azaspirene profile

azaspirene: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	11089957
MeSH ID	M0444086

Synonyms (10)

Synonym
azaspirene
461644-34-8
(5s,8r,9r)-2-(1e,3e)-1,3-hexadien-1-yl-8,9-dihydroxy-3-methyl-8-(phenylmethyl)-1-oxa-7-azaspiro(4.4)non-2-ene-4,6-dione
07570zaf3a ,
unii-07570zaf3a
azaspirene [mi]
1-oxa-7-azaspiro(4.4)non-2-ene-4,6-dione, 2-(1e,3e)-1,3-hexadien-1-yl-8,9-dihydroxy-3-methyl-8-(phenylmethyl)-, (5s,8r,9r)-
1-oxa-7-azaspiro(4.4)non-2-ene-4,6-dione, 2-((1e,3e)-1,3-hexadienyl)-8,9-dihydroxy-3-methyl-8-(phenylmethyl)-, (5s,8r,9r)-
(-)-azaspirene
(5s,8r,9r)-8-benzyl-2-[(1e,3e)-hexa-1,3-dienyl]-8,9-dihydroxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione

Research Excerpts

Treatment

Excerpt	Reference	Relevance
"Azaspirene treatment reduced the number of tumor-induced blood vessels."	( Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation. Asami, Y; Beebe, K; Kakeya, H; Kojima, S; Komi, Y; Neckers, L; Nishikawa, K; Osada, H, 2008)	2.51

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (57.14)	29.6817
2010's	3 (42.86)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.36 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.44 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.36)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (14.29%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
phenylnitrene [no description available]	2.03	1	0

Condition	Relationship Strength	Studies
Infections, Plasmodium [description not available]	3.09	1
Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.	3.09	1
Angiogenesis, Pathologic [description not available]	2.47	2
Cancer of the Uterus [description not available]	2.11	1
Carcinosarcoma A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)	7.11	1
Uterine Neoplasms Tumors or cancer of the UTERUS.	2.11	1

azaspirene

Description