chondroitin sulfate binding

Definition

Target type: molecularfunction

Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). [GOC:kmv, ISBN:0198506732]

Chondroitin sulfate binding is a molecular function that describes the ability of proteins to interact with chondroitin sulfate, a glycosaminoglycan (GAG) component of the extracellular matrix (ECM). Chondroitin sulfate is a linear polysaccharide composed of repeating disaccharide units of N-acetylgalactosamine and glucuronic acid, modified by sulfation. It plays a crucial role in structural integrity, cell signaling, and development.

Proteins that bind chondroitin sulfate typically possess specific domains or motifs that recognize and interact with the sulfate groups and the sugar backbone of chondroitin sulfate. These interactions are often mediated by electrostatic interactions, hydrogen bonds, and hydrophobic interactions.

The molecular function of chondroitin sulfate binding is involved in a wide range of biological processes, including:

* **ECM organization and integrity:** Chondroitin sulfate binding proteins help to assemble and maintain the structural integrity of the ECM. They can interact with other ECM components, such as collagen and hyaluronan, to form complex structures that provide support and cushioning for tissues.
* **Cell adhesion and migration:** Chondroitin sulfate binding proteins can facilitate cell adhesion and migration by interacting with cell surface receptors. These interactions can influence cell behavior, such as proliferation, differentiation, and wound healing.
* **Signal transduction:** Chondroitin sulfate binding proteins can act as receptors or co-receptors for signaling molecules. They can bind to growth factors or other signaling molecules and initiate intracellular signaling cascades, leading to changes in gene expression or cellular function.
* **Development:** Chondroitin sulfate binding proteins play important roles in development, particularly in the formation and maintenance of cartilage, bone, and other tissues. They can influence cell fate and morphogenesis.

The specific biological roles of chondroitin sulfate binding proteins vary depending on the protein and its cellular context. However, their ability to interact with chondroitin sulfate is fundamental to their function and is essential for a wide range of biological processes.'
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Proteins (1)

Compounds (4)