histone H2AK5 acetyltransferase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5). [EC:2.3.1.48]
Histone H2AK5 acetyltransferase activity refers to the enzymatic activity of proteins that specifically acetylate lysine 5 on histone H2A. This modification plays a crucial role in regulating gene expression and chromatin structure. Acetylation of lysine 5 on histone H2A is generally associated with increased gene transcription. The addition of an acetyl group to lysine 5 neutralizes its positive charge, which weakens the interaction between the histone and DNA. This, in turn, allows for greater accessibility of the DNA to transcription factors and other regulatory proteins. The specific mechanisms by which H2AK5 acetylation influences gene expression are complex and depend on the context of the cellular environment. However, several studies have demonstrated that H2AK5 acetylation is involved in a wide range of cellular processes, including DNA replication, DNA repair, and cell differentiation. In addition to its role in gene expression, H2AK5 acetylation has also been implicated in other cellular processes, such as DNA replication and repair. For instance, H2AK5 acetylation has been shown to promote the recruitment of DNA repair proteins to sites of DNA damage, suggesting a role in the repair of damaged DNA. H2AK5 acetylation is a dynamic process that is regulated by the interplay of histone acetyltransferases (HATs) and histone deacetylases (HDACs). HATs, such as the p300/CBP and GCN5 families of enzymes, catalyze the addition of acetyl groups to lysine residues on histones, including H2AK5. Conversely, HDACs, such as the HDAC1/2 and SIRT1 families of enzymes, remove acetyl groups from histones, including H2AK5. The balance between HAT and HDAC activity determines the acetylation status of H2AK5 and ultimately contributes to the regulation of gene expression and other cellular processes.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Histone acetyltransferase KAT5 | A histone acetyltransferase KAT5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92993] | Homo sapiens (human) |
Compounds (5)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| epigallocatechin gallate | (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis) | flavans; gallate ester; polyphenol | antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite |
| coenzyme a | adenosine 3',5'-bisphosphate | coenzyme; Escherichia coli metabolite; mouse metabolite | |
| anacardic acid | anacardic acid : A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities. anacardic acid: isolated from Anacardium occidentale; monophenol monooxygenase inhibitor | hydroxy monocarboxylic acid; hydroxybenzoic acid | anti-inflammatory agent; antibacterial agent; anticoronaviral agent; apoptosis inducer; EC 2.3.1.48 (histone acetyltransferase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; neuroprotective agent; plant metabolite |
| 2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acid | hydroxybenzoic acid | ||
| 1,2-bis(isothiazol-5-yl)disulfane | 1,2-bis(isothiazol-5-yl)disulfane: structure in first source |