Page last updated: 2024-10-24

all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity

Definition

Target type: molecularfunction

Catalysis of the reaction: H2O + all-trans-retinyl palmitate = 11-cis-retinol + H+ + palmitate. [RHEA:31775]

All-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity, is a crucial enzyme in the visual cycle responsible for the regeneration of 11-cis retinal, the chromophore essential for light perception. This enzyme catalyzes the hydrolysis of all-trans-retinyl palmitate, a storage form of vitamin A, to all-trans retinol. Subsequently, all-trans retinol is isomerized to 11-cis retinol, which binds to opsin, a protein in the photoreceptor cells, to form rhodopsin, the primary photoreceptor molecule. This process is essential for the detection of light and the transmission of visual signals to the brain.'
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Proteins (2)

ProteinDefinitionTaxonomy
Retinoid isomerohydrolase [no definition available]Bos taurus (cattle)
Retinoid isomerohydrolaseA retinal pigment epithelium-specific 65 kDa protein that is encoded in the genome of chicken. [PRO:DNx]Gallus gallus (chicken)

Compounds (2)

CompoundDefinitionClassesRoles
retinylamineretinylamine: structure
phenyl-n-tert-butylnitronephenyl-N-tert-butylnitrone: a spin-trapping agent