ganglioside GP1c binding
Definition
Target type: molecularfunction
Binding to ganglioside GP1c. [GO_REF:0000067, GOC:TermGenie, PMID:1454804]
Ganglioside GP1c binding is a molecular function that describes the ability of a molecule to interact with the ganglioside GP1c, a complex glycolipid found on the surface of cells. GP1c is a member of the ganglioside family, which are characterized by their sialic acid content and their role in cell signaling and recognition. GP1c is particularly abundant in the nervous system, where it plays a role in neuronal development and function.
The binding of molecules to GP1c can have a variety of effects, depending on the nature of the molecule and its specific interaction with the ganglioside. For example, some molecules may bind to GP1c and activate signaling pathways, while others may block the binding of other molecules to GP1c, thereby inhibiting signaling.
The molecular function of ganglioside GP1c binding is of particular interest to researchers studying the nervous system, as it is involved in a variety of processes, including:
* **Neurite outgrowth:** GP1c is known to play a role in the growth and development of neuronal axons.
* **Synaptic plasticity:** The binding of molecules to GP1c can influence the strength and stability of synapses, which are the junctions between neurons.
* **Cell adhesion:** GP1c can interact with other cell surface molecules to mediate cell adhesion, which is essential for the formation and maintenance of tissues.
* **Viral entry:** Some viruses, such as the rabies virus, use GP1c as a receptor to enter cells.
The study of ganglioside GP1c binding is an active area of research, and new insights into its role in cell biology and disease are constantly being made. This research has the potential to lead to new therapies for a variety of neurological disorders.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Prosaposin | A prosaposin that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07602] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| fenretinide | 4-hydroxyphenyl retinamide : A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids. Fenretinide: A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent. | monocarboxylic acid amide; retinoid | antineoplastic agent; antioxidant |