all-trans-retinol binding
Definition
Target type: molecularfunction
Binding to all-trans-retinol. [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452]
All-trans-retinol binding is a molecular function that describes the ability of a protein or molecule to bind to all-trans-retinol, a critical precursor of vitamin A. This binding is essential for the transport, storage, and metabolism of retinol. Retinol is a crucial molecule involved in a wide range of biological processes, including vision, growth, cell differentiation, immune function, and reproduction. All-trans-retinol binding proteins, such as retinol-binding protein (RBP), are responsible for transporting retinol from the liver to various tissues throughout the body. RBP binds to retinol with high affinity, protecting it from degradation and ensuring its efficient delivery to target cells. Upon reaching target tissues, retinol is released from RBP and taken up by cells via specific receptors. Inside cells, retinol is converted into its active forms, retinaldehyde and retinoic acid, which mediate diverse biological functions. The binding of retinol to proteins like RBP is a highly regulated process, involving specific interactions between the protein and retinol molecule. These interactions are essential for maintaining retinol homeostasis and ensuring its proper utilization by the body.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Cytochrome P450 2W1 | A cytochrome P450 2W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TAV3] | Homo sapiens (human) |
Compounds (4)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| tranylcypromine | (1R,2S)-tranylcypromine : A 2-phenylcyclopropan-1-amine that is the (1R,2S)-enantiomer of tranylcypromine. tranylcypromine : A racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine). Tranylcypromine: A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311) | 2-phenylcyclopropan-1-amine | |
| proadifen hydrochloride | |||
| pirlindole | pirlindole: RN given refers to parent cpd; synonym pyrazidol refers to mono-HCl; structure in Negwer, 5th ed, #2812 | carbazoles | |
| kaf156 | ganaplacide: antimalarial |