histone H4 methyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue. [PMID:28450737]

Histone H4 methyltransferases (H4MTases) are a family of enzymes responsible for catalyzing the transfer of a methyl group from a donor molecule, typically S-adenosyl methionine (SAM), to specific lysine residues on histone H4. This methylation event is a crucial epigenetic modification that plays a key role in regulating gene expression, DNA replication, and chromosome stability. H4MTases recognize specific histone H4 sequences and position them within their active sites, facilitating the transfer of a methyl group to the target lysine residue. The precise location and extent of methylation on histone H4 can influence the recruitment of other proteins, such as chromatin remodeling complexes, transcription factors, and DNA repair enzymes. H4MTases are essential for proper chromatin structure and function, and dysregulation of their activity can lead to developmental defects, cancer, and other diseases.'
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Proteins (8)

Compounds (9)