Page last updated: 2024-12-07
amplidione
Description
Amplidione is a natural product with a complex polycyclic structure. It is a potent inhibitor of the enzyme farnesyltransferase, which is involved in the biosynthesis of prenylated proteins. Amplidione has been shown to have anti-cancer activity in vitro and in vivo. It is also a promising lead compound for the development of new antifungal agents. The synthesis of Amplidione has been achieved by several groups. The most efficient synthesis involves a series of ring-closing metathesis reactions. Amplidione is studied because of its interesting biological activity and its potential as a drug candidate. Its unique structure and activity make it a valuable tool for studying the mechanisms of protein prenylation. Amplidione is also being investigated for its potential use in treating a variety of diseases, including cancer and fungal infections.'
Amplidione: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 119667 |
| CHEMBL ID | 2105366 |
| SCHEMBL ID | 310129 |
| MeSH ID | M0042422 |
Synonyms (32)
| Synonym |
|---|
| ld 4610 |
| oxazidione [inn:dcf] |
| 1,3-indandione, 2-(morpholinomethyl)-2-phenyl- |
| 2-(morpholinomethyl)-2-phenyl-1,3-indandione |
| 2-phenyl-2-morpholinomethylindane-1,3-dione |
| phenyl-2-morpholinomethyl-2-indanedione |
| oxazidionum [inn-latin] |
| transidione |
| mofedione |
| 2-(morpholinomethyl)-2-phenyl-1,3-indanedione |
| oxaziziona [inn-spanish] |
| brn 1021293 |
| oxazidione |
| amplidione |
| einecs 248-550-2 |
| 27591-42-0 |
| 2-(morpholin-4-ylmethyl)-2-phenylindene-1,3-dione |
| oxaziziona |
| unii-opc1bn901y |
| oxazidionum |
| opc1bn901y , |
| CHEMBL2105366 |
| oxazidione [inn] |
| oxazidione [mi] |
| SCHEMBL310129 |
| oxazidion |
| AKOS030530572 |
| 2-(morpholinomethyl)-2-phenyl-1h-indene-1,3(2h)-dione |
| ld4610; transidione; amplidione |
| Q27285779 |
| 2-[(morpholin-4-yl)methyl]-2-phenyl-1h-indene-1,3(2h)-dione |
| DTXSID40872001 |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 13.13
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 13.13 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.92 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |