dihydroceramidase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine. [GOC:mah, PMID:10900202]

Dihydroceramidase activity is a hydrolase activity that catalyzes the hydrolysis of N-acylsphingosine, a ceramide analog, to sphingosine and a fatty acid. This reaction is a key step in the degradation of ceramides, which are important signaling molecules involved in a variety of cellular processes, including apoptosis, cell growth, and differentiation. Dihydroceramidase activity is also involved in the regulation of sphingolipid metabolism, which is important for maintaining cell membrane structure and function. Dihydroceramidase activity is found in a variety of tissues, including the brain, liver, and kidney. It is thought to play a role in a variety of physiological and pathological processes, including inflammation, neurodegeneration, and cancer.'
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Proteins (1)

Compounds (1)