Page last updated: 2024-12-11
thermorubin
Description
thermorubin: antibiotic produced by Thermoactinomyces antibioticus [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
thermorubin : Antibiotic substance produced by Thermoactinomyces antibioticus. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 5458199 |
| CHEMBL ID | 2261578 |
| CHEBI ID | 48480 |
| SCHEMBL ID | 11023994 |
| MeSH ID | M0047598 |
Synonyms (19)
| Synonym |
|---|
| 3687kkh84l , |
| unii-3687kkh84l |
| 11006-83-0 |
| 1h-anthra(2,3-c)pyran-8-acetic acid, 10,11-dimethoxy-12-hydroxy-9-(3-hydroxy-3-(2-hydroxyphenyl)-1-oxo-2-propenyl)-3-(methoxycarbonyl)-1-oxo- |
| 37577-75-6 |
| nsc105760 , |
| thermorubin |
| 10,11-dimethoxy-12-hydroxy-9-(3-hydroxy-3-(2-hydroxyphenyl)-1-oxo-2-propenyl)-3-(methoxycarbonyl)-1-oxo-1h-anthra(2,3-c)pyran-8-acetic acid |
| thermorubin a |
| CHEBI:48480 , |
| {12-hydroxy-9-[(2z)-3-hydroxy-3-(2-hydroxyphenyl)prop-2-enoyl]-10,11-dimethoxy-3-(methoxycarbonyl)-1-oxo-1h-naphtho[2,3-g]isochromen-8-yl}acetic acid |
| 2-[12-hydroxy-9-[(z)-3-hydroxy-3-(2-hydroxyphenyl)prop-2-enoyl]-10,11-dimethoxy-3-methoxycarbonyl-1-oxonaphtho[3,2-g]isochromen-8-yl]acetic acid |
| ue3qvk518u , |
| unii-ue3qvk518u |
| CHEMBL2261578 , |
| 1h-anthra(2,3-c)pyran-8-acetic acid, 12-hydroxy-9-(3-hydroxy-3-(2-hydroxyphenyl)-1-oxo-2-propen-1-yl)-10,11-dimethoxy-3-(methoxycarbonyl)-1-oxo- |
| SCHEMBL11023994 |
| bdbm50487936 |
| Q27121230 |
Research Excerpts
Overview
Thermorubin (THR) is an aromatic anthracenopyranone antibiotic active against both Gram-positive and Gram-negative bacteria. It is a small-molecule inhibitor of bacterial protein synthesis. The molecular mechanism of its action was unclear.
| Excerpt | Reference | Relevance |
|---|
| "Thermorubin (THR) is an aromatic anthracenopyranone antibiotic active against both Gram-positive and Gram-negative bacteria. " | ( Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin.
Gagnon, MG; Grachev, AA; Konevega, AL; Marina, VI; Maviza, TP; Osterman, IA; Paleskava, A; Paranjpe, MN; Polikanov, YS; Sergiev, PV; Tolicheva, OA, 2023) | 2.57 |
| "Thermorubin (THB) is a long-known broad-spectrum ribosome-targeting antibiotic, but the molecular mechanism of its action was unclear. " | ( Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria.
Emmerich, A; Mandava, CS; Parajuli, NP; Pavlov, MY; Sanyal, S, 2023) | 2.74 |
| "Thermorubin is a small-molecule inhibitor of bacterial protein synthesis, but relatively little is known about the molecular mechanism by which it blocks translation. " | ( The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome.
Bulkley, D; Johnson, F; Steitz, TA, 2012) | 2.17 |
Drug Classes (3)
| Class | Description |
|---|
| naphthoisochromene | |
| dicarboxylic acid monoester | A monoester of a dicarboxylic acid. |
| methyl ester | Any carboxylic ester resulting from the formal condensation of a carboxy group with methanol. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 23.22
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 23.22 (24.57) | | Research Supply Index | 2.20 (2.92) | | Research Growth Index | 4.83 (4.65) | | Search Engine Demand Index | 21.17 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |