Page last updated: 2024-10-24

gamma-catenin binding

Definition

Target type: molecularfunction

Binding to catenin complex gamma subunit. [GOC:bf]

Gamma-catenin binding is a crucial molecular interaction involved in the regulation of cell adhesion and signaling pathways. It is primarily mediated by the protein gamma-catenin, also known as plakoglobin, which acts as a linker molecule connecting cadherin adhesion receptors to the actin cytoskeleton. This binding event plays a pivotal role in maintaining cell-cell junctions, promoting cell-cell adhesion, and orchestrating various cellular processes, including:

- **Adherens Junction Formation and Stability:** Gamma-catenin, through its binding to cadherins, contributes to the assembly and stability of adherens junctions, which are specialized cell-cell adhesion structures that play a vital role in tissue integrity and development.

- **Signal Transduction:** Gamma-catenin serves as a platform for the recruitment and activation of various signaling molecules, including kinases and phosphatases, that regulate cell growth, differentiation, and survival.

- **Actin Cytoskeleton Dynamics:** By binding to both cadherins and actin filaments, gamma-catenin links the cell adhesion machinery to the underlying cytoskeleton, thereby influencing cytoskeletal organization and cell shape.

- **Cell Migration and Morphogenesis:** Gamma-catenin's ability to regulate cell adhesion and cytoskeletal dynamics is critical for processes like cell migration, wound healing, and embryonic development.

- **Tumor Suppression:** Gamma-catenin has been implicated in tumor suppression, with studies showing its involvement in suppressing cell proliferation and promoting cell adhesion.

In summary, gamma-catenin binding is a complex and essential molecular interaction that underpins various fundamental cellular processes, highlighting its significance in maintaining tissue integrity, regulating cell signaling, and contributing to normal physiological function.'
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Proteins (4)

ProteinDefinitionTaxonomy
Transcription factor 7-like 2A transcription factor 7-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQB0]Homo sapiens (human)
Receptor-type tyrosine-protein phosphatase etaA receptor-type tyrosine-protein phosphatase eta that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q12913]Homo sapiens (human)
Adenomatous polyposis coli proteinAn adenomatous polyposis coli protein that is encoded in the genome of human. [PMID:11283619, PMID:20823832, PRO:KER]Homo sapiens (human)
Cadherin-1A cadherin-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P12830]Homo sapiens (human)

Compounds (12)

CompoundDefinitionClassesRoles
1-(2-naphthalenyl)-3-[(phenylmethyl)-propan-2-ylamino]-1-propanoneZM39923: structure in first sourcenaphthalenes
beta-lapachonebeta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.

beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
benzochromenone;
orthoquinones
anti-inflammatory agent;
antineoplastic agent;
plant metabolite
vitamin k 3Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.1,4-naphthoquinones;
vitamin K
angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
salvinsalvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae)abietane diterpenoid;
carbotricyclic compound;
catechols;
monocarboxylic acid
angiogenesis modulating agent;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
food preservative;
HIV protease inhibitor;
plant metabolite
toxoflavintoxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7.

toxoflavin: azapteridine antibiotic; structure
carbonyl compound;
pyrimidotriazine
antibacterial agent;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite;
toxin;
virulence factor;
Wnt signalling inhibitor
celastrolmonocarboxylic acid;
pentacyclic triterpenoid
anti-inflammatory drug;
antineoplastic agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Hsp90 inhibitor;
metabolite
nsc 953971,4-naphthoquinones
cercosporincercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora.

cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants
ag-213tyrphostin 47: inhibits protein-tyrosine kinase activity of EGF-R both in vitro and in living cells;
rottlerinrottlerin : A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.

rottlerin: an angiogenesis inhibitor; an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III; RN refers to (E)-isomer; do not confuse this chalcone with an anthraquinone that is also called rottlerin (RN 481-72-1);
aromatic ketone;
benzenetriol;
chromenol;
enone;
methyl ketone
anti-allergic agent;
antihypertensive agent;
antineoplastic agent;
apoptosis inducer;
K-ATP channel agonist;
metabolite
gw-5074
ucn 1028 ccalphostin C: structure given in first source; isolated from Cladosporium cladosporioides