macrophage migration inhibitory factor binding

Definition

Target type: molecularfunction

Binding to the cytokine, macrophage migration inhibitory factor. [GOC:BHF, PMID:19601712]

Macrophage migration inhibitory factor (MIF) binding is a complex process that involves the interaction of MIF with its cognate receptor, CD74, and the subsequent activation of downstream signaling pathways. This interaction plays a crucial role in a wide range of biological processes, including inflammation, immunity, and cancer.

MIF is a pro-inflammatory cytokine that is produced by various cells, including macrophages, lymphocytes, and epithelial cells. It is involved in the regulation of immune responses, particularly in the activation of macrophages and T cells. MIF binds to CD74, which is a type I transmembrane protein that is widely expressed on various cell types. Upon binding to CD74, MIF triggers a cascade of intracellular signaling events.

The molecular mechanisms underlying MIF-mediated signaling are not fully understood, but several pathways have been implicated. One pathway involves the activation of the MAPK signaling cascade, leading to the phosphorylation of ERK, JNK, and p38 MAP kinases. These kinases play important roles in regulating cell proliferation, differentiation, and survival.

Another pathway involves the activation of the PI3K/Akt signaling pathway, which promotes cell survival and inhibits apoptosis. MIF binding to CD74 can also activate the NF-κB signaling pathway, which is a key regulator of inflammation and immune responses.

The activation of these signaling pathways by MIF has been shown to have diverse effects on cells. MIF promotes the recruitment and activation of macrophages, the production of inflammatory cytokines, and the proliferation and survival of cancer cells.

Overall, MIF binding to CD74 is a critical event that initiates a series of intracellular signaling pathways that regulate a variety of biological processes. This interaction plays a significant role in inflammation, immunity, and cancer development. The precise molecular mechanisms underlying these effects are still under investigation, but further research is expected to provide a better understanding of the role of MIF in health and disease.'
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Proteins (2)

Compounds (3)