pantetheine kinase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate. [EC:2.7.1.34, MetaCyc:PANTETHEINE-KINASE-RXN]

Pantetheine kinase activity is an enzymatic function responsible for the phosphorylation of pantetheine. This reaction is crucial in the biosynthesis of coenzyme A (CoA), a vital cofactor involved in numerous metabolic pathways. The enzyme catalyzes the transfer of a phosphate group from ATP to the 4'-hydroxyl group of pantetheine, forming pantetheine-4'-phosphate. This phosphorylation step is essential for the subsequent steps in CoA biosynthesis, which involve the addition of a molecule of cysteine and an adenine nucleotide. Pantetheine kinase is a highly conserved enzyme found in all living organisms, and its activity is critical for maintaining cellular metabolism. It plays a key role in energy production, lipid metabolism, and amino acid metabolism. In addition to its role in CoA biosynthesis, pantetheine kinase has also been implicated in other cellular processes, such as oxidative stress response and apoptosis. Dysregulation of pantetheine kinase activity has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic disorders.'
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Proteins (1)

Compounds (2)