Page last updated: 2024-09-05

alagebrium and thiazoles

alagebrium has been researched along with thiazoles in 80 studies

Compound Research Comparison

Studies (alagebrium)	Trials (alagebrium)	Recent Studies (post-2010) (alagebrium)	Studies (thiazoles)	Trials (thiazoles)	Recent Studies (post-2010) (thiazoles)
83	10	31	33,179	2,100	12,330

Research

Studies (80)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	47 (58.75)	29.6817
2010's	29 (36.25)	24.3611
2020's	4 (5.00)	2.80

Authors

Authors	Studies
Asif, M; Brines, M; Cerami, A; Egan, J; Jyothirmayi, GN; Lopez, S; Masurekar, MR; Regan, TJ; Torres, RL; Ulrich, P; Vasan, S; Wagle, D; Williams, C	1
Grill, V; Hiramatsu, S; Inoue, K; Tajirl, Y	1
Melton, L	1
Brines, M; Cerami, A; Egan, JJ; Ingram, DK; Lakatta, EG; Lane, M; Roth, GS; Spurgeon, H; Ulrich, P; Vaitkevicius, PV; Vasan, S; Wagle, DR; Wuerth, JP	1
Cerami, A; Ulrich, P	1
Doggrell, SA	1
Capriotti, AR; deGroof, RC; Kass, DA; Kawaguchi, M; Lakatta, EG; Scuteri, A; Shapiro, EP	1
Hendriks, M; Levels, AA; Mentink, CJ; Wolffenbuttel, BH	1
Kawakami, M; Kuroki, M	1
Burns, WC; Burrell, LM; Candido, R; Cooper, ME; Dean, RG; Forbes, JM; Ritchie, RH; Thallas, V; Thomas, MC; Tikellis, C; Twigg, SM	1
Kass, DA	1
Jyothirmayi, GN; Liu, J; Malhotra, A; Masurekar, MR; Meggs, LG; Regan, TJ; Vatner, DE; Vatner, SF	1
Burns, WC; Cooper, ME; Forbes, JM; Founds, HW; Jerums, G; Thallas, V; Thomas, MC	1
Cooper, M; Forbes, J; Jerums, G; Osicka, T; Panagiotopoulos, S	1
Foiles, P; Founds, H; Vasan, S	1
Ahn, J; Frohlich, ED; Susic, D; Varagic, J	2
Allen, TJ; Burns, WC; Candido, R; Cooper, ME; Deemer, EK; Forbes, JM; Jandeleit-Dahm, KA; Lassila, M; Thallas, V; Thomas, MC; Thorpe, SM; Thorpe, SR; Yee, LT	1
Allen, TJ; Burns, WC; Calkin, AC; Candido, R; Cooper, ME; Forbes, JM; Jandeleit-Dahm, KA; Lassila, M; Seah, KK; Thallas, V; Thomas, MC	1
Bach, LA; Boner, G; Cooper, ME; Forbes, JM; Haller, H; Lindschau, C; Meier, M; Rizkalla, B; Thallas-Bonke, V	1
Bakris, GL; Bank, AJ; Kass, DA; Neutel, JM; Oparil, S; Preston, RA	1
Cooper, ME	1
Degroof, RC; Hundley, WG; Kitzman, DW; Little, WC; O'Brien, TX; Zile, MR	1
Redfield, MM	1
Tuttle, KR; Williams, ME	1
Cui, H; Li, S; Wang, LL; Zhong, W	1
Imaizumi, T; Yamagishi, S	1
Nakamura, J	1
Allen, TJ; Jandeleit-Dahm, KA; Lassila, M	1
Bivalacqua, TJ; Cellek, S; Foxwell, NA; Gur, S; Hellstrom, WJ; Kendirci, M; Usta, MF	1
O'Rourke, MF	1
Basgen, J; Brem, H; Cai, W; Li, Z; Peppa, M; Uribarri, J; Vlassara, H; Zhang, JG	1
Cooper, ME; Soldatos, G	1
Arnstein, M; Cooper, ME; Coughlan, MT; Forbes, JM; Gasser, A; Long, DM; Pete, J; Thallas-Bonke, V; Thorpe, SR; Tong, DC	1
Scuteri, A	1
Capriotti, A; Clattenburg, L; Corretti, MC; Gerstenblith, G; Kass, DA; Melenovsky, V; Zieman, SJ	1
Chin-Dusting, JP; Cooper, ME; Coughlan, MT; Forbes, JM; Hoang, A; Murphy, AJ; O'Brien, R; Sviridov, D; Thomas, MC	1
Cooper, ME; Coughlan, MT; Forbes, JM	1
Gangula, PR; Jeyabal, PV; Kumar, R; Micci, MA; Pasricha, PJ	1
Barter, PJ; Brown, BE; Davies, MJ; Nobécourt, E; Rye, KA; Yadav, S; Zeng, J	1
Cooper, ME; Forbes, JM; Sourris, KC	1
Bialkowski, K; Bierhaus, A; Cooper, ME; Coughlan, MT; Forbes, JM; Harcourt, BE; Pete, J; Tan, A; Thomas, MC; Tikellis, C	1
Meyer, DM; Mills, LD; Mohammed, SF; Owan, TE; Redfield, MM; Schalkwijk, CG; Shapiro, BP	1
Hartog, JW; Voors, AA; Willemsen, S	1
Cheng, YL; Guo, Y; Lu, M; Qian, J	1
Desai, KM; Dhar, A; Wu, L	1
Andrikopoulos, S; Bierhaus, A; Cooper, ME; Coughlan, MT; Forbes, JM; Harcourt, BE; O'Brien, RC; Penfold, S; Sourris, KC; Tan, AL; Thallas-Bonke, V; Thomas, MC	1
Hartog, JW; Hummel, YM; Posma, JL; van Veldhuisen, DJ; van Wijk, LM; Voors, AA; Willemsen, S	1
Gabelt, BT; Kaufman, PL; Kiland, JA; Lütjen-Drecoll, E; Tezel, G	1
Ferrucci, L; Nicklett, EJ; Semba, RD	1
Andrikopoulos, S; Bierhaus, A; Chand, V; Cooper, ME; Coughlan, MT; de Courten, B; de Courten, MP; Dougherty, SL; Forbes, JM; Harcourt, BE; Kingwell, BA; Morley, AL; Penfold, SA; Sourris, KC; Thallas-Bonke, V; Thomas, MC; Walker, KZ	1
Choi, WJ; Ha, H; Huh, JY; Jeong, LS; Kim, J; Kim, WY; Kwon, MK; Lee, GT; Lee, HB; Nagai, R; Park, J	1
Forbes, J; Griffith, R; Horne, S; Krautwald, M; Leech, D; Münch, G; Rahmadi, A; Steele, ML	1
Hartog, JW; Hillege, HL; Hummel, YM; Posma, JL; van Veldhuisen, DJ; van Wijk, LM; Voors, AA; Willemsen, S	1
Fassot, C; Freidja, ML; Henrion, D; Loufrani, L; Tarhouni, K; Toutain, B	1
Barodka, V; Benjo, AM; Berkowitz, DE; Daher, JP; Gupta, G; Levine, BD; Lussman, C; Nyhan, SM; Pellakuru, L; Ryoo, S; Shoukas, AA; Steppan, J; Tran, H; White, AR	1
Bierhaus, A; Cooper, ME; Gray, SP; Jandeleit-Dahm, KA; Jiaze, L; Pickering, R; Soro-Paavonen, A; Thomas, MC; Tikellis, C; Tsorotes, D; Watson, AM; Wong, B	1
Bugatti, S; Damman, K; Hartog, JW; Hummel, YM; Metra, M; Sipkens, JS; van Veldhuisen, DJ; Voors, AA; Willemsen, S	1
Yamagishi, S	1
Engelen, L; Schalkwijk, CG; Stehouwer, CD	1
Abdullah, SM; Adams-Huet, B; Barkley, KW; Bhella, PS; Boyd, KN; Carrick-Ranson, G; Fujimoto, N; Hastings, JL; Levine, BD; Livingston, SA; Palmer, D; Shafer, KM; Shibata, S	1
Hopman, MT; Levine, BD; Olde Rikkert, MG; Oudegeest-Sander, MH; Smits, P; Thijssen, DH; van Dijk, AP	1
Desai, KM; Dhar, A; Dhar, I; Wu, L	1
Gao, Z; Guan, R; Li, G; Li, H; Tian, W; Uwais, Z; Wang, L; Xin, Z	1
Chen, W; Cheng, X; Cui, H; He, K; Li, S; Wang, L; Zhang, B; Zhong, W	1
Kyriazis, M	1
André-Frei, V; Bechetoille, N; Berthod, F; Cadau, S; Leoty-Okombi, S; Pain, S	1
Kersten, JR; LaDisa, JF; Passerini, AG; Rajamani, A; Schrepfer, S; Toth, JM; Wang, H; Weihrauch, D	1
Chan, DC; Chiang, CK; Chiu, CY; Liu, SH; Sheu, ML; Tsai, KS; Yang, RS; Yang, TH	1
Bhat, A; Desai, KM; Dhar, A; Dhar, I	1
Atlı, Ö; Burukoğlu, D; Ergun, B; Ilgın, S; Musmul, A; Sırmagül, B	1
Borg, DJ; Forbes, JM	1
Boyd, K; Carrick-Ranson, G; Fujimoto, N; Hastings, JL; Levine, BD; Palmer, MD; Shafer, KM; Shibata, S	1
Babu, MS; Bhat, A; Desai, KM; Dhar, A; Dhar, I; Kalra, J; Malapati, P; Medapi, B; Sriram, D; Udumula, MP	1
Chao, TF; Chen, YJ; Kao, YH; Lee, TI; Lee, TW	1
Allen, MR; Avin, KG; Chen, NX; Creecy, A; Metzger, CE; Moe, SM; Nickolas, TL; O'Neill, K; Srinivasan, S; Wallace, JM	1
Qi, L; Wang, R; Yu, HZ	1
Feng, B; Li, Z; Yang, P	1
Ender Caylan, A; Gurbuz, N; Gurkan, R; Surmen Usta, S; Usta, MF	1

Reviews

22 review(s) available for alagebrium and thiazoles

Article	Year
Protein glycation, diabetes, and aging. Recent progress in hormone research, 2001, Volume: 56 Topics: Aging; Animals; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Models, Chemical; Thiazoles	2001
ALT-711 decreases cardiovascular stiffness and has potential in diabetes, hypertension and heart failure. Expert opinion on investigational drugs, 2001, Volume: 10, Issue:5 Topics: Animals; Diabetes Mellitus; Heart Failure; Humans; Hypertension; Thiazoles	2001
[Aminoguanidine and other AGE inhibitors]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9 Topics: Amides; Animals; Arteriosclerosis; Cardiovascular Diseases; Cataract; Clinical Trials as Topic; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Retinopathy; Disease Models, Animal; Drug Design; Glycation End Products, Advanced; Guanidines; Humans; Hydrazines; Hypoglycemic Agents; Thiadiazoles; Thiazoles; Thiazolidines	2002
Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease. Archives of biochemistry and biophysics, 2003, Nov-01, Volume: 419, Issue:1 Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Enzyme Inhibitors; Forecasting; Glycation End Products, Advanced; Guanidines; Humans; Protein Kinase C; Ramipril; Renin-Angiotensin System; Thiazoles	2003
Therapeutic potential of breakers of advanced glycation end product-protein crosslinks. Archives of biochemistry and biophysics, 2003, Nov-01, Volume: 419, Issue:1 Topics: Aging; Animals; Clinical Trials as Topic; Cross-Linking Reagents; Diabetes Mellitus; Diastole; Drug Evaluation, Preclinical; Elasticity; Glycation End Products, Advanced; Guanidines; Humans; Hypertrophy, Left Ventricular; Molecular Structure; Myocardium; Proteins; Skin; Thiazoles	2003
Crosslink breakers: a new approach to cardiovascular therapy. Current opinion in cardiology, 2004, Volume: 19, Issue:4 Topics: Aging; Animals; Blood Pressure; Cardiovascular Diseases; Collagen; Comorbidity; Cross-Linking Reagents; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Hypertension; Kidney Failure, Chronic; Rats; Thiazoles; Treatment Outcome	2004
Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process. American journal of hypertension, 2004, Volume: 17, Issue:12 Pt 2 Topics: Aging; Animals; Blood Pressure; Blood Vessels; Cardiovascular Agents; Cardiovascular Diseases; Controlled Clinical Trials as Topic; Glycation End Products, Advanced; Heart Failure; Humans; Hypertension; Thiazoles	2004
Importance of advanced glycation end products in diabetes-associated cardiovascular and renal disease. American journal of hypertension, 2004, Volume: 17, Issue:12 Pt 2 Topics: Animals; Atherosclerosis; Blood Glucose; Cardiomyopathies; Cardiovascular Agents; Diabetic Angiopathies; Diabetic Nephropathies; Fibrosis; Glycation End Products, Advanced; Humans; Myocardium; Thiazoles	2004
Treating diastolic heart failure with AGE crosslink breakers: thinking outside the heart failure box. Journal of cardiac failure, 2005, Volume: 11, Issue:3 Topics: Animals; Clinical Trials as Topic; Collagen; Drug Evaluation, Preclinical; Glycation End Products, Advanced; Heart Failure; Humans; Thiazoles; Ventricular Dysfunction, Left	2005
The next generation of diabetic nephropathy therapies: an update. Advances in chronic kidney disease, 2005, Volume: 12, Issue:2 Topics: Animals; Diabetic Nephropathies; Disease Progression; Enzyme Inhibitors; Glycation End Products, Advanced; Glycosaminoglycans; Humans; Indoles; Maleimides; Models, Animal; Protein Kinase C; Pyridoxamine; Renal Agents; Thiazoles	2005
[Targeted AGEes and AGEs cross-link in drug discovery: preventing and reversing arterial sclerosis in aging and diabetes]. Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:1 Topics: Aging; Animals; Arteries; Arteriosclerosis; Blood Pressure; Diabetes Mellitus; Glycation End Products, Advanced; Guanidines; Humans; Thiazoles	2005
[Progress on the drug therapy for diabetic microangiopathies: AGE inhibitors]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6 Topics: Animals; Clinical Trials as Topic; Depression, Chemical; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Humans; Oxidative Stress; Pyridoxamine; Thiadiazoles; Thiamine; Thiazoles; Thiazolidines	2005
[Development of therapeutic agents for diabetic neuropathies]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6 Topics: Aldehyde Reductase; Antioxidants; C-Peptide; Diabetic Neuropathies; Drug Design; Enzyme Inhibitors; Genetic Therapy; Glycation End Products, Advanced; Hedgehog Proteins; Humans; Indoles; Maleimides; Nerve Growth Factor; Oxidative Stress; Polymers; Protein Kinase C; Rhodanine; Thiadiazoles; Thiamine; Thiazoles; Thiazolidines; Trans-Activators; Vascular Endothelial Growth Factor A	2005
Advanced glycation end products in diabetes-associated atherosclerosis and renal disease: interventional studies. Annals of the New York Academy of Sciences, 2005, Volume: 1043 Topics: Amides; Animals; Arteriosclerosis; Diabetic Angiopathies; Diabetic Nephropathies; Glycation End Products, Advanced; Humans; Hydrazines; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles	2005
Advanced glycation end products and vascular structure and function. Current hypertension reports, 2006, Volume: 8, Issue:6 Topics: Animals; Atherosclerosis; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Endothelium, Vascular; Glycation End Products, Advanced; Humans; Lymphocyte Activation; Receptor for Advanced Glycation End Products; Thiazoles	2006
Role of the AGE crosslink breaker, alagebrium, as a renoprotective agent in diabetes. Kidney international. Supplement, 2007, Issue:106 Topics: Angiotensin-Converting Enzyme Inhibitors; Diabetic Nephropathies; Glycation End Products, Advanced; Humans; Isoenzymes; Protein Kinase C; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Renin-Angiotensin System; Thiazoles	2007
Therapeutic interruption of advanced glycation in diabetic nephropathy: do all roads lead to Rome? Annals of the New York Academy of Sciences, 2008, Volume: 1126 Topics: Carnosine; Diabetes Complications; Diabetic Neuropathies; Glycation End Products, Advanced; Humans; Reactive Oxygen Species; Thiazoles	2008
Does accumulation of advanced glycation end products contribute to the aging phenotype? The journals of gerontology. Series A, Biological sciences and medical sciences, 2010, Volume: 65, Issue:9 Topics: Aging; Bone and Bones; Brain; Diet; Enzyme Inhibitors; Erythrocytes; Eye; Food Analysis; Glycation End Products, Advanced; Guanidines; Humans; Inflammation; Kidney; Liver; Longevity; Muscle, Skeletal; Myocardium; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Tendons; Thiazoles	2010
Potential clinical utility of advanced glycation end product cross-link breakers in age- and diabetes-associated disorders. Rejuvenation research, 2012, Volume: 15, Issue:6 Topics: Aging; Animals; Cross-Linking Reagents; Diabetes Complications; Glycation End Products, Advanced; Humans; Thiazoles	2012
Current therapeutic interventions in the glycation pathway: evidence from clinical studies. Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:8 Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Enzyme Inhibitors; Evidence-Based Medicine; Female; Glycation End Products, Advanced; Guanidines; Humans; Hyperglycemia; Male; Pyridoxamine; Thiamine; Thiazoles; Treatment Outcome	2013
Targeting advanced glycation with pharmaceutical agents: where are we now? Glycoconjugate journal, 2016, Volume: 33, Issue:4 Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Maillard Reaction; Thiazoles	2016
Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases. Cellular and molecular life sciences : CMLS, 2019, Volume: 76, Issue:20 Topics: Actin Cytoskeleton; Animals; Calcium; Cardiotonic Agents; Diabetic Cardiomyopathies; Gene Expression Regulation; Glycation End Products, Advanced; Guanidines; Humans; Myocardial Reperfusion Injury; Myocarditis; Oxidative Stress; Receptor for Advanced Glycation End Products; Signal Transduction; Thiazoles; Vascular Stiffness; Vitamin D	2019

Trials

10 trial(s) available for alagebrium and thiazoles

Article	Year
Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation, 2001, Sep-25, Volume: 104, Issue:13 Topics: Aged; Arteries; Blood Pressure; Cardiac Output; Compliance; Double-Blind Method; Drug Tolerance; Elasticity; Female; Forecasting; Glycation End Products, Advanced; Humans; Male; Middle Aged; Thiazoles	2001
The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure. Journal of cardiac failure, 2005, Volume: 11, Issue:3 Topics: Aged; Aorta; Blood Flow Velocity; Blood Pressure; Echocardiography; Exercise Test; Female; Glycation End Products, Advanced; Heart Failure; Humans; Magnetic Resonance Imaging; Male; Oxygen Consumption; Prospective Studies; Quality of Life; Surveys and Questionnaires; Thiazoles; Ventricular Dysfunction, Left	2005
Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension. Journal of hypertension, 2007, Volume: 25, Issue:3 Topics: Aged; Aging; Blood Pressure; Carotid Arteries; Collagen; Elasticity; Endothelium, Vascular; Female; Glycation End Products, Advanced; Humans; Hypertension; Intercellular Adhesion Molecule-1; Male; Manometry; Matrix Metalloproteinase 9; Middle Aged; Peripheral Vascular Diseases; Single-Blind Method; Thiazoles; Transforming Growth Factor beta1; Vascular Cell Adhesion Molecule-1; Vasodilation	2007
Effects of alagebrium, an advanced glycation end-product breaker, in patients with chronic heart failure: study design and baseline characteristics of the BENEFICIAL trial. European journal of heart failure, 2010, Volume: 12, Issue:3 Topics: Diastole; Double-Blind Method; Echocardiography, Stress; Exercise Test; Exercise Tolerance; Female; Glycation End Products, Advanced; Health Status Indicators; Heart Failure; Humans; Male; Middle Aged; Oxygen Consumption; Research Design; Stroke Volume; Surveys and Questionnaires; Systole; Thiazoles; Ventricular Function, Left	2010
Targeted reduction of advanced glycation improves renal function in obesity. Kidney international, 2011, Volume: 80, Issue:2 Topics: Adolescent; Adult; Animals; Cross-Over Studies; Diet; Glycation End Products, Advanced; Humans; Inflammation; Kidney; Kidney Diseases; Male; Mice; Mice, Knockout; Middle Aged; Obesity; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles; Young Adult	2011
Effects of alagebrium, an advanced glycation endproduct breaker, on exercise tolerance and cardiac function in patients with chronic heart failure. European journal of heart failure, 2011, Volume: 13, Issue:8 Topics: Aged; Cardiovascular Agents; Chronic Disease; Diagnostic Techniques, Cardiovascular; Double-Blind Method; Exercise Tolerance; Female; Glycation End Products, Advanced; Heart Failure; Humans; Male; Middle Aged; Prospective Studies; Thiazoles	2011
Functional and hemodynamic cardiac determinants of exercise capacity in patients with systolic heart failure. The American journal of cardiology, 2012, Nov-01, Volume: 110, Issue:9 Topics: Age Factors; Aged; Analysis of Variance; Cardiac Output; Chi-Square Distribution; Double-Blind Method; Exercise Test; Exercise Tolerance; Heart Failure, Systolic; Heart Rate; Hemodynamics; Humans; Linear Models; Male; Middle Aged; Predictive Value of Tests; Prognosis; Prospective Studies; Risk Assessment; Sex Factors; Stroke Volume; Survival Rate; Thiazoles	2012
Cardiovascular effects of 1 year of alagebrium and endurance exercise training in healthy older individuals. Circulation. Heart failure, 2013, Volume: 6, Issue:6 Topics: Aged; Aged, 80 and over; Aging; Cardiovascular System; Dose-Response Relationship, Drug; Double-Blind Method; Exercise Test; Exercise Tolerance; Female; Follow-Up Studies; Heart Ventricles; Humans; Male; Middle Aged; Prospective Studies; Reference Values; Thiazoles; Time Factors; Ventricular Function, Left	2013
The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: a randomized factorial design trial. Experimental gerontology, 2013, Volume: 48, Issue:12 Topics: Age Factors; Aged; Aging; Blood Flow Velocity; Cardiovascular Diseases; Endothelium, Vascular; Exercise Test; Exercise Therapy; Female; Glycation End Products, Advanced; Humans; Male; Oxygen Consumption; Physical Fitness; Plethysmography; Pulse Wave Analysis; Risk Assessment; Risk Factors; Sedentary Behavior; Thiazoles; Time Factors; Treatment Outcome; Vascular Stiffness; Vasoconstriction; Vasodilation	2013
The effect of 1 year of Alagebrium and moderate-intensity exercise training on left ventricular function during exercise in seniors: a randomized controlled trial. Journal of applied physiology (Bethesda, Md. : 1985), 2016, 08-01, Volume: 121, Issue:2 Topics: Aged; Combined Modality Therapy; Exercise; Exercise Therapy; Female; Humans; Male; Oxygen Consumption; Risk Reduction Behavior; Sedentary Behavior; Thiazoles; Treatment Outcome; Ventricular Function, Left	2016

Other Studies

48 other study(ies) available for alagebrium and thiazoles

Article	Year
An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness. Proceedings of the National Academy of Sciences of the United States of America, 2000, Mar-14, Volume: 97, Issue:6 Topics: Aging; Animals; Diastole; Dogs; Elasticity; Glycation End Products, Advanced; Heart Rate; Hemodynamics; Male; Myocardium; Stroke Volume; Systole; Thiazoles; Ventricular Function	2000
Improvement by aminoguanidine of insulin secretion from pancreatic islets grafted to syngeneic diabetic rats. Biochemical pharmacology, 2000, Jul-15, Volume: 60, Issue:2 Topics: Animals; B-Lymphocytes; Diabetes Mellitus, Experimental; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Proinsulin; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Thiazoles; Transplantation, Isogeneic	2000
Age breakers. Rupturing the body's sugar-protein bonds might turn back the clock. Scientific American, 2000, Volume: 283, Issue:1 Topics: Aging; Carbohydrate Metabolism; Collagen; Elasticity; Glycation End Products, Advanced; Humans; Proteins; Thiazoles	2000
A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys. Proceedings of the National Academy of Sciences of the United States of America, 2001, Jan-30, Volume: 98, Issue:3 Topics: Aging; Animals; Arteries; Blood Pressure; Echocardiography; Glycation End Products, Advanced; Heart Rate; Hemodynamics; Injections, Intramuscular; Macaca mulatta; Male; Muscle, Smooth, Vascular; Pulse; Stroke Volume; Thiazoles; Time Factors; Ventricular Function, Left	2001
Clinical trial to pharmacologically reverse the effects of ageing and diabetes. Diabetes, obesity & metabolism, 2000, Volume: 2, Issue:4 Topics: Aging; Clinical Trials, Phase II as Topic; Diabetes Mellitus; Double-Blind Method; Female; Glycation End Products, Advanced; Humans; Male; Middle Aged; Multicenter Studies as Topic; Thiazoles	2000
Glucose-mediated cross-linking of collagen in rat tendon and skin. Clinica chimica acta; international journal of clinical chemistry, 2002, Volume: 321, Issue:1-2 Topics: Animals; Calorimetry, Differential Scanning; Collagen; Cross-Linking Reagents; Glucose; Male; Protein Structure, Secondary; Rats; Rats, Wistar; Sensitivity and Specificity; Skin; Tail; Tendons; Thiazoles; Time Factors	2002
A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes. Circulation research, 2003, Apr-18, Volume: 92, Issue:7 Topics: Animals; Blood Pressure; Body Weight; Collagen; Cytokines; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glycation End Products, Advanced; Heart Ventricles; Hypertrophy, Left Ventricular; Immunohistochemistry; Male; Myocardium; Natriuretic Peptide, Brain; Organ Size; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles	2003
Getting better without AGE: new insights into the diabetic heart. Circulation research, 2003, Apr-18, Volume: 92, Issue:7 Topics: Animals; Collagen; Cytokines; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glycation End Products, Advanced; Heart Ventricles; Hypertrophy, Left Ventricular; Natriuretic Peptide, Brain; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles	2003
Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:6 Topics: Aging; Animals; Blood Glucose; Collagen Type I; Collagen Type III; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dogs; Glycation End Products, Advanced; Hemodynamics; Male; Myocardium; Solubility; Thiazoles	2003
The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:12 Topics: Albuminuria; Animal Population Groups; Animals; Blood Pressure; Collagen; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Glycation End Products, Advanced; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kidney; Kinetics; Lysine; Models, Biological; Rats; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Solubility; Thiazoles; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrosine	2003
Cardiovascular and renal effects of a collagen cross-link breaker (ALT 711) in adult and aged spontaneously hypertensive rats. American journal of hypertension, 2004, Volume: 17, Issue:4 Topics: Animals; Blood Pressure; Cardiac Output; Cardiovascular System; Coronary Circulation; Dose-Response Relationship, Drug; Heart Rate; Heart Ventricles; Hydroxyproline; Kidney; Liver; Male; Models, Animal; Models, Cardiovascular; Rats; Rats, Inbred SHR; Regional Blood Flow; Thiazoles; Vascular Resistance	2004
Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis. Diabetes, 2004, Volume: 53, Issue:7 Topics: Actins; Animals; Aorta; Arteriosclerosis; Collagen; Cytokines; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Oxidation-Reduction; Skin; Thiazoles	2004
Accelerated nephropathy in diabetic apolipoprotein e-knockout mouse: role of advanced glycation end products. Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:8 Topics: Actins; Animals; Apolipoproteins E; Blood Pressure; Body Weight; Collagen Type I; Collagen Type IV; Diabetic Nephropathies; Glycation End Products, Advanced; Kidney; Lipid Metabolism; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles; Transforming Growth Factor beta; Transforming Growth Factor beta1	2004
Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway. Diabetes, 2004, Volume: 53, Issue:11 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Extracellular Matrix Proteins; Glycation End Products, Advanced; Guanidines; Kidney Cortex; Male; Protein Kinase C; Protein Kinase C-alpha; Protein Transport; Rats; Rats, Sprague-Dawley; Thiazoles	2004
The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocin-induced diabetic rats: preventive versus curative treatment. The journal of sexual medicine, 2006, Volume: 3, Issue:2 Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dose-Response Relationship, Drug; Glycation End Products, Advanced; Guanidines; Immunohistochemistry; Impotence, Vasculogenic; Male; Rats; Rats, Sprague-Dawley; Streptozocin; Thiazoles	2006
Alagebrium: benefit on peripheral arteries. Journal of cardiac failure, 2006, Volume: 12, Issue:7 Topics: Arteries; Cardiac Output, Low; Humans; Thiazoles	2006
Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711). American journal of nephrology, 2006, Volume: 26, Issue:5 Topics: Animals; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Lysine; Mice; Mice, Mutant Strains; Thiazoles	2006
Combination therapy with the advanced glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: synergy or redundancy? Endocrinology, 2007, Volume: 148, Issue:2 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cytosol; Diabetes Mellitus, Experimental; Drug Synergism; Drug Therapy, Combination; Enzyme Activation; Glycation End Products, Advanced; Kidney; Lysine; Male; Mitochondria; NF-kappa B; Oxidative Stress; Protein Kinase C; Ramipril; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Renin-Angiotensin System; Superoxide Dismutase; Thiazoles; Vascular Endothelial Growth Factor A	2007
Slowing arterial aging: how far have we progressed? Journal of hypertension, 2007, Volume: 25, Issue:3 Topics: Aging; Blood Pressure; Glycation End Products, Advanced; Humans; Hypertension; Peripheral Vascular Diseases; Thiazoles	2007
Advanced glycation of apolipoprotein A-I impairs its anti-atherogenic properties. Diabetologia, 2007, Volume: 50, Issue:8 Topics: Apolipoprotein A-I; Atherosclerosis; ATP-Binding Cassette Transporters; Biological Transport; CD11b Antigen; Cell Line; Cells, Cultured; Cholesterol; Electrophoresis, Polyacrylamide Gel; Glycation End Products, Advanced; Glycosylation; Guanidines; HeLa Cells; Humans; Lipid Metabolism; Lipoproteins, HDL; Phospholipids; Ribose; Thiazoles; Transfection	2007
Inhibitors of advanced glycation end-products prevent loss of enteric neuronal nitric oxide synthase in diabetic rats. Neurogastroenterology and motility, 2008, Volume: 20, Issue:3 Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Experimental; Duodenum; Enteric Nervous System; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Guanidines; Immunohistochemistry; Male; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiazoles	2008
Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I. Diabetologia, 2008, Volume: 51, Issue:6 Topics: Apolipoprotein A-I; Arginine; Cross-Linking Reagents; Glycosylation; Guanidines; Humans; Lipoproteins, HDL; Lysine; Metformin; Phosphatidylcholine-Sterol O-Acyltransferase; Pyridoxamine; Pyruvaldehyde; Thiazoles; Tryptophan	2008
Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs. American journal of physiology. Endocrinology and metabolism, 2008, Volume: 295, Issue:2 Topics: Animals; Cardiomegaly; Cardiotonic Agents; Diet; Dietary Fats; Endomyocardial Fibrosis; Glycation End Products, Advanced; Immunohistochemistry; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocarditis; Oxidative Stress; Random Allocation; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Superoxides; Thiazoles	2008
Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines. Circulation, 2008, Sep-02, Volume: 118, Issue:10 Topics: Aging; Animals; Aorta; Collagen; Dogs; Drug Evaluation, Preclinical; Elastin; Glycation End Products, Advanced; Heart Ventricles; Hypertension; Lysine; Muscle, Smooth, Vascular; Thiazoles; Vasa Vasorum; Vascular Resistance; Ventricular Function, Left	2008
Letter by Hartog et al. regarding article, "Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines". Circulation, 2009, Mar-17, Volume: 119, Issue:10 Topics: Animals; Arginine; Collagen; Cross-Linking Reagents; Dogs; Glycation End Products, Advanced; Hypertension; Lysine; Muscle, Smooth, Vascular; Thiazoles	2009
Alagebrium chloride protects the heart against oxidative stress in aging rats. The journals of gerontology. Series A, Biological sciences and medical sciences, 2009, Volume: 64, Issue:6 Topics: Aging; Animals; DNA, Mitochondrial; Echocardiography; Female; Glutathione Peroxidase; Glycation End Products, Advanced; Heart; Myocardium; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiazoles	2009
Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats. British journal of pharmacology, 2010, Volume: 159, Issue:1 Topics: Adipose Tissue; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucose; Glucose Intolerance; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Male; Phosphorylation; Pyruvaldehyde; Rats; Rats, Sprague-Dawley; Thiazoles; Tyrosine	2010
Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy. American journal of physiology. Renal physiology, 2010, Volume: 298, Issue:3 Topics: Adenosine Triphosphate; Albuminuria; Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet; Disease Models, Animal; Disease Progression; Glycation End Products, Advanced; Glycolysis; Ion Channels; Kidney; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Superoxides; Thiazoles; Time Factors; Uncoupling Protein 2	2010
Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage. Transactions of the American Ophthalmological Society, 2009, Volume: 107 Topics: Accommodation, Ocular; Animals; Anterior Eye Segment; Eye; Female; Glaucoma, Open-Angle; Glycation End Products, Advanced; Immunohistochemistry; Injections; Intraocular Pressure; Macaca mulatta; Microscopy, Electron; Optic Disk; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Refraction, Ocular; Retina; Thiazoles; Vitreous Body	2009
Renoprotective antioxidant effect of alagebrium in experimental diabetes. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:11 Topics: Acute Kidney Injury; Albuminuria; Animals; Antioxidants; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hydrogen Peroxide; Immunoenzyme Techniques; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; NADPH Oxidases; Oxidative Stress; Protein Kinase C; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger; Thiazoles	2011
The advanced glycation end product-lowering agent ALT-711 is a low-affinity inhibitor of thiamine diphosphokinase. Rejuvenation research, 2011, Volume: 14, Issue:4 Topics: Animals; Binding Sites; Cattle; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme Assays; Glycation End Products, Advanced; Inhibitory Concentration 50; Kidney; Kinetics; Models, Molecular; Nucleoside-Diphosphate Kinase; Protein Kinase Inhibitors; Thiamine; Thiamine Pyrophosphate; Thiazoles	2011
The AGE-breaker ALT-711 restores high blood flow-dependent remodeling in mesenteric resistance arteries in a rat model of type 2 diabetes. Diabetes, 2012, Volume: 61, Issue:6 Topics: Animals; Blood Pressure; Diabetes Mellitus, Type 2; Endothelium, Vascular; Glycation End Products, Advanced; Male; Mesenteric Arteries; Rats; Rats, Zucker; Thiazoles; Vascular Resistance; Vasodilation	2012
Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness. Experimental gerontology, 2012, Volume: 47, Issue:8 Topics: Aging; Animals; Diastole; Drug Evaluation, Preclinical; Glycation End Products, Advanced; Hemodynamics; Male; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Systole; Thiazoles; Vascular Stiffness; Ventricular Function, Left	2012
Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice. Diabetes, 2012, Volume: 61, Issue:8 Topics: Albuminuria; Animals; Apolipoproteins E; Diabetes Mellitus, Experimental; Fibrosis; Glomerular Mesangium; Glomerulonephritis; Glycation End Products, Advanced; Male; Mice; Mice, Knockout; Nephritis; Oxidative Stress; Quinapril; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Tetrahydroisoquinolines; Thiazoles	2012
Methylglyoxal, a reactive glucose metabolite, increases renin angiotensin aldosterone and blood pressure in male Sprague-Dawley rats. American journal of hypertension, 2014, Volume: 27, Issue:3 Topics: Aldosterone; Angiotensins; Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Catecholamines; Cells, Cultured; Disease Models, Animal; Hypertension; Male; NF-kappa B; Pyruvaldehyde; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Renin; Renin-Angiotensin System; RNA Interference; RNA, Messenger; Signal Transduction; Thiazoles; Time Factors; Up-Regulation	2014
AGE-breaker ALT-711 plus insulin could restore erectile function in streptozocin-induced type 1 diabetic rats. The journal of sexual medicine, 2014, Volume: 11, Issue:6 Topics: Animals; Apoptosis; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Erectile Dysfunction; Hypoglycemic Agents; Insulin; Male; Malondialdehyde; Nitric Oxide Synthase Type I; Oxidative Stress; Penile Erection; Penis; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles	2014
Alagebrium (ALT-711) improves the anti-hypertensive efficacy of nifedipine in diabetic-hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension, 2014, Volume: 37, Issue:10 Topics: Animals; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Endothelin-1; Epoprostenol; Heart Rate; Hypertension; Male; Nifedipine; Nitric Oxide; Rats; Rats, Wistar; Thiazoles	2014
The impracticality of biomedical rejuvenation therapies: translational and pharmacological barriers. Rejuvenation research, 2014, Volume: 17, Issue:4 Topics: Aging; Biotechnology; Glycation End Products, Advanced; Humans; Lysosomes; Medication Adherence; Pharmacology; Polypharmacy; Rejuvenation; Telomere; Thiazoles; Translational Research, Biomedical	2014
In vitro glycation of an endothelialized and innervated tissue-engineered skin to screen anti-AGE molecules. Biomaterials, 2015, Volume: 51 Topics: Animals; Capillaries; Cattle; Cell Differentiation; Cells, Cultured; Collagen; Cytoskeleton; Dermis; Endothelial Cells; Fibroblasts; Filaggrin Proteins; Glycation End Products, Advanced; Glycosylation; Glyoxal; Guanidines; Humans; Keratinocytes; Lysine; Mice; Neurons; Protective Agents; Skin; Thiazoles; Tissue Engineering	2015
Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats. American journal of physiology. Heart and circulatory physiology, 2015, Volume: 309, Issue:7 Topics: Animals; Aorta, Abdominal; Collagen; Diabetes Mellitus; Glycation End Products, Advanced; Graft Occlusion, Vascular; Male; Neointima; Obesity; Rats; Rats, Zucker; Receptor for Advanced Glycation End Products; Shear Strength; Stents; Stress, Mechanical; Thiazoles; Transforming Growth Factor beta; Vascular Resistance	2015
Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway. The Journal of pathology, 2016, Volume: 238, Issue:3 Topics: Aged; AMP-Activated Protein Kinases; Animals; Atrophy; Case-Control Studies; Diabetes Mellitus; Diabetes Mellitus, Experimental; Down-Regulation; Glycation End Products, Advanced; Humans; Male; MAP Kinase Signaling System; Mice; Muscle Fatigue; Muscle Fibers, Skeletal; Muscle Proteins; Muscle Weakness; Muscle, Skeletal; Muscular Diseases; Receptor for Advanced Glycation End Products; Regeneration; Signal Transduction; SKP Cullin F-Box Protein Ligases; Thiazoles	2016
Alagebrium attenuates methylglyoxal induced oxidative stress and AGE formation in H9C2 cardiac myocytes. Life sciences, 2016, Feb-01, Volume: 146 Topics: Animals; bcl-2-Associated X Protein; Caspase 3; Cell Line; Cells, Cultured; Free Radical Scavengers; Glucose; Glycation End Products, Advanced; Myocytes, Cardiac; NF-kappa B; Oxidative Stress; Pyruvaldehyde; Rats; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Thiazoles	2016
Matrix metalloproteinases are possible targets in monocrotaline-induced pulmonary hypertension: investigation of anti-remodeling effects of alagebrium and everolimus. Anatolian journal of cardiology, 2017, Volume: 17, Issue:1 Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Everolimus; Hypertension, Pulmonary; Male; Matrix Metalloproteinases; Monocrotaline; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Thiazoles; Vasodilator Agents	2017
Pharmacological evaluation of novel alagebrium analogs as methylglyoxal scavengers in vitro in cardiac myocytes and in vivo in SD rats. International journal of cardiology, 2016, Nov-15, Volume: 223 Topics: Animals; Cells, Cultured; Drug Evaluation, Preclinical; Glycation End Products, Advanced; Male; Myocytes, Cardiac; Pyruvaldehyde; Rats; Rats, Sprague-Dawley; Thiazoles	2016
Effect of Advanced Glycation End-Products (AGE) Lowering Drug ALT-711 on Biochemical, Vascular, and Bone Parameters in a Rat Model of CKD-MBD. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2020, Volume: 35, Issue:3 Topics: Animals; Chronic Kidney Disease-Mineral and Bone Disorder; Minerals; Pharmaceutical Preparations; Rats; Renal Insufficiency, Chronic; Thiazoles	2020
Electrochemical Quantitation of Supramolecular Excipient@Drug Complexation: A General Assay Strategy Based on Competitive Host Binding with Surface-Immobilized Redox Guest. Analytical chemistry, 2020, 01-21, Volume: 92, Issue:2 Topics: Adamantane; Binding Sites; Bridged-Ring Compounds; Electrochemical Techniques; Ferrous Compounds; Imidazoles; Macromolecular Substances; Metallocenes; Molecular Structure; Oxidation-Reduction; Quaternary Ammonium Compounds; Surface Properties; Thiazoles	2020
Effect of atorvastatin on AGEs-induced injury of cerebral cortex via inhibiting NADPH oxidase -NF-κB pathway in ApoE Molecular biology reports, 2020, Volume: 47, Issue:12 Topics: Amyloid beta-Peptides; Animals; Anticholesteremic Agents; Apolipoproteins E; Atorvastatin; Cerebral Cortex; Diet, High-Fat; Gene Expression Regulation; Glycation End Products, Advanced; Immunohistochemistry; Inflammation; Male; Mice; Mice, Knockout; NADPH Oxidases; Neurons; Oxidative Stress; Receptor for Advanced Glycation End Products; Signal Transduction; Thiazoles; Transcription Factor RelA	2020
The therapeutic effect of ALT-711 on erectile function in rats treated with high-level AGEs (advanced glycation end products) containing diet. International journal of impotence research, 2022, Volume: 34, Issue:2 Topics: Animals; Diabetes Mellitus, Experimental; Diet; Erectile Dysfunction; Glycation End Products, Advanced; Male; Nitric Oxide Synthase Type III; Penile Erection; Penis; Rats; Rats, Sprague-Dawley; Thiazoles	2022