chondroitin hydrolase activity

Definition

Target type: molecularfunction

Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]. [GOC:mengo_curators, PMID:18390555]

Chondroitin hydrolase activity is a type of enzymatic activity that involves the hydrolysis of chondroitin sulfate, a major component of cartilage. Chondroitin sulfate is a glycosaminoglycan, a long, unbranched polysaccharide chain that is composed of repeating disaccharide units. These disaccharides are composed of N-acetylgalactosamine and glucuronic acid, with a sulfate group attached to the N-acetylgalactosamine. Chondroitin hydrolases catalyze the cleavage of the glycosidic bond between these disaccharide units, leading to the degradation of chondroitin sulfate. This enzymatic activity is crucial for the turnover and remodeling of cartilage tissue. Chondroitin hydrolases can be found in a variety of organisms, including bacteria, fungi, and animals. In humans, chondroitin hydrolases are produced by chondrocytes, the cells that make up cartilage. These enzymes are involved in the maintenance of cartilage homeostasis, and their activity is regulated by a variety of factors, including growth factors, cytokines, and hormones. Dysregulation of chondroitin hydrolase activity has been implicated in the development of osteoarthritis, a degenerative joint disease. There are several different types of chondroitin hydrolases, each with its own specific substrate specificity and catalytic mechanism. Some chondroitin hydrolases are specific for chondroitin sulfate, while others can also hydrolyze other glycosaminoglycans, such as hyaluronic acid and dermatan sulfate. Chondroitin hydrolases are important enzymes in the degradation and metabolism of cartilage. They play a role in cartilage turnover and remodeling, and their dysregulation has been implicated in the development of osteoarthritis.'
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Proteins (1)

Compounds (4)