proline binding

Definition

Target type: molecularfunction

Binding to proline. [GOC:pm, GOC:TermGenie, PMID:7730362]

Proline binding is a molecular function that describes the ability of a protein or other molecule to bind to the amino acid proline. Proline is a unique amino acid with a cyclic side chain, which gives it a rigid and constrained structure. This unique structure allows proline to play important roles in protein folding and stability, as well as in protein-protein interactions.

Proline binding can occur through a variety of mechanisms, including hydrogen bonding, hydrophobic interactions, and electrostatic interactions. The specific mechanism of proline binding will depend on the structure of the binding site and the nature of the interacting molecules.

Proline binding is important for a wide range of cellular processes, including:

* **Protein folding and stability:** Proline residues often occur in turns and loops in proteins, where they can help to stabilize the protein structure. Proline binding can also help to promote the formation of specific protein conformations.
* **Protein-protein interactions:** Proline residues can be involved in interactions between different proteins. These interactions can be important for signaling pathways, enzyme activity, and other cellular processes.
* **Enzyme activity:** Some enzymes require proline binding for their catalytic activity. For example, prolyl hydroxylases are enzymes that modify proline residues in proteins, and their activity is dependent on proline binding.

Proline binding is a complex and multifaceted process that plays a vital role in many cellular functions. Understanding the molecular mechanisms of proline binding is essential for understanding the behavior of proteins and other molecules in cells.'
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Proteins (1)

Compounds (1)