Compounds > laxaphycin b
Page last updated: 2024-11-12

laxaphycin b

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Description

Laxaphycin B: cyclic peptide from blue-green algae [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16116433
CHEMBL ID438989
MeSH IDM0488768

Synonyms (2)

Synonym
laxaphycin b
CHEMBL438989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (49)

Assay IDTitleYearJournalArticle
AID280528Antiproliferative activity against drug-sensitive CCRF-CEM cells after 72 hrs in presence of 2 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280533Antiproliferative activity against teniposide-resistant CEM/VM1 after 72 hrs in presence of 0.2 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280506Cytotoxicity against human A459 cells after 48 hrs by Hoechst 33342 assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280544Interaction index, ratio of IC50 for CCRF-CEM cells in presence of 1 uM laxaphycin A/IC50 for CCRF-CEM cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280518Cytotoxicity against mouse L929 cells after 48 hrs by Hoechst 33342 assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280541Increase in cytotoxicity in human DLD1 cells at 2 uM after 48 hrs in presence of 2 uM laxaphycin A by RRT assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280525Antiproliferative activity against drug-sensitive CCRF-CEM cells after 72 hrs in presence of 0.2 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280523Ratio of IC50 for teniposide-resistant CEM/VM1 cells over IC50 for drug-sensitive CCRF-CEM cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280512Cytotoxicity against human DLD1cells after 48 hrs by Hoechst 33342 assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280527Antiproliferative activity against drug-sensitive CCRF-CEM cells after 72 hrs in presence of 1 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280530Antiproliferative activity against vinblastine-resistant CEM/VLB100 after 72 hrs in presence of 0.4 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280520Cytotoxicity against vinblastine-resistant CEM/VLB100 cells after 72 hrs2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280539Increase in cytotoxicity in human DLD1 cells at 2 uM after 48 hrs in presence of 1 uM laxaphycin A by RRT assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280531Antiproliferative activity against vinblastine-resistant CEM/VLB100 after 72 hrs in presence of 1 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280526Antiproliferative activity against drug-sensitive CCRF-CEM cells after 72 hrs in presence of 0.4 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280537Survival of human DLD1 cells at 2 uM after 48 hrs by RRT assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280517Cytotoxicity against mouse L929 cells after 48 hrs by RRT2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280534Antiproliferative activity against teniposide-resistant CEM/VM1 after 72 hrs in presence of 0.4 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280516Cytotoxicity against human fibroblasts after 48 hrs by Hoechst 33342 assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280547Interaction index, ratio of IC50 for CEM/VM1 cells in presence of 0.4 uM laxaphycin A/IC50 for CEM/VM1 cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280551Interaction index, ratio of IC50 for CEM/VLB100 cells in presence of 0.4 uM laxaphycin A/IC50 for CEM/VLB100 cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280504Cytotoxicity against human PA1 cells after 48 hrs by Hoechst 33342 assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280521Cytotoxicity against teniposide-resistant CEM/VM1 cells after 72 hrs2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280553Interaction index, ratio of IC50 for CEM/VLB100 cells in presence of 2 uM laxaphycin A/IC50 for CEM/VLB100 cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280542Interaction index, ratio of IC50 for CCRF-CEM cells in presence of 0.2 uM laxaphycin A/IC50 for CCRF-CEM cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280510Cytotoxicity against human MCF7 cells after 48 hrs by Hoechst 33342 assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280513Cytotoxicity against human androgen-resistant PC3 cells after 48 hrs by RRT2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280545Interaction index, ratio of IC50 for CCRF-CEM cells in presence of 2 uM laxaphycin A/IC50 for CCRF-CEM cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280540Increase in cytotoxicity in human DLD1 cells at 2 uM after 48 hrs in presence of 1.5 uM laxaphycin A by RRT assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280550Interaction index, ratio of IC50 for CEM/VLB100 cells in presence of 0.2 uM laxaphycin A/IC50 for CEM/VLB100 cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280529Antiproliferative activity against vinblastine-resistant CEM/VLB100 after 72 hrs in presence of 0.2 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280548Interaction index, ratio of IC50 for CEM/VM1 cells in presence of 1 uM laxaphycin A/IC50 for CEM/VM1 cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280507Cytotoxicity against human M4Beu cells after 48 hrs by RRT2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280514Cytotoxicity against human androgen-resistant PC3 cells after 48 hrs by Hoechst 33342 assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280508Cytotoxicity against human M4Beu cells after 48 hrs by Hoechst 33342 assay2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280515Cytotoxicity against human fibroblasts after 48 hrs by RRT2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280519Cytotoxicity against drug-sensitive CCRF-CEM cells after 72 hrs2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280511Cytotoxicity against human DLD1cells after 48 hrs by RRT2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280509Cytotoxicity against human MCF7 cells after 48 hrs by RRT2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280543Interaction index, ratio of IC50 for CCRF-CEM cells in presence of 0.4 uM laxaphycin A/IC50 for CCRF-CEM cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280536Antiproliferative activity against teniposide-resistant CEM/VM1 after 72 hrs in presence of 2 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280552Interaction index, ratio of IC50 for CEM/VLB100 cells in presence of 1 uM laxaphycin A/IC50 for CEM/VLB100 cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280546Interaction index, ratio of IC50 for CEM/VM1 cells in presence of 0.2 uM laxaphycin A/IC50 for CEM/VM1 cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280535Antiproliferative activity against teniposide-resistant CEM/VM1 after 72 hrs in presence of 1 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280532Antiproliferative activity against vinblastine-resistant CEM/VLB100 after 72 hrs in presence of 2 uM laxaphycin A2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280505Cytotoxicity against human A459 cells after 48 hrs by RRT2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280522Ratio of IC50 for vinblastine-resistant CEM/VLB100 cells over IC50 for drug-sensitive CCRF-CEM cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280549Interaction index, ratio of IC50 for CEM/VM1 cells in presence of 2 uM laxaphycin A/IC50 for CEM/VM1 cells2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
AID280503Cytotoxicity against human PA1 cells after 48 hrs by RRT2007Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
Total structure and inhibition of tumor cell proliferation of laxaphycins.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's3 (42.86)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.60 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.60)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
vinblastine
[no description available]		2.0310
surfactin peptide
surfactin peptide: antineoplastic product isolated from Bacillus sp.		3.1410
laxaphycin a
Laxaphycin A: cyclic peptide from blue-green algae		2.4920
daptomycin
[no description available]		3.1410
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.2510
Malignant Melanoma
[description not available]		02.2510
Cancer of Ovary
[description not available]		02.2510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.2510
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.2510
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.2510
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.2510