Page last updated: 2024-11-12
laxaphycin a
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
Laxaphycin A: cyclic peptide from blue-green algae [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 16116570 |
| CHEMBL ID | 434574 |
| MeSH ID | M0488767 |
Synonyms (7)
| Synonym |
|---|
| laxaphycin a |
| CHEMBL434574 |
| MLS003235795 |
| smr001918759 |
| cyclo[d-alloisoleucyl-l-leucylglycyl-(3r)-3-aminooctanoyl-l-homoseryl-(2e)-2-amino-2-butenoyl-(4r)-4-hydroxy-l-prolyl-l-homoseryl-d-phenylalanyl-d-leucyl-l-isoleucyl] |
| DTXSID001339230 |
| 145680-51-9 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (19)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1594463 | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 24 hrs by LDH release assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | Structure and biological evaluation of new cyclic and acyclic laxaphycin-A type peptides. |
| AID1391568 | Synergistic antiproliferative activity against human HCT116 cells assessed as combination index at 100 uM after 48 hrs in presence of 10 uM laxaphycin B4 by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. |
| AID1391560 | Synergistic antiproliferative activity against human HCT116 cells assessed as combination index at 10 uM after 48 hrs in presence of 0.32 uM laxaphycin B4 by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. |
| AID1594462 | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 6 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | Structure and biological evaluation of new cyclic and acyclic laxaphycin-A type peptides. |
| AID1391567 | Synergistic antiproliferative activity against human HCT116 cells assessed as combination index at 320 uM after 48 hrs in presence of 32 uM laxaphycin B4 by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. |
| AID280538 | Antiproliferative activity against human DLD1 cells at 5 uM after 48 hrs by RRT assay | 2007 | Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6 | Total structure and inhibition of tumor cell proliferation of laxaphycins. |
| AID1391562 | Synergistic antiproliferative activity against human HCT116 cells assessed as combination index at 1 uM after 48 hrs in presence of 0.032 uM laxaphycin B4 by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. |
| AID1391558 | Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. |
| AID280519 | Cytotoxicity against drug-sensitive CCRF-CEM cells after 72 hrs | 2007 | Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6 | Total structure and inhibition of tumor cell proliferation of laxaphycins. |
| AID280520 | Cytotoxicity against vinblastine-resistant CEM/VLB100 cells after 72 hrs | 2007 | Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6 | Total structure and inhibition of tumor cell proliferation of laxaphycins. |
| AID1391557 | Synergistic antiproliferative activity against human HCT116 cells assessed as combination index at 10 uM after 48 hrs in presence of 1 uM laxaphycin B4 by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. |
| AID1391571 | Synergistic antiproliferative activity against human HCT116 cells assessed as combination index at 1 uM after 48 hrs in presence of 0.1 uM laxaphycin B4 by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. |
| AID280521 | Cytotoxicity against teniposide-resistant CEM/VM1 cells after 72 hrs | 2007 | Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6 | Total structure and inhibition of tumor cell proliferation of laxaphycins. |
| AID1391569 | Synergistic antiproliferative activity against human HCT116 cells assessed as combination index at 32 uM after 48 hrs in presence of 3.2 uM laxaphycin B4 by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. |
| AID1594461 | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 24 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | Structure and biological evaluation of new cyclic and acyclic laxaphycin-A type peptides. |
| AID1391570 | Synergistic antiproliferative activity against human HCT116 cells assessed as combination index at 3.2 uM after 48 hrs in presence of 0.32 uM laxaphycin B4 by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. |
| AID1391559 | Synergistic antiproliferative activity against human HCT116 cells assessed as combination index at 32 uM after 48 hrs in presence of 1 uM laxaphycin B4 by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. |
| AID280524 | Antiproliferative activity against CCRF-CEM cells at 20 uM after 72 hrs | 2007 | Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6 | Total structure and inhibition of tumor cell proliferation of laxaphycins. |
| AID1391561 | Synergistic antiproliferative activity against human HCT116 cells assessed as combination index at 3.2 uM after 48 hrs in presence of 0.1 uM laxaphycin B4 by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (4)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 13.13
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.13) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||