proteasome core complex binding

Definition

Target type: molecularfunction

Binding to a proteasome core complex. [GOC:TermGenie, PMID:16096059]

Proteasome core complex binding is a molecular function associated with proteins that interact with the core particle of the proteasome. The proteasome is a large, multi-protein complex responsible for degrading ubiquitinated proteins. The core particle is the catalytic subunit of the proteasome, containing active sites that break down peptide bonds within target proteins. Proteins that bind to the proteasome core complex can have a variety of roles, including:

* **Targeting substrates:** Some proteins act as adaptors or chaperones, delivering ubiquitinated proteins to the proteasome for degradation. They may also facilitate the unfolding of the target protein, making it accessible to the proteasome's active sites.
* **Regulating proteasome activity:** Other proteins may bind to the proteasome core complex and modulate its activity, either enhancing or inhibiting its proteolytic function. This regulation can be important for controlling cellular processes that are dependent on protein degradation.
* **Stabilizing the proteasome:** Some proteins may interact with the proteasome core complex to provide structural support and maintain its integrity.

Overall, proteasome core complex binding is a crucial process that ensures efficient protein degradation within cells. It plays a vital role in numerous cellular processes, including cell cycle regulation, immune response, and stress response.'
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Proteins (1)

Compounds (1)