Page last updated: 2024-10-24

undecaprenyl-diphosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate. [PMID:18411271, RHEA:28094]

Undecaprenyl-diphosphatase activity is a critical enzymatic function involved in the biosynthesis of bacterial cell wall components. This enzyme specifically hydrolyzes the pyrophosphate bond in undecaprenyl diphosphate (UPP), a lipid carrier molecule essential for the transfer of peptidoglycan precursors across the bacterial cell membrane. The catalytic process releases undecaprenyl monophosphate (UMP) and inorganic pyrophosphate (PPi), effectively deactivating UPP and enabling its recycling. This activity is crucial for maintaining the integrity of the cell wall and ensuring proper bacterial cell growth and division. The enzyme utilizes a specific mechanism for substrate recognition and catalysis, often involving metal ions like magnesium (Mg2+) or manganese (Mn2+) for optimal activity. The precise details of the catalytic mechanism can vary depending on the specific bacterial species and enzyme structure.'
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Proteins (1)

ProteinDefinitionTaxonomy
Undecaprenyl-diphosphataseAn undecaprenyl-diphosphatase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P60932]Escherichia coli K-12

Compounds (1)

CompoundDefinitionClassesRoles
baci-imhomodetic cyclic peptide;
polypeptide;
zwitterion
antibacterial agent;
antimicrobial agent