acronine and acridone

acronine has been researched along with acridone* in 2 studies

Other Studies

2 other study(ies) available for acronine and acridone

Article	Year
Synthesis and cytotoxic activity of some new azapyranoxanthenone aminoderivatives. Bioorganic & medicinal chemistry, 2003, Oct-15, Volume: 11, Issue:21 A series of novel azapyranoxanthenones, bearing structural similarity to the acridone alkaloid acronycine have been designed and synthesized. Their in vitro cytotoxicities against the murine L1210 leukemia and the human solid tumor HT-29 cell lines have been investigated. The new derivatives exhibited interesting cytotoxic activity and were more potent than the parent compound. Topics: Acridines; Acridones; Acronine; Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Inhibitory Concentration 50; Leukemia L1210; Mice	2003
Synthesis of the acridone alkaloids glyfoline and congeners. Structure-activity relationship studies of cytotoxic acridones. Journal of medicinal chemistry, 1992, Jul-10, Volume: 35, Issue:14 Glyfoline (4, 1,6-dihydroxy-10-methyl-2,3,4,5-tetramethoxyacridin-9-one) and its congeners were synthesized for evaluation of their cytotoxicity. A detailed structure-activity relationships (SAR) of these acridone derivatives were also studied. To study the SAR of glyfoline analogues, substituent(s) at C-1 and C-6 and at the heterocyclic nitrogen of glyfoline nucleus were modified. Nitro- and amino-substituted glyfoline analogues were also synthesized to study the effects of substituent(s) (electron-withdrawing vs electron-donating) on their cytotoxicity. These compounds were synthesized via the Ullmann condensation of anthranilic acids with iodobenzenes or 2-chlorobenzoic acids with aniline derivatives. The SAR studies showed that 1-hydroxy-9-acridones were more active than their 1-OMe derivatives against cell growth of human leukemic HL-60 cells in culture. Replacement of NMe of glyfoline with NH or N(CH2)2NEt2 resulted in either total loss or dramatic reduction of cytotoxicity. Glyfoline congeners with nitro function at the A-ring were inactive, while compounds with amino substituent were shown to be cytotoxic in vitro. Topics: Acridines; Acridones; Antineoplastic Agents; Cell Survival; Drug Screening Assays, Antitumor; Humans; Structure-Activity Relationship; Tumor Cells, Cultured	1992

Article

Year

Synthesis and cytotoxic activity of some new azapyranoxanthenone aminoderivatives.

Bioorganic & medicinal chemistry, 2003, Oct-15, Volume: 11, Issue:21

A series of novel azapyranoxanthenones, bearing structural similarity to the acridone alkaloid acronycine have been designed and synthesized. Their in vitro cytotoxicities against the murine L1210 leukemia and the human solid tumor HT-29 cell lines have been investigated. The new derivatives exhibited interesting cytotoxic activity and were more potent than the parent compound.

Topics: Acridines; Acridones; Acronine; Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Inhibitory Concentration 50; Leukemia L1210; Mice

2003

Synthesis of the acridone alkaloids glyfoline and congeners. Structure-activity relationship studies of cytotoxic acridones.

Journal of medicinal chemistry, 1992, Jul-10, Volume: 35, Issue:14

Glyfoline (4, 1,6-dihydroxy-10-methyl-2,3,4,5-tetramethoxyacridin-9-one) and its congeners were synthesized for evaluation of their cytotoxicity. A detailed structure-activity relationships (SAR) of these acridone derivatives were also studied. To study the SAR of glyfoline analogues, substituent(s) at C-1 and C-6 and at the heterocyclic nitrogen of glyfoline nucleus were modified. Nitro- and amino-substituted glyfoline analogues were also synthesized to study the effects of substituent(s) (electron-withdrawing vs electron-donating) on their cytotoxicity. These compounds were synthesized via the Ullmann condensation of anthranilic acids with iodobenzenes or 2-chlorobenzoic acids with aniline derivatives. The SAR studies showed that 1-hydroxy-9-acridones were more active than their 1-OMe derivatives against cell growth of human leukemic HL-60 cells in culture. Replacement of NMe of glyfoline with NH or N(CH2)2NEt2 resulted in either total loss or dramatic reduction of cytotoxicity. Glyfoline congeners with nitro function at the A-ring were inactive, while compounds with amino substituent were shown to be cytotoxic in vitro.

Topics: Acridines; Acridones; Antineoplastic Agents; Cell Survival; Drug Screening Assays, Antitumor; Humans; Structure-Activity Relationship; Tumor Cells, Cultured

1992