D3 vitamins binding

Definition

Target type: molecularfunction

Binding to D3 vitamins. [GOC:bf, GOC:TermGenie, PMID:9127467]

Vitamin D3, also known as cholecalciferol, is a secosteroid hormone that plays a crucial role in calcium homeostasis and bone metabolism. Its molecular function involves binding to the vitamin D receptor (VDR), a nuclear receptor protein, to regulate gene expression. Upon binding to VDR, vitamin D3 undergoes a series of metabolic transformations, including hydroxylation in the liver and kidneys, to form its active form, 1,25-dihydroxyvitamin D3 (calcitriol). Calcitriol then translocates to the nucleus and binds to VDR, forming a complex that interacts with specific DNA sequences known as vitamin D response elements (VDREs) located in the promoter regions of target genes. This interaction leads to the activation or repression of gene transcription, depending on the specific target gene. The genes regulated by vitamin D3 signaling are involved in various cellular processes, including calcium absorption in the intestines, bone mineralization, immune function, cell growth and differentiation, and inflammation. In summary, the molecular function of vitamin D3 binding involves its interaction with the VDR, leading to gene regulation and modulation of calcium homeostasis, bone metabolism, and other cellular processes.'
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Proteins (1)

Compounds (4)