inositol 1,3,4,5 tetrakisphosphate binding
Definition
Target type: molecularfunction
Binding to inositol 1,3,4,5 tetrakisphosphate. [GOC:go_curators]
Inositol 1,3,4,5-tetrakisphosphate (IP4) binding is a crucial molecular function in cellular signaling pathways, particularly those involving calcium homeostasis, membrane trafficking, and cellular growth. IP4, a second messenger molecule derived from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), exerts its effects through interactions with specific IP4-binding proteins. These proteins, known as IP4 receptors, exhibit high affinity for IP4 and often possess other functional domains, such as protein kinase or phosphatase activity. Binding of IP4 to these receptors triggers a cascade of downstream events, leading to the regulation of cellular processes. One key role of IP4 binding is in calcium signaling. IP4 can activate calcium release channels in the endoplasmic reticulum, leading to an increase in cytosolic calcium concentration. This calcium surge initiates various downstream pathways, including muscle contraction, enzyme activation, and gene expression. Additionally, IP4 binding is implicated in membrane trafficking, including vesicle formation, exocytosis, and endocytosis. IP4-binding proteins often play a role in the assembly and function of protein complexes involved in these processes, ensuring the proper transport of molecules within the cell. Furthermore, IP4 binding is linked to cell growth and proliferation. IP4 can activate signaling pathways that promote cell division and survival, suggesting its involvement in the regulation of cellular growth and development. In summary, inositol 1,3,4,5-tetrakisphosphate binding serves as a crucial signaling mechanism, regulating various cellular processes through its interactions with specific receptor proteins. These interactions trigger downstream events that influence calcium homeostasis, membrane trafficking, and cell growth, underscoring the significance of IP4 binding in maintaining cellular function and homeostasis.'
```
"
Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Inositol 1,4,5-trisphosphate receptor type 3 | An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14573] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| inositol 1,4,5-trisphosphate | Inositol 1,4,5-Trisphosphate: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. | myo-inositol trisphosphate | mouse metabolite |