inorganic triphosphate phosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: H2O + inorganic triphosphate = diphosphate + phosphate. [EC:3.6.1.25, RHEA:14157]

Inorganic triphosphate phosphatase activity catalyzes the hydrolysis of inorganic triphosphate (ITP) to inorganic diphosphate (IDP) and inorganic phosphate (Pi). ITP is a nucleoside triphosphate similar to ATP, but with inosine instead of adenine. This enzymatic activity is crucial for a variety of cellular processes, including:

- **Energy metabolism:** ITP can serve as an energy source in some metabolic pathways, and its hydrolysis by inorganic triphosphate phosphatase can contribute to the generation of energy in the form of Pi.

- **Signal transduction:** ITP can act as a signaling molecule in certain pathways, and its hydrolysis by inorganic triphosphate phosphatase can regulate these signaling cascades.

- **Phosphate homeostasis:** By hydrolyzing ITP, inorganic triphosphate phosphatase contributes to the regulation of phosphate levels within the cell, which is essential for various biological processes.

- **Purine metabolism:** ITP is an intermediate in purine nucleotide biosynthesis, and inorganic triphosphate phosphatase can play a role in the regulation of this metabolic pathway.

- **Nucleic acid synthesis:** ITP can be incorporated into RNA during transcription, and its hydrolysis by inorganic triphosphate phosphatase may influence this process.

- **Protein synthesis:** ITP can be used as an energy source for protein synthesis, and its hydrolysis by inorganic triphosphate phosphatase may regulate this process.

- **Regulation of enzyme activity:** ITP can act as an allosteric effector for certain enzymes, and its hydrolysis by inorganic triphosphate phosphatase can modulate the activity of these enzymes.

In summary, inorganic triphosphate phosphatase activity is a fundamental enzymatic activity involved in various cellular processes, including energy metabolism, signal transduction, phosphate homeostasis, purine metabolism, nucleic acid synthesis, protein synthesis, and the regulation of enzyme activity.'
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Proteins (1)

Compounds (1)