Page last updated: 2024-10-24
interleukin-1 type II receptor antagonist activity
Definition
Target type: molecularfunction
Blocks the binding of interleukin-1 to interleukin-1 type II receptors. [GOC:ebc]
Interleukin-1 type II receptor antagonist activity describes the ability of a molecule to inhibit the biological activity of interleukin-1 (IL-1) by binding to the IL-1 type II receptor (IL-1RII). IL-1RII is a decoy receptor that lacks the intracellular signaling domain required for IL-1 signaling. By binding to IL-1RII, antagonist molecules prevent IL-1 from binding to the signaling receptor, IL-1RI, thereby inhibiting downstream signaling pathways and the subsequent inflammatory responses. This mechanism effectively serves as a negative regulator of IL-1 activity, preventing excessive inflammation and tissue damage.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Interleukin-1 receptor antagonist protein | An interleukin-1 receptor antagonist protein that is encoded in the genome of human. [PRO:CNA, UniProtKB:P18510] | Homo sapiens (human) |
Compounds (2)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| ubenimex | ubenimex: growth inhibitor | ||
| angiotensin ii, des-asp(1)-des-arg(2)-ile(5)- | angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-: 3-8 hexapeptide fragment of angiotensin II; smallest potent angiotensin II antagonist | organic molecular entity |