myosin II binding

Definition

Target type: molecularfunction

Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]

Myosin II is a motor protein that plays a crucial role in muscle contraction and other cellular processes. It binds to actin filaments, a key component of the cytoskeleton, and uses ATP hydrolysis to generate force and movement. The molecular function of myosin II binding involves a complex interplay of protein-protein interactions and conformational changes.

Here is a detailed breakdown:

**1. Actin Binding:** Myosin II contains a globular head domain that binds to actin filaments. This binding is highly specific and occurs at a specific site on the actin molecule. The interaction between myosin II and actin is crucial for the formation of actomyosin complexes, which are essential for muscle contraction and other cellular movements.

**2. ATP Hydrolysis:** Myosin II is an ATPase, meaning it can hydrolyze ATP to release energy. This energy is used to power the movement of myosin II along actin filaments. The hydrolysis of ATP causes a conformational change in the myosin II head, leading to a "power stroke" that propels the myosin II molecule along the actin filament.

**3. Conformational Changes:** The binding of ATP and its subsequent hydrolysis induce significant conformational changes in the myosin II molecule. These changes alter the affinity of myosin II for actin, allowing for a cyclical process of binding, movement, and detachment.

**4. Regulation:** The activity of myosin II is tightly regulated by a variety of factors, including calcium ions, phosphorylation, and other regulatory proteins. These regulatory mechanisms ensure that myosin II activity is controlled and coordinated with cellular needs.

**5. Diverse Functions:** Myosin II binding plays a crucial role in various cellular processes, including:
* Muscle contraction: Myosin II is the primary motor protein responsible for muscle contraction.
* Cell migration: Myosin II contributes to the movement of cells by driving the formation of stress fibers and lamellipodia.
* Cytokinesis: Myosin II is essential for the division of the cytoplasm during cell division.
* Organelle transport: Myosin II can move organelles within cells along actin tracks.
* Vesicle trafficking: Myosin II is involved in the movement of vesicles and other cargo within cells.

In summary, myosin II binding is a complex and essential process that involves a series of protein-protein interactions, conformational changes, and regulatory mechanisms. It plays a crucial role in a wide range of cellular functions, from muscle contraction to cell migration and organelle transport.'
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Proteins (1)

Compounds (1)