histone H2A acetyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine. [EC:2.3.1.48]

Histone H2A acetyltransferase activity involves the enzymatic transfer of an acetyl group from acetyl coenzyme A (acetyl-CoA) to the ε-amino group of lysine residues on histone H2A. This post-translational modification plays a crucial role in regulating chromatin structure and gene expression. Histone acetylation generally leads to a more relaxed chromatin state, facilitating the access of transcription factors and other regulatory proteins to DNA. The acetylation of H2A can occur at specific lysine residues, and the precise location of acetylation can influence the functional outcome. For instance, acetylation at lysine 5 (K5) has been linked to increased transcription, while acetylation at lysine 119 (K119) has been implicated in DNA repair. The activity of histone H2A acetyltransferases is tightly regulated by various factors, including cellular signaling pathways, developmental cues, and environmental stresses. Dysregulation of histone H2A acetyltransferase activity has been associated with various human diseases, including cancer and neurodevelopmental disorders.'
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Proteins (1)

Compounds (5)