lysophosphatidic acid binding

Definition

Target type: molecularfunction

Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors. [GOC:curators]

Lysophosphatidic acid (LPA) is a bioactive phospholipid that acts as a signaling molecule involved in a wide range of cellular processes, including cell growth, proliferation, migration, differentiation, and survival. LPA exerts its effects by binding to specific G protein-coupled receptors (GPCRs) known as LPA receptors.

LPA binding to its receptors triggers a cascade of intracellular signaling events. The primary mechanism involves the activation of heterotrimeric G proteins, which are coupled to the receptor. Upon LPA binding, the receptor undergoes conformational changes that activate the G protein, leading to the dissociation of its α subunit from the βγ subunits.

The activated α subunit can interact with downstream signaling molecules, including phospholipases, adenylyl cyclases, and ion channels, resulting in the production of second messengers, such as inositol trisphosphate (IP3) and diacylglycerol (DAG). These second messengers further activate downstream signaling pathways, including the phosphoinositide 3-kinase (PI3K)/AKT pathway, the mitogen-activated protein kinase (MAPK) pathway, and the Rho/ROCK pathway.

The activation of these signaling pathways ultimately leads to the regulation of various cellular functions, including cytoskeletal reorganization, gene expression, and cell cycle progression.

In summary, LPA binding to its receptors initiates a complex series of intracellular signaling events that involve the activation of G proteins, the production of second messengers, and the activation of downstream signaling pathways, ultimately leading to the regulation of various cellular processes.'
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Proteins (2)

Compounds (6)