ganglioside GT1b binding
Definition
Target type: molecularfunction
Binding to ganglioside GT1b. [GO_REF:0000067, GOC:TermGenie, PMID:1454804]
Ganglioside GT1b binding is a molecular function associated with proteins that interact with the complex glycosphingolipid, GT1b. GT1b, a member of the ganglioside family, is characterized by its unique structure, featuring a ceramide backbone with a complex oligosaccharide chain terminating in a sialic acid residue. This interaction plays a critical role in various biological processes, including cell signaling, cell adhesion, and neuronal development. The molecular function of GT1b binding involves the recognition and interaction of proteins with the specific structural features of GT1b. This recognition can be mediated by various mechanisms, including hydrogen bonding, electrostatic interactions, and hydrophobic interactions. The specific amino acid residues and their arrangement within the protein binding site determine the affinity and specificity of the interaction. Once bound, proteins can trigger downstream signaling cascades or modulate cellular functions by interacting with other proteins or cellular components. For instance, GT1b binding proteins can influence the activation of growth factor receptors, leading to cell proliferation and differentiation. Furthermore, these proteins can contribute to the formation of cell-cell junctions, promoting cell adhesion and tissue integrity. In the context of neuronal development, GT1b binding is crucial for axonal growth, synapse formation, and neuronal migration. The precise mechanisms underlying these functions are still being investigated, but it is evident that GT1b binding proteins play a multifaceted role in regulating cellular processes. These interactions are highly specific and often involve complex molecular recognition events, highlighting the intricate nature of biological systems.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Prosaposin | A prosaposin that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07602] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| fenretinide | 4-hydroxyphenyl retinamide : A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids. Fenretinide: A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent. | monocarboxylic acid amide; retinoid | antineoplastic agent; antioxidant |