histone H2A acetyltransferase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine. [EC:2.3.1.48]
Histone H2A acetyltransferase activity involves the enzymatic transfer of an acetyl group from acetyl coenzyme A (acetyl-CoA) to the ε-amino group of lysine residues on histone H2A. This post-translational modification plays a crucial role in regulating chromatin structure and gene expression. Histone acetylation generally leads to a more relaxed chromatin state, facilitating the access of transcription factors and other regulatory proteins to DNA. The acetylation of H2A can occur at specific lysine residues, and the precise location of acetylation can influence the functional outcome. For instance, acetylation at lysine 5 (K5) has been linked to increased transcription, while acetylation at lysine 119 (K119) has been implicated in DNA repair. The activity of histone H2A acetyltransferases is tightly regulated by various factors, including cellular signaling pathways, developmental cues, and environmental stresses. Dysregulation of histone H2A acetyltransferase activity has been associated with various human diseases, including cancer and neurodevelopmental disorders.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Histone acetyltransferase KAT5 | A histone acetyltransferase KAT5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92993] | Homo sapiens (human) |
Compounds (5)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| epigallocatechin gallate | (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis) | flavans; gallate ester; polyphenol | antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite |
| coenzyme a | adenosine 3',5'-bisphosphate | coenzyme; Escherichia coli metabolite; mouse metabolite | |
| anacardic acid | anacardic acid : A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities. anacardic acid: isolated from Anacardium occidentale; monophenol monooxygenase inhibitor | hydroxy monocarboxylic acid; hydroxybenzoic acid | anti-inflammatory agent; antibacterial agent; anticoronaviral agent; apoptosis inducer; EC 2.3.1.48 (histone acetyltransferase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; neuroprotective agent; plant metabolite |
| 2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acid | hydroxybenzoic acid | ||
| 1,2-bis(isothiazol-5-yl)disulfane | 1,2-bis(isothiazol-5-yl)disulfane: structure in first source |