Page last updated: 2024-12-06

10H-phenothiazine 5-oxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

10H-phenothiazine 5-oxide is a chemical compound that is structurally related to phenothiazine, a known antipsychotic drug. However, 10H-phenothiazine 5-oxide itself is not a drug.

Here's why it is important for research:

* **Precursor to Drugs:** It serves as a valuable synthetic precursor to various pharmacologically active compounds, including:
* **Antipsychotics:** Phenothiazine derivatives, like chlorpromazine and thioridazine, are widely used in the treatment of schizophrenia and other mental health disorders. 10H-phenothiazine 5-oxide can be used to synthesize these drugs.
* **Antihistamines:** Some derivatives are used in antihistamine medications for treating allergies.
* **Antiparasitic agents:** Certain derivatives are used in veterinary medicine to treat parasitic infections.

* **Biological Studies:** 10H-phenothiazine 5-oxide itself is not a drug, but it is used in research studies to:
* **Study the mechanism of action of phenothiazine derivatives:** By studying its interactions with biological systems, researchers can gain insights into how these drugs work.
* **Develop new drugs:** It can serve as a starting point for the development of new and improved drugs with similar pharmacological properties.
* **Explore its own potential biological activity:** While not currently used clinically, it is being investigated for potential therapeutic applications in different areas.

**Overall, 10H-phenothiazine 5-oxide is a valuable tool for research in drug development, biological studies, and the understanding of how phenothiazine derivatives work.** It is important to note that this compound is not used clinically itself, but rather as a starting point for further development.

Cross-References

ID SourceID
PubMed CID71014
CHEMBL ID1396515
CHEBI ID125466
SCHEMBL ID342511

Synonyms (42)

Synonym
1207-71-2
phenothiazine s-oxide
phenothiazine 5-oxide
nsc-3554
usaf do-16
nsc3554
nsc 3554
brn 0152295
phenothiazine-5-oxide
ai3-17437
smr000841349
MLS001242794
10h-phenothiazine 5-oxide ,
10h-phenothiazine, 5-oxide
phenothiazine, 5-oxide
CHEBI:125466
AKOS000281841
sr-01000852665
SR-01000852665-2 ,
STK802590
NCGC00247391-01
4-27-00-01215 (beilstein handbook reference)
10h-phenothiazine,5-oxide
HMS2201K15
HMS3341B02
SCHEMBL342511
DSAFSORWJPSMQS-UHFFFAOYSA-N
cid_71014
bdbm65852
CHEMBL1396515
Q27216086
DTXSID0074471
mfcd00053824
AT27299
BS-50659
BAA20771
10h-5lambda4-phenothiazin-5-one
EN300-309225
10h-5|e?-phenothiazin-5-one
10h-phenothiazine5-oxide
8SVJ4R3Y3D
Z1509140237
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenothiazines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
67.9K proteinVaccinia virusPotency2.23870.00018.4406100.0000AID720579
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency100.00000.354828.065989.1251AID504847
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
NADPH oxidase 1Homo sapiens (human)IC50 (µMol)20.00000.04401.26095.5000AID2538
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]