n-(4-carboxycyclohexylmethyl)maleimide n-hydroxysuccinimide ester profile

N-(4-carboxycyclohexylmethyl)maleimide N-hydroxysuccinimide ester: used in the preparation of rabbit Fab'-peroxidase conjugates [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate : An N-hydroxysuccinimide ester derived from 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	125175
CHEBI ID	63174
SCHEMBL ID	45664
SCHEMBL ID	181744
MeSH ID	M0084457

Synonyms (78)

Synonym
64987-85-5
nsc344483
nsc-344483
smcc
4-(n-maleimidomethyl)cyclohexanecarboxylic acid n-hydroxysuccinimide ester, >=98%, powder
n-(4-carboxycyclohexylmethyl)maleimide n-hydroxysuccinimide ester
(2,5-dioxopyrrolidin-1-yl) 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxylate
n-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate
A8849
n-succinimidyl 4-(n-maleimidomethyl)cyclohexane-1-carboxylate;2,5-dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)methyl)cyclohexanecarboxylate
4-(n-maleimidomethyl)cyclohexanecarboxylic acid n-succinimidyl ester
n-succinimidyl 4-(n-maleimidomethyl)cyclohexanecarboxylate
trans-4-(maleimidomethyl)cyclohexanecarboxylic acid-nhs
4-(maleimidomethyl)cyclohexanecarboxylic acid-nhs
n-succinimidyl 4-(n-maleimidomethyl)cyclohexane-1-carboxylate
c16h18n2o6
AKOS016014151
2,5-dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)methyl)cyclohexanecarboxylate
unii-b357p1g1if
n-smc-carboxylate
n-hydroxysuccinimidyl 4-(n-maleimidomethylcyclohexane)-1-carboxylate
1h-pyrrole-2,5-dione, 1-((4-(((2,5-dioxo-1-pyrrolidinyl)oxy)carbonyl)cyclohexyl)methyl)-
nsc 344483
n-succinimidyl-4-(n-maleimidomethyl)cyclohexane-1-carboxylic acid
b357p1g1if ,
BP-20230
BP-20408
71875-81-5
FT-0604024
FT-0604078
succinimidyl 4-(n-maleimidomethyl)cyclohexane-1-carboxylate
CHEBI:63174
1-[(4-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}cyclohexyl)methyl]-1h-pyrrole-2,5-dione
AM84931
2,5-dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)methyl)cyclohexane-1-carboxylate
AKOS015900701
2,5-dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)methyl)cy clohexanecarboxylate
succinimidyl-4-(n-maleimidomethyl)cyclohexane-1-carboxylate
cyclohexanecarboxylic acid, 4-((2,5-dihydro-2,5-dioxo-1h-pyrrol-1-yl)methyl)-, 2,5-dioxo-1-pyrrolidinyl ester
SCHEMBL45664
SCHEMBL181744
mfcd08274640
trans-n-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate
2,5-dioxopyrrolidin-1-yl 4-[(2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)methyl]cyclohexanecarboxylate
JJAHTWIKCUJRDK-UHFFFAOYSA-N
trans-2,5-dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)methyl)cyclohexanecarboxylate
AC-28738
DTXSID30215307
mfcd00009634
4-(maleimidomethyl)cyclohexane-1-carboxylic acid n-hydroxysuccinimide ester
smcc;(2,5-dioxopyrrolidin-1-yl) 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxylate;trans-2,5-dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)methyl)cyclohexanecarboxylate
J-507381
2,5-dioxopyrrolidin-1-yl (1r,4r)-4-[(2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)methyl]cyclohexane-1-carboxylate
AS-74774
BP-25107
CS-0058807
CS-B1513
2,5-dioxo-3-pyrrolidin-1-yl 4-[(2,5-dioxo-3-pyrrolin-1-yl)methyl]cyclohexanecarboxylate
succinimido 4-(n-maleimidomethyl)cyclohexanecarboxylate
HY-42360
SY019092
smcc crosslinker
succinimidyl trans-4-(maleimidylmethyl) cyclohexane-1-carboxylate
trans-2,5-dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)methyl)cyclohexane-1-carboxylate
succinimidyl 4-(n-maleimidomethyl)cyclohexanecarboxylate
Q27132436
AS-11123
BCP10445
AMY21359
n-succinimidyl 4-(n-maleimidomethyl)cycl
D70437
Q27274295
mal-amchc-osu
WCA87581
n-succinimidyl 4-(n-maleimidomethyl)cyclohexanecarboxylate (2mg*5)
U0143
trans-4-(maleimidomethyl)cyclohexanecarboxylic acid-nhs ester
SY034493

Class	Description
maleimides	Compounds containing a cyclic dicarboximide skeleton in which the two carboacyl groups on nitrogen together with the nitrogen itself form a 1H-pyrrole-2,5-dione structure.
N-hydroxysuccinimide ester	An ester of N-hydroxysuccinimide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (11.54)	18.7374
1990's	6 (23.08)	18.2507
2000's	5 (19.23)	29.6817
2010's	11 (42.31)	24.3611
2020's	1 (3.85)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	33 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
furosemide Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.. furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.	2	1	chlorobenzoic acid; furans; sulfonamide	environmental contaminant; loop diuretic; xenobiotic
glutaral Glutaral: One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.. glutaraldehyde : A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.	2	1	dialdehyde	cross-linking reagent; disinfectant; fixative
triiodothyronine Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.. 3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.	2	1	2-halophenol; amino acid zwitterion; iodophenol; iodothyronine	human metabolite; mouse metabolite; thyroid hormone
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2.13	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
stearylamine stearylamine: RN given refers to parent cpd. octadecan-1-amine : An 18-carbon primary aliphatic amine.	2.02	1	primary aliphatic amine	film-forming compound
fluorescein-5-isothiocyanate Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.	1.99	1	fluorescein isothiocyanate
dithiothreitol 1,4-dimercaptobutane-2,3-diol : A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group.. 1,4-dithiothreitol : The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.	2.44	2	1,4-dimercaptobutane-2,3-diol; butanediols; dithiol; glycol; thiol	chelator; human metabolite; reducing agent
technetium Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, and atomic number 43. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.	1.97	1	manganese group element atom
n-succinimidyl 3-(2-pyridyldithio)propionate N-succinimidyl 3-(2-pyridyldithio)propionate: heterobifunctional reagent	1.99	1
maytansine Maytansine: An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.. maytansine : An organic heterotetracyclic compound and 19-membered macrocyclic lactam antibiotic originally isolated from the Ethiopian shrub Maytenus serrata but also found in other Maytenus species. It exhibits cytotoxicity against many tumour cell lines.	3.02	4	alpha-amino acid ester; carbamate ester; epoxide; maytansinoid; organic heterotetracyclic compound; organochlorine compound	antimicrobial agent; antimitotic; antineoplastic agent; plant metabolite; tubulin modulator
diamide Diamide: A sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian cells.	1.99	1	1,1'-azobis(N,N-dimethylformamide)
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	1.99	1	carbon group element atom; metalloid atom; nonmetal atom
oligonucleotides [no description available]	2.11	1
15-amino-4,7,10,13-tetraoxapentadecanoic acid 15-amino-4,7,10,13-tetraoxapentadecanoic acid: structure in first source	2.05	1
hirudin Hirudin: A 65-residue polypeptide from LEECHES.	1.99	1
cyclosporine Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).	2.02	1
cord factors Cord Factors: Toxic glycolipids composed of trehalose dimycolate derivatives. They are produced by MYCOBACTERIUM TUBERCULOSIS and other species of MYCOBACTERIUM. They induce cellular dysfunction in animals.	2.13	1
metallothionein Metallothionein: A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.	1.97	1

Condition	Relationship Strength	Studies
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.31	1
Breast Cancer [description not available]	2.21	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.21	1
Malignant Melanoma [description not available]	2.11	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.11	1
Koch's Disease [description not available]	2.13	1
Pulmonary Consumption [description not available]	2.13	1
Tuberculosis Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.	2.13	1
Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung.	2.13	1
Central Nervous System Lyme Disease [description not available]	2.13	1
Adenocarcinoma, Basal Cell [description not available]	2.05	1
Adenocarcinoma Of Kidney [description not available]	2.05	1
Cancer of Colon [description not available]	2.05	1
Cancer of Kidney [description not available]	2.05	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.05	1
Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.	2.05	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.05	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	2.05	1
Germinoblastoma [description not available]	1.96	1
Lymphoma A general term for various neoplastic diseases of the lymphoid tissue.	1.96	1

n-(4-carboxycyclohexylmethyl)maleimide n-hydroxysuccinimide ester

Description

Cross-References

Synonyms (78)

Drug Classes (2)

Research

Studies (26)

Market Indicators

Research Demand Index: 11.30

Study Types

n-(4-carboxycyclohexylmethyl)maleimide n-hydroxysuccinimide ester

Description

Cross-References

Synonyms (78)

Drug Classes (2)

Research

Studies (26)

Market Indicators

Research Demand Index: 11.30

Study Types

Related Drugs (18)

Related Conditions (20)