all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
Definition
Target type: molecularfunction
Catalysis of the reaction: H2O + all-trans-retinyl palmitate = 11-cis-retinol + H+ + palmitate. [RHEA:31775]
All-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity, is a crucial enzyme in the visual cycle responsible for the regeneration of 11-cis retinal, the chromophore essential for light perception. This enzyme catalyzes the hydrolysis of all-trans-retinyl palmitate, a storage form of vitamin A, to all-trans retinol. Subsequently, all-trans retinol is isomerized to 11-cis retinol, which binds to opsin, a protein in the photoreceptor cells, to form rhodopsin, the primary photoreceptor molecule. This process is essential for the detection of light and the transmission of visual signals to the brain.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Retinoid isomerohydrolase | [no definition available] | Bos taurus (cattle) |
| Retinoid isomerohydrolase | A retinal pigment epithelium-specific 65 kDa protein that is encoded in the genome of chicken. [PRO:DNx] | Gallus gallus (chicken) |
Compounds (2)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| retinylamine | retinylamine: structure | ||
| phenyl-n-tert-butylnitrone | phenyl-N-tert-butylnitrone: a spin-trapping agent |