alkylglycerol kinase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H+. [EC:2.7.1.93, RHEA:16937]
Alkylglycerol kinase activity catalyzes the phosphorylation of diacylglycerol (DAG) and monoalkylglycerol (MAG) to form phosphatidic acid (PA) and alkylglycerol phosphate (AGP), respectively. This reaction is crucial for the biosynthesis of phospholipids, essential components of cell membranes. Alkylglycerol kinase activity plays a significant role in various cellular processes, including signal transduction, lipid metabolism, and membrane trafficking. It is involved in the production of PA, a key signaling molecule, and AGP, a precursor for ether phospholipids. Alkylglycerol kinase activity is also linked to the regulation of cell growth and proliferation. It is essential for maintaining membrane integrity and fluidity, and it plays a role in the formation of lipid rafts, specialized membrane domains involved in cellular signaling.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Diacylglycerol kinase alpha | A diacylglycerol kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23743] | Homo sapiens (human) |
Compounds (7)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| r 59022 | R 59022: diacylglycerol kinase inhibitor; structure given in first source; platelet activator factor antagonist | diarylmethane | |
| dioctanoyl ethylene glycol | |||
| ritanserin | ritanserin : A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action. Ritanserin: A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure. | organofluorine compound; piperidines; thiazolopyrimidine | antidepressant; antipsychotic agent; anxiolytic drug; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; serotonergic antagonist |
| cochlioquinone a | cochlioquinone A: from Helminthosporium sativum; competitive inhibitor of ivermectin binding; RN from Chem Abstract Index Guide 1990; structure given in first source | oxanes | |
| r 59949 | R 59949: diacylglycerol kinase inhibitor | diarylmethane | |
| 1-monooleoyl-rac-glycerol | 1-oleoylglycerol : A 1-monoglyceride where the acyl group is oleoyl. monooleoylglycerol : A monoglyceride in which the acyl group is oleoyl with the position of acylation unspecified. Peceol: lipid excipient containing readily dispersible mixture of mono- & diglycerides of oleic acid | 1-acylglycerol 18:1; monooleoylglycerol | plant metabolite |
| stemphone | stemphone: structure given in first source |