5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: a 5'-end (N2,N2,N7-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GMP. Can also use (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA as a substrate. [PMID:24742626, PMID:32723815]

5\\'-(N(7)-methyl 5\\'-triphosphoguanosine)-[mRNA] diphosphatase activity is an enzymatic activity that removes the diphosphate group from the 5\\' end of capped mRNA molecules, specifically the N7-methylguanosine cap. This activity is crucial for the proper processing and degradation of mRNA. The removal of the diphosphate group exposes the 5\\' monophosphate group, which can then be recognized by other enzymes involved in mRNA metabolism. For example, the 5\\' monophosphate group can be recognized by decapping enzymes, which remove the entire 5\\' cap, leading to mRNA degradation. Additionally, the 5\\' monophosphate group can be recognized by exonucleases, which degrade mRNA from the 5\\' end. In summary, the 5\\'-(N(7)-methyl 5\\'-triphosphoguanosine)-[mRNA] diphosphatase activity plays a vital role in regulating mRNA stability and degradation by controlling the accessibility of the 5\\' end of mRNA molecules to other enzymes involved in mRNA metabolism.'
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Proteins (1)

Compounds (2)