Page last updated: 2024-09-02

2,3-bis(3'-hydroxybenzyl)butyrolactone and glucose, (beta-d)-isomer

2,3-bis(3'-hydroxybenzyl)butyrolactone has been researched along with glucose, (beta-d)-isomer in 26 studies

Compound Research Comparison

Studies
(2,3-bis(3'-hydroxybenzyl)butyrolactone)
Trials
(2,3-bis(3'-hydroxybenzyl)butyrolactone)
Recent Studies (post-2010)
(2,3-bis(3'-hydroxybenzyl)butyrolactone)
Studies
(glucose, (beta-d)-isomer)
Trials
(glucose, (beta-d)-isomer)
Recent Studies (post-2010) (glucose, (beta-d)-isomer)
3193212421,95688310,747

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.85)18.2507
2000's9 (34.62)29.6817
2010's12 (46.15)24.3611
2020's4 (15.38)2.80

Authors

AuthorsStudies
Kitts, DD; Thompson, LU; Wijewickreme, AN; Yuan, YV1
Hattori, M; Li, Y; Meselhy, MR; Qin, GW; Wang, LQ1
Arts, IC; Hollman, PC; Kuijsten, A; Vree, TB1
Alpert, CA; Blaut, M; Clavel, T; Doré, J; Henderson, G; Philippe, C; Rigottier-Gois, L1
Bügel, S; Hallund, J; Ravn-Haren, G; Tetens, I; Tholstrup, T1
Blaut, M; Clavel, T; Doré, J; Engst, W; Henderson, G1
Blaut, M; Clavel, T; Doré, J; Gavini, F; Lippman, R1
Hu, C; Kitts, DD; Yuan, YV1
Akao, T; Hattori, M; Jin, JS; Kakiuchi, N; Min, BS; Nakamura, N; Zhao, YF1
Cao, R; Cui, S; Gagnon, N; Mir, PS; Petit, HV1
Ayella, A; Iwamoto, T; Jiang, Y; Lim, S; Lin, D; Tomich, J; Wang, W1
Britten, M; Côrtes, C; Gagnon, N; Giroux, HJ; Matumoto-Pintro, PT; Petit, HV1
Amaretti, A; Leonardi, A; Raimondi, S; Roncaglia, L; Rossi, M1
Debouche, C; During, A; Larondelle, Y; Raas, T1
Dou, DQ; Han, XY; He, F; Kang, TG; Pan, Q; Tan, RQ; Wang, J; Wang, W1
Bastías, JM; Estévez, AM; Figuerola, F; Fuentealba, C; Muñoz, O1
Alcorn, J; Krol, ES; Michel, D; Muir, AD; Mukker, JK1
Jan, KC; Liu, TC; Yang, BB1
Alcorn, J; Krol, ES; Muir, AD; Mukker, JK; Singh, RS1
Amaretti, A; García-Villalba, R; Leonardi, A; Quartieri, A; Raimondi, S; Rossi, M; Tomàs-Barberàn, F1
Chen, CY; Chen, LH; Chen, WG; Huang, Y; Qin, LQ; Ren, GY1
Bowers, LW; Camp, KK; Fabian, CJ; Ford, NA; Hursting, SD; Kimler, BK; Lineberger, CG; Punjala, A; Rossi, EL1
Dhaini, J; Haykal, T; Hodroj, MH; Rizk, S; Tannous, S1
Feng, X; Liu, L; Ma, CM; Xu, HY; Zhang, G; Zhang, L; Zheng, Z; Zhuang, CC1
Alcorn, J; Guo, Y; Mustafa, R; Purdy, SK; Reaney, MJT; Shen, J; Tse, TJ; Yang, X1
Luo, J; Sun, L; Wang, P; Xu, Q; Yu, L; Zhang, L; Zheng, Z; Zhou, J; Zuo, D1

Trials

2 trial(s) available for 2,3-bis(3'-hydroxybenzyl)butyrolactone and glucose, (beta-d)-isomer

ArticleYear
A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women.
    The Journal of nutrition, 2006, Volume: 136, Issue:1

    Topics: 4-Butyrolactone; Butylene Glycols; Cross-Over Studies; Denmark; Double-Blind Method; Female; Flax; Glucosides; Humans; Lignans; Lipids; Middle Aged; Postmenopause

2006
Technical note: Quantification of lignans in the urine, milk, and plasma of flaxseed cake-fed dairy sheep.
    Journal of dairy science, 2021, Volume: 104, Issue:1

    Topics: 4-Butyrolactone; Animal Feed; Animals; Butylene Glycols; Flax; Glucosides; Lignans; Milk; Seeds; Sheep

2021

Other Studies

24 other study(ies) available for 2,3-bis(3'-hydroxybenzyl)butyrolactone and glucose, (beta-d)-isomer

ArticleYear
Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone.
    Molecular and cellular biochemistry, 1999, Volume: 202, Issue:1-2

    Topics: 4-Butyrolactone; Animals; Antioxidants; Butylene Glycols; Emulsions; Estrogens; Flax; Free Radical Scavengers; Glucosides; Hydroxides; Lignans; Linoleic Acid; Lipid Peroxidation; Mammals; Oxidation-Reduction; Seeds

1999
Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone.
    Chemical & pharmaceutical bulletin, 2000, Volume: 48, Issue:11

    Topics: 4-Butyrolactone; Animals; Butylene Glycols; Culture Media; Estrogens; Eubacterium; Feces; Glucosides; Humans; Intestines; Lignans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Peptostreptococcus; Rats; Rats, Wistar

2000
Pharmacokinetics of enterolignans in healthy men and women consuming a single dose of secoisolariciresinol diglucoside.
    The Journal of nutrition, 2005, Volume: 135, Issue:4

    Topics: 4-Butyrolactone; Adult; Blood Specimen Collection; Butylene Glycols; Dietary Supplements; Female; Glucosides; Humans; Lignans; Male; Reference Values

2005
Intestinal bacterial communities that produce active estrogen-like compounds enterodiol and enterolactone in humans.
    Applied and environmental microbiology, 2005, Volume: 71, Issue:10

    Topics: 4-Butyrolactone; Actinobacteria; Adult; Bacteria, Anaerobic; Butylene Glycols; Colony Count, Microbial; Culture Media; Female; Flow Cytometry; Glucosides; Humans; In Situ Hybridization, Fluorescence; Intestines; Lignans; Male; Middle Aged; Peptostreptococcus; Phytoestrogens

2005
Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside.
    FEMS microbiology ecology, 2006, Volume: 55, Issue:3

    Topics: 4-Butyrolactone; Bacteria, Anaerobic; Butylene Glycols; Culture Media; Glucosides; Humans; Intestines; Lignans; Phylogeny

2006
Clostridium saccharogumia sp. nov. and Lactonifactor longoviformis gen. nov., sp. nov., two novel human faecal bacteria involved in the conversion of the dietary phytoestrogen secoisolariciresinol diglucoside.
    Systematic and applied microbiology, 2007, Volume: 30, Issue:1

    Topics: 4-Butyrolactone; Adult; Base Composition; Butylene Glycols; Clostridium; Colon; Culture Media; Dietary Carbohydrates; DNA; DNA, Ribosomal; Feces; Genotype; Glucosides; Gram-Positive Rods; Humans; Lignans; Male; Molecular Sequence Data; Nucleic Acid Hybridization; Phenotype; Phylogeny; Phytoestrogens; RNA, Ribosomal, 16S

2007
Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:11

    Topics: 4-Butyrolactone; Animals; Biphenyl Compounds; Butylene Glycols; Flax; Free Radical Scavengers; Glucosides; Hydrazines; Lignans; Liposomes; Mammals; Molecular Structure; Picrates; Seeds

2007
Enantioselective dehydroxylation of enterodiol and enterolactone precursors by human intestinal bacteria.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:11

    Topics: 4-Butyrolactone; Bacteria, Anaerobic; Biotransformation; Butylene Glycols; Eubacterium; Feces; Glucosides; Humans; Hydroxylation; Intestines; Lignans; Molecular Structure; Phylogeny; RNA, Bacterial; RNA, Ribosomal, 16S; Stereoisomerism

2007
Milk concentration of the mammalian lignan enterolactone, milk production, milk fatty acid profile, and digestibility in dairy cows fed diets containing whole flaxseed or flaxseed meal.
    The Journal of dairy research, 2009, Volume: 76, Issue:3

    Topics: 4-Butyrolactone; Animals; Butylene Glycols; Cattle; Diet; Digestion; Fatty Acids; Flax; Glucosides; Lactation; Lignans; Male; Milk; Seeds

2009
Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucoside.
    Nutrition research (New York, N.Y.), 2010, Volume: 30, Issue:11

    Topics: 4-Butyrolactone; Adenocarcinoma; Anticarcinogenic Agents; Butylene Glycols; Cell Cycle; Cell Line, Tumor; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cyclin A; Cytostatic Agents; Dietary Carbohydrates; Dose-Response Relationship, Drug; Glucosides; Glycosides; Humans; Lignans; Mass Spectrometry

2010
Effect of flaxseed lignans added to milk or fed to cows on oxidative degradation of dairy beverages enriched with polyunsaturated fatty acids.
    The Journal of dairy research, 2011, Volume: 78, Issue:1

    Topics: 4-Butyrolactone; Animals; Antioxidants; Butylene Glycols; Cattle; Diet; Fatty Acids, Unsaturated; Female; Flax; Food, Fortified; Glucosides; Hot Temperature; Lignans; Milk; Oxidation-Reduction; Oxidative Stress; Photochemical Processes

2011
Role of bifidobacteria in the activation of the lignan secoisolariciresinol diglucoside.
    Applied microbiology and biotechnology, 2011, Volume: 92, Issue:1

    Topics: 4-Butyrolactone; Bifidobacterium; Biotransformation; Butylene Glycols; Glucosides; Lignans

2011
Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells.
    The Journal of nutrition, 2012, Volume: 142, Issue:10

    Topics: 4-Butyrolactone; Anti-Inflammatory Agents; Butylene Glycols; Caco-2 Cells; Cell Differentiation; Chemokine CCL2; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Furans; Glucosides; Humans; Interleukin-1beta; Interleukin-6; Interleukin-8; Intestines; Lignans; NF-kappa B; Plant Extracts; Signal Transduction

2012
Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC.
    Fitoterapia, 2013, Volume: 86

    Topics: 4-Butyrolactone; Animals; Arctium; Chromatography, High Pressure Liquid; Feces; Fruit; Furans; Glucosides; Lignans; Male; Plant Extracts; Rats, Sprague-Dawley

2013
Bioaccessibility of lignans from flaxseed (Linum usitatissimum L.) determined by single-batch in vitro simulation of the digestive process.
    Journal of the science of food and agriculture, 2014, Volume: 94, Issue:9

    Topics: 4-Butyrolactone; Bacteria, Anaerobic; Biological Availability; Butylene Glycols; Colon; Fatty Acids, Volatile; Fermentation; Flax; Glucosides; Humans; In Vitro Techniques; Lignans; Seeds

2014
Permeability and conjugative metabolism of flaxseed lignans by Caco-2 human intestinal cells.
    Journal of natural products, 2014, Jan-24, Volume: 77, Issue:1

    Topics: 4-Butyrolactone; Algorithms; Butylene Glycols; Caco-2 Cells; Chromatography, High Pressure Liquid; Flax; Glucosides; Humans; Intestinal Mucosa; Lignans; Molecular Structure; Permeability

2014
Gene expression profiling of sesaminol triglucoside and its tetrahydrofuranoid metabolites in primary rat hepatocytes.
    International journal of food sciences and nutrition, 2014, Volume: 65, Issue:8

    Topics: 4-Butyrolactone; Animals; ATP-Binding Cassette Transporters; Cytochrome P-450 Enzyme System; Dioxoles; Furans; Gene Expression; Gene Expression Profiling; Glucosides; Hepatocytes; Inactivation, Metabolic; Lignans; Liver; Mammals; Plant Extracts; Rats, Sprague-Dawley; Seeds; Sesamum

2014
Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats.
    The British journal of nutrition, 2015, Mar-14, Volume: 113, Issue:5

    Topics: 4-Butyrolactone; Administration, Oral; Animals; Biological Availability; Butylene Glycols; Dietary Supplements; Dose-Response Relationship, Drug; Estrogens; Flax; Glucosides; Half-Life; Injections, Intravenous; Intestinal Absorption; Kinetics; Lignans; Male; Metabolic Clearance Rate; Phytoestrogens; Random Allocation; Rats, Wistar; Seeds

2015
Detection of novel metabolites of flaxseed lignans in vitro and in vivo.
    Molecular nutrition & food research, 2016, Volume: 60, Issue:7

    Topics: 4-Butyrolactone; Adult; Bifidobacterium pseudocatenulatum; Butylene Glycols; Dietary Supplements; Feces; Female; Flax; Furans; Gastrointestinal Microbiome; Glucosides; Humans; Intestinal Mucosa; Intestines; Lignans; Male; Middle Aged; Prebiotics; Probiotics; Young Adult

2016
The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2016, Volume: 41, Issue:12

    Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Butylene Glycols; Cell Line, Tumor; Cell Proliferation; Dietary Supplements; Flax; Gene Expression Regulation, Neoplastic; Glucosides; Glycosides; Humans; Lignans; Male; Models, Molecular; Molecular Docking Simulation; Neoplasm Proteins; Prostate; Prostatic Hyperplasia; Random Allocation; Rats; Rats, Wistar; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA Interference; Seeds

2016
The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth.
    Breast cancer research and treatment, 2019, Volume: 173, Issue:3

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Biomarkers; Butylene Glycols; Cell Line, Tumor; Cell Survival; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flax; Gene Expression Profiling; Glucosides; Immunohistochemistry; Lignans; Mammary Neoplasms, Animal; Mice; NF-kappa B; Signal Transduction

2019
The anti-cancer effect of flaxseed lignan derivatives on different acute myeloid leukemia cancer cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 132

    Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Apoptosis; Butylene Glycols; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Child; Female; Flax; Glucosides; Humans; Leukemia, Myeloid, Acute; Lignans; Plant Extracts; Reactive Oxygen Species; Seeds

2020
Oral Pharmacokinetics of Enriched Secoisolariciresinol Diglucoside and Its Polymer in Rats.
    Journal of natural products, 2021, 06-25, Volume: 84, Issue:6

    Topics: 4-Butyrolactone; Animals; Biological Availability; Butylene Glycols; Female; Flax; Glucosides; Lignans; Molecular Structure; Polymers; Rats; Rats, Wistar; Seeds

2021
Secoisolariciresinol diglucoside-derived metabolite, enterolactone, attenuates atopic dermatitis by suppressing Th2 immune response.
    International immunopharmacology, 2022, Volume: 111

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Butylene Glycols; Child, Preschool; Dermatitis, Atopic; Dinitrochlorobenzene; Glucosides; Humans; Immunity; Lignans; Mice; Mice, Inbred BALB C; Skin

2022
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