acetogenins has been researched along with annonacin* in 5 studies
1 review(s) available for acetogenins and annonacin
| Article | Year |
|---|---|
Pharmacological Activities of Soursop (
Soursop ( Topics: Acetogenins; Annona; Furans; Humans; Lactones; Plant Extracts; Plant Leaves | 2022 |
4 other study(ies) available for acetogenins and annonacin
| Article | Year |
|---|---|
An evaluation of the quality of Annona muricata leaf products.
Annona muricata, also known as graviola, is traditionally used for the treatment of a range of disorders including cancer. Interest in A. muricata use has increased in recent years. This study investigated the quality and safety of a selection of commercially available A. muricata leaf products.. Seven commercially available products were purchased via online shopping sites. Each product was assessed for quality indicators including weight variation, quantification of the bioactive constituent annonacin, presence of annonaceous acetogenins and contaminants. The samples were evaluated by thin-layer chromatography, high-performance liquid chromatography, liquid chromatography-mass spectroscopy, low-resolution mass spectrometry and nuclear magnetic resonance spectroscopy. Microbial analysis was carried out in accordance with the British Pharmacopoeia. Heavy metals were analysed by inductive coupled plasma mass spectrometry.. Of the seven products analysed, one product contained less than half of the content stated on the label. The labelled dosage recommendation varied between products. There was a high variation in annonacin concentration (1.05-3.09 mg/g) and the presence of annonaceous acetogenins. One of the products was found to have a total aerobic microbial count above the United States Pharmacopoeia limit.. The variation in the indicators of quality and safety of commercially available A. muricata leaf products tested have implications for clinicians and people living with cancer who use these herbal products. Topics: Acetogenins; Annona; Humans; Neoplasms; Plant Extracts; Plant Leaves | 2023 |
Evaluation of Genotoxicity and Toxicity of
Cancer is a multifactorial organic dysfunction for which great efforts are being devoted in searching for new treatments and therapeutic adjuvants. Topics: Acetogenins; Annona; Plant Extracts; Seeds | 2022 |
Synthesis of annonacin isolated from Annona densicoma.
A total synthesis of annonacin (1) was accomplished by using versatile chiral building block 2 for synthesizing the mono-tetrahydrofuran (THF) annonaceous acetogenins. Topics: Acetogenins; Annona; Furans; Lactones; Stereoisomerism | 2010 |
In vitro antitumor structure-activity relationships of threo/trans/threo mono-tetrahydrofuranic acetogenins: correlations with their inhibition of mitochondrial complex I.
In this study we evaluated a mono-tetrahydrofuranic subgroup of natural acetogenins that had shown in previous enzyme inhibition studies different potency trends compared with the bis-tetrahydrofuranic acetogenin subgroup. The compounds were tested against colon, breast, lung, liver, and ovarian tumor cell lines. A drug-resistant ovarian cell line was also included in the panel. In general the compounds were more potent than doxorubicin. The goal was to determine how well the mitochondrial complex I inhibition correlates with the in vitro antitumor potency of these natural mono-tetrahydrofuranic acetogenins and of some derivatives. The results indicate that both the reduction of the terminal gamma-lactone after its translactonization and the introduction of an hydroxylimine group in the alkyl chain, near the mono-tetrahydrofuranic moiety, increased the antitumor activity, even against the doxorubicin-resistant cell line. Topics: Acetogenins; Antineoplastic Agents; Cell Line, Tumor; Electron Transport Complex I; Fatty Alcohols; Furans; Humans; Inhibitory Concentration 50; Lactones; Molecular Structure; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles | 2003 |