armadillo repeat domain binding
Definition
Target type: molecularfunction
Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation. [GOC:BHF, GOC:mah, GOC:vk, InterPro:IPR000225]
Armadillo repeat domains are protein-protein interaction modules that are found in a wide variety of proteins. They are characterized by a series of repeated motifs, each of which consists of approximately 40 amino acids. These repeats fold into a helical structure that forms a groove, which can bind to other proteins. The binding of armadillo repeat domains to their targets is often mediated by specific amino acid sequences that are located within the groove. These sequences can be highly conserved, suggesting that they play an important role in the interaction. Armadillo repeat domains are involved in a wide variety of cellular processes, including signal transduction, cell adhesion, and transcription. They are also found in proteins that are involved in diseases such as cancer and Alzheimer's disease. The specific molecular function of armadillo repeat domain binding will depend on the specific protein that contains the domain. However, in general, armadillo repeat domains are involved in mediating protein-protein interactions, which are essential for many cellular processes.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Transcription factor 7-like 2 | A transcription factor 7-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQB0] | Homo sapiens (human) |
Compounds (4)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| salvin | salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae) | abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid | angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite |
| toxoflavin | toxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. toxoflavin: azapteridine antibiotic; structure | carbonyl compound; pyrimidotriazine | antibacterial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; toxin; virulence factor; Wnt signalling inhibitor |
| cercosporin | cercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora. cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants | ||
| ucn 1028 c | calphostin C: structure given in first source; isolated from Cladosporium cladosporioides |