowitz, SD; Regehr, WG | 1 |
| Chen, RZ; Fong, TM; Frassetto, A | 1 |
| Cunha, RA; Davis, RJ; Degroot, A; Köfalvi, A; Nomikos, GG; Rebola, N; Rodrigues, RJ; Wade, MR | 1 |
| Nelson, SB; Sjöström, PJ; Turrigiano, GG | 1 |
| Gardner, EL; Gilbert, JG; Li, X; Pak, AC; Peng, XQ; Xi, ZX | 1 |
| Chabot, JG; Jhamandas, K; Ma, W; Quirion, R; Trang, T | 1 |
| McMahon, LR | 2 |
| Echegoyen, JC; Howard, AL; Morgan, RJ; Neu, A; Soltesz, I | 1 |
| Liu, C; Walker, JM | 1 |
| de la Cal, C; Elverdin, JC; Fernández-Solari, J; Iribarne, M; McCann, SM; Prestifilippo, JP; Rettori, V; Suburo, AM | 1 |
| Ballini, C; Blandina, P; Cenni, G; Della Corte, L; Formigli, L; Giannoni, P; Mackie, K; Mannaioni, PF; Nosi, D; Passani, MB | 1 |
| Beierlein, M; Regehr, WG | 1 |
| Cavalier, M; Cohen-Solal, C; Guiramand, J; Lanté, F; Vignes, M | 1 |
| Baik, SK; Dehpour, AR; Gaskari, SA; Lee, SS; Liu, H; Moezi, L | 1 |
| Hama, A; Sagen, J | 1 |
| Galea, LA; Gorzalka, BB; Hill, MN; Kambo, JS; Sun, JC | 1 |
| Nguyen, QH; Wagner, EJ | 1 |
| Blair, RE; Carter, DS; DeLorenzo, RJ; Deshpande, LS; Martin, BR; Sombati, S | 1 |
| Cross-Mellor, SK; Ossenkopp, KP; Parker, LA; Piomelli, D | 1 |
| Jarrett, MM; Parker, LA; Scantlebury, J | 1 |
| Aguiar, DC; Guimarães, FS; Moreira, FA | 1 |
| Banafshe, HR; Dehpour, AR; Ejtemaei Mehr, S; Ghazi-Khansari, M | 1 |
| Hou, MC; Huang, YT; Lee, FY; Lee, SD; Lee, TY; Lin, HC; Wang, YW; Yang, YY | 2 |
| Beaulieu, P; Desroches, J; Guindon, J | 1 |
| Landa, L; Slais, K; Sulcova, A | 1 |
| Ceranowicz, P; Cieszkowski, J; Dembiński, A; Dembiński, M; Hładki, W; Konturek, PC; Konturek, SJ; Pawlik, WW; Tomaszewska, R; Warzecha, Z | 1 |
| Ali, N; Chapman, V; Chimenti, M; de Lago, E; Fernandez-Ruiz, J; Kendall, DA; Millns, PJ; Ryland, E | 1 |
| Bennett, T; Gardiner, SM; Randall, MD; Wheal, AJ | 2 |
| Massoudi, R; Moghaddam, AH; Roohbakhsh, A; Zarrindast, MR | 1 |
| Daws, LC; Frazer, A; Giuffrida, A; Gould, GG; Owens, WA; Price, DA; Roberts, JL | 1 |
| Laitinen, JT; Lehtonen, M; Palomäki, VA; Savinainen, JR | 1 |
| Cameron-Smith, D; Cavuoto, P; Hatzinikolas, G; McAinch, AJ; Wittert, GA | 1 |
| Gardiner, SM; O'Sullivan, SE; Randall, MD | 1 |
| Baimoukhametova, DV; Bains, JS; Oliet, SH; Piet, R | 1 |
| Braida, D; Castiglioni, C; Guidali, C; Limonta, V; Parolaro, D; Realini, N; Rubino, T; Sala, M; Viganò, D | 1 |
| Blair, RE; DeLorenzo, RJ; Deshpande, LS; Martin, BR; Nagarkatti, N; Sombati, S | 1 |
| Su, JY; Vo, AC | 1 |
| Ballmaier, M; Bortolato, M; Gessa, G; Heinz, A; Rizzetti, C; Spano, P; Zoli, M | 1 |
| Czesnik, D; Kuduz, J; Manzini, I; Schild, D | 1 |
| Chocyk, A; Maćkowiak, M; Markowicz-Kula, K; Wedzony, K | 1 |
| Hentges, ST | 1 |
| Pamplona, FA; Pandolfo, P; Prediger, RD; Takahashi, RN | 1 |
| Frenguelli, BG; Hormuzdi, SG; Irving, AJ; Youssef, FF | 1 |
| Gorzalka, BB; Hill, MN; Karacabeyli, ES | 1 |
| Jhamandas, K; Sutak, M; Trang, T | 1 |
| Barsy, B; Freund, TF; Hájos, N; Haller, J; Mátyás, F; Mikics, E; Németh, B; Soproni, K; Varga, B | 1 |
| Cristino, L; Davison, JS; Di Marzo, V; Guglielmotti, V; Oland, LD; Pittman, QJ; Sharkey, KA; Starowicz, K; Van Sickle, MD | 1 |
| Bianchi, R; Borsani, E; Labanca, M; Rodella, LF | 1 |
| Deng, C; Huang, XF; South, T | 1 |
| Kreitzer, AC; Malenka, RC; Singla, S | 1 |
| Bermudez-Silva, FJ; Fuentes, E; Juan-Pico, P; Nadal, A; Rodríguez de Fonseca, F; Sanchez-Vera, I; Serrano, A; Suárez, J | 1 |
| Cox, JM; Ho, J; Wagner, EJ | 1 |
| Liu, SJ | 1 |
| Cisneros, M; Di Marzo, V; Matias, I; Navarro, L; Petrosino, S; Prospéro-García, O; Rueda-Orozco, PE; Soria-Gómez, E | 1 |
| Adermark, L; Lovinger, DM; Park, BS; Yin, HH | 1 |
| Koek, W; McMahon, LR | 1 |
| Beaulieu, P; Dani, M; Desroches, J; Guindon, J | 1 |
| Bátkai, S; Harvey-White, J; Kechrid, R; Kunos, G; Mukhopadhyay, P; Pacher, P | 1 |
| Ali, AB | 1 |
| Hsu, KS; Huang, CC; Liang, YC | 1 |
| Brown, C; Fan, P; Makriyannis, A; McLaughlin, PJ; Olszewska, T; Olzewska, T; Pang, Y; Parker, LA; Peng, Y; Salamone, JD; Sink, KS; Thakur, GA; Vemuri, VK; Wood, JA | 1 |
| Beierlein, M; Fioravante, D; Regehr, WG | 1 |
| Mitchell, VA; Vaughan, CW; Vuong, LA | 1 |
| Corbillé, AG; Girault, JA; Hervé, D; Ledent, C; Lutz, B; Marsicano, G; Valjent, E | 1 |
| Boctor, SY; France, CP; Koek, W; Martinez, JL | 1 |
| Ahmadi, S; Nouri, M; Zarrindast, MR | 1 |
| Araya, KA; David Pessoa Mahana, C; González, LG | 1 |
| Beaulieu, P; Dani, M; Guindon, J; Lambert, C | 1 |
| Adermark, L; Lovinger, DM; Yin, HH | 1 |
| Guidali, C; Massi, P; Parolaro, D; Realini, N; Rubino, T; Valenti, M; Vigano, D | 1 |
| Gorzalka, BB; Hill, MN; Morrish, AC | 1 |
| Freund, TF; Hájos, N; Ledent, C; Németh, B | 1 |
| Iatsenko, NM; Lozova, NO; Tsintsadze, TSh | 1 |
| Allescher, HD; Broedl, UC; Göke, B; Lutz, B; Marsicano, G; Sibaev, A; Storr, M; Yuece, B | 1 |
| Dillon, C; Gardner, EL; Gilbert, J; Li, X; Pak, AC; Peng, XQ; Spiller, K; Xi, ZX | 1 |
| Gorzalka, BB; Hill, MN; McLaughlin, RJ; Morrish, AC | 1 |
| Dehpour, AR; Ghasemi, M; Shafaroodi, H | 1 |
| Cao, XH; Fu, H; Liu, LJ; Ming, ZY; Xiao, JM | 1 |
| Galicia, O; Martínez-Vargas, M; Montes-Rodriguez, CJ; Navarro, L; Prospero-García, O; Rueda-Orozco, PE; Soria-Gomez, E | 1 |
| Kendall, DA; Ralevic, V; Wilkinson, JD | 1 |
| Bahremand, A; Dehpour, AR; Ghasemi, M; Gholizadeh, S; Shafaroodi, H; Sharifzadeh, M | 1 |
| Greenwood, R; Jayamanne, A; Mitchell, VA; Vaughan, CW | 1 |
| Blundell, JE; Rodgers, JR; Tallett, AJ | 1 |
| Hudson, B; Jollimore, CA; Kelly, ME; McIntosh, BT; Yegorova, S | 1 |
| Barde, YA; Hofbauer, KG; Lecourt, AC; Nicholson, JR; Peter, JC | 1 |
| El Manira, A; Kyriakatos, A | 1 |
| Makriyannis, A; Olszewska, T; Salamone, JD; Sink, KS; Vemuri, VK | 1 |
| Balaban, PM; Bezuglov, VV; Bobrov, MY; Bravarenko, NI; Ierusalimsky, VN; Lemak, MS; Malyshev, AY; Storozhuk, MV | 1 |
| Dobrunz, LE; Speed, HE | 1 |
| Shoaib, M | 1 |
| Adermark, L; Lovinger, DM | 1 |
| Cachope, R; Mackie, K; O'Brien, J; Pereda, AE; Triller, A | 1 |
| Alizadeh, AM; Haghparast, A; Khani, A; Motamedi, F; Naderi, N; Rezaii, N; Saber-Tehrani, A | 1 |
| Bedini, A; Börner, C; Höllt, V; Kraus, J | 1 |
| McDougall, JJ; Schuelert, N | 1 |
| Flatt, PR; Frizzell, N; Hunter, K; Irwin, N | 1 |
| Miller, MJ; Reuter, BK; Sharkey, KA; Wallace, JL | 1 |
| Shimizu, T; Yokotani, K | 1 |
| Brunell, S; McCulloch, M; Spear, L; Xu, Y; Zhou, X | 1 |
| Hajós, M; Hoffmann, WE; Kocsis, B | 1 |
| Bani, D; Cinci, L; Giannini, L; Mannaioni, PF; Mariottini, C; Masini, E; Mastroianni, R; Nistri, S; Passani, MB; Vannacci, A | 1 |
| Flatt, PR; Hunter, K; Irwin, N | 1 |
| Di Marzo, V; Hasenöhrl, RU; Molleman, A; Thiemann, G | 1 |
| Alger, BE; Mohammadi, MH; Reich, CG | 1 |
| Ma, YL; Stephens, GJ; Weston, SE; Whalley, BJ | 1 |
| Carnevali, O; Migliarini, B | 2 |
| De Oliveira Alvares, L; Diehl, F; Genro, BP; Quillfeldt, JA | 1 |
| Bosetti, F; Tomita, YA; Toscano, CD; Ueda, Y; Vicini, S | 1 |
| Araque, A; Navarrete, M | 2 |
| Dehpour, AR; Ejtemaei Mehr, S; Ghasemi, M; Javadi, P; Kalbasi Anaraki, D; Paydar, MJ; Sadeghi, M; Sianati, S | 1 |
| d'amico, A; de Filippis, D; de Man, JG; de Winter, BY; Esposito, G; Herman, AG; Iuvone, T; Pelckmans, PA; Steardo, L | 1 |
| Finn, DP; Kelly, JP; O'Driscoll, M; Roche, M | 1 |
| Bifulco, M; Gazzerro, P; Laezza, C; Malfitano, AM; Pisanti, S; Santoro, A | 1 |
| Kim, HS; Kwon, J; Lee, ES; Lee, YM; Park, SH; Uhm, KO | 1 |
| Abayev, Y; Bodnar, RJ; Gerges, M; Kandova, E; Miner, P; Sclafani, A; Styler, E; Touzani, K; Wapniak, R | 1 |
| Cinar, R; Freund, TF; Katona, I; Mackie, K; Szucs, M | 1 |
| Donaldson, LF; Kelly, S | 1 |
| Araújo, JR; Azevedo, I; Gonçalves, P; Martel, F | 1 |
| Campos, AC; Guimarães, FS | 1 |
| Aguiar, DC; Corrêa, FM; Guimarães, FS; Lisboa, SF; Resstel, LB | 1 |
| Ferrara, M; Mathes, CM; Rowland, NE | 2 |
| Bear, MF; Heynen, AJ; Liu, CH; Shuler, MG | 1 |
| Ballesteros, I; Chancellor, MB; Coyle, CH; de Miguel, F; Hayn, MH; Tyagi, P; Tyagi, S; Yoshimura, N | 1 |
| da Fonseca Pacheco, CM; da Fonseca Pacheco, D; de Castro Perez, A; de Francischi, JN; Duarte, ID; Klein, A | 1 |
| Aubin, HJ; Forget, B; Goldberg, SR; Le Foll, B | 1 |
| Bonnefont, J; Chapuy, E; Daulhac, L; Eschalier, A; Etienne, M; Ledent, C; Libert, F; Mallet, C | 1 |
| Dennis, I; Stephens, GJ; Whalley, BJ | 1 |
| Méndez-Díaz, M; Montes-Rodriguez, CJ; Prospéro-García, O; Rueda-Orozco, PE; Soria-Gomez, E | 1 |
| Biala, G; Kruk, M | 1 |
| Bahremand, A; Dehpour, AR; Ghasemi, M; Gholizadeh, S; Nasrabady, SE; Shafaroodi, H | 1 |
| Fujino, H; Hirabayashi, T; Kaneko, M; Mashimo, M; Murayama, T; Nabemoto, M; Nakamura, H; Okuma, Y; Saito, T; Someya, A; Yamaguchi, N | 1 |
| Barbour, B; Brunel, N; Buisseret, P; de Solages, C; Hakim, V; Isope, P; Léna, C; Rousseau, C; Szapiro, G | 1 |
| de Oliveira Alvares, L; Diehl, F; Molina, VA; Pasqualini Genro, B; Quillfeldt, JA | 1 |
| Itakura, C; Katayama, M; Niimi, K; Takahashi, E | 1 |
| Cristino, L; Di Marzo, V; Drago, F; Leggio, GM; Micale, V; Petrosino, S; Tamburella, A | 2 |
| Castillo, E; Gannon, RL; Sanford, AE | 1 |
| Duan, Y; Jain, S; Liao, C; Nicholson, RA | 1 |
| Bow, JP; Hodge, J; Makriyannis, A; McLaughlin, PJ; Plyler, KS; Salamone, JD; Vemuri, VK; Wisniecki, A | 1 |
| Huang, Y; Sarihi, A; Tsumoto, T; Yasuda, H | 1 |
| Gustafsson, SB; Jacobsson, SO; Jonsson, M; Lindgren, T | 1 |
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| Marichal-Cancino, BA; Méndez-Díaz, M; Prospéro-García, O; Ruiz-Contreras, AE; Sánchez-Fuentes, A | 1 |
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| Baker, DA; Doncheck, EM; Ganzman, GS; Hillard, CJ; Mantsch, JR; McReynolds, JR; Vranjkovic, O | 1 |
| Gibson, JR; Masiulis, I; Powell, CM; Speed, HE | 1 |
| Haghparast, A; Jahangirvand, M; Moradi, M; Pirasteh, AH; Yazdi, F | 1 |
| Cox, CD; Gall, CM; Geschwind, DH; Karsten, CA; Lee, D; Peñagarikano, O; Piomelli, D; Wei, D | 1 |
| Azogu, I; de la Tremblaye, PB; Knowles, MD; Plamondon, H | 1 |
| Crestani, AP; de Oliveira Alvares, L; Mello E Souza, T; Quillfeldt, JA; Sachser, RM | 1 |
| Dehpour, AR; Haj-Mirzaian, A; Kordjazy, N; Nikoui, V; Ostadhadi, S | 1 |
| Asadbegi, M; Karamian, R; Komaki, A; Nazari, M; Sarihi, A; Shahidi, S | 1 |
| Gao, F; Ji, M; Li, F; Li, Q; Miao, Y; Qian, WJ; Sun, XH; Wang, SY; Wang, Z; Yang, W | 1 |
| Aguiar, DC; Almeida-Santos, AF; Gobira, PH; Guimaraes, FS; Moreira, FA | 1 |
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| Biala, G; Kruk-Slomka, M | 1 |
| Hott, SC; Lisboa, SF; Resstel, LB; Uliana, DL | 1 |
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| Arbabi, E; Atyabi, F; Dinarvand, R; Hassanzadeh, P | 1 |
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| Martinez, LA; Meisel, RL; Mermelstein, PG; Peterson, BM | 1 |
| Ghasemzadeh, Z; Mohammadmirzaei, N; Rezayof, A | 1 |
| Esmaeili, MH; Ezzatpanah, S; Haghparast, A; Reisi, Z | 2 |
| Ghasemzadeh, Z; Ofogh, SN; Rezayof, A; Sardari, M | 1 |
| Hah, JH; Jeong, WJ; Oh, SM; Park, SW; Sung, MW | 1 |
| Benini, R; Costa-Ferreira, W; Crestani, CC; Gomes-de-Souza, L; Oliveira, LA; Rodella, P | 1 |
| Dekanic, A; Nistri, A; Veeraraghavan, P | 1 |
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| Hinz, B; Ivanov, I; Scholl, A | 1 |
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| Banaszkiewicz, I; Biala, G; Budzynska, B; Kruk-Slomka, M; Slomka, T | 1 |
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| Ganji, A; Komaki, A; Komaki, H; Nazari, M; Salehi, I; Sarihi, A; Shahidi, S | 1 |
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| Amini-Khoei, H; Amiri, S; Dehpour, AR; Ghesmati, M; Haj-Mirzaian, A; Shafaroodi, H; Zahir, M | 1 |
| Gao, G; Heng, L; Jia, D; Qu, L; Song, J; Wang, X; Wang, Y; Zhang, H | 1 |
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| Wang, F; Wu, L; Yao, L; Zhang, H; Zhao, X | 1 |
| Cox, CD; Gall, CM; Jia, Y; Jung, KM; Lynch, G; Palmer, LC; Pham, DT; Piomelli, D; Rumbaugh, G; Wang, W | 1 |
| Antunes-Rodrigues, J; Borges, BC; Elias, LLK; Rivas, PMS; Rorato, R; Vechiato, FMV | 1 |
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| Abush, H; Akirav, I; Mizrachi Zer-Aviv, T; Segev, A; Shoshan, N | 1 |
| Calixto, JB; Costa, R; Freitas, CS; Manjavachi, MN; Matias, DO; Passos, GF; Segat, GC | 1 |
| Hoffmann, A; Menescal-de-Oliveira, L; Wolkers, CPB | 1 |
| Baker, D; Pryce, G | 1 |
| Barron, LM; DeBaker, MC; Doncheck, EM; Frick, KM; Hillard, CJ; Liddiard, GT; Mantsch, JR; Tuscher, JJ; Urbanik, LA | 1 |
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| Aritake, K; Cherasse, Y; Kaushik, MK; Kikura-Hanajiri, R; Malyshevskaya, O; Uchiyama, N; Urade, Y | 1 |
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| Cheng, J; Jiang, C; Wu, J; Yu, J; Zhou, X; Zong, Y | 1 |
| Baumbach, JL; McCormick, CM; Simone, JJ | 2 |
| Baker, DA; Cravatt, BF; Doncheck, EM; Graf, EN; Hillard, CJ; Li, Y; Liu, QS; Mantsch, JR; McReynolds, JR; Ogasawara, D; Vranjkovic, O | 1 |
| Fanarioti, E; Giompres, P; Mitsacos, A; Natsaridis, E; Perdikaris, P; Tsarouchi, M | 1 |
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| Górska, J; Poleszak, E; Serefko, A; Szopa, A; Wlaź, A; Wlaź, P; Wośko, S; Wróbel, A | 1 |
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| Arnason, JT; Cal, V; Cayer, C; Harris, CS; Kent, P; Liu, R; Merali, Z | 1 |
| Crews, FT; Grant, ML; Jones, VM; Khatri, D; Laroche, G; Mukhopadhyay, S; Vetreno, RP | 1 |
| Anli, G; Bilir, KA; Gunduz, O; Ozkan, E; Ulugol, A | 1 |
| Fang, Q; Shi, X; Wang, P; Xu, B; Zhang, M; Zhang, Q; Zhang, R; Zhang, T; Zhao, W; Zheng, T | 1 |
| Li, B; Li, Z; Zhang, D; Zhang, G | 1 |
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| Akirav, I; Fidelman, S; Hillard, CJ; Lange, R; Mizrachi Zer-Aviv, T | 1 |
| Guo, F; Sun, X; Wang, M; Xu, L; Yang, D; Zhang, D | 1 |
| Corcoran, L; Finn, DP; McGowan, F; Rea, K; Roche, M | 1 |
| Allahtavakoli, M; Bazmandegan, G; Moghadam-Ahmadi, A; Rahmani, MR; Shamsizadeh, A | 1 |
| Aliebrahimi, S; Ghahremani, MH; Gholizadeh, F; Ostad, SN; Shadboorestan, A | 1 |
| Castro, A; Cheer, JF; Conn, PJ; Covey, DP; Dantrassy, HM; Mateo, Y; Yohn, SE | 1 |
| Becker, HC; Harlan, BA; Riegel, AC; Woodward, JJ | 1 |
| Fernandes, PD; Giorno, TBS; Moreira, IGDS; Rezende, CM | 1 |
| Fang, G; Wang, Y | 2 |
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| Alaei, H; Azizi, F; Fartootzadeh, R; Reisi, P | 3 |
| Aboud, M; Comai, S; De Gregorio, D; Enns, J; Gobbi, G; Lopez-Canul, M; Maione, S; McLaughlin, RJ; Ochoa-Sanchez, R; Posa, L | 1 |
| Haghparast, A; Khaleghzadeh-Ahangar, H; Khodagholi, F; Shaerzadeh, F | 1 |
| Amiri, S; Dehpour, AR; Ghasemi, M; Haj-Mirzaian, A; Hassanipour, M; Khoshnoodi, M; Ostadhadi, S; Shafaroodi, H; Sharifzadeh, M; Shirzadian, A | 1 |
| Cruz-Martínez, AM; Escartín-Pérez, RE; Florán-Garduño, B; López-Alonso, VE; Mancilla-Díaz, JM; Tejas-Juárez, JG | 1 |
| Hohmann, AG; Iyer, V; Makriyannis, A; Saberi, SA; Slivicki, RA; Vemuri, VK | 1 |
| Choudhury, S; Garg, SK; Gari, M; Nakade, UP; Sharma, A; Sharma, P; Shukla, A; Singh, P | 1 |
| Ho, WK; Kim, HH; Lee, SH; Park, JM | 1 |
| Babinska, Z; Bari, M; D'Addario, C; Di Bartolomeo, M; Di Marco, R; Di Marzo, V; Drago, F; Drazanova, E; Giurdanella, G; Iannotti, FA; Maccarrone, M; Mechoulam, R; Micale, V; Pekarik, V; Piscitelli, F; Ruda-Kucerova, J; Salomone, S; Starcuk, Z; Stark, T; Sulcova, A; Wotjak, CT | 1 |
| Kossakowski, R; Malinowska, B; Pędzińska-Betiuk, A; Weresa, J | 1 |
| Allman, BL; Desai, SJ; Jobson, CEL; Laviolette, SR; Norris, C; Pereira, B; Rajakumar, N; Renard, J; Szkudlarek, HJ | 1 |
| Cunha, RA; de Carvalho, C; Ferreira, SG; Kincheski, GC; Leffa, DT; Machado, NJ; Pandolfo, P; Porciúncula, LO; Rosa, FD; Souza, CM; Souza, DO; Takahashi, RN | 1 |
| Aguilera-Portillo, G; Colonnello, A; Galván-Arzate, S; Kotlar, I; Pedraza-Chaverri, J; Rangel-López, E; Santamaría, A; Serratos, IN; Túnez, I; Wajner, M | 1 |
| Bagdy, G; Bogáthy, E; Kostyalik, D; Petschner, P; Vas, S | 1 |
| Aguiar, DC; Bastos, JR; Coimbra, CC; Costa, RB; Hott, SC; Mansur, FS; Moreira, FA; Resstel, LB; Viana, TG | 1 |
| Coimbra, NC; Dos Anjos-Garcia, T | 1 |
| Duarte, IDG; Pacheco, DDF; Romero, TRL | 1 |
| Correa, FM; Fassini, A; Guimarães, FS; Hartmann, A; Lisboa, SF; Resstel, LB; Scopinho, A | 1 |
| Luchtenburg, FJ; Richardson, MK; Schaaf, MJM | 1 |
| Deyama, S; Domoto, M; Esaki, H; Fukao, A; Hinoi, E; Ito, S; Kaneda, K; Kaneko, S; Sasase, H; Zhang, T | 1 |
| Bendová, Z; Červená, K; Filipovská, E; Kyclerová, H; Moravcová, S; Novotný, J; Pačesová, D; Spišská, V | 1 |
| Frias, CP; Hoogenraad, CC; Hu, HY; Kruijssen, DLH; Rózsa, B; Wierenga, CJ | 1 |
| Coutinho, D; Gomes, FV; Guimarães, FS; Hartmann, A; Lisboa, SF; Sonego, AB | 1 |
| Gianessi, CA; Groman, SM; Jiang, M; Taylor, JR; Thompson, SL; van der Stelt, M | 1 |
| Amancio-Belmont, O; Estrada-González, V; Méndez-Díaz, M; Prospéro-García, O; Ruiz-Contreras, AE | 1 |
| Mehrpouya-Bahrami, P; Miranda, K; Nagarkatti, M; Nagarkatti, PS | 1 |
| Huang, JY; Middleton, TP; Protti, DA | 1 |
| Bi, GH; Galaj, E; He, Y; Xi, ZX | 1 |
| Barros, M; Caixeta, FV; Gonczarowska, N; Maior, RS; Malcher-Lopes, R; Nishijo, H; Tomaz, C | 1 |
| Ali, DW; Allison, WT; Amin, MR; Kanyo, R; Sufian, MS | 1 |
| Bekar, LK; Nedergaard, M; Smith, NA | 1 |
| Arslan, R; Bektas, N; Dikmen, DY; Okcay, Y | 1 |
| Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS | 1 |
| Gao, X; Gou, X; Hu, F; Lao, K; Lv, B; Meng, X; Zhang, R; Zhang, X; Zheng, Y | 1 |
| Augusto, PSA; Braga, AV; Coelho, MM; Costa, FC; Costa, SOAM; Dutra, MMGB; Goulart, FA; Machado, RR; Melo, ISF; Morais, MI; Rodrigues, FF | 1 |
| Cossio, D; Johnston, C; Lopez, HH; Michas, Z; Stadler, H | 1 |
| Campeau, S; Day, HEW; Garcia, RJ; Newsom, RJ; O'Neill, CE; Osterlund, C; Stafford, J | 1 |
| Benini, R; Costa-Ferreira, W; Crestani, CC; Gomes-de-Souza, L; Oliveira, LA | 1 |
| Coimbra, NC; de Fátima Dos Santos Sampaio, M; de Souza Crippa, JA; Dos Anjos-Garcia, T; Falconi-Sobrinho, LL; Khan, AU; Menescal-de-Oliveira, L | 1 |
| Atanes, P; Choudhary, P; Huang, GC; Liu, B; Persaud, SJ; Pingitore, A; Ruz-Maldonado, I | 1 |
| Christianson, JP; Gaillardetz, GP; Hill, MN; Varela, JA; Worley, NB | 1 |
| Diwan, M; Giacobbe, P; Gidyk, DC; Gouveia, FV; Hamani, C; Lipsman, N; Nobrega, JN; Vimalanathan, A | 1 |
| Alcaino, A; Chávez, AE; Fuenzalida, M; Schmachtenberg, O; Tapia, F; Vielma, AH | 1 |
| Baumbach, JL; McCormick, CM; McPherson, J; Simone, JJ | 1 |
| Babaie, J; Ghanbari, MM; Joneidi, M; Kiani, B; Sayyah, M | 1 |
| da Cunha, JM; Godoi, MM; Junior, HZ; Zanoveli, JM | 1 |
| Dong, X; Jiang, J; Jiang, Y; Liu, X; Ye, Y; Zhang, D; Zhu, R | 1 |
| Kvachadze, I; Tsagareli, MG; Tsagareli, N; Tsiklauri, N | 1 |
| Alimohammadzadeh, K; Islami Vaghar, M; Mohammadi-Mahdiabadi-Hasani, MH; Nasehi, M; Rezaie, M; Vaseghi, S; Zarrindast, MR | 1 |
| Aschner, M; García-Hernández, VM; Meneses-García, A; Ortega-Gómez, A; Prospero-García, O; Rangel-López, E; Ruiz-García, E; Santamaría, A; Torres-Román, AL | 1 |
| Akbarabadi, A; Borzabadi, S; Khalifeh, S; Nasehi, M; Sadat-Shirazi, MS; Sadeghi-Adl, M; Shahini, F; Zarrindast, MR | 1 |
| Liu, S; Liu, X; Lu, Y; Wu, Y; Xie, Y; Yang, R; Zhou, D; Zhou, Y | 1 |
| Chung, YC; Jin, BK; Wi, R | 1 |
| Almada, RC; Coimbra, NC; da Silva, JA; Dos Anjos-Garcia, T; Pigatto, GR; Wotjak, CT | 1 |
| Chen, P; Cheng, J; Gou, X; Guo, H; Lao, K; Lu, B; Zhang, R | 1 |
| Escayg, A; Gado, F; Manera, C; Shapiro, L | 1 |
| Berthoux, C; Castillo, PE; Jensen, KR; Nasrallah, K | 1 |
| Ghanbari, MM; Loron, AG; Sayyah, M | 1 |
| Bianchi, PC; Costa-Ferreira, W; Crestani, CC; Cruz, FC; Gomes-de-Souza, L; Tomeo, RA | 1 |
| Hara, K; Haranishi, Y; Terada, T | 1 |
| Aguiar, DC; Batista, LA; de Araújo Moreira, F | 1 |
| Baker, CA; Bolton, MM; Bonnan, A; Christie, JM; Rowan, MMJ | 1 |
| Cankara, FN; Çelik, ZB; Günaydın, C | 1 |
| Fichna, J; Polepally, PR; Świerczyński, M; Szymaszkiewicz, A; Talar, M; Zielińska, M; Zjawiony, JK | 1 |
| Coimbra, NC; de Freitas, RL; Luongo, L; Maione, S; Malvestio, RB; Medeiros, AC; Medeiros, P; Negrini-Ferrari, SE; Oliveira-Silva, M; Padovan, CM | 1 |
| Han, J; Huang, M; Luo, L; Ma, X; Shi, H; Su, C; Wang, A; Wang, H; Wang, W; Wu, K; Xu, T; Xu, X; Yuan, T | 1 |
| Cartarozzi, LP; Chiarotto, GB; Guimarães, FS; Oliveira, ALR; Perez, M | 1 |
| Dahlén, A; Guo, S; Melgoza, A; Wagle, M; Zarei, M | 1 |
| Costa-Ferreira, W; Crestani, CC; Gomes-de-Souza, L; Mendonça, MM; Xavier, CH | 1 |
| Abbasnejad, M; Esmaeili-Mahani, S; Kooshki, R; Pourrahimi, AM; Raoof, M | 1 |
| Faraji, N; Hasanein, P; Karimi, SA; Komaki, A; Komaki, H; Noorbakhsh, M; Reza Nikoo, M; Shahidi, S | 1 |
| Li, Y; Liu, B; Shi, H; Tian, Y; Wu, P; Zhang, Y; Zheng, J | 1 |
Reviews
6 review(s) available for am 251 and piperidines
| Article | Year |
|---|---|
Inverse agonism and neutral antagonism at cannabinoid CB1 receptors.
Topics: Animals; Benzofurans; Cannabinoids; Morpholines; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
A role for cannabinoid CB1 receptors in mood and anxiety disorders.
Topics: Affect; Animals; Anxiety Disorders; Cannabinoid Receptor Modulators; Dronabinol; Humans; Models, Animal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2005 |
GPR55: a new member of the cannabinoid receptor clan?
Topics: Amides; Animals; Arachidonic Acids; Cannabinoids; Dronabinol; Endocannabinoids; Ethanolamines; Humans; Oleic Acids; Palmitic Acids; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled | 2007 |
Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: insights from pre-clinical and clinical studies.
Topics: Animals; Brain; Cannabinoid Receptor Modulators; Clinical Trials as Topic; Drug Evaluation, Preclinical; Emotions; Humans; Motivation; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Secondary Prevention; Smoking Cessation; Tobacco Use Disorder | 2008 |
CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant).
Topics: Animals; Anti-Obesity Agents; Appetite Depressants; Dronabinol; Humans; Ligands; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Rimonabant | 2012 |
Regulation of endocannabinoid release by G proteins: a paracrine mechanism of G protein-coupled receptor action.
Topics: Angiotensin II; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Glycerides; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Paracrine Communication; Paraventricular Hypothalamic Nucleus; Piperidines; Pyrazoles; Rats; Receptor, Angiotensin, Type 1; Receptor, Cannabinoid, CB1 | 2012 |
Trials
1 trial(s) available for am 251 and piperidines
| Article | Year |
|---|---|
Voluntary exercise augments acute effects of CB1-receptor inverse agonist on body weight loss in obese and lean mice.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Female; Mice; Mice, Inbred C57BL; Mice, Obese; Physical Conditioning, Animal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Thinness; Weight Loss | 2004 |
Other Studies
897 other study(ies) available for am 251 and piperidines
| Article | Year |
|---|---|
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors.
Topics: Animals; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dronabinol; Hippocampus; Iodine Radioisotopes; Isotope Labeling; Male; Mice; Mice, Inbred Strains; Motor Activity; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tissue Distribution | 1996 |
Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors.
Topics: Animals; Autoradiography; Brain; Cyclohexanols; Iodine Radioisotopes; Male; Mice; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug | 1997 |
Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cytochrome P-450 Enzyme Inhibitors; Dronabinol; Embryo Implantation; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Endocannabinoids; Enzyme Inhibitors; Female; Glycerides; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.
Topics: Animals; Cannabinoids; Guinea Pigs; Humans; In Vitro Techniques; Intestine, Small; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Piperidines; Prosencephalon; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Spleen; Structure-Activity Relationship; Vas Deferens | 1999 |
Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism.
Topics: Annexin A5; Apoptosis; Benzoxazines; DNA Fragmentation; Dronabinol; Fluorescent Antibody Technique; Humans; Indoles; Male; Mitochondria; Morpholines; Naphthalenes; Pertussis Toxin; Piperidines; Prostatic Neoplasms; Protein Binding; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Sphingosine; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1.
Topics: Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Male; Nerve Growth Factor; Pertussis Toxin; Piperidines; Prostatic Neoplasms; Protein Binding; Proto-Oncogene Proteins c-raf; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells.
Topics: Animals; Axonal Transport; Calcium; Cannabinoids; Egtazic Acid; Excitatory Postsynaptic Potentials; Hot Temperature; Kinetics; Neurotransmitter Agents; Piperidines; Purkinje Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Synapses | 2001 |
The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets.
Topics: Analgesics, Opioid; Animals; Antiemetics; Benzoxazines; Ferrets; Male; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Vomiting | 2001 |
Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Arachidonic Acids; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Pyrilamine; Quinoxalines; Rats; Rats, Wistar; Rimonabant; Signal Transduction; Stereoisomerism; Theophylline; Vasodilation | 2001 |
CB2 cannabinoid receptor-mediated peripheral antinociception.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Indoles; Male; Morpholines; Naphthalenes; Pain Measurement; Peripheral Nervous System; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug | 2001 |
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
Topics: Analgesics, Non-Narcotic; Arachidonic Acids; Blotting, Western; Brain Neoplasms; Cannabinoid Receptor Modulators; Cell Line; Central Nervous System; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
CP55,940 increases intracellular Ca2+ levels in Madin-Darby canine kidney cells.
Topics: Animals; Calcium; Cannabinoids; Cell Line; Cyclohexanols; Dogs; Estrenes; Extracellular Space; Indicators and Reagents; Inositol 1,4,5-Trisphosphate; Kidney; Morpholines; Piperidines; Pyrazoles; Pyrrolidinones; Receptors, Cannabinoid; Receptors, Drug | 2001 |
Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries.
Topics: Amides; Animals; Arachidonic Acids; Capsaicin; Coronary Vessels; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Ethanolamines; Gap Junctions; Glycyrrhetinic Acid; In Vitro Techniques; Indoles; Indomethacin; Male; Palmitic Acids; Peptides; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Tetraethylammonium; Vasodilation | 2001 |
2-Arachidonoylglycerol and anandamide oppositely modulate norepinephrine release from the rat heart sympathetic nerves.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Dronabinol; Endocannabinoids; Glycerides; Male; Myocardium; Neurotransmitter Agents; Norepinephrine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Sympathetic Nervous System | 2001 |
Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Mice; Mice, Knockout; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Cannabinoid; Receptors, Drug; Receptors, Metabotropic Glutamate | 2001 |
Delta 9-tetrahydrocannabinol induces the apoptotic pathway in cultured cortical neurones via activation of the CB1 receptor.
Topics: Animals; Caspase 3; Caspases; Cells, Cultured; Cerebral Cortex; Cytochrome c Group; DNA Fragmentation; Dronabinol; Hallucinogens; Neurons; Piperidines; Poly(ADP-ribose) Polymerases; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug | 2001 |
Short-term retrograde inhibition of GABAergic synaptic currents in rat Purkinje cells is mediated by endogenous cannabinoids.
Topics: Action Potentials; Animals; Benzoxazines; Calcium Signaling; Cannabinoids; Cerebellum; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Membrane Potentials; Morpholines; Naphthalenes; Neural Inhibition; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Purkinje Cells; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Synaptic Transmission | 2002 |
Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-beta.
Topics: 1-Methyl-3-isobutylxanthine; Autocrine Communication; Blotting, Northern; Blotting, Western; Camphanes; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Dronabinol; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; GTP-Binding Proteins; Humans; Immunoenzyme Techniques; Lymphocytes; Models, Biological; Paracrine Communication; Piperidines; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; RNA; Transforming Growth Factor beta; Up-Regulation; Virulence Factors, Bordetella | 2002 |
Complex regional haemodynamic effects of anandamide in conscious rats.
Topics: Adrenergic beta-Agonists; Animals; Arachidonic Acids; Atropine; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Consciousness; Dose-Response Relationship, Drug; Endocannabinoids; Hemodynamics; Hindlimb; Male; Oxazines; Piperidines; Polyunsaturated Alkamides; Propanolamines; Pyrazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Serotonin; Serotonin Antagonists; Sodium Chloride; Splanchnic Circulation; Wakefulness | 2002 |
Influence of the CB(1) receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats.
Topics: Adrenergic beta-Antagonists; Animals; Benzoxazines; Cannabinoids; Cardiovascular System; Dronabinol; Drug Interactions; Hemodynamics; Male; Morpholines; Naphthalenes; Piperidines; Propanolamines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 2002 |
Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum.
Topics: Action Potentials; Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Cerebellar Cortex; Dendrites; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Interneurons; Morpholines; Naphthalenes; Neural Inhibition; Organ Culture Techniques; Piperidines; Potassium Channel Blockers; Purkinje Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Synapses; Synaptic Transmission | 2002 |
Inhibition of methamphetamine self-administration in rats by cannabinoid receptor antagonist AM 251.
Topics: Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Conditioning, Operant; Dose-Response Relationship, Drug; Ligands; Male; Methamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reinforcement Schedule; Self Administration; Substance Abuse, Intravenous | 2002 |
Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cattle; Ciliary Body; Cornea; Endocannabinoids; Enzyme Stability; Female; Glycerides; Intraocular Pressure; Iris; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug | 2002 |
Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers.
Topics: Animals; Axons; Benzoxazines; Capsaicin; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Male; Morpholines; Naphthalenes; Nerve Fibers; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Reflex, Monosynaptic; Synaptic Transmission | 2002 |
Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus.
Topics: Animals; Calcium; Cannabinoid Receptor Modulators; Cannabinoids; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Evoked Potentials; GTP-Binding Proteins; Hippocampus; In Vitro Techniques; Interneurons; Male; Mice; Mice, Knockout; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Metabotropic Glutamate; Receptors, Muscarinic | 2002 |
Flurbiprofen inhibits capsaicin induced calcitonin gene related peptide release from rat spinal cord via an endocannabinoid dependent mechanism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Capsaicin; Cyclooxygenase Inhibitors; Dinoprostone; Dronabinol; Endocannabinoids; Fatty Acids, Unsaturated; Flurbiprofen; Immunoassay; In Vitro Techniques; Phospholipases A; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Spinal Cord | 2003 |
Intrathecally applied flurbiprofen produces an endocannabinoid-dependent antinociception in the rat formalin test.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cannabinoid Receptor Modulators; Cyclooxygenase Inhibitors; Dinoprostone; Endocannabinoids; Enzyme Inhibitors; Flurbiprofen; Formaldehyde; In Vitro Techniques; Injections, Spinal; Male; Mice; Muscle Contraction; Muscle, Smooth; Pain Measurement; Phospholipases A; Phospholipases A2; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Vas Deferens | 2003 |
BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates.
Topics: Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Humans; Indomethacin; Inositol Phosphates; Ligands; Morpholines; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Second Messenger Systems | 2003 |
Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice.
Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Dietary Fats; Dose-Response Relationship, Drug; Eating; Insulin; Leptin; Male; Mice; Mice, Inbred C57BL; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Triglycerides | 2003 |
Endocannabinoids mediate rapid retrograde signaling at interneuron right-arrow pyramidal neuron synapses of the neocortex.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cell Communication; Endocannabinoids; Fatty Acids, Unsaturated; Interneurons; Mice; Morpholines; Naphthalenes; Neocortex; Neural Inhibition; Organ Culture Techniques; Piperidines; Pyramidal Cells; Pyrazoles; Signal Transduction | 2003 |
Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Antineoplastic Agents; Behavior, Animal; Benzoxazines; Cannabinoids; Cholinesterase Inhibitors; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; Indoles; Injections, Spinal; Male; Morpholines; Naphthalenes; Neostigmine; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 2003 |
Topical cannabinoid antinociception: synergy with spinal sites.
Topics: Administration, Topical; Analgesics; Animals; Benzoxazines; Cannabinoids; Dose-Response Relationship, Drug; Injections, Spinal; Mice; Mice, Inbred BALB C; Morpholines; Naphthalenes; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Spinal Cord | 2003 |
Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cannabinoid Receptor Modulators; Dendrites; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Morpholines; Naphthalenes; Neural Inhibition; Organ Culture Techniques; Piperidines; Presynaptic Terminals; Purkinje Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2003 |
Mediation of amphetamine-induced long-term depression of synaptic transmission by CB1 cannabinoid receptors in the rat amygdala.
Topics: Amphetamine; Amygdala; Animals; Arachidonic Acids; Benzoxazines; Calcium; Calcium Channels; Central Nervous System Stimulants; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; In Vitro Techniques; Ligands; Long-Term Synaptic Depression; Male; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2003 |
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Chromatography, High Pressure Liquid; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Radioactivity; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synaptosomes; Tritium | 2003 |
An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors.
Topics: Adenosine A1 Receptor Antagonists; Adenosine Deaminase; Animals; Arachidonic Acids; Cerebellum; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Organophosphonates; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2003 |
Cannabinoids decrease corticostriatal synaptic transmission via an effect on glutamate uptake.
Topics: Amino Acids; Animals; Cannabinoids; Cerebral Cortex; Corpus Striatum; Dronabinol; Glutamic Acid; In Vitro Techniques; Male; Neural Inhibition; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Synaptic Transmission; Xanthenes | 2003 |
Cannabinoid CB1 receptor activation does not prevent the toxicity of glutamate towards embryonic chick telencephalon primary cultures.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Cyclohexanols; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Endocannabinoids; Excitatory Amino Acid Antagonists; Glutamic Acid; L-Lactate Dehydrogenase; Models, Animal; Neurons; Pipecolic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Telencephalon | 2003 |
Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice.
Topics: Affect; Animals; Antidepressive Agents; Feeding Behavior; Infusions, Parenteral; Male; Mice; Mice, Knockout; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2003 |
Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro.
Topics: Amidohydrolases; Analysis of Variance; Animals; Animals, Newborn; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Drug Interactions; Electric Stimulation; Electrophysiology; Endocannabinoids; Excitatory Postsynaptic Potentials; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Long-Term Potentiation; Male; Morpholines; Naphthalenes; Neurons; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rimonabant; Sleep | 2004 |
Novel form of LTD induced by transient, partial inhibition of the Na,K-pump in rat hippocampal CA1 cells.
Topics: Animals; Drug Interactions; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Evoked Potentials; Hippocampus; Imidazoles; In Vitro Techniques; Indoles; Long-Term Synaptic Depression; Male; Maleimides; Neural Inhibition; Neurons; Ouabain; Peptides; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Time Factors | 2004 |
Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Endocannabinoids; Hypotension; Male; Neurons; Nitroprusside; Pain; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Trigeminal Caudal Nucleus; Vasodilation | 2004 |
Synthesis, biological evaluation, and structural studies on N1 and C5 substituted cycloalkyl analogues of the pyrazole class of CB1 and CB2 ligands.
Topics: Animals; Biochemistry; CHO Cells; Cricetinae; Drug Evaluation, Preclinical; Humans; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship | 2004 |
Inhibition of voltage-sensitive sodium channels by the cannabinoid 1 receptor antagonist AM 251 in mammalian brain.
Topics: Animals; Batrachotoxins; Brain; Cannabinoid Receptor Antagonists; Drug Interactions; Male; Membrane Potentials; Mice; Piperidines; Pyrazoles; Sodium Channels; Synaptosomes; Veratridine | 2004 |
Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice.
Topics: Animals; Appetite Regulation; Body Weight; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Drug Synergism; Homeostasis; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Obesity; Opioid Peptides; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2004 |
Cannabinoid CB1 receptor-mediated modulation of evoked dopamine release and of adenylyl cyclase activity in the human neocortex.
Topics: Adenylyl Cyclases; Amygdala; Animals; Arachidonic Acids; Benzoxazines; Binding Sites; Colforsin; Cyclic AMP; Cyclohexanols; Dopamine; Dronabinol; Electric Stimulation; Endocannabinoids; Female; Humans; Ligands; Male; Morpholines; Naphthalenes; Neocortex; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Synaptosomes; Tetrodotoxin; Tritium | 2004 |
Experimental parkinsonism alters anandamide precursor synthesis, and functional deficits are improved by AM404: a modulator of endocannabinoid function.
Topics: Acyltransferases; Amidohydrolases; Amphetamine; Analysis of Variance; Animals; Antiparkinson Agents; Arachidonic Acids; Behavior, Animal; Brain Chemistry; Cell Count; Central Nervous System Stimulants; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Endocannabinoids; Functional Laterality; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rotation; Serotonin Antagonists; Serotonin Receptor Agonists; Substantia Nigra; Tyrosine 3-Monooxygenase | 2004 |
Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors.
Topics: Animals; Cannabinoids; Endotoxins; Heart; Heart Rate; Hemodynamics; Hypotension; Male; Mice; Mice, Knockout; Myocardial Contraction; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Vascular Resistance | 2004 |
AMPA receptor-mediated presynaptic inhibition at cerebellar GABAergic synapses: a characterization of molecular mechanisms.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Benzoxazines; Calcium; Calcium Channel Blockers; Cerebellum; Chelating Agents; Colforsin; Cyclopropanes; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Wistar; Receptors, AMPA; Ryanodine; Synapses; Triazines; Triazoles | 2004 |
Anandamide decreases glomerular filtration rate through predominant vasodilation of efferent arterioles in rat kidneys.
Topics: Animals; Arachidonic Acids; Arterioles; Blood Pressure; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Endocannabinoids; Glomerular Filtration Rate; Immunohistochemistry; Kidney; Kidney Glomerulus; Male; Microscopy, Fluorescence; Nephrons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2004 |
Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury.
Topics: Animals; Benzoxazines; Burns; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Hot Temperature; Hyperalgesia; Indoles; Male; Morpholines; Naphthalenes; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Pain Measurement; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Reflex; Skin | 2004 |
Cannabinoids enhance N-methyl-D-aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices.
Topics: Action Potentials; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cyclohexanols; Drug Interactions; Electrophysiology; Endocannabinoids; Excitatory Amino Acid Agonists; In Vitro Techniques; Locus Coeruleus; Male; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Endocannabinoid transport tightly controls 2-arachidonoyl glycerol actions in the hippocampus: effects of low temperature and the transport inhibitor AM404.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Biological Transport; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Excitatory Postsynaptic Potentials; Glycerides; Hippocampus; In Vitro Techniques; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Temperature; Tritium | 2004 |
Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Synergism; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hippocampus; In Vitro Techniques; Isoenzymes; Male; Meloxicam; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Prostaglandin-Endoperoxide Synthases; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazines; Thiazoles | 2004 |
Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Benzoxazines; Brain Stem; Calcium Signaling; Cannabinoid Receptor Modulators; Endocannabinoids; Evoked Potentials, Auditory, Brain Stem; Glycine; Ion Transport; Morpholines; Naphthalenes; Nerve Endings; Patch-Clamp Techniques; Picrotoxin; Piperidines; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Resorcinols; Scopolamine; Synaptic Transmission; Xanthenes | 2004 |
Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
Topics: Animals; Cannabinoids; Gastrointestinal Transit; Lipopolysaccharides; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Time Factors | 2004 |
CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzoxazines; Dose-Response Relationship, Drug; Drug Synergism; Male; Maze Learning; Mice; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentylenetetrazole; Piperidines; Pyrazoles; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Opioid; Seizures; Statistics, Nonparametric; Time Factors | 2004 |
Endocannabinoid-mediated metaplasticity in the hippocampus.
Topics: Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Radiation; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Neuronal Plasticity; Neurons; Picrotoxin; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Synapses; Time Factors | 2004 |
Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Dose-Response Relationship, Drug; Eating; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Inbred Lew; Receptor, Cannabinoid, CB1; Time Factors | 2004 |
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Blood Pressure; Camphanes; Carbamates; Dronabinol; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Models, Cardiovascular; Myocardial Contraction; Myocardium; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Up-Regulation; Vascular Resistance; Vasodilation; Ventricular Function, Left | 2004 |
Involvement of CB1-receptors and beta-adrenoceptors in the regional hemodynamic responses to lipopolysaccharide infusion in conscious rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Consciousness; Disease Models, Animal; Drug Interactions; Endotoxemia; Lipopolysaccharides; Male; Piperidines; Propanolamines; Propranolol; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Adrenergic, beta; Sympathetic Nervous System; Tachycardia; Vasodilation | 2005 |
Cannabinoid receptor I activation markedly inhibits human decidualization.
Topics: Apoptosis; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cyclic AMP; Decidua; DNA-Binding Proteins; Endometrium; Female; Fibroblasts; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; In Situ Nick-End Labeling; Insulin-Like Growth Factor Binding Protein 1; Laminin; Left-Right Determination Factors; Morpholines; Naphthalenes; Piperidines; Prolactin; Pyrazoles; Receptor, Cannabinoid, CB1; RNA, Messenger; Stromal Cells; Tissue Inhibitor of Metalloproteinase-3; Transcription Factors; Transforming Growth Factor beta | 2005 |
In vitro metabolism of diarylpyrazoles, a novel group of cannabinoid receptor ligands.
Topics: Animals; Chromatography, High Pressure Liquid; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Morpholines; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Rimonabant | 2005 |
AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation.
Topics: Animals; Arachidonic Acids; Capsaicin; Constriction; Dose-Response Relationship, Drug; Endocannabinoids; Immunohistochemistry; Indoles; Male; Physical Stimulation; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord | 2005 |
Amnestic effect of intrahippocampal AM251, a CB1-selective blocker, in the inhibitory avoidance, but not in the open field habituation task, in rats.
Topics: Animals; Arousal; Avoidance Learning; Cannabinoids; Dominance, Cerebral; Dose-Response Relationship, Drug; Exploratory Behavior; Fear; Habituation, Psychophysiologic; Hippocampus; Inhibition, Psychological; Injections; Male; Memory, Short-Term; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Retention, Psychology | 2005 |
CB(1) cannabinoid receptor stimulation modulates transient receptor potential vanilloid receptor 1 activities in calcium influx and substance P Release in cultured rat dorsal root ganglion cells.
Topics: Animals; Bradykinin; Calcium; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Capsaicin; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dose-Response Relationship, Drug; Dronabinol; Enzyme Induction; Enzyme Inhibitors; Ganglia, Spinal; Isoquinolines; Male; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Substance P; Sulfonamides; Time Factors | 2005 |
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoxazines; Blotting, Western; Calcium; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neurotransmitter Agents; Piperidines; Potassium; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synapses; Synaptosomes; Tetrodotoxin; Tritium; Tyrosine 3-Monooxygenase; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2 | 2005 |
Induction of cyclooxygenase-2 by anandamide in cerebral microvascular endothelium.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Cell Culture Techniques; Cells, Cultured; Cyclooxygenase 2; Endocannabinoids; Endothelium, Vascular; Enzyme Induction; Kinetics; Mice; Piperidines; Polyunsaturated Alkamides; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Telencephalon; Thymidine | 2005 |
mGluRs induce a long-term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors.
Topics: Animals; Animals, Newborn; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Indoles; Long-Term Synaptic Depression; Maleimides; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Protein Subunits; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Spider Venoms; Synaptic Transmission; Ventral Tegmental Area | 2005 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
CB1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat.
Topics: Animals; Benzoxazines; Brain; Dronabinol; Electrodes, Implanted; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation | 2005 |
Stimulation of cannabinoid (CB1) and prostanoid (EP2) receptors opens BKCa channels and relaxes ocular trabecular meshwork.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Adult; Aged; Animals; Benzoxazines; Calcium; Calcium Channel Blockers; Cannabinoids; Carbachol; Cattle; Cells, Cultured; Cholinergic Agonists; Cyclic AMP; Cyclohexanols; Endothelin-1; Humans; In Vitro Techniques; Ion Channel Gating; Middle Aged; Morpholines; Naphthalenes; Patch-Clamp Techniques; Peptides; Piperidines; Potassium Channels, Calcium-Activated; Prostanoic Acids; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Prostaglandin E; Stimulation, Chemical; Trabecular Meshwork | 2005 |
Differential effects of endocannabinoids on [(3)H]-GABA uptake in the rat globus pallidus.
Topics: Animals; Arachidonic Acids; Binding, Competitive; Cannabinoid Receptor Modulators; Endocannabinoids; gamma-Aminobutyric Acid; Globus Pallidus; Glycerides; In Vitro Techniques; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Tritium | 2005 |
Sex differences in the cannabinoid modulation of an A-type K+ current in neurons of the mammalian hypothalamus.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; Benzoxazines; beta-Endorphin; Calcium Channel Blockers; Cannabinoids; Dose-Response Relationship, Drug; Drug Interactions; Female; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Sex Characteristics; Tetrodotoxin | 2005 |
Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors.
Topics: Animals; Apoptosis; Bone and Bones; Bone Density; Bone Resorption; Camphanes; Carrier Proteins; Cells, Cultured; Female; Indoles; Ligands; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoclasts; Ovariectomy; Piperidines; Pyrazoles; Rabbits; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2005 |
Functional role of the endocannabinoid system and AMPA/kainate receptors in 5-HT2A receptor-mediated wet dog shakes.
Topics: Amphetamines; Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Ketanserin; Male; Piperidines; Pyrazoles; Quinoxalines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT2A; Receptors, AMPA; Receptors, Kainic Acid; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Receptor Agonists | 2005 |
Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arachidonic Acids; Desipramine; Dose-Response Relationship, Drug; Dronabinol; Male; Motor Activity; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Swimming | 2005 |
The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats.
Topics: Animals; Appetite Depressants; Avoidance Learning; Conditioning, Psychological; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Male; Nausea; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Taste | 2005 |
Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Hypothalamus; Male; Neuropeptide Y; Organ Culture Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley | 2005 |
Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Bile Ducts; Cardiomyopathies; Endocannabinoids; Gene Expression; Liver Cirrhosis, Experimental; Male; Myocardial Contraction; Papillary Muscles; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrodotoxin; Ventricular Function, Left | 2005 |
Regulation of IPSP theta rhythm by muscarinic receptors and endocannabinoids in hippocampus.
Topics: Action Potentials; Amino Acids; Animals; Cannabinoid Receptor Modulators; Carbachol; Cholinergic Agonists; Endocannabinoids; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Neural Inhibition; Piperidines; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Spectrum Analysis; Synapses; Theta Rhythm; Time Factors; Xanthenes | 2005 |
Cannabinoids modulate synaptic activity in the rat supraoptic nucleus.
Topics: Anesthetics, Local; Animals; Cannabinoids; Cyclohexanols; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Membrane Potentials; Neurons, Afferent; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Supraoptic Nucleus; Synapses; Tetrodotoxin | 2005 |
The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis.
Topics: Acute Disease; Animals; Arachidonic Acids; Blood Pressure; Disease Models, Animal; Endocannabinoids; Fluorescent Antibody Technique, Indirect; Immunohistochemistry; Male; Pancreatitis, Acute Necrotizing; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Survival Rate; Taurocholic Acid; Time Factors | 2005 |
Anxiogenic profile of AM-251, a selective cannabinoid CB1 receptor antagonist, in plus-maze-naïve and plus-maze-experienced mice.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2005 |
The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats.
Topics: Adamantane; Animals; Dose-Response Relationship, Drug; Dronabinol; Mice; Muscarinic Antagonists; Pattern Recognition, Visual; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Scopolamine; Task Performance and Analysis | 2005 |
Behavioral pharmacological properties of a novel cannabinoid 1',1'-dithiolane delta8-THC analog, AMG-3.
Topics: Animals; Behavior, Animal; Binding, Competitive; Cannabinoids; Catalepsy; Cell Membrane; Cerebral Cortex; Cyclohexanols; Dose-Response Relationship, Drug; Male; Molecular Structure; Motor Activity; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Time Factors; Tritium | 2005 |
Effects of cannabinoid receptor activation on rabbit bisected vas deferens strips.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Dose-Response Relationship, Drug; Endocannabinoids; In Vitro Techniques; Indoles; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Naloxone; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Sympathetic Nervous System; Vas Deferens | 2005 |
Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus.
Topics: Animals; Arachidonic Acids; Benzoxazines; Benzyl Compounds; Cannabinoid Receptor Modulators; Cannabinoids; Endocannabinoids; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycerides; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Polyunsaturated Alkamides; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Supraoptic Nucleus; Synaptic Transmission | 2005 |
AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion.
Topics: Animals; Body Weight; Central Nervous System; Drug Tolerance; Eating; Male; Piperidines; Pyrazoles; Rats; Rats, Inbred Lew; Receptor, Cannabinoid, CB1; Taste | 2006 |
Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus.
Topics: Adenosine; Analgesics; Animals; Benzoxazines; Calcium Channel Blockers; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity; Time Factors | 2005 |
Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum.
Topics: Animals; Aspartic Acid; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cerebellum; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Radiation; Electric Stimulation; Endocannabinoids; Epistasis, Genetic; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Long-Term Synaptic Depression; Membrane Potentials; Methoxyhydroxyphenylglycol; Morpholines; Naphthalenes; Neurons; Nitrendipine; Patch-Clamp Techniques; Piperidines; Pyrazoles; Quinpirole; Rats; Rats, Sprague-Dawley; Sulpiride; Time Factors | 2005 |
Subcellular localization of type 1 cannabinoid receptors in the rat basal ganglia.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Basal Ganglia; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Morpholines; Naphthalenes; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2006 |
Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats.
Topics: Animals; Arachidonic Acids; Camphanes; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Antagonism; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism | 2006 |
Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Apamin; Barium; Benzopyrans; Caffeine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Charybdotoxin; Diclofenac; Dimethyl Sulfoxide; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Guanethidine; Guinea Pigs; Ileum; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Relaxation; Muscle, Smooth; Myosin Light Chains; Nitroarginine; Papaverine; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Protein Serine-Threonine Kinases; Pyrazoles; Receptor, Cannabinoid, CB1; rho-Associated Kinases; Tetraethylammonium; Vasodilator Agents | 2006 |
Activation of cannabinoid CB1 receptors induces glucose intolerance in rats.
Topics: Animals; Arachidonic Acids; Blood Glucose; Cannabinoid Receptor Modulators; Endocannabinoids; Glucose Intolerance; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2006 |
F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist.
Topics: Alanine; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Gene Expression; Humans; Indoles; Molecular Structure; Pertussis Toxin; Phenylalanine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Tritium | 2006 |
AM251, a selective antagonist of the CB1 receptor, inhibits the induction of long-term potentiation and induces retrograde amnesia in rats.
Topics: Amnesia, Retrograde; Animals; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reaction Time; Receptor, Cannabinoid, CB1 | 2006 |
Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain.
Topics: Acute Disease; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Area Under Curve; Cannabinoid Receptor Modulators; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Endocannabinoids; Ibuprofen; Indoles; Inflammation; Male; Pain; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Random Allocation; Rats | 2006 |
Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism.
Topics: Antineoplastic Agents; Apoptosis; Cannabinoids; Cell Line, Tumor; Cell Proliferation; Humans; Inhibitory Concentration 50; Pancreatic Neoplasms; Piperidines; Pyrazoles; Receptors, Cannabinoid | 2006 |
The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Benzoxazines; Cerebellar Cortex; Female; Hippocampus; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Immunoelectron; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Purkinje Cells; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity; Subcellular Fractions; Synaptic Membranes | 2006 |
The effects of cannabinoids on contextual conditioned fear in CB1 knockout and CD1 mice.
Topics: Amygdala; Animals; Benzoxazines; Cannabinoids; Conditioning, Psychological; Cues; Electroshock; Exploratory Behavior; Fear; Hippocampus; Ligands; Male; Mice; Mice, Knockout; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction | 2006 |
Influence of intracerebroventricular administration of cannabinergic drugs on morphine state-dependent memory in the step-down passive avoidance test.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Benzoxazines; Injections, Intraventricular; Male; Memory; Mice; Morphine; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2006 |
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Neuronal Plasticity; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Time Factors | 2006 |
Cannabinoid modulation of electrically evoked pH and oxygen transients in the nucleus accumbens of awake rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cerebrovascular Circulation; Electric Stimulation; Energy Metabolism; Hydrogen-Ion Concentration; Male; Medial Forebrain Bundle; Morpholines; Naphthalenes; Nucleus Accumbens; Oxygen Consumption; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis.
Topics: Animals; Antidepressive Agents, Tricyclic; Cannabinoid Receptor Modulators; Cortisone; Depressive Disorder, Major; Desipramine; Disease Models, Animal; Drug Administration Schedule; Endocannabinoids; Gene Expression Regulation; Hippocampus; Hypothalamo-Hypophyseal System; Male; Norepinephrine; Paraventricular Hypothalamic Nucleus; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Psychological; Up-Regulation | 2006 |
Blockade of cannabinoid CB1 receptors alters contextual learning and memory.
Topics: Animals; Learning; Male; Memory; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1 | 2006 |
Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists.
Topics: Animals; Appetitive Behavior; Attention; Cues; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Habituation, Psychophysiologic; Injections, Intraperitoneal; Maze Learning; Motivation; Orientation; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reversal Learning | 2006 |
Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs.
Topics: Action Potentials; Amygdala; Animals; Association Learning; Behavior, Animal; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Fear; Male; Morpholines; Naphthalenes; Neuronal Plasticity; Neurons; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley | 2006 |
2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts.
Topics: Animals; Arachidonic Acids; Blood Pressure; Cannabinoid Receptor Modulators; Coronary Vessels; Endocannabinoids; Glycerides; Heart; Heart Rate; Indoles; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Regional Blood Flow | 2006 |
Sustained elevation of dendritic calcium evokes widespread endocannabinoid release and suppression of synapses onto cerebellar Purkinje cells.
Topics: Animals; Calcium; Cannabinoid Receptor Modulators; Cerebellum; Dendrites; Dose-Response Relationship, Radiation; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; In Vitro Techniques; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Synapses; Time Factors | 2006 |
Effects of the CB1 cannabinoid receptor inverse agonist AM251 on food intake and body weight in mice lacking mu-opioid receptors.
Topics: Animals; Appetite Regulation; Body Weight; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Mice; Mice, Knockout; Opioid Peptides; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu | 2006 |
CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action.
Topics: Acetylcholine; Animals; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Hippocampus; Immunoassay; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Models, Biological; Neurons; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Rimonabant; Vesicular Acetylcholine Transport Proteins | 2006 |
Multiple forms of long-term plasticity at unitary neocortical layer 5 synapses.
Topics: Animals; Animals, Newborn; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Free Radical Scavengers; Imidazoles; In Vitro Techniques; Neocortex; Neuronal Plasticity; Neurons; NG-Nitroarginine Methyl Ester; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses | 2007 |
Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Recurrence; Reward | 2006 |
The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells.
Topics: Analysis of Variance; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Line; Cell Movement; Chemotaxis; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Endothelial Cells; Flow Cytometry; Humans; Indoles; Interleukin-8; L-Lactate Dehydrogenase; Morpholines; Naphthalenes; Neutrophils; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Thapsigargin; Tumor Necrosis Factor-alpha | 2006 |
Spinal modulation of calcitonin gene-related peptide by endocannabinoids in the development of opioid physical dependence.
Topics: Animals; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Drug Administration Schedule; Endocannabinoids; Ganglia, Spinal; Hot Temperature; Immunologic Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociceptors; Opioid-Related Disorders; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RNA, Messenger; Spinal Cord; Substance Withdrawal Syndrome | 2006 |
Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; Animals; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cocaine; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Ketamine; Macaca mulatta; Male; Midazolam; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2006 |
Opposing modifications in intrinsic currents and synaptic inputs in post-traumatic mossy cells: evidence for single-cell homeostasis in a hyperexcitable network.
Topics: Animals; Animals, Newborn; Computer Simulation; Craniocerebral Trauma; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Models, Neurological; Mossy Fibers, Hippocampal; Nerve Net; Neurons; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyrazoles; Pyrimidines; Rats; Sodium Channel Blockers; Tetraethylammonium; Tetrodotoxin | 2007 |
Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Hot Temperature; Hyperalgesia; In Vitro Techniques; Morpholines; Naphthalenes; Neurons; Nociceptors; Pain; Peripheral Nervous System Diseases; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord | 2006 |
Inhibition of salivary secretion by activation of cannabinoid receptors.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Colforsin; Cyclic AMP; Endocannabinoids; Immunohistochemistry; Indoles; Male; Methacholine Chloride; Norepinephrine; Parasympathomimetics; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Saliva; Submandibular Gland; Sympathomimetics | 2006 |
Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with Delta9-tetrahydrocannabinol.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Hallucinogens; Humans; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Macaca mulatta; Male; Midazolam; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2006 |
Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Bicuculline; Cannabinoid Receptor Modulators; Cannabinoids; Cell Differentiation; Chromatography, High Pressure Liquid; Endocannabinoids; GABA Antagonists; gamma-Aminobutyric Acid; Histamine; Hypothalamus; Immunohistochemistry; Male; Microdialysis; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Time Factors; Wakefulness | 2006 |
Local interneurons regulate synaptic strength by retrograde release of endocannabinoids.
Topics: Action Potentials; Animals; Calcium Chloride; Calcium Signaling; Cannabinoid Receptor Modulators; Cerebellar Cortex; Egtazic Acid; Endocannabinoids; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Interneurons; Lipoprotein Lipase; Mice; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2006 |
Developmental switch from LTD to LTP in low frequency-induced plasticity.
Topics: Age Factors; Animals; Animals, Newborn; Benzoxazines; Calcium Channel Blockers; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Morpholines; N-Methylaspartate; Naphthalenes; Phenylacetates; Piperidines; Pyrazoles; Rats | 2006 |
Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.
Topics: Animals; Arachidonic Acids; Bile Ducts; Blood Flow Velocity; Blood Pressure; Blotting, Western; Capsaicin; Cardiac Output; Disease Models, Animal; Endocannabinoids; Hyperemia; Indoles; Liver Circulation; Liver Cirrhosis, Biliary; Male; Mesenteric Artery, Superior; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Splanchnic Circulation; Time Factors; TRPV Cation Channels; Vascular Resistance; Vasodilation; Vasodilator Agents | 2006 |
Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Hindlimb; Hyperesthesia; Male; Morpholines; Naphthalenes; Nociceptors; Pain Threshold; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Spinal Cord Compression; Spinal Cord Injuries; Thoracic Vertebrae | 2007 |
Endocannabinoids modulate stress-induced suppression of hippocampal cell proliferation and activation of defensive behaviours.
Topics: Aggression; Animals; Arachidonic Acids; Behavior, Animal; Bromodeoxyuridine; Cannabinoid Receptor Modulators; Cell Count; Cell Proliferation; Endocannabinoids; Enzyme Inhibitors; Hippocampus; Immunohistochemistry; Male; Neural Inhibition; Odorants; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Stress, Psychological; Thiazoles | 2006 |
CB(1) cannabinoid receptors inhibit the glutamatergic component of KCl-evoked excitation of locus coeruleus neurons in rat brain slices.
Topics: Action Potentials; Analysis of Variance; Animals; Benzoxazines; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agents; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Locus Coeruleus; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Picrotoxin; Piperidines; Potassium Chloride; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Time Factors | 2007 |
Estrogen differentially modulates the cannabinoid- induced presynaptic inhibition of amino acid neurotransmission in proopiomelanocortin neurons of the arcuate nucleus.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Electric Stimulation; Estradiol; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; In Vitro Techniques; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Pro-Opiomelanocortin; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Receptors, Glutamate; Statistics, Nonparametric | 2006 |
Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Benzoxazines; Cells, Cultured; Disease Models, Animal; Drug Interactions; Epilepsy; Hippocampus; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Synaptic Transmission | 2007 |
Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Association Learning; Avoidance Learning; Benzamides; Carbamates; Conditioning, Classical; Dose-Response Relationship, Drug; Endocannabinoids; Injections, Intraperitoneal; Lithium Chloride; Male; Nausea; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Vomiting | 2007 |
Effect of delta9-tetrahydrocannabinol on quinine palatability and AM251 on sucrose and quinine palatability using the taste reactivity test.
Topics: Animals; Avoidance Learning; Cannabinoid Receptor Agonists; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Food Preferences; Male; Piperidines; Psychotropic Drugs; Pyrazoles; Quinine; Rats; Receptors, Cannabinoid; Single-Blind Method; Sucrose; Taste | 2007 |
Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray.
Topics: Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Male; Maze Learning; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2007 |
Cyclosporine attenuates the adenylyl cyclase superactivation induced by chronic cannabinoid treatment.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cell Line, Tumor; Cyclosporine; Humans; Immunosuppressive Agents; Morpholines; Naphthalenes; Piperidines; Pyrazoles | 2007 |
Effect of chronic CB1 cannabinoid receptor antagonism on livers of rats with biliary cirrhosis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonate 5-Lipoxygenase; Collagen; Leukotriene D4; Liver; Liver Cirrhosis, Biliary; Male; Mesenteric Artery, Superior; Microcirculation; Phospholipases A; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Regional Blood Flow; Thromboxane B2; Transforming Growth Factor beta; Vascular Resistance | 2007 |
The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptors.
Topics: Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Biphenyl Compounds; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Glycerides; Indoles; Male; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2007 |
Impact of cannabinoid receptor ligands on behavioural sensitization to antiaggressive methamphetamine effects in the model of mouse agonistic behaviour.
Topics: Agonistic Behavior; Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Central Nervous System Stimulants; Drug Administration Schedule; Drug Interactions; Indoles; Ligands; Male; Methamphetamine; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Random Allocation; Receptors, Cannabinoid; Statistics, Nonparametric | 2006 |
Cannabinoids in acute gastric damage and pancreatitis.
Topics: Acute Disease; Animals; Arachidonic Acids; Cannabinoids; Ceruletide; DNA; Endocannabinoids; Gastric Mucosa; Interleukin-1beta; Male; Pancreas; Pancreatitis; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Restraint, Physical; Stomach Ulcer; Stress, Physiological | 2006 |
Effects of inhibition of fatty acid amide hydrolase vs. the anandamide membrane transporter on TRPV1-mediated calcium responses in adult DRG neurons; the role of CB receptors.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium; Capsaicin; Carbamates; Cells, Cultured; Dopamine; Drug Interactions; Endocannabinoids; Fura-2; Furans; Ganglia, Spinal; Male; Membrane Potentials; Membrane Transport Proteins; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2006 |
Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro.
Topics: Animals; Arachidonic Acids; Benzoxazines; Blood Pressure; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Mesenteric Arteries; Morpholines; Muscle, Skeletal; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Renal Circulation; Splanchnic Circulation; Time Factors; Vascular Resistance; Vasoconstriction; Vasodilation; Vasodilator Agents | 2007 |
Role of dorsal hippocampal cannabinoid receptors and nitric oxide in anxiety like behaviours in rats using the elevated plus-maze test.
Topics: Analgesics; Animals; Anxiety; Arginine; Benzoxazines; Cannabinoids; Enzyme Inhibitors; Hippocampus; Male; Microinjections; Morpholines; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Stereotaxic Techniques | 2007 |
CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Cannabinoids; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Piperidines; Presynaptic Terminals; Pyrazoles; Receptor, Cannabinoid, CB1; Synaptosomes | 2007 |
Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography.
Topics: Animals; Arachidonic Acids; Autoradiography; Benzamides; Binding, Competitive; Brain; Carbamates; Cryoultramicrotomy; Drug Interactions; Endocannabinoids; Enzyme Inhibitors; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Organophosphonates; Piperidines; Pyrazoles; Radiography; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sulfones | 2007 |
Effects of cannabinoid receptors on skeletal muscle oxidative pathways.
Topics: Adult; AMP-Activated Protein Kinases; Arachidonic Acids; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Female; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Heat-Shock Proteins; Humans; Male; Multienzyme Complexes; Muscle Fibers, Skeletal; Muscle, Skeletal; Obesity; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Piperidines; Polyunsaturated Alkamides; Protein Kinases; Protein Serine-Threonine Kinases; Pyrazoles; Receptor, Cannabinoid, CB1; RNA, Messenger; Thinness; Transcription Factors | 2007 |
The in vitro and in vivo cardiovascular effects of Delta9-tetrahydrocannabinol in rats made hypertensive by chronic inhibition of nitric-oxide synthase.
Topics: Animals; Blood Pressure; Dronabinol; Enzyme Inhibitors; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Vasodilation | 2007 |
Retrograde regulation of GABA transmission by the tonic release of oxytocin and endocannabinoids governs postsynaptic firing.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoxazines; Calcium; Cannabinoid Receptor Modulators; Egtazic Acid; Endocannabinoids; Extracellular Fluid; Female; gamma-Aminobutyric Acid; Hypothalamus, Anterior; Male; Morpholines; Naphthalenes; Oxytocin; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2007 |
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models.
Topics: Animals; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Carbamates; Disease Models, Animal; Dopamine; Dopamine D2 Receptor Antagonists; Endocannabinoids; Excitatory Postsynaptic Potentials; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Mice, Transgenic; Morpholines; Naphthalenes; Neostriatum; Neuronal Plasticity; Oxidopamine; Parkinson Disease; Piperidines; Psychomotor Performance; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Reserpine; Synapses | 2007 |
Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats.
Topics: Adenosine Triphosphate; Aminoacetonitrile; Analysis of Variance; Animals; Behavior, Animal; Brain; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinase Type 2; CREB-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Male; Maze Learning; Motor Activity; Piperidines; Proto-Oncogene Proteins c-fos; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley | 2007 |
Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus.
Topics: Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cells, Cultured; Disease Models, Animal; Drug Interactions; Drug Tolerance; Hippocampus; Lorazepam; Magnesium; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2007 |
2-Arachidonylglyceryl ether and abnormal cannabidiol-induced vascular smooth muscle relaxation in rabbit pulmonary arteries via receptor-pertussis toxin sensitive G proteins-ERK1/2 signaling.
Topics: Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids; Glycerides; In Vitro Techniques; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pertussis Toxin; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pulmonary Artery; Pyrazoles; Rabbits; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Resorcinols; Rimonabant; Vasodilation; Vasodilator Agents | 2007 |
Cannabinoid receptor antagonists counteract sensorimotor gating deficits in the phencyclidine model of psychosis.
Topics: Animals; Brain; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Phencyclidine; Piperidines; Psychoses, Substance-Induced; Pyrazoles; Rats; Receptors, Cannabinoid; Reflex, Startle; Rimonabant; Schizophrenia; Sensation Disorders; Synaptic Transmission | 2007 |
Cannabinoid action in the olfactory epithelium.
Topics: Action Potentials; Animals; Calcium Signaling; Cannabinoids; In Vitro Techniques; Larva; Olfactory Mucosa; Olfactory Receptor Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Xenopus laevis | 2007 |
Acute activation of CB1 cannabinoid receptors transiently decreases PSA-NCAM expression in the dentate gyrus of the rat hippocampus.
Topics: Animals; Cannabinoids; Cell Count; Cell Differentiation; Cell Proliferation; Dentate Gyrus; Dose-Response Relationship, Drug; Doublecortin Domain Proteins; Doublecortin Protein; Down-Regulation; Dronabinol; Excitatory Amino Acid Antagonists; Immunohistochemistry; Ki-67 Antigen; Male; Memory Disorders; Microtubule-Associated Proteins; Neural Cell Adhesion Molecule L1; Neuronal Plasticity; Neurons; Neuropeptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sialic Acids; Stem Cells; Time Factors | 2007 |
Synaptic regulation of proopiomelanocortin neurons can occur distal to the arcuate nucleus.
Topics: Afferent Pathways; Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; Benzoxazines; Calcium Channel Blockers; Functional Laterality; Green Fluorescent Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pro-Opiomelanocortin; Pyrazoles; Synapses | 2007 |
Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2.
Topics: Aging; Animals; Anxiety; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Cannabinoid; Species Specificity | 2007 |
Cannabinoid modulation of neuronal function after oxygen/glucose deprivation in area CA1 of the rat hippocampus.
Topics: Animals; Benzoxazines; Cannabinoids; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Space; Female; Glucose; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2007 |
Estrogen recruits the endocannabinoid system to modulate emotionality.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Modulators; Emotions; Endocannabinoids; Estrogens; Female; Maze Learning; Ovariectomy; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Swimming | 2007 |
Involvement of cannabinoid (CB1)-receptors in the development and maintenance of opioid tolerance.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Tolerance; Ganglia, Spinal; Injections, Spinal; Male; Morphine; Nociceptors; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Calcitonin Gene-Related Peptide | 2007 |
Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmission.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Anxiety; Benzoxazines; Cannabinoids; Chlordiazepoxide; Excitatory Postsynaptic Potentials; Exploratory Behavior; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Ligands; Male; Mice; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2007 |
Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret.
Topics: Acrylamides; Animals; Antiemetics; Arachidonic Acids; Area Postrema; Autonomic Pathways; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Cannabinoids; Capsaicin; Dopamine; Emetics; Endocannabinoids; Ferrets; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Solitary Nucleus; TRPV Cation Channels; Vagus Nerve; Vomiting | 2007 |
AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain.
Topics: Animals; Arachidonic Acids; Capsaicin; Endocannabinoids; Immunohistochemistry; Indoles; Inflammation; Male; Pain; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Spinal Cord; TRPV Cation Channels | 2007 |
AM 251 and beta-Funaltrexamine reduce fat intake in a fat-preferring strain of mouse.
Topics: Analysis of Variance; Animals; Choice Behavior; Dietary Fats; Eating; Energy Intake; Food Preferences; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Phenotype; Piperidines; Pyrazoles | 2007 |
Mechanisms for synapse specificity during striatal long-term depression.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Corpus Striatum; Excitatory Postsynaptic Potentials; Long-Term Synaptic Depression; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synapses; Synaptic Transmission | 2007 |
Role of cannabinoid CB2 receptors in glucose homeostasis in rats.
Topics: Animals; Cannabinoid Receptor Modulators; Glucose; Homeostasis; Immunohistochemistry; Islets of Langerhans; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2007 |
Cannabinoid-induced hyperphagia: correlation with inhibition of proopiomelanocortin neurons?
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Body Weight; Cannabinoids; Dose-Response Relationship, Drug; Drug Interactions; Eating; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agents; Guinea Pigs; Hyperphagia; Hypothalamus; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Piperidines; Pro-Opiomelanocortin; Pyrazoles; Statistics as Topic | 2007 |
Biphasic modulation of GABA release from stellate cells by glutamatergic receptor subtypes.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebellum; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Mice; Morpholines; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Pyrazoles; Quinoxalines; Receptors, AMPA | 2007 |
Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Arcuate Nucleus of Hypothalamus; Benzyl Compounds; Cannabinoid Receptor Modulators; Eating; Endocannabinoids; Glycerides; Hypothalamus; Immunohistochemistry; Male; Nucleus Accumbens; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Serotonin; Time Factors | 2007 |
Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum.
Topics: Animals; Animals, Newborn; Central Nervous System Depressants; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Ethanol; Evoked Potentials; In Vitro Techniques; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulpiride; Synaptic Transmission; Time Factors | 2007 |
Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice.
Topics: Animals; Benzoxazines; Cannabinoids; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Hypothermia; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2007 |
Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Hyperalgesia; Indoles; Male; Morpholines; Naphthalenes; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sciatic Nerve; Sciatic Neuropathy | 2007 |
Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats.
Topics: Amidohydrolases; Animals; Blood Pressure; Cannabinoid Receptor Modulators; Carbon Tetrachloride; Disease Models, Animal; Endocannabinoids; Liver Cirrhosis; Male; Myocardial Contraction; Myocardium; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2007 |
Presynaptic Inhibition of GABAA receptor-mediated unitary IPSPs by cannabinoid receptors at synapses between CCK-positive interneurons in rat hippocampus.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Cannabinoid Receptor Modulators; Cholecystokinin; Dose-Response Relationship, Radiation; Electric Stimulation; Endocannabinoids; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Male; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, GABA-A; Synapses | 2007 |
The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.
Topics: Analgesics; Analysis of Variance; Animals; Benzoxazines; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Hyperalgesia; Hyperesthesia; Indoles; Male; Morpholines; Naphthalenes; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Time Factors; Trigeminal Nerve Diseases | 2007 |
The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats.
Topics: Adamantane; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Cyclic AMP; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Eating; Male; Motor Activity; Nausea; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement, Psychology | 2008 |
Differential expression of posttetanic potentiation and retrograde signaling mediate target-dependent short-term synaptic plasticity.
Topics: Animals; Animals, Newborn; Cerebellum; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Gene Expression; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Piperidines; Probability; Pyrazoles; Rats; Rats, Sprague-Dawley; Signal Transduction; Synapses | 2007 |
Actions of N-arachidonyl-glycine in a rat neuropathic pain model.
Topics: Analgesics; Animals; Arachidonic Acids; Area Under Curve; Camphanes; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Glycine; Hyperalgesia; Male; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Sciatica | 2008 |
Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Signal-Regulated MAP Kinases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Mutation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction | 2007 |
The cannabinoid CB1 receptor antagonist AM251 does not modify methamphetamine reinstatement of responding.
Topics: Animals; Body Temperature; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Dronabinol; Infusions, Intravenous; Injections, Intraperitoneal; Male; Methamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Self Administration; Time Factors | 2007 |
Cannabinoid CB1 receptors of the dorsal hippocampus are important for induction of conditioned place preference (CPP) but do not change morphine CPP.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Calcium Channel Blockers; Conditioning, Operant; Dose-Response Relationship, Drug; Hippocampus; Male; Microinjections; Morphine; Morpholines; Motor Activity; Naloxone; Naphthalenes; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2007 |
Role of cannabinoid CB1 receptors and Gi/o protein activation in the modulation of synaptosomal Na+,K+-ATPase activity by WIN55,212-2 and delta(9)-THC.
Topics: Animals; Benzoxazines; Brain; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Enzyme Inhibitors; Female; GTP-Binding Protein alpha Subunits, Gi-Go; In Vitro Techniques; Mice; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Ouabain; Pertussis Toxin; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Sodium-Potassium-Exchanging ATPase; Synaptosomes | 2007 |
The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Hot Temperature; Hyperalgesia; Indoles; Male; Neuralgia; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Sciatic Nerve | 2007 |
Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.
Topics: Animals; Animals, Newborn; Cannabinoid Receptor Modulators; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; In Vitro Techniques; Neurons; Neurotensin; Patch-Clamp Techniques; Piperidines; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2008 |
CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour.
Topics: Amygdala; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Brain; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Hippocampus; Male; Maze Learning; Microinjections; Motor Activity; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Time Factors | 2008 |
Endocannabinoid modulation of male rat sexual behavior.
Topics: Amidohydrolases; Animals; Appetitive Behavior; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Consummatory Behavior; Dose-Response Relationship, Drug; Ejaculation; Endocannabinoids; Enzyme Inhibitors; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Sexual Behavior, Animal | 2008 |
Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Blood Pressure; Cannabinoids; Cardiovascular System; Consciousness; Endocannabinoids; Heart Rate; Hindlimb; Hypertension; Infusions, Intravenous; Injections, Intravenous; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptor, Cannabinoid, CB1; Renal Circulation; Species Specificity; Splanchnic Circulation; Vascular Resistance; Vasodilation | 2007 |
CB1 receptor-dependent and -independent inhibition of excitatory postsynaptic currents in the hippocampus by WIN 55,212-2.
Topics: Animals; Animals, Newborn; Benzoxazines; Calcium Channel Blockers; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1 | 2008 |
[The synthetic cannabinoid analog WIN 55,212-2 potentiates the amplitudes of glycine-activated currents].
Topics: Animals; Benzoxazines; Cannabinoids; Cells, Cultured; Chlorides; Glycine; Morpholines; Naphthalenes; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Glycine | 2007 |
Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Electric Stimulation; Endocannabinoids; Intestinal Mucosa; Intestines; Male; Membrane Potentials; Mice; Mice, Knockout; Muscle, Smooth; Myoelectric Complex, Migrating; Neuromuscular Junction; Organ Culture Techniques; Peristalsis; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reflex; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reward; Rimonabant; Self Administration | 2008 |
Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dentate Gyrus; Depression; Disease Models, Animal; Dronabinol; Hippocampus; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Psychological; Swimming | 2007 |
Elevation of pentylenetetrazole-induced seizure threshold in cholestatic mice: interaction between opioid and cannabinoid systems.
Topics: Animals; Anticonvulsants; Bile Ducts; Cannabinoid Receptor Modulators; Cholestasis; Disease Models, Animal; Dose-Response Relationship, Drug; Ligation; Male; Mice; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pentylenetetrazole; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid; Seizures; Time Factors | 2008 |
Effects of WIN55,212-2 on voltage-gated sodium channels in trigeminal ganglion neurons of rats.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Ion Channel Gating; Membrane Potentials; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Sodium Channels; Trigeminal Ganglion | 2008 |
A potential function of endocannabinoids in the selection of a navigation strategy by rats.
Topics: Animals; Arachidonic Acids; Blotting, Western; Cannabinoid Receptor Modulators; Circadian Rhythm; Darkness; Endocannabinoids; Hippocampus; Immunohistochemistry; Light; Male; Maze Learning; Microinjections; Neostriatum; Orientation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2008 |
Delta 9-tetrahydrocannabinol inhibits electrically-evoked CGRP release and capsaicin-sensitive sensory neurogenic vasodilatation in the rat mesenteric arterial bed.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Methoxamine; Neurons, Afferent; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Ruthenium Red; Time Factors; Vasodilation | 2007 |
Role of Ca2+-dependent potassium channels in in vitro anandamide-mediated mesenteric vasorelaxation in rats with biliary cirrhosis.
Topics: Acetylcholine; Animals; Apamin; Arachidonic Acids; Cannabinoid Receptor Modulators; Charybdotoxin; Common Bile Duct; Dose-Response Relationship, Drug; Endocannabinoids; Glyburide; Ligation; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Male; Mesenteric Artery, Superior; Nitroprusside; Peptides; Phenylephrine; Piperidines; Polyunsaturated Alkamides; Potassium; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Potassium Chloride; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2007 |
Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Pentylenetetrazole; Piperidines; Pyrazoles; Seizures | 2007 |
Actions of the endocannabinoid transport inhibitor AM404 in neuropathic and inflammatory pain models.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Carrier Proteins; Disease Models, Animal; Endocannabinoids; Freund's Adjuvant; Inflammation; Ligation; Male; Motor Activity; Pain; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sciatic Nerve; Sciatic Neuropathy; Time Factors | 2007 |
Acute anorectic response to cannabinoid CB1 receptor antagonist/inverse agonist AM 251 in rats: indirect behavioural mediation.
Topics: Animals; Appetite Depressants; Dose-Response Relationship, Drug; Drug Inverse Agonism; Eating; Feeding Behavior; Grooming; Injections, Intraperitoneal; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Satiety Response; Weight Gain; Weight Loss | 2007 |
Agonist-dependent cannabinoid receptor signalling in human trabecular meshwork cells.
Topics: Arachidonic Acids; Benzoxazines; Blotting, Western; Calcium Signaling; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Line; Cells, Cultured; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Trabecular Meshwork; Type C Phospholipases | 2007 |
Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function.
Topics: Animals; Antibodies, Blocking; Antibodies, Monoclonal; Appetite Depressants; Blotting, Western; Body Temperature; Brain-Derived Neurotrophic Factor; Cardiovascular System; Data Interpretation, Statistical; Eating; Hypothalamus; In Vitro Techniques; Injections, Intraventricular; Male; Melanocyte-Stimulating Hormones; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Melanocortin, Type 4; Signal Transduction; Stereotaxic Techniques; Telemetry | 2007 |
Long-term plasticity of the spinal locomotor circuitry mediated by endocannabinoid and nitric oxide signaling.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Endocannabinoids; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Lampreys; Motor Activity; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Nitric Oxide; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Metabotropic Glutamate; Signal Transduction; Spinal Cord; Synaptic Transmission; Time | 2007 |
Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior.
Topics: Animals; Benzazepines; Choice Behavior; Conditioning, Operant; Dopamine Antagonists; Feeding Behavior; Food Preferences; Injections, Intraperitoneal; Male; Motivation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Salicylamides | 2008 |
Cannabinoid regulation in identified synapse of terrestrial snail.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Radiation; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; Nervous System; Neurons; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Snails; Synapses; Tritium | 2007 |
Developmental decrease in short-term facilitation at Schaffer collateral synapses in hippocampus is mGluR1 sensitive.
Topics: Action Potentials; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Benzoates; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Phosphinic Acids; Piperidines; Propanolamines; Pyrazoles; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Synapses; Temperature | 2008 |
The cannabinoid antagonist AM251 attenuates nicotine self-administration and nicotine-seeking behaviour in rats.
Topics: Animals; Cannabinoids; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Food; Male; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Reinforcement, Psychology; Secondary Prevention; Self Administration; Tobacco Use Disorder | 2008 |
Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Corpus Striatum; Endocannabinoids; Furans; gamma-Aminobutyric Acid; Glutamic Acid; Glycerides; Long-Term Synaptic Depression; Membrane Potentials; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Synapses; Synaptic Transmission | 2007 |
Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids.
Topics: Analysis of Variance; Animals; Benzoxazines; Cannabinoid Receptor Modulators; Connexins; Cyclic AMP-Dependent Protein Kinases; Dopamine; Electric Stimulation; Endocannabinoids; Eye Proteins; Gap Junctions; Goldfish; Inhibitory Postsynaptic Potentials; Methoxyhydroxyphenylglycol; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Synapses; Synaptic Transmission; Tyrosine 3-Monooxygenase | 2007 |
Interaction between cannabinoid compounds and diazepam on anxiety-like behaviour of mice.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Data Interpretation, Statistical; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; GABA Modulators; Hypnotics and Sedatives; Male; Mice; Morpholines; Naphthalenes; Piperidines; Postural Balance; Pyrazoles; Receptor, Cannabinoid, CB1 | 2008 |
Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes.
Topics: Acetylation; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Cyclic AMP; Electroporation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Genes, Reporter; Humans; Interleukin-4; Jurkat Cells; Kinetics; Piperidines; Plasmids; Promoter Regions, Genetic; Pyrazoles; Receptor, Cannabinoid, CB1; STAT6 Transcription Factor; Statistics as Topic; T-Lymphocytes; Transcription, Genetic; Transfection | 2008 |
Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees.
Topics: Afferent Pathways; Anilides; Animals; Arachidonic Acids; Cinnamates; Knee Joint; Male; Nociceptors; Osteoarthritis, Knee; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2008 |
Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice.
Topics: Animals; Blood Glucose; Body Weight; Eating; Female; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Mice; Mice, Obese; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2008 |
A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient.
Topics: Animals; Antiemetics; Antipruritics; Cell Line; Croton; Ferrets; Male; Mice; Mice, Inbred C57BL; Morphine Derivatives; Nausea; Piperidines; Plant Extracts; Proanthocyanidins; Pruritus; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Vomiting | 2008 |
Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats.
Topics: Adrenal Medulla; Animals; Arachidonic Acids; Arginine Vasopressin; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Catecholamines; Cyclohexanones; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Epinephrine; Glycerides; Indoles; Injections, Intraventricular; Male; Morpholines; Naphthalenes; Norepinephrine; Organophosphonates; Piperidines; Pyrazoles; Rats; Rats, Wistar | 2008 |
Determination of endocannabinoid receptor antagonist SR141716 (rimonabant) in plasma by liquid chromatograph tandem mass spectrometry.
Topics: Animals; Area Under Curve; Calibration; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Chemical Fractionation; Chromatography, High Pressure Liquid; Drug Stability; Endocannabinoids; Feasibility Studies; Humans; Piperidines; Pyrazoles; Quality Control; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Reference Standards; Rimonabant; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
Activation of cannabinoid-1 receptors disrupts sensory gating and neuronal oscillation: relevance to schizophrenia.
Topics: Acoustic Stimulation; Action Potentials; Animals; Biological Clocks; Brain; Cyclohexanols; Disease Models, Animal; Electroencephalography; Evoked Potentials, Auditory; Fourier Analysis; Gait Disorders, Neurologic; Male; Maximum Tolerated Dose; Neural Pathways; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Wakefulness | 2008 |
Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antigens; Asthma; Camphanes; Cyclic AMP; Cyclohexanols; Deoxyguanosine; DNA Damage; Guinea Pigs; Humans; Leukocytes; Lung; Male; Mast Cells; Models, Biological; Ovalbumin; Piperidines; Prostaglandin D2; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tumor Necrosis Factor-alpha | 2008 |
Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice.
Topics: Animals; Appetite; Area Under Curve; Blood Glucose; Body Weight; Dietary Fats; Drug Evaluation, Preclinical; Drug Interactions; Eating; Female; Gastric Inhibitory Polypeptide; Glucose Intolerance; Glucose Tolerance Test; Injections, Intraperitoneal; Insulin; Insulin Resistance; Mice; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2008 |
The CB(1) cannabinoid receptor antagonist AM251 attenuates amphetamine-induced behavioural sensitization while causing monoamine changes in nucleus accumbens and hippocampus.
Topics: Amphetamine; Animals; Behavior, Animal; Biogenic Monoamines; Dopamine; Hippocampus; Hydroxyindoleacetic Acid; Male; Mice; Motor Activity; Nucleus Accumbens; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Serotonin | 2008 |
Endocannabinoid modulation of fear responses: learning and state-dependent performance effects.
Topics: Amygdala; Animals; Cannabinoid Receptor Modulators; Conditioning, Psychological; Cues; Data Interpretation, Statistical; Endocannabinoids; Extinction, Psychological; Fear; Hippocampus; Learning; Male; Memory; Mental Recall; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Psychomotor Performance; Pyrazoles; Receptor, Cannabinoid, CB1 | 2008 |
The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum.
Topics: Animals; Benzoxazines; Bicuculline; Cannabinoids; Cerebellum; Dronabinol; Electrophysiology; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Synapses; Synaptic Transmission | 2008 |
Anandamide modulates growth and lipid metabolism in the zebrafish Danio rerio.
Topics: Animals; Arachidonic Acids; Endocannabinoids; Gene Expression Regulation, Developmental; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Larva; Lipid Metabolism; Liver; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Sterol Regulatory Element Binding Proteins; Zebrafish | 2008 |
Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Cannabinoid Receptor Modulators; Endocannabinoids; gamma-Aminobutyric Acid; Hippocampus; Male; Memory; Motor Activity; Neural Inhibition; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2008 |
Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice.
Topics: Analysis of Variance; Animals; Autoradiography; Celecoxib; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Enzyme-Linked Immunosorbent Assay; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Membrane Potentials; Membrane Proteins; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Seizures; Statistics, Nonparametric; Sulfonamides; Synaptic Transmission | 2008 |
Endocannabinoids mediate neuron-astrocyte communication.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Astrocytes; Calcium; Cannabinoid Receptor Modulators; Cell Communication; Egtazic Acid; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Photolysis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Type C Phospholipases; Valine | 2008 |
Modulation by female sex hormones of the cannabinoid-induced catalepsy and analgesia in ovariectomized mice.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Catalepsy; Dose-Response Relationship, Drug; Estradiol; Estrogens; Female; Hot Temperature; Mice; Morpholines; Naphthalenes; Ovariectomy; Pain Measurement; Piperidines; Progesterone; Pyrazoles | 2008 |
Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Cannabidiol; Capsaicin; Gastric Emptying; Gastrointestinal Motility; Intestine, Small; Lipopolysaccharides; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sensory System Agents; Sepsis | 2008 |
Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats.
Topics: Anilides; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cinnamates; Cytokines; Drug Synergism; Indoles; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2008 |
Reply to the letter to the editor "Long-term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer".
Topics: Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Antineoplastic Agents; Carcinoma; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Humans; Mice; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2008 |
AM251 suppresses the viability of HepG2 cells through the AMPK (AMP-activated protein kinase)-JNK (c-Jun N-terminal kinase)-ATF3 (activating transcription factor 3) pathway.
Topics: Activating Transcription Factor 3; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Cannabinoids; Cell Line, Tumor; Cell Survival; Humans; JNK Mitogen-Activated Protein Kinases; Multienzyme Complexes; Phosphorylation; Piperidines; Protein Serine-Threonine Kinases; Pyrazoles; Ribonucleotides; Signal Transduction | 2008 |
Role of systemic endocannabinoid CB-1 receptor antagonism in the acquisition and expression of fructose-conditioned flavor-flavor preferences in rats.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Food Preferences; Fructose; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Saccharin; Sweetening Agents; Taste | 2008 |
Reciprocal inhibition of G-protein signaling is induced by CB(1) cannabinoid and GABA(B) receptor interactions in rat hippocampal membranes.
Topics: Allosteric Regulation; Animals; Benzoxazines; Binding, Competitive; Cell Membrane; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, GABA-B; Signal Transduction | 2008 |
Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo.
Topics: Animals; Arachidonic Acids; Male; Neurons; Nociceptors; Pain Measurement; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2008 |
Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells.
Topics: Arachidonic Acids; Caco-2 Cells; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Deoxyglucose; Dronabinol; Endocannabinoids; Humans; Indoles; Intestinal Absorption; Piperidines; Polyunsaturated Alkamides; Pyrazoles | 2008 |
Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats.
Topics: Animals; Anti-Anxiety Agents; Cannabidiol; Dose-Response Relationship, Drug; Male; Microinjections; Periaqueductal Gray; Piperazines; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Serotonin Antagonists | 2008 |
Activation of CB1 cannabinoid receptors in the dorsolateral periaqueductal gray reduces the expression of contextual fear conditioning in rats.
Topics: Animals; Arachidonic Acids; Blood Pressure; Conditioning, Operant; Endocannabinoids; Fear; Heart Rate; Male; Microinjections; Neurotransmitter Uptake Inhibitors; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2008 |
Cannabinoid-1 receptor antagonists reduce caloric intake by decreasing palatable diet selection in a novel dessert protocol in female rats.
Topics: Animals; Appetite Depressants; Body Weight; Diet; Drug Administration Schedule; Eating; Energy Intake; Female; Food Preferences; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Cannabinoid receptor blockade reveals parallel plasticity mechanisms in different layers of mouse visual cortex.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Evoked Potentials, Visual; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Vision, Monocular; Visual Cortex; Visual Pathways | 2008 |
Functional and immunohistochemical characterization of CB1 and CB2 receptors in rat bladder.
Topics: Animals; Calcitonin Gene-Related Peptide; Dronabinol; Female; Indoles; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tissue Culture Techniques; Urinary Bladder | 2008 |
The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors.
Topics: Amidohydrolases; Analgesics, Opioid; Animals; Arachidonic Acids; Benzamides; Benzomorphans; Cannabinoid Receptor Modulators; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Indoles; Male; Morphine; Organophosphonates; Pain; Pain Measurement; Piperazines; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia.
Topics: Acetaminophen; Analgesia; Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Endocannabinoids; Male; Mice; Mice, Knockout; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Serotonin; Serotonin | 2008 |
Effects of Delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes.
Topics: Animals; Benzoxazines; Cannabinoids; Cerebellum; Data Interpretation, Statistical; Dronabinol; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Membranes; Mice; Morpholines; Naphthalenes; Olfactory Pathways; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2008 |
Impairment of endocannabinoids activity in the dorsolateral striatum delays extinction of behavior in a procedural memory task in rats.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Corpus Striatum; Drug Administration Schedule; Endocannabinoids; Extinction, Psychological; Male; Maze Learning; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Statistics as Topic | 2008 |
Cannabinoid receptor ligands suppress memory-related effects of nicotine in the elevated plus maze test in mice.
Topics: Animals; Behavior, Animal; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Dose-Response Relationship, Drug; Drug Therapy, Combination; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Maze Learning; Memory; Mice; Morpholines; Naphthalenes; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Retention, Psychology | 2008 |
The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoids; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Injections, Intraperitoneal; Male; Mice; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Piperidines; Pyrazoles; Seizures | 2008 |
Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclic AMP; Cytosol; Dronabinol; Endocannabinoids; Glycerides; Group IV Phospholipases A2; Mice; Mice, Inbred ICR; PC12 Cells; Phosphorylation; Piperidines; Protein Kinase C; Proto-Oncogene Proteins c-fyn; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Signal Transduction; src-Family Kinases; Type C Phospholipases | 2008 |
High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum.
Topics: Action Potentials; Anesthesia; Animals; Benzodiazepines; Benzoxazines; Biological Clocks; Cannabinoids; Cerebellum; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Inhibitory Postsynaptic Potentials; Male; Models, Neurological; Morpholines; Naphthalenes; Picrotoxin; Piperidines; Purkinje Cells; Pyrazoles; Quinoxalines; Rats; Rats, Wistar; Reaction Time | 2008 |
Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Conditioning, Operant; Endocannabinoids; Extinction, Psychological; Hippocampus; Male; Memory; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2008 |
Additive subthreshold dose effects of cannabinoid CB(1) receptor antagonist and selective serotonin reuptake inhibitor in antidepressant behavioral tests.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mice; Mice, Inbred CBA; Models, Animal; Morpholines; Motor Activity; Nomifensine; Piperidines; Pyrazoles; Reboxetine; Receptor, Cannabinoid, CB1; Rimonabant; Selective Serotonin Reuptake Inhibitors; Sertraline; Swimming | 2008 |
Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels.
Topics: Amidohydrolases; Anilides; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzamides; Brain; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cinnamates; Diazepam; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Serotonin; TRPV Cation Channels | 2009 |
Cannabinoids and hamster circadian activity rhythms.
Topics: Analgesics; Animals; Benzofurans; Cannabinoids; Circadian Rhythm; Cricetinae; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2008 |
The cannabinoid receptor agonist CP-55,940 and ethyl arachidonate interfere with [(3)H]batrachotoxinin A 20 alpha-benzoate binding to sodium channels and inhibit sodium channel function.
Topics: Animals; Arachidonic Acids; Batrachotoxins; Brain; Cannabinoid Receptor Agonists; Cyclohexanols; Mice; Piperidines; Pyrazoles; Sodium Channels; Veratridine | 2008 |
The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats.
Topics: Animals; Appetite; Behavior, Animal; Feeding Behavior; Grooming; Injections, Intraperitoneal; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Satiety Response | 2008 |
Roles of endocannabinoids in heterosynaptic long-term depression of excitatory synaptic transmission in visual cortex of young mice.
Topics: Age Factors; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Calcium; Cannabinoid Receptor Modulators; Dose-Response Relationship, Radiation; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Immunoglobulin G; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Neural Pathways; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptor, trkB; Visual Cortex | 2008 |
Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antioxidants; Cannabinoid Receptor Antagonists; Cannabinoids; Cell Proliferation; Cell Survival; Colonic Neoplasms; Cyclic AMP; Dronabinol; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Fatty Acids, Unsaturated; Fluorouracil; Humans; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Piperidines; Pyrazoles; Receptors, Cannabinoid; Thymidine; Tumor Cells, Cultured | 2009 |
Chronic psychoemotional stress impairs cannabinoid-receptor-mediated control of GABA transmission in the striatum.
Topics: Animals; Chronic Disease; Corpus Striatum; Dronabinol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamates; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Glucocorticoid; Social Environment; Stress, Psychological; Synaptic Transmission | 2008 |
Regulation of bone mass, osteoclast function, and ovariectomy-induced bone loss by the type 2 cannabinoid receptor.
Topics: Animals; Bone and Bones; Bone Density; Bone Marrow Cells; Bone Resorption; Cannabinoids; Cells, Cultured; Coculture Techniques; Drug Evaluation, Preclinical; Drug Inverse Agonism; Female; Indoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; Osteoclasts; Ovariectomy; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2 | 2008 |
Inhibition of endocannabinoid metabolism attenuates enhanced hippocampal neuronal activity induced by kainic acid.
Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Hippocampus; Kainic Acid; Male; Neural Inhibition; Neurons; Piperidines; Pyrazoles; Rats | 2008 |
Oxytocin knockout mice: a model for studying stress-related and ingestive behaviours.
Topics: Animals; Body Temperature; Corticosterone; Crosses, Genetic; Environment; Feeding Behavior; Female; Fever; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxytocin; Piperidines; Pregnancy; Pyrazoles; Receptor, Cannabinoid, CB1; Stress, Psychological | 2008 |
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.
Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Carbamates; Carrageenan; Disease Models, Animal; Inflammation; Oxazoles; Pain; Piperidines; PPAR gamma; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Tyrosine | 2008 |
Effects of acute low-dose combined treatment with naloxone and AM 251 on food intake, feeding behaviour and weight gain in rats.
Topics: Animals; Drug Interactions; Eating; Feeding Behavior; Grooming; Male; Motor Activity; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Weight Gain | 2009 |
Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Hyperthyroidism; Hypothyroidism; In Vitro Techniques; Male; Piperidines; Pituitary Gland; Polyunsaturated Alkamides; Pyrazoles; Radioimmunoassay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Thyrotropin; Thyroxine; Triiodothyronine | 2008 |
Inhibiting parabrachial fatty acid amide hydrolase activity selectively increases the intake of palatable food via cannabinoid CB1 receptors.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brachial Plexus; Eating; Enzyme Inhibitors; Fluorescent Antibody Technique; Food Preferences; Immunohistochemistry; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Serotonin; Stimulation, Chemical | 2008 |
Effects of CB1 receptor antagonist within the nucleus accumbens on the acquisition and expression of morphine-induced conditioned place preference in morphine-sensitized rats.
Topics: Analysis of Variance; Animals; Association Learning; Behavior, Animal; Cannabinoid Receptor Modulators; Conditioning, Classical; Dose-Response Relationship, Drug; Male; Microinjections; Morphine; Narcotics; Nucleus Accumbens; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Statistics, Nonparametric | 2009 |
Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation.
Topics: Action Potentials; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Drug Interactions; Freund's Adjuvant; Inflammation; Male; Nerve Fibers, Myelinated; Neural Conduction; Nociceptors; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Skin | 2008 |
Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Autoradiography; Behavior, Animal; Cannabinoid Receptor Modulators; Conditioning, Operant; Eating; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Preferences; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Narcotic Antagonists; Peptides; Piperidines; Pons; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Sulfur Isotopes; Time Factors; Xanthines | 2008 |
Effects of a cannabinoid receptor (CB) 1 antagonist AM251 on behavioral sensitization to nicotine in a rat model of novelty-seeking behavior: correlation with hippocampal 5HT.
Topics: Animals; Behavior, Animal; Bupropion; Dose-Response Relationship, Drug; Exploratory Behavior; Hippocampus; Locomotion; Male; Microdialysis; Models, Animal; Nicotine; Nicotinic Agonists; Phenotype; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Serotonin; Smoking Cessation | 2009 |
Cannabinoid receptor antagonism increases female sexual motivation.
Topics: Animals; Cannabinoid Receptor Antagonists; Estradiol; Female; Motivation; Motor Activity; Ovariectomy; Piperidines; Posture; Progesterone; Pyrazoles; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Stimulation, Chemical | 2009 |
The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Blotting, Western; Camphanes; Carbamates; Cattle; Endocannabinoids; Epithelium; Fallopian Tubes; Female; Immunohistochemistry; Male; Microscopy, Fluorescence; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sperm Motility; Sperm-Ovum Interactions; Spermatozoa | 2009 |
A novel role for the endocannabinoid system during zebrafish development.
Topics: Animals; Cannabinoid Receptor Modulators; Embryo, Nonmammalian; Embryonic Development; Endocannabinoids; Female; Gene Expression Regulation, Developmental; Locomotion; Male; Oogenesis; Ovary; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; RNA Transport; RNA, Messenger; Zebrafish | 2009 |
Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages.
Topics: Animals; Arachidonic Acids; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Benzoxazines; Cannabinoid Receptor Modulators; CD36 Antigens; Cell Survival; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Lipoproteins, LDL; Macrophages, Peritoneal; Mice; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; PPAR gamma; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Signal Transduction | 2009 |
Sensory deprivation unmasks a PKA-dependent synaptic plasticity mechanism that operates in parallel with CaMKII.
Topics: Action Potentials; Analysis of Variance; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cannabinoids; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Excitatory Amino Acid Agents; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Neurons; Piperidines; Point Mutation; Protein Kinase Inhibitors; Pyrazoles; Receptors, AMPA; Sensory Deprivation; Vibrissae | 2008 |
D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Chromones; Cocaine; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Drug Combinations; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Long-Term Synaptic Depression; Male; Mesencephalon; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2 | 2008 |
Activation of CB1 cannabinoid receptors impairs memory consolidation and hippocampal polysialylated neural cell adhesion molecule expression in contextual fear conditioning.
Topics: Animals; Conditioning, Psychological; Dentate Gyrus; Doublecortin Domain Proteins; Doublecortin Protein; Dronabinol; Fear; Freezing Reaction, Cataleptic; Gene Expression; Ki-67 Antigen; Male; Memory Disorders; Microtubule-Associated Proteins; Neural Cell Adhesion Molecule L1; Neuropeptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sialic Acids | 2009 |
Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity.
Topics: Action Potentials; Animals; Arachidonic Acids; Calcium Channel Agonists; Calcium Channels, L-Type; Cannabinoid Receptor Modulators; Endocannabinoids; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neostriatum; Neuronal Plasticity; Neurons; Organ Culture Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synapses; Synaptic Transmission | 2009 |
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
Topics: Acute Disease; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Blood Pressure; Cannabinoids; Carbamates; Consciousness; Endocannabinoids; Hindlimb; Hypertension; Infusions, Intravenous; Injections, Intravenous; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Renal Circulation; Splanchnic Circulation; Vascular Resistance; Vasodilation | 2009 |
Effect of cannabinoids upon the uptake of folic acid by BeWo cells.
Topics: Arachidonic Acids; Carrier Proteins; Cell Culture Techniques; Cell Line, Tumor; Cyclohexanols; Dronabinol; Drug Administration Schedule; Endocannabinoids; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Hydrogen-Ion Concentration; Indoles; Membrane Transport Proteins; Piperidines; Placenta; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cell Surface | 2009 |
Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats.
Topics: Analysis of Variance; Animals; Appetite Regulation; Arachidonic Acids; Cannabinoid Receptor Modulators; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Eating; Endocannabinoids; Food Preferences; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Satiation | 2009 |
Modulation of anxiety by acute blockade and genetic deletion of the CB(1) cannabinoid receptor in mice together with biogenic amine changes in the forebrain.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Biogenic Amines; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Locomotion; Male; Maze Learning; Mice; Mice, Knockout; Piperidines; Prosencephalon; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Statistics as Topic | 2009 |
Chronic nicotine alters cannabinoid-mediated locomotor activity and receptor density in periadolescent but not adult male rats.
Topics: Adolescent; Aging; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dronabinol; Female; Humans; Male; Motor Activity; Nicotine; Nicotinic Agonists; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid | 2009 |
D2 receptor-mediated inhibition of dopamine release in the rat striatum in vitro is modulated by CB1 receptors: studies using fast cyclic voltammetry.
Topics: Animals; Benzoxazines; Dopamine; Dopamine Agonists; Electrochemistry; In Vitro Techniques; Ligands; Morpholines; Naphthalenes; Neostriatum; Piperidines; Pyrazoles; Quinpirole; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2 | 2009 |
Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.
Topics: Analysis of Variance; Animals; Animals, Inbred Strains; Anticonvulsants; Arachidonic Acids; Arginine; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures | 2009 |
Influence of intracerebroventricular or intraperitoneal administration of cannabinoid receptor agonist (WIN 55,212-2) and inverse agonist (AM 251) on the regulation of food intake and hypothalamic serotonin levels.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cerebral Ventricles; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Eating; Extracellular Fluid; Gene Expression; Genes, fos; Hydroxyindoleacetic Acid; Hypothalamus; Injections, Intraperitoneal; Male; Microdialysis; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Serotonin | 2009 |
Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory.
Topics: Amygdala; Animals; Avoidance Learning; Benzoxazines; Cannabinoid Receptor Modulators; Corticosterone; Endocannabinoids; Male; Memory; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2009 |
Distinct functional and anatomical architecture of the endocannabinoid system in the auditory brainstem.
Topics: Animals; Animals, Newborn; Auditory Pathways; Benzoxazines; Biophysics; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cochlear Nucleus; Cyclohexanones; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; In Vitro Techniques; Lipoprotein Lipase; Membrane Potentials; Mice; Mice, Inbred ICR; Microscopy, Immunoelectron; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Protease Inhibitors; Pyrazoles; Receptor, Cannabinoid, CB1; Synaptic Potentials; Time Factors | 2009 |
Goldfish CB1 mRNA expression is affected by fasting and anandamide administration.
Topics: Actins; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Fasting; Female; Gene Expression; Goldfish; Male; Piperidines; Polymerase Chain Reaction; Polyunsaturated Alkamides; Prosencephalon; Pyrazoles; Receptor, Cannabinoid, CB1; Rhombencephalon; RNA, Messenger; Time Factors | 2009 |
Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA.
Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Drug Antagonism; Electroacupuncture; Endocannabinoids; gamma-Aminobutyric Acid; Hemodynamics; Male; Periaqueductal Gray; Piperidines; Pyrazoles; Pyridazines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reflex; Stomach; Sympathetic Nervous System | 2009 |
AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors.
Topics: Animals; Anticholesteremic Agents; Apoptosis; Camphanes; Cell Line; Cholesterol; Enzyme Inhibitors; Ketocholesterols; Macrophages; Mice; Piperidines; Pyrazoles; Sterol O-Acyltransferase | 2009 |
Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically.
Topics: Animals; Biophysics; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cannabinoid Receptor Modulators; Chelating Agents; Chick Embryo; Egtazic Acid; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Agents; Guanosine Diphosphate; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Long-Term Synaptic Depression; Mesencephalon; Methoxyhydroxyphenylglycol; Neurons; Patch-Clamp Techniques; Peptide Fragments; Pertussis Toxin; Piperidines; Presynaptic Terminals; Pyrazoles; Synapses; Thionucleotides | 2009 |
Cannabinoid CB1 receptors are expressed in the mouse urinary bladder and their activation modulates afferent bladder activity.
Topics: Action Potentials; Analysis of Variance; Animals; Cannabinoids; Female; Fluorescent Antibody Technique; In Vitro Techniques; Mice; Mice, Inbred C57BL; Microelectrodes; Neurons, Afferent; Physical Stimulation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urinary Bladder | 2009 |
Neurotensin inhibition of GABAergic transmission via mGluR-induced endocannabinoid signalling in rat periaqueductal grey.
Topics: Adamantane; Animals; Cannabinoid Receptor Modulators; Endocannabinoids; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Imidazoles; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Miniature Postsynaptic Potentials; Neural Inhibition; Neurons; Neurotensin; Pain; Periaqueductal Gray; Piperidines; Presynaptic Terminals; Pyrazoles; Pyridines; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, Neurotensin; Synaptic Transmission; Tetrodotoxin; Time Factors | 2009 |
Electroacupuncture modulates vlPAG release of GABA through presynaptic cannabinoid CB1 receptors.
Topics: Animals; Chromatography, High Pressure Liquid; Electroacupuncture; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Neurons; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Sympathetic Nervous System | 2009 |
Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system.
Topics: Acupuncture Points; Animals; Behavior, Animal; Brain Chemistry; Brain Ischemia; Cannabinoid Receptor Modulators; Cerebral Infarction; Chromatography, High Pressure Liquid; Electroacupuncture; Endocannabinoids; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RNA, Messenger; RNA, Small Interfering | 2009 |
Cannabinoid receptor 1 signalling dampens activity and mitochondrial transport in networks of enteric neurones.
Topics: Animals; Benzoxazines; Biological Transport; Calcium Signaling; Cannabinoid Receptor Modulators; Cells, Cultured; Enteric Nervous System; Female; Fluorescent Dyes; Guinea Pigs; Male; Mitochondria; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant; Signal Transduction; Synaptic Vesicles | 2009 |
Noradrenergic control of associative synaptic plasticity by selective modulation of instructive signals.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Animals, Newborn; Biophysics; Brimonidine Tartrate; Calcium; Calcium Signaling; Cerebellum; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; In Vitro Techniques; Long-Term Synaptic Depression; Neural Pathways; Neuronal Plasticity; Norepinephrine; Patch-Clamp Techniques; Phosphinic Acids; Piperidines; Propanolamines; Purinergic P1 Receptor Antagonists; Purkinje Cells; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Synapses; Xanthines | 2009 |
Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.
Topics: Animals; Appetite Depressants; Cannabinoid Receptor Antagonists; Dronabinol; Eating; Fasting; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Solvents; Weight Gain | 2009 |
Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat-an animal model of attention deficit hyperactivity disorder.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Benzoxazines; Blood Pressure; Cannabinoids; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Morpholines; Motivation; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Inbred SHR; Rats, Wistar; Spatial Behavior | 2009 |
Endogenous anandamide and cannabinoid receptor-2 contribute to electroacupuncture analgesia in rats.
Topics: Animals; Arachidonic Acids; Chromatography, High Pressure Liquid; Electroacupuncture; Endocannabinoids; Freund's Adjuvant; Hindlimb; Hot Temperature; Hyperalgesia; Indoles; Male; Pain; Pain Management; Physical Stimulation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Skin | 2009 |
Selective lack of tolerance to delayed gastric emptying after daily administration of WIN 55,212-2 in the rat.
Topics: Animals; Benzoxazines; Body Weight; Cannabinoids; Dose-Response Relationship, Drug; Eating; Gastric Emptying; Gastrointestinal Motility; Gastrointestinal Tract; Gastrointestinal Transit; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2009 |
Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Cannabinoids; Desipramine; Dronabinol; Female; Male; Norepinephrine; Piperidines; Prazosin; Propranolol; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sex Characteristics; Substance Withdrawal Syndrome; Swimming; Synaptic Transmission | 2009 |
Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Binding, Competitive; Brain; Cyclohexanols; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Emotions; Injections, Subcutaneous; Male; Mice; Models, Animal; Motor Activity; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Salvia; Swimming | 2009 |
Neurochemical evidence that stimulation of CB1 cannabinoid receptors on GABAergic nerve terminals activates the dopaminergic reward system by increasing dopamine release in the rat nucleus accumbens.
Topics: Animals; Benzoxazines; Bicuculline; Dopamine; Electric Stimulation; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Morpholines; Naphthalenes; Nerve Endings; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reward | 2009 |
Not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to Purkinje cell synaptic transmission in young adult rodents.
Topics: Aging; Animals; Calcium; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Cerebellum; Endocannabinoids; Enzyme Inhibitors; Glutamic Acid; Humans; In Vitro Techniques; Lactones; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Orlistat; Piperidines; Purkinje Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Synaptic Transmission | 2009 |
Effects of cannabinoids infused into the dorsal hippocampus upon memory formation in 3-days apomorphine-treated rats.
Topics: Animals; Apomorphine; Avoidance Learning; Benzazepines; Benzoxazines; Cannabinoids; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Hippocampus; Male; Memory; Mental Recall; Morpholines; Naphthalenes; Neuropsychological Tests; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sulpiride; Time Factors | 2009 |
The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Brain; Cannabinoids; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Injections, Intraventricular; Male; Penicillins; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Seizures | 2009 |
CB1 cannabinoid receptor participates in the vascular hyporeactivity resulting from hemorrhagic shock in rats.
Topics: Animals; Blotting, Western; Gene Expression Regulation; Hypotension; Male; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; Shock, Hemorrhagic; Survival Rate | 2009 |
Cannabinoid CB(1) receptor activation stimulates neurite outgrowth and inhibits capsaicin-induced Ca(2+) influx in an in vitro model of diabetic neuropathy.
Topics: Animals; Calcium; Capsaicin; Diabetic Neuropathies; Dose-Response Relationship, Drug; Dronabinol; Glucose; Hyperglycemia; Indoles; Nerve Growth Factor; Neurites; Neurogenesis; Neurons; Neuroprotective Agents; PC12 Cells; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Sensory System Agents | 2009 |
Somatic spikes regulate dendritic signaling in small neurons in the absence of backpropagating action potentials.
Topics: Action Potentials; Age Factors; Analysis of Variance; Animals; Benzofurans; Biophysical Phenomena; Calcium; Cerebellum; Dendrites; Electric Stimulation; Ethers, Cyclic; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Nerve Net; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Glutamate; Signal Transduction; Sodium; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2009 |
N-arachidonyl dopamine sensitizes rat capsaicin-sensitive lung vagal afferents via activation of TRPV1 receptors.
Topics: Adenosine; Animals; Arachidonic Acids; Capsaicin; Dopamine; Hemodynamics; Male; Nerve Fibers; Neurons, Afferent; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Respiration, Artificial; Respiratory Mechanics; TRPV Cation Channels; Vagus Nerve | 2009 |
Measurement of affective state during chronic nicotine treatment and withdrawal by affective taste reactivity in mice: the role of endocannabinoids.
Topics: Affect; Animals; Avoidance Learning; Cannabinoid Receptor Modulators; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome; Taste; Tobacco Use Disorder | 2009 |
Metaplasticity of hypothalamic synapses following in vivo challenge.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Biophysics; Carbolines; Clonidine; Down-Regulation; Drug Interactions; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Glutamic Acid; Guanosine Diphosphate; Hypothalamus; In Vitro Techniques; Intracranial Hemorrhages; Long-Term Synaptic Depression; Male; Microinjections; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Synapses; Thionucleotides; Yohimbine | 2009 |
Anandamide-induced cell death: dual effects in primary rat decidual cell cultures.
Topics: Animals; Apoptosis; Arachidonic Acids; beta-Cyclodextrins; Cannabinoid Receptor Modulators; Cell Death; Cells, Cultured; Cholesterol; Decidua; Dose-Response Relationship, Drug; Endocannabinoids; Female; Membrane Lipids; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Rats; Receptor, Cannabinoid, CB1 | 2009 |
Endocannabinoids mediate tachykinin-induced effects in the lamprey locomotor network.
Topics: Action Potentials; Analgesics; Animals; Benzoxazines; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Amino Acid Agonists; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Lampreys; Locomotion; Models, Biological; Morpholines; N-Methylaspartate; Naphthalenes; Nerve Net; Neural Pathways; Neurotransmitter Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Spinal Cord; Substance P; Tachykinins | 2009 |
Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors.
Topics: Acetaminophen; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Endocannabinoids; Injections, Intraventricular; Interpersonal Relations; Male; Mice; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1 | 2009 |
Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Eating; Food Deprivation; Injections, Intraventricular; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reinforcement, Psychology | 2009 |
Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Colon; Dose-Response Relationship, Drug; Endocannabinoids; Guinea Pigs; In Vitro Techniques; Indoles; Motor Neurons; Neural Inhibition; Peristalsis; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex; Sensory Receptor Cells; Substance P; Vasoactive Intestinal Peptide | 2009 |
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Capsaicin; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Epilepsy; GABA Antagonists; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Picrotoxin; Piperidines; Pyrazoles; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Dopamine D3; Serotonin; TRPV Cation Channels | 2009 |
Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor.
Topics: Analgesics, Opioid; Animals; Indoles; Male; Mice; Morphine; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2009 |
Evidences of cannabinoids-induced modulation of paroxysmal events in an experimental model of partial epilepsy in the rat.
Topics: Animals; Anticonvulsants; Benzoxazines; Brain; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Disease Models, Animal; Electric Stimulation; Epilepsies, Partial; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2009 |
Inhibition of fatty-acid amide hydrolase and CB1 receptor antagonism differentially affect behavioural responses in normal and PCP-treated rats.
Topics: Amidohydrolases; Amphetamine; Animals; Autoradiography; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Cyclohexanols; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Hallucinogens; Interpersonal Relations; Male; Memory, Short-Term; Motor Activity; Neuropsychological Tests; Phencyclidine; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Sulfur Isotopes; Time Factors | 2010 |
Role of endocannabinoid system in the ventral hippocampus of rats in the modulation of anxiety-like behaviours.
Topics: Amidohydrolases; Animals; Anxiety; Baclofen; Behavior, Animal; Benzamides; Bicuculline; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; GABA Antagonists; Hippocampus; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2009 |
The endocannabinoid transport inhibitor AM404 modulates nociception in cholestasis.
Topics: Animals; Arachidonic Acids; Biological Transport; Camphanes; Cannabinoid Receptor Modulators; Cholestasis; Endocannabinoids; Male; Naloxone; Opioid Peptides; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2009 |
Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum.
Topics: Action Potentials; Animals; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cerebral Cortex; Corpus Striatum; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Female; Glycine; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Mice, Knockout; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Phenylacetates; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Adenosine A2; Synapses; Triazines; Triazoles | 2009 |
Selection of a palatable dietary option is not preferentially reduced by cannabinoid CB1 receptor antagonist AM251 in female C57Bl/6J mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Choice Behavior; Diet; Dietary Fats; Dietary Sucrose; Energy Intake; Female; Food Preferences; Mice; Mice, Inbred C57BL; Nutritive Value; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Time Factors | 2009 |
Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding.
Topics: Age Factors; Animals; Appetite Depressants; Body Composition; Dietary Fats; Energy Intake; Hyperphagia; Ion Channels; Leptin; Male; Mitochondrial Proteins; Obesity; Piperidines; Pyrazoles; Rats; Rats, Inbred F344; Receptor, Cannabinoid, CB1; STAT3 Transcription Factor; Uncoupling Protein 1; Weight Gain | 2009 |
Endogenous cannabinoids induce fever through the activation of CB1 receptors.
Topics: Animals; Arachidonic Acids; Body Temperature; Body Temperature Regulation; Cannabinoid Receptor Modulators; Cannabinoids; Endocannabinoids; Fever; Lipopolysaccharides; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2009 |
FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats.
Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Choice Behavior; Conditioning, Psychological; Dietary Sucrose; Extinction, Psychological; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Species Specificity; Substance Withdrawal Syndrome | 2009 |
Cannabinoid 1 receptor mediation of spinal cord ischemic tolerance induced by limb remote ischemia preconditioning in rats.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Indoles; Ischemia; Ischemic Preconditioning; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reperfusion Injury; Spinal Cord | 2009 |
Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Corticosterone; Dronabinol; Drug Interactions; Endocannabinoids; Hypothalamo-Hypophyseal System; Male; Microinjections; Piperidines; Pituitary-Adrenal System; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Restraint, Physical; Signal Transduction; Stress, Psychological | 2009 |
Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.
Topics: Analgesics; Arrestins; beta-Arrestins; Cannabinoid Receptor Agonists; Cannabinoids; Cell Line; Cyclohexanols; Humans; Ligands; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Obesity; Phosphorylation; Piperidines; Protein Kinase C; Protein Kinase C beta; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant | 2009 |
Signaling pathways from cannabinoid receptor-1 activation to inhibition of N-methyl-D-aspartic acid mediated calcium influx and neurotoxicity in dorsal root ganglion neurons.
Topics: Animals; Benzoxazines; Calcium; Camphanes; Cell Culture Techniques; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Ganglia, Spinal; Mice; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction | 2009 |
Endocannabinoid 1 and 2 (CB(1); CB(2)) receptor agonists affect negatively cow luteal function in vitro.
Topics: Adenine; Adenosine; Animals; Arachidonic Acids; Cattle; Corpus Luteum; Dinoprost; Dinoprostone; Female; In Vitro Techniques; Indoles; Organophosphonates; Piperidines; Pregnancy; Progesterone; Pyrazoles; Pyrrolidines; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2009 |
Voluntary exercise and sucrose consumption enhance cannabinoid CB1 receptor sensitivity in the striatum.
Topics: Animals; Baclofen; Bicuculline; Corpus Striatum; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Exploratory Behavior; Food Preferences; GABA Agonists; GABA Antagonists; Inhibitory Postsynaptic Potentials; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Physical Conditioning, Animal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Statistics, Nonparametric; Stress, Psychological; Sucrose; Time Factors | 2010 |
Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish.
Topics: Animals; Arachidonic Acids; Brain Chemistry; Cannabinoid Receptor Modulators; Eating; Endocannabinoids; Food Deprivation; Glycerides; Liver; Neuropeptide Y; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; RNA, Messenger; Sea Bream; Water | 2010 |
Anxiety-like behavior induced by histaminergic agents can be prevented by cannabinoidergic WIN55,212-2 injected into the dorsal hippocampus in mice.
Topics: Animals; Anxiety; Benzoxazines; Exploratory Behavior; Hippocampus; Histamine; Histamine Antagonists; Male; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Pyrilamine; Ranitidine | 2010 |
Sub-chronic administration of AM251, CB1 receptor antagonist, within the nucleus accumbens induced sensitization to morphine in the rat.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Catheterization; Conditioning, Classical; Dose-Response Relationship, Drug; Locomotion; Morphine; Nucleus Accumbens; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Space Perception; Time Factors | 2009 |
The cannabinoid CB1 receptor is involved in the anxiolytic, sedative and amnesic actions of benzodiazepines.
Topics: Alprazolam; Amnesia; Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Benzodiazepines; CA1 Region, Hippocampal; GTP-Binding Protein gamma Subunits; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Nervous System Diseases; Organ Specificity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Severity of Illness Index | 2010 |
The influence of ACEA--a selective cannabinoid CB1 receptor agonist on whole blood and platelet-poor plasma serotonin concentrations.
Topics: Animals; Arachidonic Acids; Blood Platelets; Enzyme-Linked Immunosorbent Assay; Female; Male; Piperidines; Plasma; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Serotonin | 2009 |
A cannabinoid CB(1) receptor antagonist ameliorates impairment of recognition memory on withdrawal from MDMA (Ecstasy).
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Gene Expression Regulation; Hallucinogens; Hippocampus; Male; Memory Disorders; Mice; Mice, Knockout; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Recognition, Psychology; Substance Withdrawal Syndrome; Time Factors | 2010 |
Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus.
Topics: Analysis of Variance; Animals; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Enzyme-Linked Immunosorbent Assay; Gastrointestinal Motility; Gastrointestinal Transit; Ileus; Interleukin-6; Jejunal Diseases; Jejunum; Lipopolysaccharides; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sepsis; Tumor Necrosis Factor-alpha | 2010 |
Effect of the CB(1) receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Endocannabinoids; gamma-Aminobutyric Acid; Male; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin | 2009 |
CB1 receptor blockade decreases ethanol intake and associated neurochemical changes in fawn-hooded rats.
Topics: Alcohol Drinking; Animals; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Male; Piperidines; Pyrazoles; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Ventral Tegmental Area | 2010 |
Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids.
Topics: Action Potentials; Animals; Arachidonic Acids; Arthritis, Experimental; Dinoprostone; Disease Models, Animal; Drug Administration Routes; Endocannabinoids; Enzyme Inhibitors; Glycerides; Indans; Injections, Spinal; Knee Joint; Male; Neurons; Pain Measurement; Physical Stimulation; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Spinal Cord; Statistics, Nonparametric | 2010 |
Integrated cannabinoid CB1 receptor transmission within the amygdala-prefrontal cortical pathway modulates neuronal plasticity and emotional memory encoding.
Topics: Amygdala; Animals; Brain Mapping; Electric Stimulation; Emotions; Long-Term Potentiation; Male; Memory; Neural Pathways; Neuronal Plasticity; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2010 |
Potentiation by WIN 55,212-2 of GABA-activated currents in rat trigeminal ganglion neurones.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; Trigeminal Ganglion | 2009 |
Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142.
Topics: Animals; Anxiety; Brain; Carbolines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Inverse Agonism; Exploratory Behavior; GABA Antagonists; Male; Maze Learning; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2010 |
Endogenous cannabinoids trigger the depolarization-induced suppression of excitation in the lateral amygdala.
Topics: Amygdala; Animals; Calcium; Cannabinoid Receptor Modulators; Electrophysiology; Excitatory Postsynaptic Potentials; Membrane Potentials; Mice; Mice, Inbred C57BL; Miniature Postsynaptic Potentials; Neural Inhibition; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Processing, Computer-Assisted; Synapses; Synaptic Transmission | 2010 |
A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy.
Topics: Animals; Arachidonic Acids; Autoradiography; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Cyclohexanols; Densitometry; Dopamine; Endocannabinoids; Environment; Glycerides; Limbic System; Lipid Metabolism; Male; Mass Spectrometry; Motor Activity; Olfactory Bulb; Piperidines; Pyrazoles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy.
Topics: Albuminuria; Animals; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibronectins; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Phosphoproteins; Piperidines; Polymerase Chain Reaction; Pyrazoles; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta1; Zonula Occludens-1 Protein | 2010 |
Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Benzoxazines; Biophysics; CA1 Region, Hippocampal; Caffeine; Calcium Channel Blockers; Dronabinol; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Picrotoxin; Piperidines; Presynaptic Terminals; Propanolamines; Pyrazoles; Quinoxalines; Receptor, Adenosine A1; Receptor, Cannabinoid, CB1; Xanthines | 2010 |
Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization.
Topics: Animals; Capsaicin; Electric Stimulation; GABA-B Receptor Antagonists; Injections, Spinal; Male; Morpholines; Neurons; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Receptors, Opioid, mu; Sensory System Agents; Spinal Cord; Spinal Nerve Roots; Substance P; TRPV Cation Channels | 2010 |
TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.
Topics: Analysis of Variance; Angiotensin II; Anilides; Animals; Capsaicin; Chelating Agents; Cinnamates; Diuretics, Osmotic; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; In Vitro Techniques; Male; Mannitol; Mice; Mice, Inbred C57BL; Mice, Knockout; Miniature Postsynaptic Potentials; Neurons; Piperidines; Pyrazines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Signal Transduction; Supraoptic Nucleus; TRPV Cation Channels; Vasoconstrictor Agents | 2010 |
WAG/Rij rats show a reduced expression of CB₁ receptors in thalamic nuclei and respond to the CB₁ receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges.
Topics: Analysis of Variance; Animals; Benzoxazines; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Gene Expression Regulation; Male; Morpholines; Movement; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Inbred ACI; Rats, Mutant Strains; Receptor, Cannabinoid, CB1; Thalamic Nuclei | 2010 |
GPR55 ligands promote receptor coupling to multiple signalling pathways.
Topics: Biological Assay; Cannabinoids; Cell Line, Transformed; Endocytosis; Humans; Ligands; Lysophospholipids; Morpholines; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Signal Transduction | 2010 |
Precipitated withdrawal counters the adverse effects of subchronic cannabinoid administration on male rat sexual behavior.
Topics: Animals; Copulation; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome | 2010 |
Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.
Topics: Adenosine A2 Receptor Antagonists; Afferent Pathways; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Central Nervous System Stimulants; Cerebral Cortex; Corpus Striatum; Endocannabinoids; Glutamic Acid; Glycerides; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Pyrimidines; Receptor, Cannabinoid, CB1; Signal Transduction | 2010 |
Effects of cannabinoid receptor antagonists on maintenance and reinstatement of methamphetamine self-administration in rhesus monkeys.
Topics: Animals; Cannabinoid Receptor Antagonists; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Macaca mulatta; Male; Methamphetamine; Piperidines; Pyrazoles; Reinforcement, Psychology; Rimonabant; Secondary Prevention; Self Administration | 2010 |
Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Animals, Suckling; Body Weight; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Corticosterone; Dietary Fats; Endocannabinoids; Fatty Acids; Female; Hypothalamo-Hypophyseal System; Insulin; Lactation; Leptin; Piperidines; Pituitary-Adrenal System; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Pyrazoles; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Regression Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Physiological | 2010 |
THC Prevents MDMA Neurotoxicity in Mice.
Topics: Animals; Astrocytes; Body Temperature; Dronabinol; Fever; Hallucinogens; Indoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Temperature | 2010 |
Opposing effects of cannabinoids and vanilloids on evoked quantal release at the frog neuromuscular junction.
Topics: Acetylcholine; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Morpholines; Naphthalenes; Neuromuscular Junction; Piperidines; Pyrazoles; Rana catesbeiana; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2010 |
Differential effects of CB(1) neutral antagonists and inverse agonists on gastrointestinal motility in mice.
Topics: Animals; Colon; Epithelium; Feces; Gastrointestinal Motility; Gastrointestinal Transit; Ileum; Immunohistochemistry; Ions; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Permeability; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Water | 2010 |
Cannabinoid CB1 receptor antagonism prevents neurochemical and behavioural deficits induced by chronic phencyclidine.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Modulators; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hippocampus; Male; Motor Activity; Phencyclidine; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Schizophrenia; Time Factors | 2011 |
Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain.
Topics: Analgesics; Animals; Bone Neoplasms; Camphanes; Cannabinoids; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Humans; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Naloxone; Osteosarcoma; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2; Spinal Cord | 2010 |
Involvement of the endocannabinoid system in periodontal healing.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cell Proliferation; Endocannabinoids; Fibroblasts; Gingival Crevicular Fluid; Glycerides; Humans; Indoles; p38 Mitogen-Activated Protein Kinases; Periodontium; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Wound Healing | 2010 |
Second-order schedules of nicotine reinforcement in rats: effect of AM251.
Topics: Animals; Appetitive Behavior; Association Learning; Brain; Conditioning, Classical; Dopamine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Motivation; Nerve Net; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Tobacco Use Disorder | 2010 |
A second-order schedule of food reinforcement in rats to examine the role of CB1 receptors in the reinforcement-enhancing effects of nicotine.
Topics: Animals; Appetitive Behavior; Association Learning; Brain; Conditioning, Classical; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Motivation; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Tobacco Use Disorder | 2010 |
AM 251 differentially effects food-maintained responding depending on food palatability.
Topics: Animal Feed; Animals; Appetite Regulation; Appetitive Behavior; Behavior, Animal; Cacao; Cannabinoids; Conditioning, Operant; Diet; Dose-Response Relationship, Drug; Drug Inverse Agonism; Edible Grain; Food Preferences; Male; Motivation; Obesity; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Taste | 2010 |
Asynchronous release of GABA via tonic cannabinoid receptor activation at identified interneuron synapses in rat CA1.
Topics: Animals; Animals, Newborn; Arachidonic Acids; CA1 Region, Hippocampal; Cannabinoid Receptor Modulators; Chelating Agents; Cholecystokinin; Dendrites; Egtazic Acid; Endocannabinoids; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Lysine; Male; Neural Inhibition; Neural Pathways; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Synapses | 2010 |
The CB1 inverse agonist AM251, but not the CB1 antagonist AM4113, enhances retention of contextual fear conditioning in rats.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Inverse Agonism; Fear; Freezing Reaction, Cataleptic; Male; Motor Activity; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Time Factors | 2010 |
Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Modulators; Dexamethasone; Endocannabinoids; Fear; Glucocorticoids; Hippocampus; Hormone Antagonists; Male; Memory; Mifepristone; Piperidines; Pyrazoles; Rats; Rats, Wistar; Stress, Psychological; Time Factors | 2010 |
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
Topics: Agatoxins; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Carbamates; Conotoxins; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycerides; Hippocampus; Homeostasis; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Morpholines; Naphthalenes; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Polyamines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2010 |
Neural encoding of psychomotor activation in the nucleus accumbens core, but not the shell, requires cannabinoid receptor signaling.
Topics: Animals; Cannabinoid Receptor Modulators; Interneurons; Male; Motor Activity; Nucleus Accumbens; Piperidines; Psychomotor Performance; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction | 2010 |
Endocannabinoid regulation of spinal nociceptive processing in a model of neuropathic pain.
Topics: Anesthesia; Animals; Arachidonic Acids; Camphanes; Cannabinoid Receptor Modulators; Central Nervous System Agents; Disease Models, Animal; Endocannabinoids; Evoked Potentials, Somatosensory; Furans; Male; Microelectrodes; Neuralgia; Neurons; Physical Stimulation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Spinal Cord; TRPV Cation Channels | 2010 |
Rapid alteration of stress-induced hypothalamic-pituitary-adrenal hormone secretion in the rat: a comparison of glucocorticoids and cannabinoids.
Topics: Adrenocorticotropic Hormone; Androstanols; Animals; Cannabinoids; Dose-Response Relationship, Drug; Feedback, Physiological; Glucocorticoids; Hormone Antagonists; Hypothalamo-Hypophyseal System; Male; Mifepristone; Paraventricular Hypothalamic Nucleus; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Glutamate; Restraint, Physical; Stress, Physiological | 2010 |
Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Corpus Striatum; Dronabinol; Endocannabinoids; Excitatory Amino Acid Antagonists; Fragile X Mental Retardation Protein; Gene Expression Regulation; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lipoprotein Lipase; Membrane Potentials; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Receptors, Kainic Acid; RNA, Small Cytoplasmic; Statistics, Nonparametric | 2010 |
Endogenous cannabinoid signaling is essential for stress adaptation.
Topics: Adaptation, Physiological; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Corticosterone; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction; Stress, Physiological | 2010 |
Dopaminergic modulation of endocannabinoid-mediated plasticity at GABAergic synapses in the prefrontal cortex.
Topics: Animals; Animals, Newborn; Benzoxazines; Cannabinoid Receptor Modulators; Chelating Agents; Dopamine; Dopamine Agents; Egtazic Acid; Endocannabinoids; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoquinolines; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Morpholines; Naphthalenes; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Protein Kinase Inhibitors; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Silver Staining; Sulfonamides; Synapses | 2010 |
The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Chlorocebus aethiops; Circadian Rhythm; COS Cells; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Drug Administration Routes; Eating; Food Deprivation; Green Fluorescent Proteins; Hemoglobins; Hyperphagia; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Peptide Fragments; Piperidines; Protein Transport; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Transfection | 2010 |
Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats.
Topics: Adrenal Medulla; Anesthesia; Animals; Arachidonic Acids; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Catecholamines; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Male; Monoacylglycerol Lipases; Piperidines; Pyrazoles; Rats; Rats, Wistar; Sympathetic Nervous System | 2010 |
Genome-wide expression profiling revealed peripheral effects of cannabinoid receptor 1 inverse agonists in improving insulin sensitivity and metabolic parameters.
Topics: Adipose Tissue; Animals; Cannabinoid Receptor Agonists; Down-Regulation; Homozygote; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Knockout; Mice, Obese; Piperidines; PPAR alpha; PPAR gamma; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Transcriptional Activation | 2010 |
Regulation of the hypothalamic-pituitary-adrenal axis circadian rhythm by endocannabinoids is sexually diergic.
Topics: Adrenocorticotropic Hormone; Animals; Cannabinoid Receptor Modulators; Circadian Rhythm; Corticosterone; Endocannabinoids; Female; Hormone Antagonists; Hypothalamo-Hypophyseal System; Male; Morpholines; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sex Characteristics | 2010 |
Participation of the endocannabinoid system in lipopolysaccharide-induced inhibition of salivary secretion.
Topics: Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Cannabinoid Receptor Modulators; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Endocannabinoids; Etanercept; Immunoglobulin G; Immunologic Factors; In Vitro Techniques; Indoles; Lipopolysaccharides; Male; Methacholine Chloride; Muscarinic Agonists; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Saliva; Salivation; Secretory Rate; Submandibular Gland; Tumor Necrosis Factor-alpha | 2010 |
Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum.
Topics: Animals; Behavior, Animal; beta-Cyclodextrins; Brain-Derived Neurotrophic Factor; Cholesterol; Cocaine; Corpus Striatum; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dronabinol; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Agents; Haloperidol; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward | 2010 |
Cannabinoid CB1 receptors in the medial prefrontal cortex modulate the expression of contextual fear conditioning.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Blood Pressure; Cannabinoid Receptor Modulators; Carbolines; Conditioning, Classical; Electroshock; Endocannabinoids; Fear; Freezing Reaction, Cataleptic; GABA Antagonists; Heart Rate; Male; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2010 |
Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Antagonists; Carbamates; Cell Line, Transformed; Chlorocebus aethiops; COS Cells; Drug Interactions; Endocannabinoids; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; Genistein; Humans; Isoflavones; Liver; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats | 2010 |
Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Dronabinol; Drug Inverse Agonism; Guinea Pigs; Ileum; Muscle Contraction; Myenteric Plexus; Piperidines; Pyrans; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Physical and functional interaction between CB1 cannabinoid receptors and beta2-adrenoceptors.
Topics: Adrenergic beta-2 Receptor Antagonists; Cell Line; Cyclic AMP Response Element-Binding Protein; Dronabinol; Energy Transfer; Extracellular Signal-Regulated MAP Kinases; Humans; Piperidines; Pyrans; Pyrazoles; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptors, Adrenergic, beta-2; Signal Transduction | 2010 |
Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids.
Topics: Animals; Cannabinoid Receptor Modulators; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Routes; Endocannabinoids; Evoked Potentials; Male; Pain; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Spinal Cord; Sulfonamides | 2010 |
Vasorelaxation to N-oleoylethanolamine in rat isolated arteries: mechanisms of action and modulation via cyclooxygenase activity.
Topics: Animals; Aorta, Thoracic; Arachidonic Acids; Caffeine; Capsaicin; Chloride Channels; Endocannabinoids; Endothelium, Vascular; Ethanolamines; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Nitric Oxide; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; Vasodilation | 2010 |
Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex.
Topics: Animals; Arachidonic Acids; Benzoxazines; Bicuculline; Cannabinoid Receptor Modulators; Endocannabinoids; Functional Laterality; Glycerides; Hyperemia; Male; Morpholines; Naphthalenes; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Somatosensory Cortex; Vibrissae | 2010 |
Involvement of 2-arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine.
Topics: Alcohol Drinking; Amidohydrolases; Animals; Arachidonic Acids; Central Nervous System Stimulants; Choice Behavior; Dopamine; Dopamine Plasma Membrane Transport Proteins; Endocannabinoids; Glycerides; Limbic System; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Neurotoxicity Syndromes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1 | 2010 |
Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability.
Topics: Algorithms; Biological Transport, Active; Caco-2 Cells; Cannabidiol; Cannabinoids; Dronabinol; Electric Impedance; Electrophysiology; Enterocytes; Humans; Intestinal Absorption; Microvilli; Permeability; Piperidines; PPAR alpha; PPAR gamma; Pyrazoles; Receptors, Cannabinoid; RNA, Messenger; Tight Junctions; TRPV Cation Channels | 2010 |
CB1 receptor antagonism impairs the induction of epileptiform activity by group I metabotropic glutamate receptor activation.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy; Excitatory Postsynaptic Potentials; Methoxyhydroxyphenylglycol; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Synaptic Transmission | 2010 |
Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells.
Topics: Benzoxazines; Blotting, Western; Capsaicin; Cell Movement; Cell Proliferation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Humans; Interleukin-6; Interleukin-8; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Pyrazoles; Quinazolines; Receptor, Cannabinoid, CB1; Transcriptional Activation; TRPV Cation Channels; Tyrphostins | 2010 |
Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: interaction between TNFalpha and endocannabinoids.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cells, Cultured; Cholestasis; Disease Models, Animal; Endocannabinoids; Furans; Heart; Ligation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocytes, Cardiac; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors.
Topics: Adolescent; Adult; Aged; Arachidonic Acids; Aspirin; Blood Platelets; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Coronary Artery Disease; Endocannabinoids; Glycerides; Humans; Indoles; Male; Middle Aged; Piperidines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazoles; Young Adult | 2010 |
Involvement of ERK 1/2 activation in electroacupuncture pretreatment via cannabinoid CB1 receptor in rats.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain Ischemia; Butadienes; Electroacupuncture; Enzyme Activation; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroprotective Agents; Nitriles; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reperfusion Injury; Signal Transduction; Up-Regulation | 2010 |
The cannabinoid 1 receptor antagonist AM251 produces nocifensive behavior via activation of ERK signaling pathway.
Topics: Analysis of Variance; Animals; Behavior, Animal; Blotting, Western; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Injections, Spinal; Male; Mice; Nitric Oxide Synthase Type I; Pain Measurement; Phosphorylation; Piperidines; Pyrazoles; Receptors, Cannabinoid; Spinal Cord | 2010 |
Oleamide administered into the nucleus accumbens shell regulates feeding behaviour via CB1 and 5-HT2C receptors.
Topics: Aminopyridines; Animals; Eating; Feeding Behavior; Hyperphagia; Hypothalamus; Indoles; Ketanserin; Male; Motor Activity; Nucleus Accumbens; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Antagonists | 2010 |
Cannabinoids excite circadian clock neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adaptation, Ocular; Analgesics; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Benzoxazines; Biophysics; Cannabinoids; Circadian Rhythm; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Male; Mice; Mice, Transgenic; Morpholines; Motor Activity; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Suprachiasmatic Nucleus; Tetrodotoxin; Valine | 2010 |
Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors.
Topics: Animals; Behavior, Animal; Cannabidiol; Diazepam; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Male; Mice; Mice, Inbred C57BL; Motor Activity; Paroxetine; Piperazines; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Synaptic Transmission | 2010 |
Inverse agonism of cannabinoid CB1 receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats.
Topics: Administration, Oral; Animals; Brain; Conditioning, Classical; Disease Models, Animal; Dose-Response Relationship, Drug; Feeding Behavior; Lithium Chloride; Male; Morpholines; Nausea; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Saccharin | 2010 |
Evidence that spatial memory deficits following bilateral vestibular deafferentation in rats are probably permanent.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Exploratory Behavior; Male; Memory Disorders; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Space Perception; Spatial Behavior; Vestibule, Labyrinth | 2010 |
A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents.
Topics: Animals; Avoidance Learning; Benzoxazines; Body Weight; Brain; Conditioning, Classical; Cyclic AMP; Dose-Response Relationship, Drug; Eating; Female; Gastrointestinal Motility; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2010 |
The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dronabinol; Dyskinesia, Drug-Induced; Levodopa; Male; Parkinsonian Disorders; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Benzoates; Biophysics; Calcium; Cannabinoid Receptor Modulators; Chelating Agents; Drug Interactions; Egtazic Acid; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Photolysis; Piperidines; Pyramidal Cells; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Resorcinols; Synaptic Transmission; Thapsigargin | 2010 |
Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain.
Topics: Analgesics; Analysis of Variance; Animals; Benzoxazines; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Male; Morpholines; Naphthalenes; Neuralgia; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Spinal Cord Injuries | 2010 |
Long-lasting recovery of psychotic-like symptoms in isolation-reared rats after chronic but not acute treatment with the cannabinoid antagonist AM251.
Topics: Acute Disease; Animals; Antipsychotic Agents; Cannabinoids; Interpersonal Relations; Male; Piperidines; Psychotic Disorders; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Recovery of Function; Social Isolation; Treatment Outcome | 2012 |
Chemical stimulation of the lateral hypothalamus induces conditioned place preference in rats: Involvement of OX1 and CB1 receptors in the ventral tegmental area.
Topics: Animals; Benzoxazoles; Carbachol; Choice Behavior; Conditioning, Operant; Dose-Response Relationship, Drug; Hypothalamic Area, Lateral; Male; Naphthyridines; Neural Pathways; Orexin Receptors; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reward; Urea; Ventral Tegmental Area | 2011 |
Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1 receptor blockade.
Topics: Animals; Cannabinoids; Dietary Fats; Energy Intake; Gene Expression Regulation; Lipid Metabolism; Muscle, Skeletal; Piperidines; PPAR gamma; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Adiponectin; Weight Gain | 2011 |
Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala.
Topics: Action Potentials; Adaptation, Psychological; Amygdala; Animals; Behavior, Animal; Cannabinoid Receptor Modulators; Conditioning, Psychological; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; GABA Antagonists; Gene Expression Regulation; In Vitro Techniques; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphinic Acids; Piperidines; Propanolamines; Pyrazoles; Pyridazines; Quinoxalines; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; Signal Transduction; Time Factors; Valine | 2011 |
Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens.
Topics: Animals; Cocaine; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nucleus Accumbens; Piperidines; Pyrazoles; Synaptic Potentials; TRPV Cation Channels | 2010 |
Attenuation of food intake in chicks by an inverse agonist of cannabinoid receptor 1 administered by either injection or ingestion in hydrocolloid carriers.
Topics: Animals; Chickens; Colloids; Drug Carriers; Eating; Female; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Sex Factors | 2011 |
Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying behavior in mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Carbamates; Drug Interactions; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Obsessive-Compulsive Disorder; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2011 |
Effects of cannabinoids on neuropeptide Y and β-endorphin expression in the rat hypothalamic arcuate nucleus.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Benzoxazines; beta-Endorphin; Cannabinoids; Feeding Behavior; Hypothalamus; Male; Morpholines; Naphthalenes; Neurons; Neuropeptide Y; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar | 2011 |
Residual effects of focal brain ischaemia upon cannabinoid CB(1) receptor density and functionality in female rats.
Topics: Animals; Autoradiography; Brain; Brain Ischemia; Cyclohexanols; Disease Models, Animal; Estradiol; Estrogens; Female; Functional Laterality; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Infarction, Middle Cerebral Artery; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sulfur Isotopes; Time Factors; Tritium | 2011 |
A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoxazines; Biophysics; Calcium Channel Blockers; Darkness; Dominance, Ocular; Electric Stimulation; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Refractory Period, Electrophysiological; Sensory Deprivation; Synaptic Transmission; Time Factors; Visual Cortex | 2010 |
Local pretreatment with the cannabinoid CB1 receptor antagonist AM251 attenuates methamphetamine intra-accumbens self-administration.
Topics: Animals; Central Nervous System Stimulants; Conditioning, Operant; Drug Interactions; Male; Methamphetamine; Microdialysis; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Self Administration | 2011 |
The actions of benzophenanthridine alkaloids, piperonyl butoxide and (S)-methoprene at the G-protein coupled cannabinoid CB₁ receptor in vitro.
Topics: Alkaloids; Animals; Benzophenanthridines; Brain; Drug Interactions; Inhibitory Concentration 50; Isoquinolines; Male; Methoprene; Mice; Piperidines; Piperonyl Butoxide; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1 | 2011 |
The effect of co-administration of the NMDA blocker with agonist and antagonist of CB1-receptor on penicillin-induced epileptiform activity in rats.
Topics: Animals; Arachidonic Acids; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Epilepsy; Excitatory Amino Acid Antagonists; Male; Memantine; Penicillins; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate | 2011 |
The endocannabinoid system modulates the valence of the emotion associated to food ingestion.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Eating; Emotions; Endocannabinoids; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Psychomotor Performance; Pyrazoles; Rats; Rats, Wistar | 2012 |
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.
Topics: Action Potentials; Afferent Pathways; Age Factors; Animals; Arthralgia; Benzamides; Carbamates; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Indoles; Iodoacetic Acid; Male; Nociceptors; Osteoarthritis; Piperidines; Pyrazoles; Rats; Rats, Wistar; Time Factors; Weight-Bearing | 2011 |
Role for cannabinoid receptors in human proximal tubular hypertrophy.
Topics: Animals; Arachidonic Acids; Cell Enlargement; Cell Line; Endocannabinoids; Humans; Indoles; Kidney Tubules, Proximal; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; TRPV Cation Channels | 2010 |
The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Carbamates; Electric Stimulation; Electrodes; Electrophysiological Phenomena; Male; Microdialysis; Microinjections; Mononeuropathies; Neurons; Nociceptors; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; RNA, Messenger; Serotonin; TRPV Cation Channels | 2011 |
Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors.
Topics: Animals; Brain Injuries; Cannabinoid Receptor Modulators; Cannabinoids; Cerebral Cortex; Estradiol; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Indoles; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; RNA, Messenger; Stereotaxic Techniques; Tissue Fixation; Vimentin; Wounds, Stab | 2011 |
Functional interaction between morphine and central amygdala cannabinoid CB1 receptors in the acquisition and expression of conditioned place preference.
Topics: Amygdala; Analysis of Variance; Animals; Arachidonic Acids; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Motor Activity; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement Schedule | 2011 |
Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB(1) receptors: a keratinocyte-dependent effect.
Topics: Arachidonic Acids; Cannabinoid Receptor Modulators; Cell Line, Tumor; Coculture Techniques; Down-Regulation; Humans; Keratinocytes; Melanins; Melanocytes; Paracrine Communication; Pigmentation Disorders; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Skin; Ultraviolet Rays | 2011 |
MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice.
Topics: Animals; Azetidines; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Inverse Agonism; Hippocampus; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Oxadiazoles; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Scopolamine | 2011 |
Cannabinoid-induced delayed gastric emptying is selectively increased upon intermittent administration in the rat: role of CB1 receptors.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Gastric Emptying; Gastrointestinal Motility; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2011 |
Cannabinoid/agonist WIN 55,212-2 reduces cardiac ischaemia–reperfusion injury in Zucker diabetic fatty rats: role of CB2 receptors and iNOS/eNOS.
Topics: Animals; Benzoxazines; Cannabinoids; Cardiotonic Agents; Coronary Vessels; Diabetes Mellitus, Type 2; Heart; Heart Rate; Indoles; Male; Morpholines; Myocardial Ischemia; Myocardial Reperfusion Injury; Naphthalenes; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2011 |
Interactions between endocannabinoid and serotonergic systems in mood disorders caused by nicotine withdrawal.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Disease Models, Animal; Drug Interactions; Endocannabinoids; Male; Mice; Mood Disorders; Motor Activity; Nicotine; Piperazines; Piperidines; Pyrazoles; Pyridines; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Smoking Cessation; Substance Withdrawal Syndrome | 2011 |
Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes.
Topics: Antiviral Agents; Arachidonic Acids; Cell Line, Tumor; Doxycycline; Gene Expression Profiling; Gene Expression Regulation, Viral; Hepacivirus; Humans; Interferon-alpha; Lipid Metabolism; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Triglycerides; Viral Core Proteins; Viral Nonstructural Proteins | 2011 |
Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice.
Topics: Animals; Central Nervous System; Glucose; Glucose Clamp Technique; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, Cannabinoid, CB1 | 2011 |
Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells.
Topics: Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Female; Glucose; GTP-Binding Protein alpha Subunit, Gi2; Humans; Immunoprecipitation; In Vitro Techniques; Indoles; Insulin-Secreting Cells; Male; Mice; Mice, Mutant Strains; Mice, Obese; Piperidines; Potassium Chloride; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Insulin; Signal Transduction | 2011 |
Obesity-dependent cannabinoid modulation of proliferation in adult neurogenic regions.
Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Cannabinoid Receptor Modulators; Cell Proliferation; Cholesterol; Dietary Fats; Energy Intake; Female; Insulin; Leptin; Male; Neurogenesis; Obesity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Triglycerides | 2011 |
Inhibition of fatty acid amide hydrolase modulates anxiety-like behavior in PCP-treated rats.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzamides; Carbamates; Enzyme Inhibitors; Male; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2011 |
Post-ictal analgesia in genetically epilepsy-prone rats is induced by audiogenic seizures and involves cannabinoid receptors in the periaqueductal gray.
Topics: Amnesia, Anterograde; Analgesia; Animals; Epilepsy, Reflex; Female; Male; Pain Threshold; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Seizures | 2011 |
Pre-training anandamide infusion within the basolateral amygdala impairs plus-maze discriminative avoidance task in rats.
Topics: Amygdala; Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Avoidance Learning; Cannabinoid Receptor Modulators; Discrimination Learning; Endocannabinoids; Male; Maze Learning; Memory; Microinjections; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2011 |
The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein.
Topics: Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; ERRalpha Estrogen-Related Receptor; Genistein; HCT116 Cells; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Nitriles; Orphan Nuclear Receptors; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Estrogen; RNA, Messenger; Thiazoles; Up-Regulation | 2011 |
The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors.
Topics: Animals; Benzofurans; Dronabinol; gamma-Aminobutyric Acid; Oocytes; Piperidines; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Recombinant Proteins; Rimonabant; Xenopus | 2012 |
Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzodioxoles; Brain; Endocannabinoids; Enzyme Inhibitors; Fear; Glycerides; Lithium Chloride; Male; Monoacylglycerol Lipases; Nausea; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Shrews; Vomiting | 2012 |
Calcium microdomains near R-type calcium channels control the induction of presynaptic long-term potentiation at parallel fiber to purkinje cell synapses.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Channels, R-Type; Calcium Signaling; Cerebellum; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Long-Term Potentiation; Membrane Microdomains; Neural Pathways; Nickel; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Phosphinic Acids; Piperidines; Presynaptic Terminals; Propanolamines; Purkinje Cells; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Spider Venoms; Tetrodotoxin; Xanthines | 2011 |
Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex.
Topics: Action Potentials; Afferent Pathways; Amygdala; Analysis of Variance; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Dose-Response Relationship, Drug; Electroshock; Fear; Functional Laterality; Male; Memory; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Smell | 2011 |
Cannabinoid receptor blockade reduces the opportunity cost at which rats maintain operant performance for rewarding brain stimulation.
Topics: Animals; Computer Simulation; Conditioning, Operant; Dopamine; Electric Stimulation; Male; Medial Forebrain Bundle; Microdialysis; Models, Neurological; Norepinephrine; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reward; Self Stimulation; Time Factors | 2011 |
New fat and new neurons: endocannabinoids control neurogenesis in obesity (Commentary on Rivera et al.).
Topics: Adipose Tissue; Body Weight; Cannabinoid Receptor Modulators; Dietary Fats; Eating; Endocannabinoids; Neurogenesis; Neurons; Obesity; Piperidines; Pyrazoles | 2011 |
Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Compulsive Behavior; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Endocannabinoids; Fluoxetine; Injections, Intraventricular; Male; Mice; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles | 2011 |
∆(9)-Tetrahydrocannabinol decreases NOP receptor density and mRNA levels in human SH-SY5Y cells.
Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Down-Regulation; Dronabinol; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Nociceptin Receptor; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm | 2012 |
The antinociceptive potency of N-arachidonoyl-dopamine (NADA) and its interaction with endomorphin-1 at the spinal level.
Topics: Acrylamides; Analgesics; Animals; Arachidonic Acids; Area Under Curve; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Oligopeptides; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Spinal Cord; TRPV Cation Channels | 2011 |
Paracetamol-induced hypothermia is independent of cannabinoids and transient receptor potential vanilloid-1 and is not mediated by AM404.
Topics: Acetaminophen; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Cannabinoids; Cinnamates; Hypothermia; Hypothermia, Induced; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2011 |
Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons.
Topics: Animals; Cannabinoid Receptor Antagonists; CHO Cells; Cricetinae; Cricetulus; Indoles; Mice; Mice, 129 Strain; Mice, Knockout; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Sensory Receptor Cells; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2011 |
Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism.
Topics: Action Potentials; Animals; Arachidonic Acids; Benzoxazines; Calcium; Cannabinoids; Endocannabinoids; Exocytosis; GABAergic Neurons; gamma-Aminobutyric Acid; Glycerides; Male; Morpholines; Mossy Fibers, Hippocampal; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2011 |
Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Bacterial Proteins; Benzoates; Benzoxazines; Calcium; Calcium Channel Blockers; Carbenoxolone; Channelrhodopsins; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Glial Fibrillary Acidic Protein; Glycine; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Luminescent Proteins; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Models, Biological; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Peptide Fragments; Phosphopyruvate Hydratase; Photic Stimulation; Piperidines; Pyrazoles; Pyridines; Sodium Channel Blockers; Statistics, Nonparametric; Tetanus Toxin; Tetrodotoxin; Transduction, Genetic | 2011 |
A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents.
Topics: Animals; Cannabidiol; Electromyography; Gastrointestinal Motility; Gastrointestinal Transit; Indoles; Inflammation; Interleukin-6; Intestines; Ligands; Lipopolysaccharides; Membrane Potentials; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Tumor Necrosis Factor-alpha | 2011 |
The cannabinoid receptor CB₁ inverse agonist AM251 potentiates the anxiogenic activity of urocortin I in the basolateral amygdala.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Urocortins | 2012 |
Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability.
Topics: Amidohydrolases; Benzamides; Benzodioxoles; Caco-2 Cells; Cannabinoids; Carbamates; Cell Survival; Enzyme Inhibitors; Humans; Indoles; Inflammation; Interferon-gamma; Intestinal Mucosa; Monoacylglycerol Lipases; Permeability; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Tumor Necrosis Factor-alpha | 2012 |
The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: inhibition by phthalate esters in vitro.
Topics: Animals; Benzoxazines; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Mice; Morpholines; Naphthalenes; Phthalic Acids; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant | 2011 |
Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Capsaicin; Depression; Dopamine; Endocannabinoids; Hindlimb Suspension; Ligands; Male; Mice; Mice, Inbred ICR; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Stress, Psychological; Swimming; TRPV Cation Channels | 2011 |
Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response.
Topics: Animals; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Corticosterone; Disease Models, Animal; Electric Stimulation; Endocannabinoids; Freezing Reaction, Cataleptic; gamma-Aminobutyric Acid; Glycerides; Hormone Antagonists; In Vitro Techniques; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Microscopy, Electron, Transmission; Mifepristone; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction; Stress, Psychological | 2011 |
Antagonism of cannabinoid 1 receptors reverses the anxiety-like behavior induced by central injections of corticotropin-releasing factor and cocaine withdrawal.
Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Corticosterone; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Hypothalamo-Hypophyseal System; Male; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome | 2012 |
Extracellular signal-regulated kinase signaling in the ventral tegmental area mediates cocaine-induced synaptic plasticity and rewarding effects.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Biophysics; Calcium Channel Blockers; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neuronal Plasticity; Patch-Clamp Techniques; Picrotoxin; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reward; Signal Transduction; Synapses; Ventral Tegmental Area | 2011 |
The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing.
Topics: Action Potentials; Analysis of Variance; Animals; Dopamine Agents; Drug Interactions; Enzyme Inhibitors; Glycerides; In Vitro Techniques; Male; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Rimonabant; Time Factors; Type C Phospholipases | 2011 |
Modulation of endocannabinoid-mediated long-lasting disinhibition of striatal output by cholinergic interneurons.
Topics: Animals; Animals, Newborn; Benzazepines; Bicuculline; Biophysics; Cannabinoid Receptor Modulators; Cholinergic Agents; Chromones; Corpus Striatum; Dopamine Antagonists; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Interneurons; Long-Term Potentiation; Models, Neurological; Neural Inhibition; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Signal Transduction; Sulpiride; Valine | 2011 |
Role of brainstem GABAergic signaling in central cannabinoid receptor evoked sympathoexcitation and pressor responses in conscious rats.
Topics: Analysis of Variance; Animals; Benzoxazines; Blood Pressure; Brain Stem; Dose-Response Relationship, Drug; Drug Interactions; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Heart Rate; Injections, Intraventricular; Male; Morpholines; Muscimol; Naphthalenes; Neurons; Norepinephrine; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Tyrosine 3-Monooxygenase; Wakefulness | 2011 |
A cannabinoid ligand, anandamide, exacerbates endotoxin-induced uveitis in rabbits.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Disease Models, Animal; Drug Synergism; Endocannabinoids; Intravitreal Injections; Leukocyte Count; Lipopolysaccharides; Male; Neutrophil Infiltration; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptor, Cannabinoid, CB1; Severity of Illness Index; Uveitis | 2011 |
Dual regulation of anterograde and retrograde transmission by endocannabinoids.
Topics: Animals; Cannabinoid Receptor Modulators; Endocannabinoids; Excitatory Postsynaptic Potentials; Male; Paraventricular Hypothalamic Nucleus; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2011 |
AM251, cannabinoids receptors ligand, improves recognition memory in rats.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Male; Maze Learning; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Recognition, Psychology; Rimonabant | 2011 |
Cannabinoid receptor involvement in stress-induced cocaine reinstatement: potential interaction with noradrenergic pathways.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Addictive; Cannabinoids; Cocaine; Conditioning, Psychological; Cyclohexanols; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Imidazoles; Isoindoles; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Self Administration; Stress, Psychological | 2012 |
Cytotoxicity of synthetic cannabinoids found in "Spice" products: the role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line.
Topics: Apoptosis; Cannabinoids; Caspase 3; Caspase Inhibitors; Cell Line, Tumor; Cell Survival; Cyclohexanols; Cysteine Proteinase Inhibitors; Drug Interactions; Humans; Indoles; Microscopy, Fluorescence; Oligopeptides; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2011 |
Analgesic effects of cannabinoid receptor agonist WIN55,212-2 in the nucleus cuneiformis in animal models of acute and inflammatory pain in rats.
Topics: Analgesics; Analysis of Variance; Animals; Area Under Curve; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hot Temperature; Inflammation; Male; Medulla Oblongata; Microinjections; Morpholines; Motor Activity; Naphthalenes; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Time Factors | 2011 |
Cannabinoid receptor 1 regulates ERK and GSK-3β-dependent glucocorticoid inhibition of osteoblast differentiation in murine MC3T3-E1 cells.
Topics: Animals; Apoptosis; Benzoxazines; Bone Matrix; Calcification, Physiologic; Cannabinoid Receptor Antagonists; Cell Differentiation; Cell Proliferation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Extracellular Signal-Regulated MAP Kinases; Gene Knockdown Techniques; Glucocorticoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Models, Biological; Morpholines; Mutant Proteins; Naphthalenes; Osteoblasts; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; RNA Interference | 2011 |
Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress.
Topics: Amygdala; Animals; Anxiety; Avoidance Learning; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Dexamethasone; Disease Models, Animal; Extinction, Psychological; Humans; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Male; Microinjections; Morpholines; Naphthalenes; Piperidines; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Sprague-Dawley; Reflex, Startle; Sensory Gating; Stress Disorders, Post-Traumatic; Stress, Physiological | 2012 |
Opposing roles for cannabinoid receptor type-1 (CB₁) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.
Topics: Anilides; Animals; Arachidonic Acids; Capsaicin; Cinnamates; Drug Interactions; Electric Stimulation; Male; Microinjections; Panic; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2012 |
Effects of neuropeptide FF system on CB₁ and CB₂ receptors mediated antinociception in mice.
Topics: Analgesia; Analgesics; Animals; Benzoxazines; Indoles; Male; Mice; Morpholines; Naloxone; Naphthalenes; Oligopeptides; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2012 |
Differential modulation of brainstem phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase 1/2 signaling underlies WIN55,212-2 centrally mediated pressor response in conscious rats.
Topics: Androstadienes; Animals; Benzoxazines; Blood Pressure; Blotting, Western; Brain Stem; Calcium Channel Blockers; Enzyme Inhibitors; Flavonoids; Heart Rate; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Naphthalenes; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Solitary Nucleus; Wortmannin | 2012 |
Tonic regulation of GABAergic synaptic activity on vasopressin neurones by cannabinoids.
Topics: Action Potentials; Animals; Arginine Vasopressin; Calcium; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Egtazic Acid; Female; GABAergic Neurons; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Vasopressins | 2012 |
AM2389, a high-affinity, in vivo potent CB1-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice.
Topics: Animals; Benzopyrans; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hypothermia; Indoles; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Time Factors | 2012 |
Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism.
Topics: Animals; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Morpholines; Naphthalenes; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Piperidines; Protein Kinase C; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synapses | 2011 |
Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.
Topics: Analysis of Variance; Animals; Animals, Newborn; Arachidonic Acids; Benzoxazines; Benzoxazoles; Biphenyl Compounds; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Disease Models, Animal; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Estrenes; gamma-Aminobutyric Acid; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Intracellular Signaling Peptides and Proteins; Lactones; Male; Morpholines; Naphthalenes; Naphthyridines; Neural Inhibition; Neural Pathways; Neuropeptides; Orexin Receptors; Orexins; Orlistat; Pain; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray; Piperidines; Pyrazoles; Pyrrolidinones; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea | 2011 |
Dorsal hippocampal cannabinoid CB1 receptors mediate the interactive effects of nicotine and ethanol on passive avoidance learning in mice.
Topics: Amnesia; Analysis of Variance; Animals; Arachidonic Acids; Avoidance Learning; CA1 Region, Hippocampal; Drug Interactions; Ethanol; Male; Mental Recall; Mice; Microinjections; Nicotine; Piperidines; Pyrazoles; Random Allocation; Receptor, Cannabinoid, CB1 | 2013 |
Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss.
Topics: Absorptiometry, Photon; Animals; Disease Models, Animal; Dogs; Eating; Energy Metabolism; Female; Glucose Tolerance Test; Obesity; Piperidines; Pyrazoles; Random Allocation; Receptor, Cannabinoid, CB1; Weight Loss | 2012 |
The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids.
Topics: Analgesics; Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclic GMP; Glyburide; Indoles; KATP Channels; Mice; Mice, Knockout; Naloxone; Nitric Oxide; Nitric Oxide Synthase Type I; Pain; Piperidines; Pyrazoles; Quaternary Ammonium Compounds; Receptors, Cannabinoid; Signal Transduction; Thionucleotides | 2011 |
Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.
Topics: Analgesics, Non-Narcotic; Animals; Arrestins; beta-Arrestin 1; beta-Arrestins; Body Temperature; Cannabinoids; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Dronabinol; Drug Combinations; Excitatory Amino Acid Antagonists; Female; Freezing Reaction, Cataleptic; Frontal Lobe; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pain Perception; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2011 |
PAX3-FOXO1 induces cannabinoid receptor 1 to enhance cell invasion and metastasis.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Myoblasts; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Oncogene Proteins, Fusion; Paired Box Transcription Factors; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rhabdomyosarcoma, Alveolar; Tumor Suppressor Protein p14ARF | 2011 |
Sustained firing of cartwheel cells in the dorsal cochlear nucleus evokes endocannabinoid release and retrograde suppression of parallel fiber synapses.
Topics: Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Biophysics; Calcium; Cannabinoid Receptor Modulators; Cochlear Nucleus; Dendrites; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; In Vitro Techniques; Male; Mice; Mice, Inbred CBA; Mice, Inbred ICR; Nerve Fibers; Neural Inhibition; Neurons; Patch-Clamp Techniques; Picrotoxin; Piperidines; Pyrazoles; Pyrrolidinones; Quinoxalines; Refractory Period, Electrophysiological; Synaptic Transmission; Tetrodotoxin; Time Factors | 2011 |
Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats.
Topics: Administration, Oral; Alcohol Deterrents; Alcohol Drinking; Animals; Animals, Outbred Strains; Baclofen; Behavior, Animal; Drug Synergism; Drug Therapy, Combination; GABA-B Receptor Agonists; Loperamide; Male; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2012 |
Polymodal activation of the endocannabinoid system in the extended amygdala.
Topics: Animals; Arachidonic Acids; Biophysics; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cannabinoid Receptor Modulators; Chromones; Cyclohexanones; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycerides; In Vitro Techniques; Long-Term Synaptic Depression; Neurons; Nimodipine; Patch-Clamp Techniques; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Septal Nuclei; Signal Transduction; Synapses; Time Factors; TRPV Cation Channels | 2011 |
Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells.
Topics: Actins; Arachidonic Acids; Benzoxazines; Biological Transport, Active; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Membrane; Cell Movement; Endocannabinoids; Glycerides; Humans; Male; Morpholines; Myosins; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Prostatic Neoplasms; Pyrazoles; rac1 GTP-Binding Protein; Receptor, Cannabinoid, CB1; rhoA GTP-Binding Protein | 2012 |
State-dependent, bidirectional modulation of neural network activity by endocannabinoids.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Benzothiadiazines; Brain; Cannabinoid Receptor Modulators; Cells, Cultured; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Mice; Mice, Transgenic; Nerve Net; Neural Inhibition; Neurons; Organophosphorus Compounds; Picrotoxin; Piperidines; Potassium Channel Blockers; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sodium Channel Blockers; Tetrodotoxin; Valine | 2011 |
Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses.
Topics: Animals; Animals, Newborn; Biophysics; Electric Stimulation; Endocytosis; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; In Vitro Techniques; Mice; Mice, Transgenic; Nerve Tissue Proteins; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Statistics, Nonparametric; Synapses; Synaptic Transmission | 2011 |
Combined stimulation of glucagon-like peptide-1 receptor and inhibition of cannabinoid CB1 receptor act synergistically to reduce food intake and body weight in the rat.
Topics: Animals; Appetite Depressants; Body Weight; Dose-Response Relationship, Drug; Drug Synergism; Eating; Energy Metabolism; Exenatide; Glucagon-Like Peptide-1 Receptor; Male; Peptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Glucagon; Venoms | 2011 |
Bidirectional plasticity in striatonigral synapses: a switch to balance direct and indirect basal ganglia pathways.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Basal Ganglia; Benzazepines; Benzoxazines; Biophysics; Cannabinoids; Chelating Agents; Corpus Striatum; Dopamine Agonists; Drug Interactions; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Long-Term Synaptic Depression; Male; Morpholines; Naphthalenes; Neural Pathways; Piperidines; Pyrazoles; Rats; Substantia Nigra; Synapses; Synaptic Transmission; Time Factors; Valine | 2011 |
Cannabinoid receptor type 1 antagonism significantly modulates basal and loud noise induced neural and hypothalamic-pituitary-adrenal axis responses in male Sprague-Dawley rats.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Hypothalamo-Hypophyseal System; Male; Neurons; Noise; Piperidines; Pituitary-Adrenal System; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Physiological | 2012 |
Effects of anandamide on potassium channels in rat ventricular myocytes: a suppression of I(to) and augmentation of K(ATP) channels.
Topics: Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Arrhythmias, Cardiac; Cardiac Electrophysiology; Dose-Response Relationship, Drug; Endocannabinoids; Heart Ventricles; Indoles; KATP Channels; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2012 |
The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB(1)).
Topics: Animals; Arachidonic Acids; Cells, Cultured; Dopamine; Excitatory Postsynaptic Potentials; Hippocampus; Mice; Nerve Degeneration; Neurons; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2012 |
The interaction between intrathecal administration of low doses of palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats.
Topics: Amides; Animals; Drug Interactions; Endocannabinoids; Ethanolamines; Injections, Spinal; Interleukin-1beta; Male; Pain; Pain Measurement; Palmitic Acids; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Spinal Cord | 2012 |
Medial prefrontal cortex endocannabinoid system modulates baroreflex activity through CB(1) receptors.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Baroreflex; Benzamides; Blood Pressure; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Glutamic Acid; Male; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2012 |
Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease.
Topics: Action Potentials; Analysis of Variance; Animals; Benzoxazines; Brain; Disease Models, Animal; Dronabinol; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agents; gamma-Aminobutyric Acid; Glutamates; Humans; Huntingtin Protein; Huntington Disease; In Vitro Techniques; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Morpholines; Motor Activity; Naphthalenes; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Patch-Clamp Techniques; Piperidines; Potassium; Pyrazoles; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Synaptosomes; Trinucleotide Repeats; Tritium; Vesicular Glutamate Transport Protein 1; Vesicular Inhibitory Amino Acid Transport Proteins | 2012 |
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.
Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium | 2012 |
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.
Topics: Analgesics; Analgesics, Opioid; Animals; Cannabinoids; Hyperalgesia; Indoles; Inflammation; Interleukin-1beta; Male; Morphine; Neuroglia; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Spinal Cord; Tumor Necrosis Factor-alpha | 2012 |
Cannabinoid receptor activation disrupts the internal structure of hippocampal sharp wave-ripple complexes.
Topics: Animals; Arachidonic Acids; Calcium; Cannabinoid Receptor Modulators; Endocannabinoids; Hippocampus; Male; Memory; Mice; Mice, Inbred C57BL; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Sleep | 2012 |
The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats.
Topics: Analysis of Variance; Anilides; Animals; Behavior, Addictive; Camphanes; Cinnamates; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Extinction, Psychological; Food; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; TRPV Cation Channels | 2012 |
Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway.
Topics: Action Potentials; Adaptation, Psychological; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Enzyme Inhibitors; Fenclonine; Glycerides; Male; Microinjections; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Serotonergic Neurons; Signal Transduction; Stress, Psychological | 2012 |
Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory.
Topics: Acoustic Stimulation; Adrenergic beta-Antagonists; Animals; Arachidonic Acids; Arousal; Benzoxazines; Cannabinoid Receptor Modulators; Conditioning, Classical; Corticosterone; Electroshock; Emotions; Endocannabinoids; Fear; Freezing Reaction, Cataleptic; Glucocorticoids; Glycerides; Hippocampus; Male; Memory; Morpholines; Naphthalenes; Piperidines; Propranolol; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Glucocorticoid | 2012 |
Metamizol, a non-opioid analgesic, acts via endocannabinoids in the PAG-RVM axis during inflammation in rats.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cannabinoid Receptor Modulators; Dipyrone; Endocannabinoids; Hyperalgesia; Inflammation; Male; Medulla Oblongata; Microinjections; Neurons; Nociceptors; Pain Measurement; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2012 |
Cannabinoids and muscular pain. Effectiveness of the local administration in rat.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Indoles; Male; Morpholines; Motor Activity; Musculoskeletal Pain; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Treatment Outcome | 2012 |
Differential role of CB1 and TRPV1 receptors on anandamide modulation of defensive responses induced by nitric oxide in the dorsolateral periaqueductal gray.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Endocannabinoids; Escape Reaction; Male; Nitric Oxide; Nitric Oxide Donors; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2012 |
Paraventricular nucleus anandamide signaling alters eating and substrate oxidation.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Eating; Endocannabinoids; Energy Metabolism; Male; Oxidation-Reduction; Paraventricular Hypothalamic Nucleus; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid | 2012 |
Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission.
Topics: Animals; Behavior, Animal; Benzamides; Carbamates; Corpus Striatum; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction; Synaptic Transmission | 2012 |
Endogenous opioid and cannabinoid mechanisms are involved in the analgesic effects of celecoxib in the central nervous system.
Topics: Analgesics; Animals; Carrageenan; Celecoxib; Central Nervous System; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Inflammation; Male; Naltrexone; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides | 2012 |
Contribution of the rostral ventromedial medulla to post-anxiety induced hyperalgesia.
Topics: Animals; Anxiety; GABA-A Receptor Agonists; Hyperalgesia; Male; Medulla Oblongata; Muscimol; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2012 |
Astrocyte signaling controls spike timing-dependent depression at neocortical synapses.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Astrocytes; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Morpholines; Naphthalenes; Neocortex; Patch-Clamp Techniques; Piperidines; Probability; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction; Sodium Channel Blockers; Synapses; Tetrodotoxin; Thalamus; Time Factors | 2012 |
Revisiting CB1 receptor as drug target in human melanoma.
Topics: Animals; Apoptosis; Arachidonic Acids; Base Sequence; Cannabinoids; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Delivery Systems; Endocannabinoids; Humans; Ligands; Liver Neoplasms; Melanoma; Mice; Mice, SCID; Microscopy, Fluorescence; Molecular Sequence Data; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Xenograft Model Antitumor Assays | 2012 |
Modulation of ATP-induced LTP by cannabinoid receptors in rat hippocampus.
Topics: Adenosine Triphosphate; Animals; Cannabinoids; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Presynaptic; Synapses | 2012 |
Cannabinoid CB1 receptors mediate the effects of corticotropin-releasing factor on the reinstatement of cocaine seeking and expression of cocaine-induced behavioural sensitization.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Electroshock; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Wistar; Receptor, Cannabinoid, CB1; Self Administration; Stress, Physiological | 2012 |
Coadministration of cannabinoid CB1-receptor and adenosine A1-receptor antagonists improves the acquisition of spatial memory in mice: participation of glutamatergic neurotransmission.
Topics: Adenosine A1 Receptor Antagonists; Animals; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Spatial Behavior; Synaptic Transmission; Xanthines | 2012 |
CB1 cannabinoid receptor activation rescues amyloid β-induced alterations in behaviour and intrinsic electrophysiological properties of rat hippocampal CA1 pyramidal neurones.
Topics: Action Potentials; Amyloid beta-Peptides; Animals; Avoidance Learning; Behavior, Animal; Benzoxazines; CA1 Region, Hippocampal; Calcium; Caspase 3; Electrophysiological Phenomena; Enzyme Activation; Male; Memory Disorders; Morpholines; Naphthalenes; Neuroprotective Agents; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2012 |
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Animals; Anisoles; Apamin; Arachidonic Acids; Benzamides; Benzyl Compounds; Cannabinoid Receptor Antagonists; Capsaicin; Carbamates; Charybdotoxin; Cyclohexanes; Endocannabinoids; Endothelium, Vascular; Imidazoles; Indoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Epoprostenol; Tetraethylammonium; TRPV Cation Channels; Vasodilation | 2012 |
The anti-nausea effects of CB1 agonists are mediated by an action at the visceral insular cortex.
Topics: Animals; Antiemetics; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cerebral Cortex; Dronabinol; Lithium Chloride; Male; Naphthalenes; Nausea; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2012 |
The endocannabinoid and endovanilloid systems interact in the rat prelimbic medial prefrontal cortex to control anxiety-like behavior.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Behavior, Animal; Capsaicin; Endocannabinoids; Male; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2012 |
[JSNP Excellent Presentation Award for AsCNP 2011: improvement of cognitive impairments on withdrawal after repeated methamphetamine by administration of a cannabinoid CB1 receptor antagonist and a COX inhibitor].
Topics: Animals; Awards and Prizes; Cognition Disorders; Cyclooxygenase Inhibitors; Diclofenac; Male; Methamphetamine; Mice; Mice, Inbred ICR; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome | 2012 |
Cannabinoid receptor-mediated regulation of neuronal activity and signaling in glomeruli of the main olfactory bulb.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Data Interpretation, Statistical; Endocannabinoids; Excitatory Amino Acid Antagonists; Female; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Nerve Net; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Signal Transduction; Synapses; Synaptic Transmission | 2012 |
Stimulation of accumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats.
Topics: Animals; Appetite; Arachidonic Acids; Cannabinoid Receptor Modulators; Diet; Diet, High-Fat; Dietary Carbohydrates; Eating; Endocannabinoids; Food Preferences; Glycerides; Hyperphagia; Male; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sucrose | 2012 |
Inhibition of cannabinoid CB1 receptor upregulates Slc2a4 expression via nuclear factor-κB and sterol regulatory element-binding protein-1 in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Arachidonic Acids; Gene Expression Regulation; Glucose Transporter Type 4; Mice; NF-kappa B; Piperidines; Promoter Regions, Genetic; Pyrazoles; Receptor, Cannabinoid, CB1; Sterol Regulatory Element Binding Protein 1; Up-Regulation | 2012 |
Chronic blockade of CB(1) receptors reverses startle gating deficits and associated neurochemical alterations in rats reared in isolation.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Brain; Cannabinoid Receptor Antagonists; Endocannabinoids; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Sensory Gating; Social Isolation | 2012 |
AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Binding, Competitive; Cannabinoid Receptor Agonists; CHO Cells; Cricetinae; Cricetulus; Drug Inverse Agonism; Humans; Kinetics; Mice; Mice, Inbred Strains; Morpholines; Narcotic Antagonists; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Recombinant Proteins; Rimonabant | 2012 |
Anti-inflammatory effect of the endocannabinoid anandamide in experimental periodontitis and stress in the rat.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Body Weight; Cannabinoid Receptor Agonists; Corticosterone; Disease Models, Animal; Endocannabinoids; Enzyme-Linked Immunosorbent Assay; Exploratory Behavior; Indoles; Interleukin-1beta; Male; Nitric Oxide Synthase; Periodontitis; Piperidines; Polyunsaturated Alkamides; Prostaglandins E; Pyrazoles; Rats; Rats, Wistar; Statistics, Nonparametric; Stress, Psychological; Tumor Necrosis Factor-alpha | 2012 |
Nicotine reinforcement is reduced by cannabinoid CB1 receptor blockade in the ventral tegmental area.
Topics: Animals; Cannabinoid Receptor Antagonists; Catheterization; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Infusions, Intraventricular; Injections, Intraventricular; Nicotine; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Self Administration; Ventral Tegmental Area | 2013 |
Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.
Topics: Analgesics; Angiotensin II; Animals; Arteries; Benzoxazines; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Mice; Mice, Knockout; Morpholines; Muscle, Skeletal; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Vasoconstriction | 2012 |
Contribution of hypothermia and CB1 receptor activation to protective effects of TAK-937, a cannabinoid receptor agonist, in rat transient MCAO model.
Topics: Amides; Animals; Benzofurans; Body Temperature; Disease Models, Animal; Hypothermia; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2012 |
Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors.
Topics: Adenosine; Analysis of Variance; Animals; CA1 Region, Hippocampal; Calcium Signaling; Ethylmaleimide; Female; Glutamic Acid; Guanosine Diphosphate; Hypoxia, Brain; Male; Patch-Clamp Techniques; Piperidines; Protein Kinase C; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Signal Transduction; Synaptic Transmission; Thionucleotides | 2012 |
The high glucose-induced stimulation of B1R and B2R expression via CB(1)R activation is involved in rat podocyte apoptosis.
Topics: Animals; Apoptosis; Bradykinin; Cell Survival; DNA Fragmentation; Endoplasmic Reticulum Stress; Gene Expression Regulation; Glucose; Hyperglycemia; Kallikrein-Kinin System; Piperidines; Podocytes; Pyrazoles; Rats; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Tetrahydroisoquinolines | 2012 |
Activation-dependent subcellular distribution patterns of CB1 cannabinoid receptors in the rat forebrain.
Topics: Animals; Cyclohexanols; Endosomes; Intracellular Space; Male; Neurons; Piperidines; Prosencephalon; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2013 |
Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: effects of the cannabinoid receptor 1 antagonist AM251.
Topics: Aging; Amygdala; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticotropin-Releasing Hormone; Exploratory Behavior; In Situ Hybridization; Interpersonal Relations; Male; Microfilament Proteins; Motor Activity; Nerve Tissue Proteins; Neuronal Plasticity; Neuropeptide Y; Neuropeptides; Nicotine; Nicotinic Agonists; Phenotype; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome | 2012 |
Involvement of the endocannabinoid system in ethanol-induced corticostriatal synaptic depression.
Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Cannabinoids; Ethanol; Excitatory Postsynaptic Potentials; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2012 |
Adaptive regulation maintains posttetanic potentiation at cerebellar granule cell synapses in the absence of calcium-dependent PKC.
Topics: Adaptation, Physiological; Analysis of Variance; Animals; Animals, Newborn; Biophysics; Calcium; Cerebellum; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; GABA Agents; Gene Expression Regulation; In Vitro Techniques; Male; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Pyrazoles | 2012 |
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB₂ receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy.
Topics: Animals; Benzylamines; Chromones; Cisplatin; Cryopyrin-Associated Periodic Syndromes; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Hyperalgesia; Indoles; Male; Paclitaxel; Peripheral Nervous System Diseases; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, CXCR4; Signal Transduction; Time Factors; Treatment Outcome | 2012 |
Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Chick Embryo; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Agonists; Female; gamma-Aminobutyric Acid; Heterocyclic Compounds, 1-Ring; Homeostasis; Male; Morpholines; Motor Neurons; Naphthalenes; Nerve Net; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction; Spinal Cord; Synaptic Potentials; Urea | 2012 |
Diet-dependent modulation of hippocampal expression of endocannabinoid signaling-related proteins in cannabinoid antagonist-treated obese rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Diet, High-Fat; Dietary Carbohydrates; Dietary Fats; Endocannabinoids; Hippocampus; Lipoprotein Lipase; Male; Monoacylglycerol Lipases; Obesity; Phospholipase D; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Weight Gain | 2013 |
Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Endocannabinoids; Inhibitory Postsynaptic Potentials; Interneurons; Male; Neocortex; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2013 |
The biarylpyrazole compound AM251 alters mitochondrial physiology via proteolytic degradation of ERRα.
Topics: Cell Line; DNA-Binding Proteins; Energy Metabolism; ERRalpha Estrogen-Related Receptor; Humans; Membrane Potential, Mitochondrial; Mitochondria; Multiprotein Complexes; Phosphorylation; Piperidines; Proteasome Endopeptidase Complex; Protein Stability; Pyrazoles; Receptors, Estrogen; Sumoylation; Ultrasonography | 2013 |
Antinociceptive action of isolated mitragynine from Mitragyna Speciosa through activation of opioid receptor system.
Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Male; Mice; Mice, Inbred ICR; Mitragyna; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Opioid; Secologanin Tryptamine Alkaloids | 2012 |
Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences.
Topics: 3,3'-Diaminobenzidine; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Choice Behavior; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Feeding Behavior; Haloperidol; Immunohistochemistry; Individuality; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Xanthines | 2012 |
Probable involvement of Ca(2+)-activated Cl(-) channels (CaCCs) in the activation of CB1 cannabinoid receptors.
Topics: Amides; Analysis of Variance; Animals; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Chloride Channels; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Ethanolamines; Hyperalgesia; Indoles; Male; Niflumic Acid; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2013 |
Participation of endocannabinoids in rapid suppression of stress responses by glucocorticoids in neonates.
Topics: Animals; Animals, Newborn; Endocannabinoids; Female; Glucocorticoids; Male; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Psychological; Time Factors | 2013 |
CB1 and CB2 contribute to antinociceptive and anti-inflammatory effects of electroacupuncture on experimental arthritis of the rat temporomandibular joint.
Topics: Acupuncture Analgesia; Animals; Arthritis, Experimental; Behavior, Animal; Down-Regulation; Electroacupuncture; Indoles; Male; Nerve Tissue Proteins; Nociception; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Temporomandibular Joint; Trigeminal Nucleus, Spinal; Up-Regulation; Zymosan | 2012 |
Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzoxazines; Callithrix; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Exploratory Behavior; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2013 |
Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance.
Topics: Animals; Dronabinol; Male; Mice; Mice, Knockout; Motor Activity; Neurons; Physical Conditioning, Animal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Ventral Tegmental Area | 2013 |
Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony.
Topics: Animals; Cannabinoids; Cerebral Cortex; Corpus Striatum; Cortical Synchronization; Cyclohexanols; Electromyography; GABAergic Neurons; Glutamic Acid; Mice; Mice, Mutant Strains; Nerve Net; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Substantia Nigra; Thalamus | 2013 |
Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis.
Topics: Acute Disease; Animals; Antiemetics; Cannabinoids; Cells, Cultured; Cytoprotection; Disease Models, Animal; Dronabinol; Lipopolysaccharides; Male; Organ Culture Techniques; Pancreatitis; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Serum; Stomach | 2012 |
The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.
Topics: Animals; Anti-Anxiety Agents; Bromodeoxyuridine; Camphanes; Cannabidiol; Cannabinoid Receptor Antagonists; Cell Cycle; Cell Line, Transformed; Cell Proliferation; Disease Models, Animal; Feeding Behavior; Glial Fibrillary Acidic Protein; Hippocampus; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Piperidines; Pyrazoles; Rimonabant; Stress, Psychological; Thymidine Kinase | 2013 |
Role of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation.
Topics: Animals; Arachidonic Acids; Arterial Pressure; Cerebrovascular Circulation; Endocannabinoids; Heart Rate; Hemodynamics; Hypercapnia; Hypertension; Hypoxia; Laser-Doppler Flowmetry; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2013 |
Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors.
Topics: Analysis of Variance; Animals; Anxiety; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Mice; Mice, Inbred ICR; Nicotine; Piperidines; Pyrazoles; Receptors, Cannabinoid; Restraint, Physical | 2013 |
Signaling cross-talk between cannabinoid and muscarinic systems actives Rho-kinase and increases the contractile responses of the bovine ciliary muscle.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbachol; Cattle; Cholinergic Agonists; Ciliary Body; Endocannabinoids; In Vitro Techniques; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Piperidines; Polyunsaturated Alkamides; Protein Kinase C; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Muscarinic M3; rho-Associated Kinases | 2013 |
Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats.
Topics: Amygdala; Analgesia; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Conditioning, Psychological; Dose-Response Relationship, Drug; Endocannabinoids; Ethanolamines; Excitatory Amino Acid Agents; Fear; Functional Laterality; GABA Agents; Glycerides; Injections, Intraventricular; Male; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, GABA; Receptors, Glutamate; Signal Transduction | 2013 |
The CB1 cannabinoid receptor mediates glucocorticoid-induced effects on behavioural and neuronal responses during lactation.
Topics: Animals; Behavior, Animal; Dexamethasone; Female; Glucocorticoids; Hypothalamus; Lactation; Maternal Behavior; Neurons; Paraventricular Hypothalamic Nucleus; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Septal Nuclei | 2013 |
Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit.
Topics: Amygdala; Animals; Benzoxazines; Cannabinoids; Electroshock; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Hippocampus; Hypothalamo-Hypophyseal System; Male; Microinjections; Mifepristone; Models, Psychological; Morpholines; Naphthalenes; Piperidines; Pituitary-Adrenal System; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Glucocorticoid; Stress, Psychological | 2013 |
Neuroprotective effects of topical CB1 agonist WIN 55212-2 on retinal ganglion cells after acute rise in intraocular pressure induced ischemia in rat.
Topics: Administration, Topical; Animals; Benzoxazines; Cell Count; Disease Models, Animal; Female; Intraocular Pressure; Morpholines; Naphthalenes; Neuroprotective Agents; Ocular Hypertension; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Tonometry, Ocular | 2013 |
Long-term CB₁ receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Up-Regulation | 2013 |
Involvement of CB1 receptors in the ventral tegmental area in the potentiation of morphine rewarding properties in acquisition but not expression in the conditioned place preference model.
Topics: Analgesics, Opioid; Animals; Association Learning; Benzoxazines; Conditioning, Operant; Male; Morphine; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reward; Ventral Tegmental Area | 2013 |
Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid
Topics: Analysis of Variance; Animals; Bicuculline; Defense Mechanisms; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Antagonists; Hyperalgesia; Hypothalamus; Instinct; Male; Microinjections; Pain Measurement; Pain Threshold; Panic; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-A | 2013 |
The role of CB1-receptors in the proconvulsant effect of leptin on penicillin-induced epileptiform activity in rats.
Topics: Animals; Convulsants; Epilepsy; Infusions, Intraventricular; Leptin; Male; Penicillins; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2013 |
Central functional response to the novel peptide cannabinoid, hemopressin.
Topics: Animals; Appetite Depressants; Behavior, Animal; Cannabinoids; Hemoglobins; Hypothalamus, Middle; Injections, Intraperitoneal; Male; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Peptide Fragments; Periaqueductal Gray; Piperidines; Pyrazoles; Random Allocation; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Satiety Response | 2013 |
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Male; Phencyclidine; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Quinazolinones; Rats; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant; Schizophrenia; Social Behavior | 2013 |
Entopeduncular nucleus endocannabinoid system modulates sleep-waking cycle and mood in rats.
Topics: Affect; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Endocannabinoids; Entopeduncular Nucleus; Immobility Response, Tonic; Male; Maze Learning; Microinjections; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rotarod Performance Test; Sleep; Sleep Stages; Wakefulness | 2013 |
Inhibitory effects of endocannabinoid on the action potential of pacemaker cells in sinoatrial nodes of rabbits.
Topics: Action Potentials; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Endocannabinoids; Indoles; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rabbits; Sinoatrial Node | 2013 |
Implication of NGF and endocannabinoid signaling in the mechanism of action of sesamol: a multi-target natural compound with therapeutic potential.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antioxidants; Benzodioxoles; Brain; Camphanes; Dose-Response Relationship, Drug; Endocannabinoids; Flurazepam; Injections, Intraperitoneal; Male; Molecular Targeted Therapy; Nerve Growth Factor; Phenols; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Signal Transduction | 2013 |
Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system.
Topics: Acetyltransferases; Analysis of Variance; Animals; Arachidonic Acids; Astrocytes; Cell Differentiation; Cells, Cultured; Endocannabinoids; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glycerides; Linoleic Acid; Mass Spectrometry; Mice; Neural Stem Cells; Piperidines; Polyunsaturated Alkamides; Pyrazoles; RNA, Messenger; Up-Regulation | 2013 |
The Cav3-Kv4 complex acts as a calcium sensor to maintain inhibitory charge transfer during extracellular calcium fluctuations.
Topics: Animals; Animals, Newborn; Antibodies; Calcium; Caveolin 3; Cerebellum; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; Extracellular Fluid; GABA Antagonists; Green Fluorescent Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Kv Channel-Interacting Proteins; Male; Nerve Fibers; Neural Inhibition; Neurons; Phosphinic Acids; Piperidines; Propanolamines; Pyrazoles; Rats; Rats, Sprague-Dawley; Shal Potassium Channels; Transfection | 2013 |
CB1 receptor signaling regulates social anxiety and memory.
Topics: Adaptation, Psychological; Animals; Anxiety; Arousal; Freezing Reaction, Cataleptic; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Social Discrimination | 2013 |
Anandamide reduces intracellular Ca2+ concentration through suppression of Na+/Ca2+ exchanger current in rat cardiac myocytes.
Topics: Aniline Compounds; Animals; Arachidonic Acids; Calcium; Cannabinoids; Cell Separation; Endocannabinoids; GTP-Binding Protein alpha Subunits, Gi-Go; Heart Ventricles; Indoles; Intracellular Space; Ion Channel Gating; Male; Myocardial Ischemia; Myocytes, Cardiac; Pertussis Toxin; Phenyl Ethers; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Sodium-Calcium Exchanger; Solutions | 2013 |
Nitric oxide-dependent long-term depression but not endocannabinoid-mediated long-term potentiation is crucial for visual recognition memory.
Topics: Animals; Cannabinoid Receptor Antagonists; Endocannabinoids; In Vitro Techniques; Long-Term Synaptic Depression; Male; Nitric Oxide; Piperidines; Pyrazoles; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Recognition, Psychology; Temporal Lobe; Visual Perception | 2013 |
Endocannabinoids mediate hyposalivation induced by inflammogens in the submandibular glands and hypothalamus.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Agonists; Dinoprostone; Endocannabinoids; Hypothalamus; Inflammation; Lipopolysaccharides; Male; Piperidines; Pyrazoles; Radioimmunoassay; Rats; Rats, Wistar; Submandibular Gland; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha; Xerostomia | 2013 |
Involvement of cannabinoid receptors in the amygdala and prefrontal cortex of rats in fear learning, consolidation, retrieval and extinction.
Topics: Amygdala; Analysis of Variance; Animals; Benzoxazines; Conditioning, Psychological; Extinction, Psychological; Fear; Male; Mental Recall; Microinjections; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2013 |
Effects of compounds that interfere with the endocannabinoid system on behaviors predictive of anxiolytic and panicolytic activities in the elevated T-maze.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzamides; Benzodiazepines; Benzoxazines; Carbamates; Endocannabinoids; Locomotion; Male; Maze Learning; Morpholines; Naphthalenes; Panic; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1 | 2013 |
Modulation of anxiety-like behavior by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray.
Topics: Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Biphenyl Compounds; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Indoles; Male; Maze Learning; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar | 2013 |
Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation.
Topics: Animals; Body Temperature; Cytokines; Data Interpretation, Statistical; Fever; Hyperalgesia; Immunity, Innate; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain Measurement; Piperidines; Poly I-C; Proto-Oncogene Proteins c-fos; Pyrazoles; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; RNA; Toll-Like Receptor 3; Toll-Like Receptor 4 | 2013 |
The role of α₂-adrenoceptors in the anti-convulsant effects of cannabinoids on pentylenetetrazole-induced seizure threshold in mice.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoids; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Pentylenetetrazole; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Adrenergic, alpha-2; Seizures; Yohimbine | 2013 |
Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cannabis; Colitis; Gastrointestinal Tract; Hydrogen Sulfide; Indoles; Male; Naproxen; Piperidines; Plant Extracts; Protective Agents; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Stomach Ulcer; Visceral Pain | 2013 |
Involvement of cannabinoid CB1 receptors in the antinociceptive effect of dipyrone.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dipyrone; Male; Mice; Mice, Inbred BALB C; Morpholines; Naphthalenes; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2013 |
Developmental effects of cannabinoids on zebrafish larvae.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cyclohexanols; Dronabinol; Embryo, Nonmammalian; Female; Larva; Lethal Dose 50; Locomotion; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Toxicity Tests, Acute; Toxicity Tests, Chronic; Zebrafish | 2013 |
Anandamide modulates the neuroendocrine responses induced by extracellular volume expansion.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Gene Expression Regulation; Infusions, Intraventricular; Male; Median Eminence; Neuroprotective Agents; Nitrates; Oxytocin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; RNA, Messenger; Saline Solution, Hypertonic; Vasopressins | 2013 |
Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats.
Topics: Animals; Anxiety; Apomorphine; Arachidonic Acids; Bicuculline; Cannabinoid Receptor Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; GABA-A Receptor Antagonists; Male; Maze Learning; Nitric Oxide Synthase; Oxadiazoles; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Quinoxalines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2013 |
Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dronabinol; Drug Partial Agonism; Lithium Chloride; Male; Nausea; Phytochemicals; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2013 |
Anandamide, cannabinoid type 1 receptor, and NMDA receptor activation mediate non-Hebbian presynaptically expressed long-term depression at the first central synapse for visceral afferent fibers.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; In Vitro Techniques; Long-Term Synaptic Depression; Male; Medulla Oblongata; Neurons; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Presynaptic Terminals; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Visceral Afferents | 2013 |
Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats.
Topics: Animals; Biomarkers; Cannabinoid Receptor Antagonists; Eating; Energy Metabolism; Fatty Liver; Insulin; Insulin Resistance; Leptin; Lipid Metabolism; Liver; Male; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Weight Gain | 2013 |
CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice.
Topics: Animals; Axons; Brain; Brain Edema; Brain Injuries; Cannabinoid Receptor Antagonists; Indoles; Male; Mice; Microglia; Minocycline; Motor Activity; Neuroprotective Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2015 |
Long-term depression of inhibitory synaptic transmission induced by spike-timing dependent plasticity requires coactivation of endocannabinoid and muscarinic receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; CA1 Region, Hippocampal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cholinergic Agents; Endocannabinoids; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synaptic Transmission; Valine | 2013 |
CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses.
Topics: Action Potentials; Animals; Animals, Newborn; CA1 Region, Hippocampal; Calcium Channel Blockers; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Agents; Female; In Vitro Techniques; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Neural Pathways; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction; Synapses; Theta Rhythm | 2013 |
Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice.
Topics: Animals; Blood Glucose; Calcium; Cannabidiol; Cell Line; Clone Cells; Cyclic AMP; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Ethanolamines; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Oleic Acids; Palmitic Acids; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Resorcinols; Time Factors | 2013 |
Suppression of outward K⁺ currents by WIN55212-2 in rat retinal ganglion cells is independent of CB1/CB2 receptors.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Dose-Response Relationship, Drug; In Vitro Techniques; Inhibitory Concentration 50; Male; Morpholines; Naphthalenes; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Retina; Retinal Ganglion Cells; Rhodamines; Visual Pathways | 2013 |
The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.
Topics: Benzoxazines; Cannabinoid Receptor Antagonists; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Eukaryotic Initiation Factor-4E; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; MicroRNAs; Morpholines; Naphthalenes; Piperidines; Protein Phosphatase 2; Pyrazoles; Repressor Proteins; Sp Transcription Factors | 2013 |
Adolescent chronic mild stress alters hippocampal CB1 receptor-mediated excitatory neurotransmission and plasticity.
Topics: Animals; Benzoxazines; Chronic Disease; Disease Models, Animal; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neuronal Plasticity; Picrotoxin; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Psychological; Synaptic Transmission | 2013 |
Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates.
Topics: Animals; Cannabinoid Receptor Antagonists; Cocaine; Conditioning, Operant; Cues; Dopamine; Dopaminergic Neurons; Endocannabinoids; Impulsive Behavior; Male; Motor Activity; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Time Factors | 2014 |
Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression.
Topics: Animals; Avoidance Learning; Benzoxazines; Body Weight; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Food Deprivation; Food Preferences; Long-Term Potentiation; Male; Morpholines; Naphthalenes; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Stress, Psychological | 2014 |
Angiotensin II-induced activation of central AT1 receptors exerts endocannabinoid-mediated gastroprotective effect in rats.
Topics: Angiotensin II; Animals; Atropine; CHO Cells; Cricetulus; Ethanol; Gastric Mucosa; Gene Expression Regulation; Injections, Intraventricular; Lactones; Lipoprotein Lipase; Male; Mice; Mice, Knockout; Orlistat; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Cannabinoid, CB1; Signal Transduction; Stomach; Stomach Ulcer; Vagotomy; Vagus Nerve | 2014 |
Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB₁ and CB₂ receptors.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Endocannabinoids; Glycerides; Hyperalgesia; Male; Mice; Mice, Knockout; Neuralgia; Pain Measurement; Pain Threshold; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2014 |
The endocannabinoid system mediates aerobic exercise-induced antinociception in rats.
Topics: Analgesia; Animals; Arachidonic Acids; Benzodioxoles; Brain; Cannabinoid Receptor Modulators; Endocannabinoids; Indoles; Male; Organophosphonates; Pain Measurement; Physical Conditioning, Animal; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2014 |
A 3D-video-based computerized analysis of social and sexual interactions in rats.
Topics: Animals; Behavior, Animal; Imaging, Three-Dimensional; Male; Motor Activity; Movement; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Sexual Behavior; Social Behavior; Video Recording | 2013 |
Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK.
Topics: Cannabidiol; Cannabinoids; Cell Differentiation; Cell Movement; Cells, Cultured; Cyclohexanes; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Indoles; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2; Resorcinols | 2014 |
Cannabinoid system of the lateral septum in the modulation of anxiety-like behaviors in rats.
Topics: Animals; Anxiety; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Exploratory Behavior; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Septum of Brain; Time Factors | 2013 |
BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Antagonists; Inhibitory Postsynaptic Potentials; Mice; Neurons; Phospholipase C beta; Phospholipase C gamma; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Somatosensory Cortex | 2014 |
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma.
Topics: Apoptosis; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Hodgkin Disease; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction; Transcription Factor RelA | 2013 |
(R,R')-4'-methoxy-1-naphthylfenoterol targets GPR55-mediated ligand internalization and impairs cancer cell motility.
Topics: Cell Movement; Drug Inverse Agonism; Endocytosis; Fenoterol; HEK293 Cells; Hep G2 Cells; Humans; Ligands; Molecular Targeted Therapy; Neoplasms; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Receptors, G-Protein-Coupled | 2014 |
Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s).
Topics: Acetylcholinesterase; Amidohydrolases; Animals; Biomarkers; Brain; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Fenitrothion; GPI-Linked Proteins; Hydrolysis; Hypertriglyceridemia; Insecticides; Liver; Male; Mice; Mice, Inbred ICR; Monoacylglycerol Lipases; Piperidines; Pyrazoles; Receptors, Cannabinoid; Triglycerides; Up-Regulation | 2014 |
Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1 receptor activity affects feeding behavior and body weight in rats fed a free-choice, high-carbohydrate diet.
Topics: Analysis of Variance; Animals; Benzoxazines; Body Weight; Dietary Carbohydrates; Drug Interactions; Exenatide; Feeding Behavior; Glucagon-Like Peptide-1 Receptor; Male; Morpholines; Naphthalenes; Peptide Fragments; Peptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Glucagon; Venoms | 2014 |
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.
Topics: Amidohydrolases; Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Benzamides; Benzoxazines; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Pain; Pain Measurement; Piperazines; Piperidines; Pyrazoles; Time Factors | 2014 |
Blockade of cannabinoid CB1 and CB2 receptors does not prevent the antipruritic effect of systemic paracetamol.
Topics: Acetaminophen; Animals; Antipruritics; Camphanes; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred BALB C; Piperidines; Pruritus; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Serotonin | 2014 |
Cannabinoid type-1 receptors in the paraventricular nucleus of the hypothalamus inhibit stimulated food intake.
Topics: Animals; Cannabinoid Receptor Antagonists; Ghrelin; Hyperphagia; Male; Membrane Potentials; Neurons; Paraventricular Hypothalamic Nucleus; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2014 |
Cannabinoid modulation of predator fear: involvement of the dorsolateral periaqueductal gray.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cats; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Fear; Male; Microinjections; Morpholines; Naphthalenes; Nitric Oxide Synthase Type I; Ornithine; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Predatory Behavior; Pyrazoles; Rats; Receptor, Cannabinoid, CB1 | 2014 |
Cannabinoid type-1 receptor ligands, alone or in combination with cocaine, affect vigilance-related behaviors of marmoset monkeys.
Topics: Analysis of Variance; Animals; Anxiety; Benzoxazines; Calcium Channel Blockers; Callithrix; Cocaine; Dopamine Uptake Inhibitors; Female; Ligands; Locomotion; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Random Allocation; Receptor, Cannabinoid, CB1; Time Factors | 2014 |
Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.
Topics: Adipose Tissue, Brown; Animals; Biomarkers; Body Composition; Body Weight; Cold Temperature; Deoxyglucose; Dioxoles; Energy Metabolism; Feeding Behavior; Glucose; Homeostasis; Hormones; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Obesity; Piperidines; Pyrazoles | 2014 |
Basolateral amygdala CB1 cannabinoid receptors mediate nicotine-induced place preference.
Topics: Amygdala; Analysis of Variance; Animals; Benzoxazines; Calcium Channel Blockers; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Microinjections; Morpholines; Motor Activity; Naphthalenes; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2014 |
Effects of endogenous cannabinoid anandamide on excitation-contraction coupling in rat ventricular myocytes.
Topics: Action Potentials; Animals; Arachidonic Acids; Caffeine; Calcium; Calcium Signaling; Endocannabinoids; Fura-2; Heart Ventricles; In Vitro Techniques; Indoles; Male; Myocardial Contraction; Myocytes, Cardiac; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sarcoplasmic Reticulum; Transport Vesicles | 2014 |
Anti-depressive mechanism of repetitive transcranial magnetic stimulation in rat: the role of the endocannabinoid system.
Topics: Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Cell Proliferation; Depression; Disease Models, Animal; Exploratory Behavior; Food Preferences; Gene Expression Regulation; Hippocampus; Male; Piperidines; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Swimming; Transcranial Magnetic Stimulation | 2014 |
Anandamide activation of CB1 receptors increases spontaneous bursting and oscillatory activity in the thalamus.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Electroencephalography; Endocannabinoids; Geniculate Bodies; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Visual Cortex | 2014 |
Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH).
Topics: Amidohydrolases; Animals; Cannabinoids; Colitis, Ulcerative; Disease Models, Animal; Dose-Response Relationship, Drug; Indoles; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Treatment Outcome | 2014 |
CB1 blockade potentiates down-regulation of lipogenic gene expression in perirenal adipose tissue in high carbohydrate diet-induced obesity.
Topics: Adipose Tissue, White; Animals; Body Weight; Diet, High-Fat; Dietary Carbohydrates; Down-Regulation; Kidney; Lipogenesis; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction; Time Factors; Transcription Factors | 2014 |
CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex.
Topics: Animals; Benzodiazepines; Benzoxazines; Central Nervous System Agents; Electric Stimulation; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Male; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Synaptic Transmission; Thiophenes | 2014 |
Low anandamide doses facilitate male rat sexual behaviour through the activation of CB1 receptors.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Copulation; Endocannabinoids; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sexual Behavior, Animal | 2014 |
Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels.
Topics: Amidohydrolases; Anilides; Animals; Anticonvulsants; Arachidonic Acids; Cinnamates; Male; Mice; Pentylenetetrazole; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Serotonin; TRPV Cation Channels | 2014 |
Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication.
Topics: AMP-Activated Protein Kinases; Arachidonic Acids; Cell Line; Cell Survival; Coculture Techniques; Cyclic AMP Response Element-Binding Protein; Endocannabinoids; Genome, Viral; Glucose Metabolism Disorders; Glucose Transporter Type 2; Glucose-6-Phosphatase; Glycerides; Hepacivirus; Hepatic Stellate Cells; Hepatitis C, Chronic; Hepatocytes; Humans; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; RNA, Messenger; RNA, Viral; Signal Transduction; Up-Regulation; Virus Replication | 2014 |
In utero cannabinoid exposure alters breathing and the response to hypoxia in newborn mice.
Topics: Animals; Animals, Newborn; Apnea; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Female; Hypoxia; Immunohistochemistry; Medulla Oblongata; Mice, Inbred C57BL; Morpholines; Naphthalenes; Periodicity; Piperidines; Plethysmography; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Receptor, Cannabinoid, CB1; Respiration; Tyrosine 3-Monooxygenase | 2014 |
Involvement of the nucleus accumbens shell glutamatergic system in ACPA-induced impairment of inhibitory avoidance memory consolidation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arachidonic Acids; Avoidance Learning; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Memory; Memory Disorders; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2014 |
Experience salience gates endocannabinoid signaling at hypothalamic synapses.
Topics: Analgesics; Animals; Animals, Newborn; Benzoxazines; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Endocannabinoids; Hypothalamus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Morpholines; Naphthalenes; Odorants; Piperidines; Potassium Chloride; Pyrazoles; Rats; Rats, Sprague-Dawley; Signal Transduction; Stress, Psychological; Swimming; Synapses | 2014 |
The CB1 receptor antagonist AM251 impairs reconsolidation of pavlovian fear memory in the rat basolateral amygdala.
Topics: Amidohydrolases; Animals; Auditory Perception; Basolateral Nuclear Complex; Benzamides; Bicuculline; Cannabinoid Receptor Antagonists; Carbamates; Conditioning, Classical; Electroshock; Enzyme Inhibitors; Fear; GABA-A Receptor Antagonists; Male; Memory; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, GABA-A | 2014 |
Vagal anandamide signaling via cannabinoid receptor 1 contributes to luminal 5-HT modulation of visceral nociception in rats.
Topics: Adult; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Endocannabinoids; Female; Humans; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Middle Aged; Nociception; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Serotonin; Vagus Nerve; Visceral Pain | 2014 |
Presynaptic calcium channel inhibition underlies CB₁ cannabinoid receptor-mediated suppression of GABA release.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Cholecystokinin; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Luminescent Proteins; Male; Mice; Mice, Transgenic; omega-Conotoxin GVIA; Piperidines; Presynaptic Terminals; Pyrazoles; Receptor, Cannabinoid, CB1; Synapses | 2014 |
Utility of intracerebral theta burst electrical stimulation to attenuate interhemispheric inhibition and to promote motor recovery after cortical injury in an animal model.
Topics: Animals; Biophysics; Brain Injuries; Disease Models, Animal; Electroencephalography; Functional Laterality; Male; Membrane Potentials; Motor Cortex; Movement Disorders; Neural Inhibition; Piperidines; Pyrazoles; Rats; Rats, Wistar; Recovery of Function; Transcranial Magnetic Stimulation | 2014 |
Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol.
Topics: Animals; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Modulators; Endocannabinoids; Glycerides; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Neuralgia; Pain; Pain Threshold; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2014 |
Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission.
Topics: Action Potentials; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Brain Stem; Capsaicin; Dopamine; Excitatory Postsynaptic Potentials; Glutamic Acid; Hot Temperature; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission; TRPV Cation Channels | 2014 |
Comparison of automated home-cage monitoring systems: emphasis on feeding behaviour, activity and spatial learning following pharmacological interventions.
Topics: Animals; Apomorphine; Cholinergic Antagonists; Dopamine Agonists; Dose-Response Relationship, Drug; Electronic Data Processing; Excitatory Amino Acid Antagonists; Exploratory Behavior; Feeding Behavior; Female; History, 20th Century; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Monitoring, Physiologic; Motor Activity; Phencyclidine; Piperidines; Pyrazoles; Scopolamine; Spatial Learning | 2014 |
The PVH as a site of CB1-mediated stimulation of thermogenesis by MC4R agonism in male rats.
Topics: Adipose Tissue, Brown; alpha-MSH; Animals; Male; Paraventricular Hypothalamic Nucleus; Peptides, Cyclic; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Melanocortin, Type 4; Thermogenesis | 2014 |
Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Modulators; Dronabinol; Indoles; Male; Mice; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Somatosensory Cortex; Tissue Culture Techniques | 2014 |
Endocannabinoid CB1 antagonists inhibit hepatitis C virus production, providing a novel class of antiviral host-targeting agents.
Topics: AMP-Activated Protein Kinases; Antiviral Agents; Cannabinoid Receptor Antagonists; Cell Line; Gene Knockdown Techniques; Hepacivirus; Humans; Lipid Metabolism; Lipogenesis; Models, Biological; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; RNA, Small Interfering; RNA, Viral; Viral Proteins; Virion; Virus Replication | 2014 |
Cannabinoids reward sensitivity in a neurodevelopmental animal model of schizophrenia: a brain stimulation reward study.
Topics: Amphetamine; Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Brain; Brain Injuries; Central Nervous System Stimulants; Conditioning, Operant; Disease Models, Animal; Dronabinol; Female; Hippocampus; Male; Morpholines; Motivation; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reward; Schizophrenia; Self Administration; Time Factors | 2014 |
Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress.
Topics: Analysis of Variance; Animals; Basolateral Nuclear Complex; Benzamides; Carbamates; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Hypothalamo-Hypophyseal System; Male; Paraventricular Hypothalamic Nucleus; Piperidines; Pituitary-Adrenal System; Pro-Opiomelanocortin; Pyrazoles; Rats; RNA, Messenger; Stress, Psychological; Swimming; Time Factors | 2014 |
The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet.
Topics: Animals; Body Weight; Cannabidiol; Cannabinoid Receptor Antagonists; Diet, High-Fat; Dietary Sucrose; Drug Combinations; Eating; Leptin; Male; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2014 |
Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury.
Topics: Aging; Analgesics, Non-Narcotic; Animals; Burns; Hyperalgesia; Injections, Spinal; Male; Neuroglia; Pain Measurement; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Spinal Cord | 2014 |
Cannabinoid-induced changes in respiration of brain mitochondria.
Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoids; Cell Respiration; Dose-Response Relationship, Drug; Dronabinol; Drug Inverse Agonism; Endocannabinoids; Energy Metabolism; Mitochondria; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction; Swine | 2014 |
Neurophysiological evidence for the presence of cannabinoid CB1 receptors in the laterodorsal tegmental nucleus.
Topics: Action Potentials; Animals; Brain Stem; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cerebellum; Excitatory Postsynaptic Potentials; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Mice; Miniature Postsynaptic Potentials; Nitric Oxide Synthase Type I; Patch-Clamp Techniques; Piperidines; Polymerase Chain Reaction; Potassium; Pyrazoles; Receptor, Cannabinoid, CB1; RNA, Messenger; Tissue Culture Techniques | 2014 |
The interaction between ghrelin and cannabinoid systems in penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Ghrelin; Infusions, Intraventricular; Male; Penicillins; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2014 |
Tapping into the endocannabinoid system to ameliorate acute inflammatory flares and associated pain in mouse knee joints.
Topics: Acute Disease; Amidohydrolases; Animals; Arthralgia; Benzamides; Carbamates; Carrageenan; Endocannabinoids; Hindlimb; Hyperalgesia; Indoles; Inflammation; Kaolin; Knee Joint; Male; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Synovitis; Weight-Bearing | 2014 |
Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex.
Topics: Age Factors; Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Developmental Disabilities; Dizocilpine Maleate; Dronabinol; Estradiol; Estrous Cycle; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Neurites; Piperidines; Prefrontal Cortex; Pyrazoles; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptic Potentials; Tritium | 2015 |
Cannabinoid type 1 and type 2 receptor antagonists prevent attenuation of serotonin-induced reflex apneas by dronabinol in Sprague-Dawley rats.
Topics: Animals; Cannabinoid Receptor Agonists; Dronabinol; Electromyography; Femoral Vein; Indoles; Male; Nodose Ganglion; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Serotonin; Sleep Apnea, Obstructive; Treatment Outcome | 2014 |
Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459.
Topics: Animals; Benzoxazines; Brain; Cannabinoid Receptor Antagonists; Cyclohexanols; Electroencephalography; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Sleep; Sleep, REM; Wakefulness | 2015 |
Anti-aversive role of the endocannabinoid system in the periaqueductal gray stimulation model of panic attacks in rats.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Male; N-Methylaspartate; Panic Disorder; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2015 |
Ethanol attenuation of long-term depression in the nucleus accumbens can be overcome by activation of TRPV1 receptors.
Topics: Animals; Ethanol; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Organ Culture Techniques; Piperidines; Pyrazoles; TRPV Cation Channels | 2014 |
Systemic or intra-amygdala infusion of an endocannabinoid CB1 receptor antagonist AM251 blocked propofol-induced anterograde amnesia.
Topics: Amnesia, Anterograde; Amygdala; Anesthetics, Intravenous; Animals; Male; Memory, Long-Term; Piperidines; Propofol; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2015 |
Differential effects of CB1 receptor agonism in behavioural tests of unconditioned and conditioned fear in adult male rats.
Topics: Animals; Anxiety; Arachidonic Acids; Conditioning, Psychological; Corticosterone; Extinction, Psychological; Fear; Male; Mental Recall; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1 | 2015 |
Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain.
Topics: Analgesics; Animals; Cannabinoid Receptor Agonists; Dronabinol; Indoles; Injections, Intramuscular; Injections, Intraperitoneal; Male; Masseter Muscle; Muscle, Skeletal; Myalgia; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid | 2014 |
The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Chlorpyrifos; Cholinesterase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Insecticides; Male; Monoacylglycerol Lipases; Neurotoxicity Syndromes; Paraoxon; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Time Factors; Tritium | 2015 |
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2.
Topics: Anilides; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morpholines; Naphthalenes; Oxazoles; Pentylenetetrazole; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Thiazolidinediones; Tyrosine | 2015 |
Anxiogenic-like effects induced by hemopressin in rats.
Topics: Anilides; Animals; Anxiety; Brain; Capsaicin; Cinnamates; Hemoglobins; Injections, Intraventricular; Male; Maze Learning; Peptide Fragments; Piperidines; Pyrazoles; Rats; Rats, Wistar | 2015 |
Differential modulation of endogenous cannabinoid CB1 and CB2 receptors in spontaneous and splice variants of ghrelin-induced food intake in conscious rats.
Topics: Animals; Eating; Endocannabinoids; Fasting; Ghrelin; Hyperphagia; Indoles; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2015 |
Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Choice Behavior; Cost-Benefit Analysis; Decision Making; Gyrus Cinguli; Male; Maze Learning; Microinjections; Motor Activity; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid | 2015 |
The endocannabinoid system in renal cells: regulation of Na(+) transport by CB1 receptors through distinct cell signalling pathways.
Topics: Animals; Benzoxazines; Biological Transport; Cyclic AMP; Endocannabinoids; Hemoglobins; Kidney; LLC-PK1 Cells; Morpholines; Naphthalenes; Peptide Fragments; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Signal Transduction; Sodium; Sodium-Potassium-Exchanging ATPase; Swine; TRPV Cation Channels | 2015 |
Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice.
Topics: Aggression; Agonistic Behavior; Animals; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Agonists; Corticosterone; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Metyrapone; Mice; Monoacylglycerol Lipases; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction | 2015 |
The role of AMP-activated protein kinase in the androgenic potentiation of cannabinoid-induced changes in energy homeostasis.
Topics: AMP-Activated Protein Kinases; Androgens; Animals; Arcuate Nucleus of Hypothalamus; Cannabinoids; Eating; Energy Metabolism; Guinea Pigs; Homeostasis; Male; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Testosterone Propionate | 2015 |
Effects of metabolites of the analgesic agent dipyrone (metamizol) on rostral ventromedial medulla cell activity in mice.
Topics: Analgesics; Animals; Arachidonic Acid; Dipyrone; Diterpenes; Drug Interactions; Extracellular Space; Male; Mechanical Phenomena; Mesencephalon; Mice; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2015 |
Endocannabinoid CB1 receptor-mediated rises in Ca(2+) and depolarization-induced suppression of inhibition within the laterodorsal tegmental nucleus.
Topics: Animals; Benzoxazines; Calcium; Endocannabinoids; Inhibitory Postsynaptic Potentials; Methoxyhydroxyphenylglycol; Mice; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Tegmentum Mesencephali | 2016 |
The spinal anti-inflammatory mechanism of motor cortex stimulation: cause of success and refractoriness in neuropathic pain?
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cytokines; Deep Brain Stimulation; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Microfilament Proteins; Motor Cortex; Myelitis; Neuralgia; Neuroglia; Pain Threshold; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Receptors, Purinergic P2X4 | 2015 |
Role of endocannabinoid signalling in the dorsolateral periaqueductal grey in the modulation of distinct panic-like responses.
Topics: Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Escape Reaction; Male; Maze Learning; Panic Disorder; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction | 2015 |
Dentate total molecular layer interneurons mediate cannabinoid-sensitive inhibition.
Topics: Action Potentials; Animals; Biophysics; Cannabinoid Receptor Modulators; Cannabinoids; Cholecystokinin; Dentate Gyrus; Electric Stimulation; In Vitro Techniques; Interneurons; Lysine; Male; Neural Inhibition; Parvalbumins; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Synapses | 2015 |
[Cannabinoid receptor 1 controls nerve growth in ectopic cyst in a rat endometriosis model].
Topics: Animals; Blotting, Western; Cysts; Disease Models, Animal; Endometriosis; Female; Peripheral Nerves; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Ubiquitin Thiolesterase | 2014 |
Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids.
Topics: Animals; Arachidonic Acids; Blood Pressure; Cardiac Output; Endocannabinoids; Gadolinium; Glycerides; Hemorrhage; Liver Cirrhosis; Macrophages; Male; Monocytes; Myocardial Contraction; Myocardium; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Ventricular Function, Left | 2015 |
Further Evidence for the Neuroplastic Role of Cannabinoids: A Study in Organotypic Hippocampal Slice Cultures.
Topics: Animals; Arachidonic Acids; Cannabinoids; Caspase 3; Cells, Cultured; Cytoskeleton; Hippocampus; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2015 |
Acute administration of a cannabinoid CB1 receptor antagonist impairs stress-induced antinociception in fish.
Topics: Animal Fins; Animals; Cannabinoid Receptor Antagonists; Fish Proteins; Fishes; Formaldehyde; Motor Activity; Nociceptive Pain; Pain Measurement; Pain Perception; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Restraint, Physical; Stress, Psychological; Time Factors | 2015 |
Antidepressant-like effects of the cannabinoid receptor ligands in the forced swimming test in mice: mechanism of action and possible interactions with cholinergic system.
Topics: Animals; Antidepressive Agents; Cannabinoids; Depressive Disorder; Disease Models, Animal; Indoles; Ligands; Male; Mice; Motor Activity; Nicotine; Oleic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Scopolamine; Swimming | 2015 |
The dual effect of CA1 NMDA receptor modulation on ACPA-induced amnesia in step-down passive avoidance learning task.
Topics: 2-Amino-5-phosphonovalerate; Amnesia; Analysis of Variance; Animals; Arachidonic Acids; Avoidance Learning; CA1 Region, Hippocampal; Cannabinoid Receptor Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Mice; Microinjections; N-Methylaspartate; Piperidines; Pyrazoles; Receptors, N-Methyl-D-Aspartate | 2015 |
Effects of cannabinoid and glutamate receptor antagonists and their interactions on learning and memory in male rats.
Topics: Animals; Avoidance Learning; Cannabinoid Receptor Antagonists; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Learning; Male; Memory; Piperidines; Pyrazoles; Rats; Rats, Wistar; Retention, Psychology | 2015 |
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Cinnamates; Disease Models, Animal; Endocannabinoids; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Interleukin-6; Lumbar Vertebrae; Male; Osteoarthritis; Pain; Pain Management; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2015 |
BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cocaine; Conditioning, Operant; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Endocannabinoids; Enzyme Inhibitors; In Vitro Techniques; Indole Alkaloids; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Piperidines; Pyrazoles; Receptors, Glutamate; RNA, Untranslated; Signal Transduction; Synapses; Time Factors | 2015 |
Novel halogenated derivates of JWH-018: Behavioral and binding studies in mice.
Topics: Animals; Binding, Competitive; Cannabinoid Receptor Agonists; Cannabinoids; Catalepsy; CHO Cells; Cricetulus; Halogenation; Humans; Hypothermia; Indoles; Male; Mice, Inbred ICR; Motor Activity; Naphthalenes; Pain Threshold; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex, Abnormal; Seizures | 2015 |
Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs.
Topics: Amidohydrolases; Animals; Anticonvulsants; Arachidonic Acids; Benzamides; Biological Transport; Brain; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Guinea Pigs; Kainic Acid; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Status Epilepticus | 2015 |
Mild, Pd-catalyzed stannylation of radioiodination targets.
Topics: Animals; Brain; Catalysis; Iodine; Iodine Radioisotopes; Isotope Labeling; Mice; Palladium; Piperidines; Pyrazoles | 2015 |
Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats.
Topics: Amidohydrolases; Animals; Camphanes; Male; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord; Urinary Bladder Neck Obstruction; Urodynamics | 2016 |
Cannabinoid receptor 1 and acute resistance exercise--In vivo and in vitro studies in human skeletal muscle.
Topics: Adaptor Proteins, Signal Transducing; Cell Cycle Proteins; Cell Line; Gene Expression; Humans; Male; MAP Kinase Signaling System; Muscle Fibers, Skeletal; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Piperidines; Protein Biosynthesis; Protein Processing, Post-Translational; Pyrazoles; Receptor, Cannabinoid, CB1; Resistance Training; Ribosomal Protein S6 Kinases, 70-kDa; Young Adult | 2015 |
Chronic administration of AM251 improves albuminuria and renal tubular structure in obese rats.
Topics: Albuminuria; Animals; Collagen; Diet, High-Fat; Humans; Kidney Tubules; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2015 |
Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model.
Topics: Animals; Blotting, Western; Diet, High-Fat; Fatty Acids; Gene Silencing; Hepatocytes; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Piperidines; Proteins; Pyrazoles; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1 | 2015 |
Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat.
Topics: Adrenal Medulla; Animals; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Catecholamines; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Immunohistochemistry; Male; Neurons; Neurotransmitter Agents; Nicotinic Agonists; Paraventricular Hypothalamic Nucleus; Piperidines; Pyrazoles; Pyridines; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2015 |
Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dioxoles; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Nociception; Pain Threshold; Piperidines; Pyrazoles; Quinolones; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2015 |
Differential Pharmacological Regulation of Sensorimotor Gating Deficit in CB1 Knockout Mice and Associated Neurochemical and Histological Alterations.
Topics: Animals; Cannabinoid Receptor Antagonists; Central Nervous System Agents; Cerebral Cortex; Cholecystokinin; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Immunohistochemistry; Male; Methylphenidate; Mice, Knockout; Neurons; Parvalbumins; Peptide Fragments; Piperidines; Prepulse Inhibition; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Adrenergic, alpha-2; Risperidone; Time Factors | 2015 |
Interaction between orexin A and cannabinoid system in the lateral hypothalamus of rats and effects of subchronic intraperitoneal administration of cannabinoid receptor inverse agonist on food intake and the nutritive utilization of protein.
Topics: Animals; Body Weight; Cannabinoid Receptor Agonists; Cannabinoids; Eating; Hypothalamic Area, Lateral; Injections, Intraperitoneal; Male; Neurons; Orexins; Piperidines; Proteins; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid | 2015 |
AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells.
Topics: Antineoplastic Agents; Apoptosis; Calcium Channels; Celecoxib; Cell Line, Tumor; Cell Survival; Cyclic AMP; Cyclooxygenase 2; Drug Inverse Agonism; Drug Synergism; G2 Phase Cell Cycle Checkpoints; Humans; Melanoma; Mutation; Nerve Tissue Proteins; Piperidines; Proto-Oncogene Proteins B-raf; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Skin Neoplasms; Sulfonamides; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2015 |
Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Avoidance Learning; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Fragile X Mental Retardation Protein; Fragile X Syndrome; Male; Memory; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Propofol; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Social Behavior | 2015 |
JWH-018 impairs sensorimotor functions in mice.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cornea; Dose-Response Relationship, Drug; Dronabinol; Ear Auricle; Hearing; Illicit Drugs; Indoles; Male; Mice; Movement; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reflex; Touch; Vibrissae; Video Recording; Vision, Ocular | 2015 |
Layer-specific endocannabinoid-mediated long-term depression of GABAergic neurotransmission onto principal neurons in mouse visual cortex.
Topics: Animals; Benzoxazines; Endocannabinoids; GABAergic Neurons; Inhibitory Postsynaptic Potentials; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Sensory Deprivation; Visual Cortex | 2015 |
Intra-accumbal CB1 receptor blockade reduced extinction and reinstatement of morphine.
Topics: Analysis of Variance; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Morphine; Narcotics; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reward; Time Factors | 2015 |
Involvement of cannabinoid receptors in infrasonic noise-induced neuronal impairment.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Endocannabinoids; Glycerides; Hippocampus; Inflammation Mediators; Interleukin-1beta; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Ultrasonic Waves | 2015 |
Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus.
Topics: Amidohydrolases; Anesthesia; Animals; Arachidonic Acids; Blood Pressure; Cannabinoids; Cerebral Cortex; Cyclohexanols; Endocannabinoids; Heart Rate; Male; Microinjections; Morpholines; Paraventricular Hypothalamic Nucleus; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2015 |
Coadministration of indomethacin and minocycline attenuates established paclitaxel-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
Topics: Animals; Female; Hyperalgesia; Indomethacin; Male; Mice; Mice, Inbred BALB C; Minocycline; Paclitaxel; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2015 |
Evidence against a critical role of CB1 receptors in adaptation of the hypothalamic-pituitary-adrenal axis and other consequences of daily repeated stress.
Topics: Adaptation, Psychological; Adrenocorticotropic Hormone; Animals; Body Weight; Cannabinoid Receptor Antagonists; Corticosterone; Disease Models, Animal; Glucose; Hypothalamo-Hypophyseal System; Male; Mice, Knockout; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Restraint, Physical; Stress, Psychological; Swimming | 2015 |
Role of Endothelium in Abnormal Cannabidiol-Induced Vasoactivity in Retinal Arterioles.
Topics: Animals; Arterioles; Cannabidiol; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Retinal Vessels; Swine; Vasodilation | 2015 |
Modulatory effects by CB1 receptors on rat spinal locomotor networks after sustained application of agonists or antagonists.
Topics: Action Potentials; Animals; Arachidonic Acids; Endocannabinoids; gamma-Aminobutyric Acid; Locomotion; Nerve Net; Neural Inhibition; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reflex; Spinal Cord; Synaptic Transmission | 2015 |
Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electrophysiological and behavioral models of temporal lobe epilepsy in the rat.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Hippocampus; Indazoles; Male; Morpholines; Naphthalenes; Nitric Oxide; Nitric Oxide Synthase; Pilocarpine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2015 |
Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Enzyme Inhibitors; Female; gamma-Aminobutyric Acid; Glycerides; Hippocampus; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Signal Transduction; Synapses; TRPV Cation Channels | 2015 |
Disruption of peri-adolescent endocannabinoid signaling modulates adult neuroendocrine and behavioral responses to stress in male rats.
Topics: Adaptation, Psychological; Adrenocorticotropic Hormone; Animals; Brain; Cannabinoid Receptor Antagonists; Corticosterone; Disease Models, Animal; Emotions; Endocannabinoids; Male; Motor Activity; Piperidines; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Restraint, Physical; Risk-Taking; Stress, Psychological | 2015 |
Microinjection of orexin-A into the rat locus coeruleus nucleus induces analgesia via cannabinoid type-1 receptors.
Topics: Analgesics; Analysis of Variance; Animals; Benzoxazoles; Carrier Proteins; Dose-Response Relationship, Drug; Formaldehyde; Locus Coeruleus; Male; Microinjections; Naphthyridines; Orexins; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Urea | 2015 |
Cannabinoids and Glucocorticoids in the Basolateral Amygdala Modulate Hippocampal-Accumbens Plasticity After Stress.
Topics: Animals; Basolateral Nuclear Complex; Benzoxazines; Hippocampus; Male; Mifepristone; Morpholines; Naphthalenes; Neural Pathways; Neuronal Plasticity; Nucleus Accumbens; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Glucocorticoid; Stress, Psychological | 2016 |
Endocannabinoids, through opioids and prostaglandins, contribute to fever induced by key pyrogenic mediators.
Topics: Animals; Arachidonic Acids; beta-Endorphin; Body Temperature; Corticotropin-Releasing Hormone; Cytokines; Endocannabinoids; Endothelin-1; Fever; Interleukin-1beta; Interleukin-6; Male; Naloxone; Narcotic Antagonists; Piperidines; Polyunsaturated Alkamides; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Tumor Necrosis Factor-alpha | 2016 |
Blockade of GPR55 in the dorsolateral striatum impairs performance of rats in a T-maze paradigm.
Topics: Animals; Azabicyclo Compounds; Benzoates; Cognition; Corpus Striatum; Glycerides; Male; Maze Learning; Memory; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, G-Protein-Coupled | 2016 |
Effects of CB1 receptor agonism and antagonism on behavioral fear and physiological stress responses in adult intact, ovariectomized, and estradiol-replaced female rats.
Topics: Animals; Anxiety; Arachidonic Acids; Conditioning, Classical; Corticosterone; Estradiol; Extinction, Psychological; Fear; Female; Mental Recall; Motor Activity; Ovariectomy; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Stress, Physiological | 2015 |
Effect of nucleus accumbens shell 5-HT4 receptors on the impairment of ACPA-induced emotional memory consolidation in male Wistar rats.
Topics: Aniline Compounds; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Emotions; Male; Maze Learning; Memory Consolidation; Memory Disorders; Motor Activity; Nootropic Agents; Nucleus Accumbens; Piperidines; Pyrazoles; Random Allocation; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists | 2016 |
Anandamide mediates cognitive judgement bias in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Bias; Calcium Channel Blockers; Carbamates; Cognition; Conditioning, Psychological; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Judgment; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats | 2016 |
Endocannabinoid Signaling in the Stress Response of Male and Female Songbirds.
Topics: Animals; Corticosterone; Endocannabinoids; Female; Hypothalamo-Hypophyseal System; Male; Molting; Piperidines; Pituitary-Adrenal System; Pyrazoles; Receptor, Cannabinoid, CB1; Reproduction; Restraint, Physical; Signal Transduction; Songbirds; Starlings; Stress, Physiological; Stress, Psychological | 2015 |
CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats.
Topics: Animals; Arachidonic Acids; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Endocannabinoids; Extinction, Psychological; Glycerides; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Self Administration; Stress, Psychological | 2016 |
Increased Cortical Inhibition in Autism-Linked Neuroligin-3R451C Mice Is Due in Part to Loss of Endocannabinoid Signaling.
Topics: Amino Acid Substitution; Animals; Autistic Disorder; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Endocannabinoids; Evoked Potentials, Somatosensory; Hippocampus; Humans; Interneurons; Male; Membrane Proteins; Mice; Nerve Tissue Proteins; Piperidines; Pyrazoles; Signal Transduction; Somatosensory Cortex; Synaptic Transmission | 2015 |
Functional interaction between OX2 and CB1 receptors in the ventral tegmental area and the nucleus accumbens in response to place preference induced by chemical stimulation of the lateral hypothalamus.
Topics: Animals; Carbachol; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Hypothalamic Area, Lateral; Isoquinolines; Male; Microinjections; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Pyrazoles; Pyridines; Rats; Receptor, Cannabinoid, CB1; Reward; Stimulation, Chemical; Ventral Tegmental Area | 2015 |
Endocannabinoid signaling mediates oxytocin-driven social reward.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Autism Spectrum Disorder; Benzamides; Benzodiazepines; Camphanes; Carbamates; Clozapine; Cocaine; Endocannabinoids; Immunohistochemistry; Infusions, Intraventricular; Lipids; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Oxytocin; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Reward; Signal Transduction; Social Behavior | 2015 |
Endocannabinoid CB1 receptor activation upon global ischemia adversely impact recovery of reward and stress signaling molecules, neuronal survival and behavioral impulsivity.
Topics: Animals; Behavior, Animal; Brain Ischemia; Cell Survival; Corticotropin-Releasing Hormone; Impulsive Behavior; Male; Neurons; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Reward; Signal Transduction; Tyrosine 3-Monooxygenase; Vesicular Glutamate Transport Protein 2 | 2016 |
The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Catheters, Indwelling; Cerebral Cortex; Conditioning, Psychological; Cyclohexanols; Extinction, Psychological; Fear; Male; Memory Consolidation; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2015 |
Involvement of opioid system in antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251 after physical stress in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Drug Inverse Agonism; Hindlimb Suspension; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid; Stress, Physiological; Swimming | 2016 |
The interactive role of CB(1) and GABA(B) receptors in hippocampal synaptic plasticity in rats.
Topics: Animals; Cannabinoid Receptor Antagonists; Electric Stimulation; Electrodes, Implanted; Excitatory Postsynaptic Potentials; GABA-B Receptor Antagonists; Hippocampus; Long-Term Potentiation; Male; Phosphinic Acids; Piperidines; Propanolamines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-B | 2016 |
Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium; Calcium Channels; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Ependymoglial Cells; Glycerides; Indoles; Male; Membrane Potentials; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2016 |
Role of the endocannabinoid 2-arachidonoylglycerol in aversive responses mediated by the dorsolateral periaqueductal grey.
Topics: Animals; Arachidonic Acids; Biphenyl Compounds; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Fluorescent Antibody Technique; Glycerides; Male; N-Methylaspartate; Panic Disorder; Periaqueductal Gray; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2016 |
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle.
Topics: Animals; Body Weight; Cell Line; Diet; Dietary Carbohydrates; Dihydrolipoamide Dehydrogenase; Electrophoresis, Gel, Two-Dimensional; Feeding Behavior; Gene Expression Regulation; Glucose; Glutathione Reductase; Male; Mice, Inbred C57BL; Mitochondria; Muscle Fibers, Skeletal; Muscles; Obesity; Oxidation-Reduction; Piperidines; Pyrazoles; Pyruvic Acid; Rats, Wistar; Receptor, Cannabinoid, CB1; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2015 |
Native CB1 receptor affinity, intrinsic activity and accumbens shell dopamine stimulant properties of third generation SPICE/K2 cannabinoids: BB-22, 5F-PB-22, 5F-AKB-48 and STS-135.
Topics: Adamantane; Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Central Nervous System Stimulants; Dopamine Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Indazoles; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Naphthalenes; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Quinolines; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2016 |
Disruption of social cognition in the sub-chronic PCP rat model of schizophrenia: Possible involvement of the endocannabinoid system.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Modulators; Cyclohexanols; Discrimination, Psychological; Disease Models, Animal; Endocannabinoids; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Odorants; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Social Behavior Disorders; Social Perception | 2016 |
CB1 receptors in the formation of the different phases of memory-related processes in the inhibitory avoidance test in mice.
Topics: Animals; Avoidance Learning; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Inhibition, Psychological; Male; Memory; Mice; Motor Activity; Neuropsychological Tests; Oleic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2016 |
Dorsolateral periaqueductal gray matter CB1 and TRPV1 receptors exert opposite modulation on expression of contextual fear conditioning.
Topics: Animals; Capsaicin; Conditioning, Classical; Fear; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Soluble Guanylyl Cyclase; TRPV Cation Channels | 2016 |
Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Line, Tumor; Cyclic AMP; Endocannabinoids; Genetic Predisposition to Disease; Glucagon-Like Peptide-1 Receptor; Glycerides; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice, Inbred C57BL; Mice, Knockout; Obesity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1 | 2016 |
The endocannabinoid system and NGF are involved in the mechanism of action of resveratrol: a multi-target nutraceutical with therapeutic potential in neuropsychiatric disorders.
Topics: Amitriptyline; Animals; Antioxidants; Brain; Camphanes; Cannabinoids; Clonazepam; Dose-Response Relationship, Drug; Endocannabinoids; Male; Nerve Growth Factor; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resveratrol; Signal Transduction; Stilbenes | 2016 |
Prevention of drug priming- and cue-induced reinstatement of MDMA-seeking behaviors by the CB1 cannabinoid receptor antagonist AM251.
Topics: Amphetamine-Related Disorders; Animals; Cannabinoid Receptor Antagonists; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rats; Self Administration | 2016 |
Antidepressant-like effect of cannabidiol injection into the ventral medial prefrontal cortex-Possible involvement of 5-HT1A and CB1 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Arachidonic Acids; Behavior, Animal; Cannabidiol; Endocannabinoids; Male; Motor Activity; Piperazines; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists | 2016 |
Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy.
Topics: Action Potentials; Animals; Dentate Gyrus; Inhibitory Postsynaptic Potentials; Interneurons; Male; Pilocarpine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Status Epilepticus; Synapses | 2016 |
Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzoxazines; Biomarkers; Brain; Cannabinoids; Indoles; Male; Malondialdehyde; Memory; Mice; Morpholines; Naphthalenes; Oxidative Stress; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2016 |
Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity.
Topics: Animals; Cannabinoid Receptor Agonists; Citrate (si)-Synthase; Diet, High-Fat; DNA-Binding Proteins; Forkhead Box Protein O1; High Mobility Group Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 1; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid | 2016 |
Involvement of Endocannabinoids in Alcohol "Binge" Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB1 Receptor Antagonists.
Topics: Amidohydrolases; Animals; Binge Drinking; Endocannabinoids; Gene Knock-In Techniques; Genetic Variation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2016 |
Concentration, population, and context-dependent effects of AM251 in zebrafish.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anxiety; Brain; Dopamine; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Hydroxyindoleacetic Acid; Locomotion; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Serotonin; Species Specificity; Zebrafish | 2016 |
Effects of cannabinoid receptor activation by CP55,940 on normal bladder function and irritation-induced bladder overactivity in non-awake anaesthetised rats.
Topics: Acetic Acid; Administration, Intravesical; Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Disease Models, Animal; Female; Indoles; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Treatment Outcome; Urinary Bladder; Urinary Bladder, Overactive; Urination; Urodynamics | 2016 |
Encapsulation of cannabinoid drugs in nanostructured lipid carriers.
Topics: Benzamides; Cannabinoids; Carbamates; Drug Carriers; Lipids; Nanostructures; Piperidines; Pyrazoles; Rimonabant | 2016 |
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Topics: Animals; Arachidonic Acids; Bicuculline; Disease Models, Animal; Endocannabinoids; Escape Reaction; GABA-A Receptor Antagonists; Male; Panic Disorder; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-A; TRPV Cation Channels; Ventromedial Hypothalamic Nucleus | 2017 |
Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys.
Topics: Animals; Chlorocebus aethiops; Electroretinography; Ependymoglial Cells; Indoles; Membrane Potentials; Photic Stimulation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Retina; Retinal Neurons | 2016 |
Capsaicin-Induced Death of Human Haematological Malignant Cell Lines Is Independent of TRPV1 Activation.
Topics: Cannabinoid Receptor Antagonists; Capsaicin; Cell Death; Cell Line, Tumor; Hematologic Neoplasms; Humans; Indoles; Oxazines; Piperidines; Pyrazoles; TRPV Cation Channels; Xanthenes | 2016 |
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Carrageenan; Disease Models, Animal; Ethanolamines; Formaldehyde; Genotype; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Ligands; Lumbar Vertebrae; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Pain Threshold; Phenotype; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Receptor, Cannabinoid, CB1; Skin; Spinal Cord Dorsal Horn; TRPV Cation Channels | 2016 |
Activation of endocannabinoid system in the rat basolateral amygdala improved scopolamine-induced memory consolidation impairment.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Basolateral Nuclear Complex; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Male; Memory Consolidation; Memory Disorders; Nootropic Agents; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Scopolamine | 2016 |
Bi-directional cannabinoid signalling in the basolateral amygdala controls rewarding and aversive emotional processing via functional regulation of the nucleus accumbens.
Topics: Analgesics, Opioid; Animals; Basolateral Nuclear Complex; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Conditioning, Classical; Dopamine Antagonists; Flupenthixol; Male; Morphine; Morpholines; Motivation; Naphthalenes; Neural Pathways; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Reward; Signal Transduction | 2017 |
Anandamide transporter-mediated regulation of the micturition reflex in urethane-anesthetized rats.
Topics: Administration, Intravenous; Anesthetics, Intravenous; Animals; Arachidonic Acids; Endocannabinoids; Female; Indoles; Membrane Transport Modulators; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex; Urethane; Urination; Urodynamics | 2016 |
Estradiol impacts the endocannabinoid system in female rats to influence behavioral and structural responses to cocaine.
Topics: Animals; Behavior, Addictive; Cocaine; Dendritic Spines; Endocannabinoids; Estradiol; Female; Motor Activity; Nucleus Accumbens; Ovariectomy; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sex Characteristics | 2016 |
Activation of cannabinoid CB1 receptors in the ventral hippocampus improved stress-induced amnesia in rat.
Topics: Amnesia; Animals; Arachidonic Acids; Hippocampus; Male; Memory Consolidation; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Stress, Psychological | 2016 |
Functional interaction between orexin-1 and CB1 receptors in the periaqueductal gray matter during antinociception induced by chemical stimulation of the lateral hypothalamus in rats.
Topics: Animals; Benzoxazoles; Carbachol; Disease Models, Animal; Hypothalamic Area, Lateral; Male; Microinjections; Naphthyridines; Orexin Receptors; Orexins; Pain; Pain Measurement; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Stimulation, Chemical; Urea | 2016 |
Basolateral amygdala CB1 cannabinoid receptors are involved in cross state-dependent memory retrieval between morphine and ethanol.
Topics: Animals; Basolateral Nuclear Complex; Benzoxazines; Ethanol; Male; Memory; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2016 |
5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells.
Topics: Alanine; Antineoplastic Agents; Apoptosis; Arachidonate 5-Lipoxygenase; Arachidonic Acids; Azoles; Benzoquinones; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Endocannabinoids; Head and Neck Neoplasms; Humans; Hydroxyurea; Isoindoles; Lipoxygenase Inhibitors; Organoselenium Compounds; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-akt; Pyrazoles; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; TRPV Cation Channels | 2016 |
Involvement of endocannabinoid neurotransmission in the bed nucleus of stria terminalis in cardiovascular responses to acute restraint stress in rats.
Topics: Acute Disease; Animals; Benzamides; Benzodioxoles; Carbamates; Cardiovascular System; Dose-Response Relationship, Drug; Endocannabinoids; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Restraint, Physical; Septal Nuclei; Stress, Psychological; Structure-Activity Relationship; Synaptic Transmission | 2016 |
A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Endocannabinoids; Glycerides; Kainic Acid; Locomotion; Motor Neurons; Neural Pathways; Neuroprotection; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Spinal Cord; Spinal Cord Injuries; Tissue Culture Techniques | 2016 |
Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses.
Topics: Animals; Calcium; Endocannabinoids; Female; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Methoxyhydroxyphenylglycol; Periaqueductal Gray; Phosphinic Acids; Piperidines; Pyrazoles; Pyridines; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses | 2017 |
Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Antagonists; Conditioning, Classical; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Morphine; Nucleus Accumbens; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward | 2016 |
Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m)RVD-hemopressin(α) and (m)VD-hemopressin(α) on memory in novel object and object location recognition tasks in normal young and Aβ1-42-treated mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Hemoglobins; Infusions, Intraventricular; Male; Memory Disorders; Mice; Morpholines; Naphthalenes; Oligopeptides; Peptide Fragments; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Recognition, Psychology | 2016 |
Ethanol modulates facial stimulation-evoked outward currents in cerebellar Purkinje cells in vivo in mice.
Topics: Action Potentials; Animals; Benzoxazines; Central Nervous System Depressants; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dronabinol; Ethanol; gamma-Aminobutyric Acid; Isoquinolines; Membrane Potentials; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Patch-Clamp Techniques; Physical Stimulation; Piperidines; Purkinje Cells; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Reflex; Signal Transduction; Sulfonamides; Thionucleotides | 2016 |
Behavioral evidence for the interaction between cannabinoids and Catha edulis F. (Khat) in mice.
Topics: Animals; Anxiety; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Catha; Endocannabinoids; Indoles; Locomotion; Male; Memory, Short-Term; Mice; Morpholines; Naphthalenes; Piperidines; Plant Extracts; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2016 |
The inhibitory effect of combination treatment with leptin and cannabinoid CB1 receptor agonist on food intake and body weight gain is mediated by serotonin 1B and 2C receptors.
Topics: Aminopyridines; Animals; Cannabinoid Receptor Agonists; Drug Synergism; Eating; Indoles; Leptin; Male; Oxadiazoles; Piperazines; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Weight Gain | 2016 |
Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on "tetrad", sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies.
Topics: Adamantane; Aggression; Animals; Behavior, Animal; Binding, Competitive; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabis; Catalepsy; Dopamine; Dronabinol; Humans; In Vitro Techniques; Indazoles; Indoles; Male; Mice; Motor Activity; Naphthalenes; Nucleus Accumbens; Pain Threshold; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex, Abnormal; Seizures | 2016 |
The GABAA receptor agonist muscimol induces an age- and region-dependent form of long-term depression in the mouse striatum.
Topics: Animals; Corpus Striatum; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Agonists; Long-Term Synaptic Depression; Male; Mice, Inbred C57BL; Muscimol; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, GABA-A; TRPV Cation Channels | 2016 |
mGluR1/5 activation in the lateral hypothalamus increases food intake via the endocannabinoid system.
Topics: Animals; Eating; Endocannabinoids; Enzyme Inhibitors; Glycine; Hypothalamic Area, Lateral; Lactones; Lipoprotein Lipase; Male; Orlistat; Phenylacetates; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2016 |
Anandamide reverses depressive-like behavior, neurochemical abnormalities and oxidative-stress parameters in streptozotocin-diabetic rats: Role of CB1 receptors.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Depression; Diabetes Mellitus, Experimental; Endocannabinoids; Indoles; Male; Norepinephrine; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Serotonin; Swimming | 2016 |
Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2.
Topics: Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Capsaicin; Cells, Cultured; Ceramides; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Partial Thromboplastin Time; Phosphorylation; Piperidines; Pyrazoles; RNA, Messenger; Signal Transduction; Sphingomyelin Phosphodiesterase; Thromboplastin; TRPV Cation Channels | 2016 |
Endocannabinoid mechanism for orofacial antinociception induced by electroacupuncture in acupoint St36 in rats.
Topics: Acupuncture Points; Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electroacupuncture; Endocannabinoids; Facial Pain; Indoles; Male; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar | 2016 |
The Influence of the CB1 Receptor Ligands on the Schizophrenia-Like Effects in Mice Induced by MK-801.
Topics: Animals; Antipsychotic Agents; Cannabinoid Receptor Modulators; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Amino Acid Antagonists; Male; Memory Disorders; Memory, Long-Term; Memory, Short-Term; Mice; Motor Activity; Oleic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Schizophrenia; Schizophrenic Psychology | 2016 |
Dorsal hippocampus cannabinoid type 1 receptors modulate the expression of contextual fear conditioning in rats: Involvement of local glutamatergic/nitrergic and GABAergic neurotransmissions.
Topics: Animals; Bicuculline; Conditioning, Psychological; Emotions; Fear; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Male; Nitric Oxide; Nitric Oxide Synthase; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2016 |
Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3.
Topics: Animals; Animals, Genetically Modified; Antipsychotic Agents; Aripiprazole; Ataxin-3; Brain; Disease Models, Animal; Drosophila; Drug Evaluation, Preclinical; Gene Expression Regulation; HEK293 Cells; Humans; Machado-Joseph Disease; Mice; Mutant Proteins; Nerve Tissue Proteins; Organ Culture Techniques; Peptides; Piperidines; Pyrans; Pyrazoles | 2016 |
Interactive effects of AM251 and baclofen on synaptic plasticity in the rat dentate gyrus.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Cannabinoid Receptor Antagonists; Dentate Gyrus; Drug Interactions; Electric Stimulation; Evoked Potentials; GABA-B Receptor Agonists; Long-Term Potentiation; Male; Microelectrodes; Piperidines; Pyrazoles; Random Allocation; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-B; Synaptic Potentials; Urethane | 2016 |
Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection.
Topics: Analysis of Variance; Aniline Compounds; Animals; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Hippocampus; Locomotion; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Recognition, Psychology; Serotonin; Serotonin Agents; Signal Detection, Psychological; Spatial Learning | 2017 |
Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release.
Topics: Animals; Axons; Benzoxazines; Cell Body; gamma-Aminobutyric Acid; Hippocampus; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Interneurons; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Microscopy; Molecular Dynamics Simulation; Morpholines; Naphthalenes; Neural Inhibition; Neuronal Plasticity; Neurons; Optical Imaging; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Protein Biosynthesis; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Ribosomes; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.
Topics: Adipose Tissue; Animals; Animals, Newborn; Brain; Diet, High-Fat; Endocannabinoids; Female; Gene Expression Regulation, Developmental; Liver; Piperidines; Pregnancy; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sex Characteristics; Signal Transduction | 2016 |
Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance.
Topics: Adipose Tissue; Aged; Dexamethasone; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glucocorticoids; Glucose; Humans; Insulin Resistance; Lipolysis; Male; Middle Aged; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2017 |
Overactivation of cannabinoid receptor type 1 in rostral ventrolateral medulla promotes cardiovascular responses in spontaneously hypertensive rats.
Topics: Animals; Arachidonic Acids; beta-Arrestin 2; Blood Pressure; Essential Hypertension; Heart Rate; Hypertension; Kidney; Male; Medulla Oblongata; Microinjections; Piperidines; Pyrazoles; Rats; Rats, Inbred SHR; Receptor, Cannabinoid, CB1; Sympathetic Nervous System | 2017 |
Role of orexin-2 and CB1 receptors within the periaqueductal gray matter in lateral hypothalamic-induced antinociception in rats.
Topics: Animals; Carbachol; Disease Models, Animal; Dose-Response Relationship, Drug; Hypothalamic Area, Lateral; Isoquinolines; Male; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pain; Periaqueductal Gray; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2017 |
Using proteomics to discover novel biomarkers for fatty liver development and response to CB1R antagonist treatment in an obese mouse model.
Topics: Animals; Biomarkers; Cannabinoid Receptor Antagonists; Diet, High-Fat; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Non-alcoholic Fatty Liver Disease; Piperidines; Proteomics; Pyrazoles; Receptors, Cannabinoid | 2017 |
AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells.
Topics: Cell Line, Transformed; Epithelial Cells; Epithelial-Mesenchymal Transition; Humans; Kidney Tubules; Piperidines; Pyrazoles | 2016 |
The involvement of cannabinoids and mTOR in the reconsolidation of an emotional memory in the hippocampal-amygdala-insular circuit.
Topics: Amygdala; Analgesics; Animals; Avoidance Learning; Benzoxazines; Brain; Cannabinoids; Cerebral Cortex; Emotions; Exploratory Behavior; Extinction, Psychological; Fear; Hippocampus; Male; Memory; Morpholines; Naphthalenes; Neural Pathways; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Differential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HT
Topics: Animals; Appetite Depressants; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Choice Behavior; Drug Inverse Agonism; Impulsive Behavior; Male; Morpholines; Piperazines; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Antagonists | 2017 |
Activation of cannabinoid receptors elicits antidepressant-like effects in a mouse model of social isolation stress.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Depression; Disease Models, Animal; Indoles; Male; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Social Isolation; Stress, Psychological | 2017 |
Enhanced ability of TRPV1 channels in regulating glutamatergic transmission after repeated morphine exposure in the nucleus accumbens of rat.
Topics: Animals; Capsaicin; Corpus Striatum; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Morphine; Narcotics; Neuronal Plasticity; Neurotransmitter Agents; Nucleus Accumbens; Piperidines; Presynaptic Terminals; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome; Synaptic Transmission; Tissue Culture Techniques; TRPV Cation Channels | 2017 |
Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in guinea pigs.
Topics: Amygdala; Animals; Brain; Dentate Gyrus; Endocannabinoids; Guinea Pigs; Hippocampus; Kainic Acid; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Status Epilepticus | 2017 |
Genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice.
Topics: Animals; Apoptosis; Butadienes; Cells, Cultured; Corpus Striatum; Dopamine; Extracellular Signal-Regulated MAP Kinases; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotoxicity Syndromes; Nitriles; Oxidative Stress; Piperidines; Protein Kinase C-delta; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Rimonabant; Sulpiride | 2017 |
N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms.
Topics: Acrylamides; Action Potentials; Age Factors; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Cannabinoid Receptor Antagonists; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Luminescent Proteins; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Pyrazoles; TRPV Cation Channels; Tyrosine 3-Monooxygenase | 2017 |
Short-term inhibition of GABAergic IPSCs induced by association of pre- and postsynaptic activation in the neonatal hippocampus.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Calcium; Endocannabinoids; Excitatory Amino Acid Agents; Female; GABAergic Neurons; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Potassium; Presynaptic Terminals; Pyramidal Cells; Pyrazoles; Rats; Statistics, Nonparametric | 2017 |
Intravenous self-administration of benzydamine, a non-steroidal anti-inflammatory drug with a central cannabinoidergic mechanism of action.
Topics: Administration, Intravenous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzydamine; Cocaine; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Heroin; Long-Term Synaptic Depression; Narcotics; Neural Pathways; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Self Administration; Synaptic Transmission | 2018 |
Properties of the corticostriatal long term depression induced by medial prefrontal cortex high frequency stimulation in vivo.
Topics: Adrenergic Agents; Animals; Animals, Newborn; Benzazepines; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Heparin-binding EGF-like Growth Factor; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways; Neurons; Oxidopamine; Piperidines; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Tyrosine 3-Monooxygenase | 2017 |
AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids.
Topics: Amidohydrolases; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Arachidonic Acids; Cells, Cultured; Endocannabinoids; Female; Male; Mice; Mice, Knockout; Neurons; Nociception; Pain Measurement; Physical Conditioning, Animal; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Ribonucleotides | 2017 |
Cannabinoid 1 receptor blockade in the dorsal hippocampus prevents the reinstatement but not acquisition of morphine-induced conditioned place preference in rats.
Topics: Animals; Blotting, Western; Cannabinoid Receptor Antagonists; Cerebral Cortex; Conditioning, Psychological; Extinction, Psychological; Gene Expression; Hippocampus; Male; Microinjections; Morphine; Narcotics; Piperidines; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Space Perception; Spatial Behavior | 2017 |
Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus.
Topics: Animals; Cerebral Cortex; Endocannabinoids; Enzyme Inhibitors; GABA Agents; Hippocampus; Lipid Metabolism; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Munc18 Proteins; Neural Pathways; Neurons; Perceptual Disorders; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Increase in hypothalamic AMPK phosphorylation induced by prolonged exposure to LPS involves ghrelin and CB1R signaling.
Topics: Adenylate Kinase; Animals; Endocannabinoids; Ghrelin; Hypothalamus; Lipopolysaccharides; Male; Neuropeptide Y; Phosphorylation; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Ghrelin; RNA, Messenger; Signal Transduction | 2017 |
CB
Topics: Animals; Benzoxazines; Central Amygdaloid Nucleus; Central Nervous System Depressants; Ethanol; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2018 |
Cannabinoids prevent the differential long-term effects of exposure to severe stress on hippocampal- and amygdala-dependent memory and plasticity.
Topics: Amidohydrolases; Amygdala; Animals; Avoidance Learning; Benzamides; Benzoxazines; Bromine; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Disease Models, Animal; Drug Combinations; Electroshock; Enzyme Inhibitors; Fear; Glutamates; Hippocampus; Magnesium; Male; Memory; Morpholines; Naphthalenes; Neuronal Plasticity; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptors, Cannabinoid; Stress Disorders, Post-Traumatic | 2017 |
Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Cannabinoid Receptor Modulators; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Indoles; Male; Neuralgia; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Piperidines; Polycyclic Sesquiterpenes; Pyrazoles; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sesquiterpenes; Spinal Cord | 2017 |
Cannabinoid system of dorsomedial telencephalon modulates behavioral responses to noxious stimulation in the fish Leporinus macrocephalus.
Topics: Analgesics; Animals; Cannabidiol; Cannabinoid Receptor Antagonists; Characiformes; Fish Proteins; Formaldehyde; Motor Activity; Neural Pathways; Nociception; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Restraint, Physical; Stress, Psychological; Telencephalon | 2017 |
Antidote to cannabinoid intoxication: the CB
Topics: Animals; Antidotes; Cannabinoid Receptor Agonists; Drug Inverse Agonism; Female; Hypothermia; Mice; Mice, Biozzi; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2017 |
17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Estradiol; Estrogens; Female; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Self Administration; Sex Factors | 2018 |
Pharmacological effects of cannabinoids on learning and memory in
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Learning; Lymnaea; Memory; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, G-Protein-Coupled | 2017 |
Natural (∆
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Electroencephalography; Electromyography; Indoles; Locomotion; Mice; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures | 2017 |
Effects of Cannabinoid Agonists and Antagonists on Sleep and Breathing in Sprague-Dawley Rats.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dronabinol; Electroencephalography; Electromyography; Indoles; Male; Piperidines; Polysomnography; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Respiration; Sleep; Sleep Apnea, Central; Sleep, REM; Vagus Nerve | 2017 |
Involvement of cannabinoid system in the nucleus accumbens on delay-based decision making in the rat.
Topics: Analysis of Variance; Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Cannabinoids; Conditioning, Operant; Decision Making; Locomotion; Male; Maze Learning; Morpholines; Naphthalenes; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reaction Time; Reinforcement Schedule; Reward | 2018 |
Cannabinoids Regulate the Diameter of Pericyte-Containing Retinal Capillaries in Rats.
Topics: Animals; Arachidonic Acids; Blotting, Western; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoids; Capillaries; Endocannabinoids; Guanylate Cyclase; Immunohistochemistry; Male; Nitric Oxide Synthase; Pericytes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Retina; Rimonabant | 2017 |
Effects of CB1 receptor antagonism and stress exposures in adolescence on socioemotional behaviours, neuroendocrine stress responses, and expression of relevant proteins in the hippocampus and prefrontal cortex in rats.
Topics: Age Factors; Animals; Animals, Newborn; Cannabinoid Receptor Antagonists; Corticosterone; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Disks Large Homolog 4 Protein; Exploratory Behavior; Female; Glutamate Decarboxylase; Hippocampus; Male; Maze Learning; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Social Behavior; Stress, Psychological | 2018 |
Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex.
Topics: Animals; Arachidonic Acids; Cocaine; Cocaine-Related Disorders; Drug-Seeking Behavior; Endocannabinoids; Extinction, Psychological; Glucocorticoids; Glycerides; Male; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Self Administration; Stress, Psychological | 2018 |
Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain.
Topics: Analgesics; Animals; Autoradiography; Benzoxazines; Binding Sites; Brain; Cannabinoids; Dopamine Plasma Membrane Transport Proteins; Gene Expression Regulation; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RNA, Messenger; Time Factors; Tritium; Tyrosine 3-Monooxygenase | 2018 |
Remote Ischemia Preconditioning Attenuates Blood-Spinal Cord Barrier Breakdown in Rats Undergoing Spinal Cord Ischemia Reperfusion Injury: Associated with Activation and Upregulation of CB1 and CB2 Receptors.
Topics: Animals; Disease Models, Animal; Down-Regulation; Femoral Artery; Indoles; Ischemic Preconditioning; Male; Permeability; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reperfusion Injury; Spinal Cord; Up-Regulation | 2017 |
Modulation of the endocannabinoid system by the fatty acid amide hydrolase, monoacylglycerol and diacylglycerol lipase inhibitors as an attractive target for secretory diarrhoea therapy.
Topics: Amidohydrolases; Animals; Benzodioxoles; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanones; Diarrhea; Endocannabinoids; Enzyme Inhibitors; Indoles; Lipoprotein Lipase; Male; Mice; Monoglycerides; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2017 |
Activation of the cannabinoid system in the nucleus accumbens affects effort-based decision making.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Choice Behavior; Decision Making; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Locomotion; Male; Maze Learning; Morpholines; Naphthalenes; Nucleus Accumbens; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Reward | 2018 |
Cannabinoids induce apathetic and impulsive patterns of choice through CB1 receptors and TRPV1 channels.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Cerebral Cortex; Choice Behavior; Dose-Response Relationship, Drug; Impulsive Behavior; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2018 |
CB
Topics: Animals; Antidepressive Agents; Behavior Rating Scale; Depression; Drug Synergism; Hypnotics and Sedatives; Ligands; Magnesium; Male; Mice; Motor Activity; Oleic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Swimming; Trace Elements; Zinc | 2018 |
Impaired glucocorticoid-mediated HPA axis negative feedback induced by juvenile social isolation in male rats.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Animals, Newborn; Corticosterone; Electroshock; Endocannabinoids; Foot; Glucocorticoids; Hippocampus; Hormone Antagonists; Hypothalamo-Hypophyseal System; Male; Mifepristone; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Social Isolation; Stress, Psychological; Time Factors | 2018 |
Sacred Maya incense, copal (Protium copal - Burseraceae), has antianxiety effects in animal models.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Burseraceae; Carrier Proteins; Ceremonial Behavior; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Exploratory Behavior; Fear; Flumazenil; Humans; Male; Maze Learning; Monoacylglycerol Lipases; Phytotherapy; Piperidines; Plant Extracts; Plants, Medicinal; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Resins, Plant; Signal Transduction; Social Behavior | 2018 |
Acute Ethanol Inhibition of Adult Hippocampal Neurogenesis Involves CB1 Cannabinoid Receptor Signaling.
Topics: Animals; Binge Drinking; Cannabinoids; Carbamates; Caspase 3; Cell Death; Cell Proliferation; Doublecortin Domain Proteins; Doublecortin Protein; Drug Interactions; Endocannabinoids; Ethanol; Hippocampus; Ki-67 Antigen; Male; Microtubule-Associated Proteins; Neurogenesis; Neuropeptides; Piperazines; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2018 |
Involvement of spinal cannabinoid receptors in the antipruritic effects of WIN 55,212-2, a cannabinoid receptor agonist.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Indoles; Male; Mice; Mice, Inbred BALB C; Morpholines; Naphthalenes; Piperidines; Pruritus; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Serotonin; Spinal Cord | 2018 |
Antinociceptive effects of the endogenous cannabinoid peptide agonist VD-hemopressin(β) in mice.
Topics: Acetic Acid; Analgesics; Animals; Area Under Curve; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Indoles; Male; Mice; Mice, Inbred Strains; Oligopeptides; Pain; Pain Measurement; Piperidines; Pyrazoles; Rotarod Performance Test; Spinal Cord | 2018 |
Activation of the cannabinoid receptor 1 by ACEA suppresses senescence in human primary chondrocytes through sirt1 activation.
Topics: Arachidonic Acids; beta-Galactosidase; Caveolin 1; Cells, Cultured; Cellular Senescence; Chondrocytes; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Female; G1 Phase Cell Cycle Checkpoints; Humans; Interleukin-1beta; Male; Middle Aged; Osteoarthritis; Piperidines; Plasminogen Activator Inhibitor 1; Pyrazoles; Receptor, Cannabinoid, CB1; Sirtuin 1 | 2018 |
Role of cannabinoid receptor type 1 in rostral ventrolateral medulla in high-fat diet-induced hypertension in rats.
Topics: Animals; Blood Pressure; Diet, High-Fat; Endocannabinoids; Gene Silencing; Heart Rate; Hypertension; Kidney; Male; Medulla Oblongata; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sympathetic Nervous System | 2018 |
Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Benzoxazines; CA1 Region, Hippocampal; Cannabinoid Receptor Antagonists; Carbamates; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Extinction, Psychological; Glycerides; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex, Startle; Stress Disorders, Post-Traumatic | 2018 |
Orexin-A and endocannabinoid signaling regulate glucose-responsive arcuate nucleus neurons and feeding behavior in obese rats.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Disease Models, Animal; Endocannabinoids; Feeding Behavior; Glucose; Male; Neurons; Obesity; Orexin Receptors; Orexins; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction | 2018 |
The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner.
Topics: Animals; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Psychological; Endocannabinoids; Fear; Pain; Pain Measurement; Piperidines; Prefrontal Cortex; Pyrazoles; Rats | 2019 |
JZL184, as a monoacylglycerol lipase inhibitor, down-regulates inflammation in a cannabinoid pathway dependent manner.
Topics: Animals; Benzodioxoles; Brain Edema; Brain Infarction; Cannabinoids; Down-Regulation; Enzyme Inhibitors; Inflammation; Interleukin-10; Male; Matrix Metalloproteinase 9; Mice; Monoacylglycerol Lipases; Piperidines; Pyrazoles; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
Assessment of Cannabinoids Agonist and Antagonist in Invasion Potential of K562 Cancer Cells
Topics: Benzoxazines; Cannabinoids; Dose-Response Relationship, Drug; Humans; K562 Cells; Morpholines; Naphthalenes; Neoplasm Invasiveness; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2019 |
Inhibition of endocannabinoid degradation rectifies motivational and dopaminergic deficits in the Q175 mouse model of Huntington's disease.
Topics: Aging; Animals; Apathy; Arachidonic Acids; Benzodioxoles; Conditioning, Operant; Disease Progression; Dopamine; Endocannabinoids; Glycerides; Huntington Disease; Male; Mice; Motivation; Piperidines; Pyrazoles; Reward | 2018 |
Opposing actions of CRF-R1 and CB1 receptors on VTA-GABAergic plasticity following chronic exposure to ethanol.
Topics: Alcoholism; Animals; Benzoxazines; Central Nervous System Depressants; Corticotropin-Releasing Hormone; Dopaminergic Neurons; Egtazic Acid; Ethanol; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neuronal Plasticity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Corticotropin-Releasing Hormone; Receptors, Presynaptic; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2018 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Piperidines; Pyrazoles; Serotonin | 2018 |
Effects of rTMS on Hippocampal Endocannabinoids and Depressive-like Behaviors in Adolescent Rats.
Topics: Age Factors; Animals; Depression; Endocannabinoids; Hippocampus; Male; Microinjections; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Transcranial Magnetic Stimulation | 2018 |
TRPV1 mediates the anticonvulsant effects of acetaminophen in mice.
Topics: Acetaminophen; Acetanilides; Acrylamides; Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Piperidines; Purines; Pyrazoles; Seizures; Time Factors; TRPV Cation Channels | 2018 |
Effects of concurrent blockade of OX2 and CB1 receptors in the ventral tegmental area on nicotine-induced place preference in rats.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Microinjections; Nicotine; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Ventral Tegmental Area | 2018 |
Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats.
Topics: Aging; Animals; Anxiety; Body Weight; Brain Chemistry; Corticosterone; Emotions; Endocannabinoids; Extinction, Psychological; Fear; Female; Male; Neuronal Plasticity; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Sex Characteristics; Social Behavior; Stress, Psychological | 2018 |
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Behavior; Feeding Behavior; Ganglia, Spinal; Hyperalgesia; Lysergic Acid Diethylamide; Male; Maze Learning; Neuralgia; Piperazines; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Swimming | 2019 |
Modulatory role of the intra-accumbal CB1 receptor in protein level of the c-fos and pCREB/CREB ratio in the nucleus accumbens and ventral tegmental area in extinction and morphine seeking in the rats.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Modulators; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Male; Morphine; Morphine Dependence; Morpholines; Naphthalenes; Narcotics; Nucleus Accumbens; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Ventral Tegmental Area | 2018 |
Acute foot-shock stress decreased seizure susceptibility against pentylenetetrazole-induced seizures in mice: Interaction between endogenous opioids and cannabinoids.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Antagonists; Convulsants; Disease Models, Animal; Electroshock; Male; Mice; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Piperidines; Pyrazoles; Receptors, Cannabinoid; Seizures; Stress, Psychological | 2018 |
CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Arachidonic Acids; Cyproheptadine; Drug Interactions; Eating; gamma-Aminobutyric Acid; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Piperazines; Piperidines; Piperidones; Pyrazoles; Pyridines; Pyrroles; Rats; Receptor, Cannabinoid, CB1; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Tritium | 2018 |
Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit.
Topics: Amidohydrolases; Analgesics, Opioid; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Brain; Cannabinoids; Carbamates; Gastrointestinal Transit; Hyperalgesia; Indoles; Mice; Mice, Inbred C57BL; Morphine; Morpholines; Neuralgia; Nociception; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2018 |
Endocannabinoid-mediated modulation of Gq protein-coupled receptor mediates vascular hyporeactivity to nor-adrenaline during polymicrobial sepsis.
Topics: Animals; Aorta; Coinfection; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; GTP-Binding Protein alpha Subunits, Gq-G11; Male; Mice; Norepinephrine; Organ Culture Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Sepsis; Vasoconstriction | 2018 |
Sexual interaction is essential for the transformation of non-copulating rats into sexually active animals by the endocannabinoid anandamide.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Endocannabinoids; Male; Naloxone; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Sexual Behavior, Animal | 2019 |
Association of mGluR-Dependent LTD of Excitatory Synapses with Endocannabinoid-Dependent LTD of Inhibitory Synapses Leads to EPSP to Spike Potentiation in CA1 Pyramidal Neurons.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Cannabinoid Receptor Antagonists; Endocannabinoids; Excitatory Postsynaptic Potentials; Female; GABA Agonists; GABA Antagonists; Long-Term Synaptic Depression; Male; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses | 2019 |
Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia.
Topics: Amides; Animals; Arachidonic Acids; Cannabidiol; Disease Models, Animal; Endocannabinoids; Ethanolamines; Female; Glycerides; Hippocampus; Interpersonal Relations; Male; Methylazoxymethanol Acetate; Motor Activity; Oleic Acids; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Puberty; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Recognition, Psychology; RNA, Messenger; Schizophrenia | 2019 |
Cannabinoid CB
Topics: Adrenergic beta-Agonists; Animals; Cannabinoid Receptor Antagonists; Drug Interactions; Heart Atria; Heart Rate; In Vitro Techniques; Indoles; Isoproterenol; Male; Myocardial Contraction; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Adrenergic, beta-1; Signal Transduction | 2019 |
Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors.
Topics: Affect; Animals; Anxiety; Behavior, Animal; Benzopyrans; Cannabidiol; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dronabinol; Executive Function; Male; Microinjections; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Social Behavior | 2019 |
Functional crosstalk of nucleus accumbens CB1 and OX2 receptors in response to nicotine-induced place preference.
Topics: Animals; Conditioning, Operant; Conditioning, Psychological; Male; Nicotine; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2019 |
Caffeine and cannabinoid receptors modulate impulsive behavior in an animal model of attentional deficit and hyperactivity disorder.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Benzoxazines; Caffeine; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Impulsive Behavior; Male; Morpholines; Naphthalenes; Piperidines; Psychotropic Drugs; Purinergic P1 Receptor Antagonists; Pyrazoles; Random Allocation; Rats, Inbred SHR; Rats, Inbred WKY | 2019 |
Anandamide Reduces the Toxic Synergism Exerted by Quinolinic Acid and Glutaric Acid in Rat Brain Neuronal Cells.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Cell Survival; Cells, Cultured; Cerebral Cortex; Drug Synergism; Endocannabinoids; Female; Glutarates; Male; Neurons; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Quinolinic Acid; Rats; Rats, Inbred WF; Receptors, Cannabinoid | 2019 |
Blockade of Serotonin 2C Receptors with SB-242084 Moderates Reduced Locomotor Activity and Rearing by Cannabinoid 1 Receptor Antagonist AM-251.
Topics: Aminopyridines; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Exploratory Behavior; Indoles; Locomotion; Male; Maze Learning; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Antagonists; Social Behavior | 2019 |
Hypothalamic endocannabinoid signalling modulates aversive responses related to panic attacks.
Topics: Animals; Arachidonic Acids; Benzamides; Biphenyl Compounds; Blood Pressure; Cannabinoids; Carbamates; Corticosterone; Dorsomedial Hypothalamic Nucleus; Endocannabinoids; Indoles; Male; Microinjections; N-Methylaspartate; Panic Disorder; Piperidines; Pyrazoles; Rats | 2019 |
Opposing roles of dorsomedial hypothalamic CB1 and TRPV1 receptors in anandamide signaling during the panic-like response elicited in mice by Brazilian rainbow Boidae snakes.
Topics: Animals; Arachidonic Acids; Boidae; Brazil; Cannabinoid Receptor Agonists; Dorsomedial Hypothalamic Nucleus; Dose-Response Relationship, Drug; Endocannabinoids; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Panic; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2019 |
Ketamine induces central antinociception mediated by endogenous cannabinoids and activation of CB
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Drug Synergism; Indoles; Infusions, Intraventricular; Ketamine; Male; Mice; Organophosphonates; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2019 |
Role of the endocannabinoid system in the dorsal hippocampus in the cardiovascular changes and delayed anxiety-like effect induced by acute restraint stress in rats.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Arterial Pressure; Behavior, Animal; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Endocannabinoids; Heart Rate; Hippocampus; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Restraint, Physical; Skin Temperature; Stress, Psychological | 2019 |
Functional characterization of the cannabinoid receptors 1 and 2 in zebrafish larvae using behavioral analysis.
Topics: Animals; Arachidonic Acids; Cannabinoids; Dark Adaptation; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Larva; Locomotion; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Zebrafish; Zebrafish Proteins | 2019 |
Effects of the synthetic cannabinoid 5F-AMB on anxiety and recognition memory in mice.
Topics: Animals; Anxiety; Cannabinoids; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Piperidines; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Recognition, Psychology | 2019 |
The effect of the cannabinoid receptor agonist and antagonist on the light-induced changes in the suprachiasmatic nucleus of rats.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Light; Male; Motor Activity; Piperidines; Pyrazoles; Rats, Wistar; Suprachiasmatic Nucleus | 2019 |
Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
Topics: Animals; Axons; CA1 Region, Hippocampal; Dendrites; Endocannabinoids; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyramidal Cells; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses | 2019 |
Cannabidiol attenuates aggressive behavior induced by social isolation in mice: Involvement of 5-HT1A and CB1 receptors.
Topics: Aggression; Animals; Cannabidiol; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Housing, Animal; Male; Mice; Motor Activity; Periaqueductal Gray; Piperazines; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Antagonists; Social Isolation | 2019 |
Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment.
Topics: Alcohol Drinking; Animals; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Antagonists; Central Nervous System Depressants; Drug-Seeking Behavior; Endocannabinoids; Ethanol; Glycerides; Habits; Lipoprotein Lipase; Lithium Chloride; Mice; Monoacylglycerol Lipases; Motivation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2020 |
CB1R mediates oleamide's reward while 5HT2cR mediates aversion in the nucleus accumbens shell of rats.
Topics: Aminopyridines; Animals; Conditioning, Operant; Extinction, Psychological; Indoles; Male; Nucleus Accumbens; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT2C; Reward; Serotonin 5-HT2 Receptor Antagonists | 2019 |
Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells.
Topics: Adaptor Proteins, Signal Transducing; Adipose Tissue; Animals; Calcium-Binding Proteins; Diet, High-Fat; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Obese; MicroRNAs; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Th1 Cells | 2019 |
Electrophysiological study of the response of ventral tegmental area non-dopaminergic neurons to nicotine after concurrent blockade of orexin receptor-2 and cannabinoid receptors-1.
Topics: Animals; Cannabinoids; Conditioning, Operant; Isoquinolines; Male; Neurons; Nicotine; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptors, Cannabinoid; Ventral Tegmental Area | 2019 |
Cannabinoids Modulate Light Signaling in ON-Sustained Retinal Ganglion Cells of the Mouse.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Evoked Potentials, Visual; Light; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Retinal Ganglion Cells; Synaptic Transmission | 2019 |
Cannabidiol inhibits sucrose self-administration by CB1 and CB2 receptor mechanisms in rodents.
Topics: Animals; Behavior, Animal; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Feeding Behavior; Indoles; Mice; Mice, Knockout; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Self Administration; Sucrose; Sweetening Agents | 2020 |
CB1 receptor antagonism in capuchin monkeys alters social interaction and aversive memory extinction.
Topics: Animals; Avoidance Learning; Cebus; Dose-Response Relationship, Drug; Fear; Female; Interpersonal Relations; Male; Memory; Piperidines; Pyrazoles; Random Allocation; Receptor, Cannabinoid, CB1; Reward | 2019 |
CB
Topics: Animals; Indoles; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Swimming; Zebrafish; Zebrafish Proteins | 2019 |
Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression.
Topics: Animals; Astrocytes; Endocannabinoids; Hippocampus; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Synapses; Synaptic Transmission | 2020 |
Cannabinoid system involves in the analgesic effect of protocatechuic acid.
Topics: Acetic Acid; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxybenzoates; Indoles; Male; Mice; Pain; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid | 2019 |
Cannabinoid receptor modulation changes the accumbal neuronal responses to morphine in the reinstatement of morphine-induced conditioned place preference.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Conditioning, Classical; Drug-Seeking Behavior; Male; Morphine; Morpholines; Naphthalenes; Narcotics; Neurons; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2020 |
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecoxib; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Oxidopamine; Pain; Parkinson Disease; Piperidines; Pyrazoles; Thienamycins | 2020 |
Effect of (m)VD-hemopressin against Aβ1-42-induced oxidative stress and apoptosis in mouse hippocampal neurons.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; bcl-2-Associated X Protein; Catalase; Cell Survival; Cells, Cultured; Hemoglobins; Hippocampus; Malondialdehyde; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Piperidines; Pyrazoles; Reactive Oxygen Species; Receptor, Cannabinoid, CB1 | 2020 |
Clindamycin inhibits nociceptive response by reducing tumor necrosis factor-α and CXCL-1 production and activating opioidergic mechanisms.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Chemokine CXCL1; Clindamycin; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Inflammation; Male; Mice; Pain; Piperidines; Pyrazoles; Tumor Necrosis Factor-alpha | 2020 |
Disrupting the endocannabinoid system in early adolescence negatively impacts sociability.
Topics: Age Factors; Analgesics; Animals; Conditioning, Operant; Cyclohexanols; Endocannabinoids; Female; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Social Interaction | 2020 |
Remote CB1 receptor antagonist administration reveals multiple sites of tonic and phasic endocannabinoid neuroendocrine regulation.
Topics: Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Corticosterone; Endocannabinoids; Hypothalamo-Hypophyseal System; Hypothalamus; Male; Neuroendocrine Cells; Neurosecretory Systems; Paraventricular Hypothalamic Nucleus; Piperidines; Pituitary-Adrenal System; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Restraint, Physical; Stress, Physiological; Stress, Psychological | 2020 |
Cannabinoid receptor type 1 in the bed nucleus of the stria terminalis modulates cardiovascular responses to stress via local N-methyl-D-aspartate receptor/neuronal nitric oxide synthase/soluble guanylate cyclase/protein kinase G signaling.
Topics: Animals; Cyclic GMP-Dependent Protein Kinases; Guanylate Cyclase; Hemodynamics; Male; Microinjections; Nitric Oxide Synthase Type I; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Restraint, Physical; Septal Nuclei; Signal Transduction; Stress, Psychological; Synaptic Transmission | 2020 |
Cannabidiol-induced panicolytic-like effects and fear-induced antinociception impairment: the role of the CB
Topics: Animals; Cannabidiol; Fear; Injections, Intraventricular; Male; N-Methylaspartate; Pain Measurement; Panic Disorder; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Ventromedial Hypothalamic Nucleus | 2020 |
The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling.
Topics: Animals; Cannabinoids; Cell Proliferation; Endocannabinoids; Female; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Signal Transduction | 2020 |
Monoacylglycerol lipase alpha inhibition alters prefrontal cortex excitability and blunts the consequences of traumatic stress in rat.
Topics: Animals; Benzodioxoles; Excitatory Postsynaptic Potentials; Male; Monoacylglycerol Lipases; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Inbred F344; Stress, Psychological | 2020 |
Endocannabinoid modulating drugs improve anxiety but not the expression of conditioned fear in a rodent model of post-traumatic stress disorder.
Topics: Animals; Anxiety; Benzamides; Benzoxazines; Carbamates; Conditioning, Psychological; Disease Models, Animal; Endocannabinoids; Fear; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rodentia; Stress Disorders, Post-Traumatic | 2020 |
Cannabinoid Signaling Selectively Modulates GABAergic Inhibitory Input to OFF Bipolar Cells in Rat Retina.
Topics: Amacrine Cells; Animals; Benzoxazines; Cell Polarity; Endocannabinoids; Feedback, Physiological; Female; GABA-A Receptor Antagonists; Glutamic Acid; Inhibitory Postsynaptic Potentials; Male; Morpholines; Naphthalenes; Patch-Clamp Techniques; Phosphinic Acids; Piperidines; Pyrazoles; Pyridines; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Retina; Retinal Bipolar Cells; Signal Transduction | 2020 |
Adolescent CB1 receptor antagonism influences subsequent social interactions and neural activity in female rats.
Topics: Animals; Anxiety; Brain Chemistry; Early Growth Response Protein 1; Endocannabinoids; Female; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Sex Characteristics; Signal Transduction; Social Interaction | 2020 |
Cannabinoid receptors and the proconvulsant effect of toxoplasmosis in mice.
Topics: Animals; Benzodioxoles; Cannabinoids; Disease Models, Animal; Indoles; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Toxoplasma; Toxoplasmosis | 2020 |
Mu-opioid and CB1 cannabinoid receptors of the dorsal periaqueductal gray interplay in the regulation of fear response, but not antinociception.
Topics: Analgesics, Opioid; Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Agonists; Fear; Freezing Reaction, Cataleptic; Male; Microinjections; N-Methylaspartate; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Somatostatin | 2020 |
Cannabinoid 1 Receptor Antagonists Play a Neuroprotective Role in Chronic Alcoholic Hippocampal Injury Related to Pyroptosis Pathway.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Caspase 1; Caspase Inhibitors; Central Nervous System Depressants; Dipeptides; Ethanol; Hippocampus; Inflammation; Interleukin-18; Interleukin-1beta; Intracellular Signaling Peptides and Proteins; Mice; Morpholines; Neuroprotective Agents; Neurotoxicity Syndromes; NLR Family, Pyrin Domain-Containing 3 Protein; para-Aminobenzoates; Phosphate-Binding Proteins; Piperidines; Pyrazoles; Pyroptosis; Receptor, Cannabinoid, CB1 | 2020 |
Endogenous opioid and cannabinoid systems contribute to antinociception produced by administration of NSAIDs into the insular cortex of rats.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Cortex; Endocannabinoids; Male; Naloxone; Nociception; Opioid Peptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Somatostatin | 2020 |
The interaction effect of sleep deprivation and cannabinoid type 1 receptor in the CA1 hippocampal region on passive avoidance memory, depressive-like behavior and locomotor activity in rats.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Behavior, Animal; CA1 Region, Hippocampal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Locomotion; Male; Memory Disorders; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sleep Deprivation; Swimming | 2021 |
Oleamide Induces Cell Death in Glioblastoma RG2 Cells by a Cannabinoid Receptor-Independent Mechanism.
Topics: Animals; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Glioblastoma; Hypnotics and Sedatives; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Inbred F344; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2020 |
The role of cannabinoid 1 receptor in the nucleus accumbens on tramadol induced conditioning and reinstatement.
Topics: Analgesics, Opioid; Animals; Conditioning, Classical; Conditioning, Psychological; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Nucleus Accumbens; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Tramadol | 2020 |
N‑linoleyltyrosine protects PC12 cells against oxidative damage via autophagy: Possible involvement of CB1 receptor regulation.
Topics: Adenine; Animals; Arachidonic Acids; Autophagy; Cell Survival; Endocannabinoids; Hydrogen Peroxide; Indoles; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tyrosine | 2020 |
Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Capsaicin; Disease Models, Animal; Dopaminergic Neurons; Humans; Indoles; Mice; Mice, Inbred C57BL; Neurogenic Inflammation; Neuroglia; Neuroprotection; Parkinson Disease; Piperidines; Pyrazoles; Receptor Cross-Talk; Receptors, Cannabinoid; Substantia Nigra; TRPV Cation Channels | 2020 |
The modulation of striatonigral and nigrotectal pathways by CB1 signalling in the substantia nigra pars reticulata regulates panic elicited in mice by urutu-cruzeiro lancehead pit vipers.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Corpus Striatum; Crotalinae; Endocannabinoids; Food Chain; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neuroanatomical Tract-Tracing Techniques; Panic; Pars Reticulata; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Staining and Labeling; Superior Colliculi; Vesicular Inhibitory Amino Acid Transport Proteins | 2021 |
(m)RVD-hemopressin (α) and (m)VD-hemopressin (α) improve the memory-impairing effect of scopolamine in novel object and object location recognition tasks in mice.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Disease Models, Animal; Endocannabinoids; Hemoglobins; Humans; Memory Disorders; Mice; Oligopeptides; Peptide Fragments; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Scopolamine | 2021 |
Transcranial direct current stimulation (tDCS) produce anti-anxiety response in acute stress exposure rats via activation of amygdala CB1R.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Receptor, Cannabinoid, CB1; Stress, Psychological; Transcranial Direct Current Stimulation | 2021 |
Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice.
Topics: Allosteric Regulation; Animals; Benzeneacetamides; Cannabinoids; Indoles; Male; Mice; Mice, Transgenic; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB2; Rotarod Performance Test; Seizures | 2021 |
Multiple cannabinoid signaling cascades powerfully suppress recurrent excitation in the hippocampus.
Topics: Action Potentials; Animals; Animals, Newborn; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Dentate Gyrus; Excitatory Postsynaptic Potentials; Gene Expression; Hippocampus; Interneurons; Long-Term Potentiation; Mice; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synapses; Synaptic Transmission | 2021 |
The ω-3 endocannabinoid docosahexaenoyl ethanolamide reduces seizure susceptibility in mice by activating cannabinoid type 1 receptors.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Docosahexaenoic Acids; Fatty Acids, Omega-3; Indoles; Male; Mice; Pentylenetetrazole; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures | 2021 |
CB
Topics: Animals; Anxiety; Cannabinoid Receptor Antagonists; Dioxoles; Endocannabinoids; Gene Expression; Male; Models, Neurological; Piperidines; Pyrazoles; Quinolones; Rats; Rats, Wistar; Restraint, Physical; Septal Nuclei; Stress, Psychological; Synaptic Transmission | 2021 |
Inhibitory effect of intrathecally administered AM404, an endocannabinoid reuptake inhibitor, on neuropathic pain in a rat chronic constriction injury model.
Topics: Animals; Arachidonic Acids; Capsaicin; Constriction; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Indoles; Male; Neuralgia; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rotarod Performance Test; Spinal Cord; TRPV Cation Channels | 2021 |
Interactions between the nitrergic and the endocannabinoid system in rats exposed to the elevated T-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Endocannabinoids; Locomotion; Male; Maze Learning; Nitric Oxide; Panic; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2021 |
Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling.
Topics: Action Potentials; Animals; Calcium Signaling; Channelrhodopsins; Dendrites; Endocannabinoids; Mice, Transgenic; Motor Activity; Neuronal Plasticity; Optogenetics; Piperidines; Purkinje Cells; Pyrazoles; Receptor, Cannabinoid, CB1; Reflex, Vestibulo-Ocular; Wakefulness | 2021 |
Cannabinoid receptor-1 has an effect on CD200 under rotenone and alpha-synuclein induced stress.
Topics: alpha-Synuclein; Animals; Antigens, CD; Astrocytes; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Humans; Insecticides; Mice; Oxidative Stress; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rotenone | 2021 |
Critical interactions between opioid and cannabinoid receptors during tolerance and physical dependence development to opioids in the murine gastrointestinal tract: proof of concept.
Topics: Analgesics, Opioid; Animals; Cannabinoids; Diterpenes, Clerodane; Drug Tolerance; Ileum; Male; Mice; Mice, Inbred BALB C; Morphine; Muscle, Smooth; Naloxone; Piperidines; Pyrazoles; Receptors, Cannabinoid; Substance Withdrawal Syndrome | 2021 |
Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT
Topics: Animals; Cannabidiol; Chronic Disease; Cobalt; Depression; Limbic System; Microinjections; Neuralgia; Piperazines; Piperidines; Prefrontal Cortex; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Sciatica; Serotonin 5-HT1 Receptor Antagonists; Swimming; Synapses | 2021 |
mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress.
Topics: Animals; Cannabinoid Receptor Antagonists; Chronic Disease; Depressive Disorder, Major; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Microinjections; Nucleus Accumbens; Pain; Piperidines; Pyrazoles; Pyridines; Receptor, Metabotropic Glutamate 5; Signal Transduction; Social Defeat; Stress, Psychological; Thiazoles | 2021 |
Short and long-term neuroprotective effects of cannabidiol after neonatal peripheral nerve axotomy.
Topics: Animals; Animals, Newborn; Axotomy; Cannabidiol; Motor Neurons; Nerve Crush; Neuroprotective Agents; Peripheral Nerve Injuries; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sciatic Nerve; Spinal Nerves | 2021 |
THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dronabinol; N-Methylaspartate; Piperidines; Psychotic Disorders; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Stereotyped Behavior; Zebrafish | 2021 |
Lateral hypothalamus involvement in control of stress response by bed nucleus of the stria terminalis endocannabinoid neurotransmission in male rats.
Topics: Animals; Cannabinoid Receptor Antagonists; Endocannabinoids; GABA Antagonists; GABAergic Neurons; Heart Rate; Hypothalamic Area, Lateral; Male; Models, Neurological; Piperidines; Psychological Distress; Pyrazoles; Pyridazines; Rats; Rats, Wistar; Septal Nuclei; Stress, Psychological; Synaptic Transmission; Tachycardia | 2021 |
The involvement of orexin 1 and cannabinoid 1 receptors within the ventrolateral periaqueductal gray matter in the modulation of migraine-induced anxiety and social behavior deficits of rats.
Topics: Animals; Anxiety; Behavior, Animal; Benzoxazoles; Male; Migraine Disorders; Naphthyridines; Orexin Receptors; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Neuropeptide; Social Behavior; Urea | 2021 |
The interactive effects of verapamil and CB1 cannabinoid receptor antagonist/inverse agonist, AM251 on passive avoidance learning and memory in rat.
Topics: Animals; Avoidance Learning; Calcium; Calcium Channels, L-Type; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Endocannabinoids; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Verapamil | 2022 |
ACEA Attenuates Oxidative Stress by Promoting Mitophagy via CB1R/Nrf1/PINK1 Pathway after Subarachnoid Hemorrhage in Rats.
Topics: Animals; Antioxidants; Apoptosis; Arachidonic Acids; Disease Models, Animal; Gene Knockdown Techniques; Male; Mitophagy; Neurons; Neuroprotective Agents; Nuclear Respiratory Factor 1; Oxidative Stress; Piperidines; Protein Kinases; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction; Subarachnoid Hemorrhage; Treatment Outcome | 2022 |