Page last updated: 2024-12-09

2-(4-bromophenyl)thiazolidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 2-(4-Bromophenyl)thiazolidine: Structure and Importance in Research

**2-(4-Bromophenyl)thiazolidine** is an organic compound with the molecular formula C9H10BrNS. It's a thiazolidine derivative, characterized by a five-membered ring containing sulfur and nitrogen atoms. The presence of a 4-bromophenyl group attached to the 2-position on the thiazolidine ring defines its specific structure.

**Importance in Research:**

This compound is significant in research for several reasons:

* **Pharmacological Activity:** Thiazolidines, in general, have demonstrated potential pharmacological activity. 2-(4-Bromophenyl)thiazolidine itself, or its derivatives, might exhibit activity as:
* **Anti-inflammatory agents:** This could be due to the potential interaction with inflammatory pathways.
* **Anti-microbial agents:** The sulfur and nitrogen atoms in the thiazolidine ring can be modified to create compounds with antimicrobial properties.
* **Anti-cancer agents:** The specific structural features of this molecule might allow for interaction with targets related to cancer growth and development.
* **Chemical Synthesis:** This compound can serve as a building block or intermediate in the synthesis of other complex molecules with desired pharmacological properties. The presence of the bromine atom allows for further functionalization and modification through various reactions.
* **Biological Studies:** 2-(4-Bromophenyl)thiazolidine can be used as a probe to study the mechanisms of action of specific enzymes or receptors related to the biological activities mentioned above.
* **Material Science:** This compound might be used to create novel materials with specific properties. For example, the thiazolidine ring might be incorporated into polymers with unique characteristics.

**Current Research:**

Currently, there is ongoing research on 2-(4-Bromophenyl)thiazolidine and its derivatives to explore its potential applications in medicine, materials science, and other fields. Researchers are investigating its synthesis, modifications, and biological activity to uncover its full potential and potential benefits.

**Note:** It's important to note that while 2-(4-Bromophenyl)thiazolidine has promising properties, further research is needed to fully understand its potential applications and safety profile.

Cross-References

ID SourceID
PubMed CID2771064
CHEMBL ID1536824
CHEBI ID105605
SCHEMBL ID2082827

Synonyms (27)

Synonym
2-(4-bromophenyl)-1,3-thiazolidine
MLS000678441
smr000323916
thiazolidine, 2-(4-bromophenyl)-
2-(p-bromophenyl)thiazolidine
brn 1211793
thiazolidine, 2-(p-bromophenyl)-
CHEBI:105605
F1912-0001
2-(4-bromophenyl)thiazolidine
AKOS003241051
NCGC00246619-01
HMS2721O10
2-(4-bromo-phenyl)-thiazolidine
67086-81-1
AKOS016050467
2-(4-bromophenyl)-1,3-thiazolane
SCHEMBL2082827
CHEMBL1536824
Q27183357
2-(4-bromo-phenyl)-thiazolidine, aldrichcpr
CS-0268106
F0804-0839
mfcd00985113
A917827
DTXSID40902630
EN300-236021
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
organobromine compoundA compound containing at least one carbon-bromine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency1.77830.004023.8416100.0000AID485290
Microtubule-associated protein tauHomo sapiens (human)Potency35.48130.180013.557439.8107AID1460; AID1468
P53Homo sapiens (human)Potency70.79460.07319.685831.6228AID504706
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency89.12510.035520.977089.1251AID504332
survival motor neuron protein isoform dHomo sapiens (human)Potency0.25120.125912.234435.4813AID1458
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.35 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.35)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]